Factors Affecting Age at Initial Autism Spectrum Disorder Diagnosis in a National Survey / Rebecca E. ROSENBERG in Autism Research and Treatment, (May 2011)  

Public ISBD [article]  inAutism Research and Treatment > (May 2011) . - 11 p. Titre : Factors Affecting Age at Initial Autism Spectrum Disorder Diagnosis in a National Survey Type de document : Texte imprimé et/ou numérique Auteurs : Rebecca E. ROSENBERG, Auteur ; Rebecca LANDA, Auteur ; J. Kiely LAW, Auteur ; Elizabeth A. STUART, Auteur ; Paul A. LAW, Auteur Année de publication : 2011 Article en page(s) : 11 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Entry into early intervention depends on both age of first parent concern (AOC) and age at initial autism spectrum disorder (ASD) diagnosis (AOD). Using data collected from a national online registry from 6214 children diagnosed with an ASD between 1994 and 2010 in the US, we analyzed the effect of individual, family, and geographic covariates on AOC and AOD in a multivariate linear regression model with random effects. Overall, no single modifiable factor associated with AOC or AOD emerged but cumulative variation in certain individual- and family-based features, as well as some geographic factors, all contribute to AOC and AOD variation. A multipronged strategy is needed for targeted education and awareness campaigns to maximize outcomes and decrease disparities in ASD care. En ligne : http://dx.doi.org/10.1155/2011/874619 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141 [article] Factors Affecting Age at Initial Autism Spectrum Disorder Diagnosis in a National Survey [Texte imprimé et/ou numérique] / Rebecca E. ROSENBERG, Auteur ; Rebecca LANDA, Auteur ; J. Kiely LAW, Auteur ; Elizabeth A. STUART, Auteur ; Paul A. LAW, Auteur . - 2011 . - 11 p. Langues : Anglais (eng) in Autism Research and Treatment > (May 2011) . - 11 p. Index. décimale : PER Périodiques Résumé : Entry into early intervention depends on both age of first parent concern (AOC) and age at initial autism spectrum disorder (ASD) diagnosis (AOD). Using data collected from a national online registry from 6214 children diagnosed with an ASD between 1994 and 2010 in the US, we analyzed the effect of individual, family, and geographic covariates on AOC and AOD in a multivariate linear regression model with random effects. Overall, no single modifiable factor associated with AOC or AOD emerged but cumulative variation in certain individual- and family-based features, as well as some geographic factors, all contribute to AOC and AOD variation. A multipronged strategy is needed for targeted education and awareness campaigns to maximize outcomes and decrease disparities in ASD care. En ligne : http://dx.doi.org/10.1155/2011/874619 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141

Intervention targeting development of socially synchronous engagement in toddlers with autism spectrum disorder: a randomized controlled trial / Rebecca LANDA in Journal of Child Psychology and Psychiatry, 52-1 (January 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-1 (January 2011) . - p. 13-21 Titre : Intervention targeting development of socially synchronous engagement in toddlers with autism spectrum disorder: a randomized controlled trial Type de document : Texte imprimé et/ou numérique Auteurs : Rebecca LANDA, Auteur ; Katherine C. HOLMAN, Auteur ; Allison H. O'NEILL, Auteur ; Elizabeth A. STUART, Auteur Année de publication : 2011 Article en page(s) : p. 13-21 Langues : Anglais (eng) Mots-clés : Autistic disorder  intervention Index. décimale : PER Périodiques Résumé : Background:  Social and communication impairments are core deficits and prognostic indicators of autism. We evaluated the impact of supplementing a comprehensive intervention with a curriculum targeting socially synchronous behavior on social outcomes of toddlers with autism spectrum disorders (ASD). Methods:  Fifty toddlers with ASD, ages 21 to 33 months, were randomized to one of two six-month interventions: Interpersonal Synchrony or Non-Interpersonal Synchrony. The interventions provided identical intensity (10 hours per week in classroom), student-to-teacher ratio, schedule, home-based parent training (1.5 hours per month), parent education (38 hours), and instructional strategies, except the Interpersonal Synchrony condition provided a supplementary curriculum targeting socially engaged imitation, joint attention, and affect sharing; measures of these were primary outcomes. Assessments were conducted pre-intervention, immediately post-intervention, and, to assess maintenance, at six-month follow-up. Random effects models were used to examine differences between groups over time. Secondary analyses examined gains in expressive language and nonverbal cognition, and time effects during the intervention and follow-up periods. Results:  A significant treatment effect was found for socially engaged imitation (p = .02), with more than doubling (17% to 42%) of imitated acts paired with eye contact in the Interpersonal Synchrony group after the intervention. This skill was generalized to unfamiliar contexts and maintained through follow-up. Similar gains were observed for initiation of joint attention and shared positive affect, but between-group differences did not reach statistical significance. A significant time effect was found for all outcomes (p < .001); greatest change occurred during the intervention period, particularly in the Interpersonal Synchrony group. Conclusions:  This is the first ASD randomized trial involving toddlers to identify an active ingredient for enhancing socially engaged imitation. Adding social engagement targets to intervention improves short-term outcome at no additional cost to the intervention. The social, language, and cognitive gains in our participants provide evidence for plasticity of these developmental systems in toddlers with ASD. http://www.clinicaltrials.gov/ct2/show/NCT00106210?term = landa&rank = 3. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02288.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=113 [article] Intervention targeting development of socially synchronous engagement in toddlers with autism spectrum disorder: a randomized controlled trial [Texte imprimé et/ou numérique] / Rebecca LANDA, Auteur ; Katherine C. HOLMAN, Auteur ; Allison H. O'NEILL, Auteur ; Elizabeth A. STUART, Auteur . - 2011 . - p. 13-21. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-1 (January 2011) . - p. 13-21 Mots-clés : Autistic disorder  intervention Index. décimale : PER Périodiques Résumé : Background:  Social and communication impairments are core deficits and prognostic indicators of autism. We evaluated the impact of supplementing a comprehensive intervention with a curriculum targeting socially synchronous behavior on social outcomes of toddlers with autism spectrum disorders (ASD). Methods:  Fifty toddlers with ASD, ages 21 to 33 months, were randomized to one of two six-month interventions: Interpersonal Synchrony or Non-Interpersonal Synchrony. The interventions provided identical intensity (10 hours per week in classroom), student-to-teacher ratio, schedule, home-based parent training (1.5 hours per month), parent education (38 hours), and instructional strategies, except the Interpersonal Synchrony condition provided a supplementary curriculum targeting socially engaged imitation, joint attention, and affect sharing; measures of these were primary outcomes. Assessments were conducted pre-intervention, immediately post-intervention, and, to assess maintenance, at six-month follow-up. Random effects models were used to examine differences between groups over time. Secondary analyses examined gains in expressive language and nonverbal cognition, and time effects during the intervention and follow-up periods. Results:  A significant treatment effect was found for socially engaged imitation (p = .02), with more than doubling (17% to 42%) of imitated acts paired with eye contact in the Interpersonal Synchrony group after the intervention. This skill was generalized to unfamiliar contexts and maintained through follow-up. Similar gains were observed for initiation of joint attention and shared positive affect, but between-group differences did not reach statistical significance. A significant time effect was found for all outcomes (p < .001); greatest change occurred during the intervention period, particularly in the Interpersonal Synchrony group. Conclusions:  This is the first ASD randomized trial involving toddlers to identify an active ingredient for enhancing socially engaged imitation. Adding social engagement targets to intervention improves short-term outcome at no additional cost to the intervention. The social, language, and cognitive gains in our participants provide evidence for plasticity of these developmental systems in toddlers with ASD. http://www.clinicaltrials.gov/ct2/show/NCT00106210?term = landa&rank = 3. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02288.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=113

Latent class analysis of early developmental trajectory in baby siblings of children with autism / Rebecca LANDA in Journal of Child Psychology and Psychiatry, 53-9 (September 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-9 (September 2012) . - p.986-96 Titre : Latent class analysis of early developmental trajectory in baby siblings of children with autism Type de document : Texte imprimé et/ou numérique Auteurs : Rebecca LANDA, Auteur ; Alden L. GROSS, Auteur ; Elizabeth A. STUART, Auteur ; Margaret L. BAUMAN, Auteur Année de publication : 2012 Article en page(s) : p.986-96 Langues : Anglais (eng) Mots-clés : Autism  trajectories  broader autism phenotype Index. décimale : PER Périodiques Résumé : Background:  Siblings of children with autism (sibs-A) are at increased genetic risk for autism spectrum disorders (ASD) and milder impairments. To elucidate diversity and contour of early developmental trajectories exhibited by sibs-A, regardless of diagnostic classification, latent class modeling was used. Methods:  Sibs-A (N = 204) were assessed with the Mullen Scales of Early Learning from age 6 to 36 months. Mullen T scores served as dependent variables. Outcome classifications at age 36 months included: ASD (N = 52); non-ASD social/communication delay (broader autism phenotype; BAP; N = 31); and unaffected (N = 121). Child-specific patterns of performance were studied using latent class growth analysis. Latent class membership was then related to diagnostic outcome through estimation of within-class proportions of children assigned to each diagnostic classification. Results:  A 4-class model was favored. Class 1 represented accelerated development and consisted of 25.7% of the sample, primarily unaffected children. Class 2 (40.0% of the sample), was characterized by normative development with above-average nonverbal cognitive outcome. Class 3 (22.3% of the sample) was characterized by receptive language, and gross and fine motor delay. Class 4 (12.0% of the sample), was characterized by widespread delayed skill acquisition, reflected by declining trajectories. Children with an outcome diagnosis of ASD were spread across Classes 2, 3, and 4. Conclusions:  Results support a category of ASD that involves slowing in early non-social development. Receptive language and motor development is vulnerable to early delay in sibs-A with and without ASD outcomes. Non-ASD sibs-A are largely distributed across classes depicting average or accelerated development. Developmental trajectories of motor, language, and cognition appear independent of communication and social delays in non-ASD sibs-A. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02558.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179 [article] Latent class analysis of early developmental trajectory in baby siblings of children with autism [Texte imprimé et/ou numérique] / Rebecca LANDA, Auteur ; Alden L. GROSS, Auteur ; Elizabeth A. STUART, Auteur ; Margaret L. BAUMAN, Auteur . - 2012 . - p.986-96. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-9 (September 2012) . - p.986-96 Mots-clés : Autism  trajectories  broader autism phenotype Index. décimale : PER Périodiques Résumé : Background:  Siblings of children with autism (sibs-A) are at increased genetic risk for autism spectrum disorders (ASD) and milder impairments. To elucidate diversity and contour of early developmental trajectories exhibited by sibs-A, regardless of diagnostic classification, latent class modeling was used. Methods:  Sibs-A (N = 204) were assessed with the Mullen Scales of Early Learning from age 6 to 36 months. Mullen T scores served as dependent variables. Outcome classifications at age 36 months included: ASD (N = 52); non-ASD social/communication delay (broader autism phenotype; BAP; N = 31); and unaffected (N = 121). Child-specific patterns of performance were studied using latent class growth analysis. Latent class membership was then related to diagnostic outcome through estimation of within-class proportions of children assigned to each diagnostic classification. Results:  A 4-class model was favored. Class 1 represented accelerated development and consisted of 25.7% of the sample, primarily unaffected children. Class 2 (40.0% of the sample), was characterized by normative development with above-average nonverbal cognitive outcome. Class 3 (22.3% of the sample) was characterized by receptive language, and gross and fine motor delay. Class 4 (12.0% of the sample), was characterized by widespread delayed skill acquisition, reflected by declining trajectories. Children with an outcome diagnosis of ASD were spread across Classes 2, 3, and 4. Conclusions:  Results support a category of ASD that involves slowing in early non-social development. Receptive language and motor development is vulnerable to early delay in sibs-A with and without ASD outcomes. Non-ASD sibs-A are largely distributed across classes depicting average or accelerated development. Developmental trajectories of motor, language, and cognition appear independent of communication and social delays in non-ASD sibs-A. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02558.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179

Prenatal exposure to fever is associated with autism spectrum disorder in the boston birth cohort / Martha BRUCATO in Autism Research, 10-11 (November 2017)  

Public ISBD [article]  inAutism Research > 10-11 (November 2017) . - p.1878-1890 Titre : Prenatal exposure to fever is associated with autism spectrum disorder in the boston birth cohort Type de document : Texte imprimé et/ou numérique Auteurs : Martha BRUCATO, Auteur ; Christine LADD-ACOSTA, Auteur ; Mengying LI, Auteur ; Deanna CARUSO, Auteur ; Xiumei HONG, Auteur ; Jamie KACZANIUK, Auteur ; Elizabeth A. STUART, Auteur ; M. Daniele FALLIN, Auteur ; Xiaobin WANG, Auteur Article en page(s) : p.1878-1890 Langues : Anglais (eng) Mots-clés : autism spectrum disorder (ASD)  environmental exposure  maternal exposure  fever  epidemiology  risk factors  minority health Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is phenotypically and etiologically heterogeneous, with evidence for genetic and environmental contributions to disease risk. Research has focused on the prenatal period as a time where environmental exposures are likely to influence risk for ASD. Epidemiological studies have shown significant associations between prenatal exposure to maternal immune activation (MIA), caused by infections and fever, and ASD. However, due to differences in study design and exposure measurements no consistent patterns have emerged revealing specific times or type of MIA exposure that are most important to ASD risk. No prior studies have examined prenatal MIA exposure and ASD risk in an under-represented minority population of African ancestry. To overcome these limitations, we estimated the association between prenatal exposure to fever and maternal infections and ASD in a prospective birth cohort of an understudied minority population in a city in the United States. No association was found between prenatal exposure to genitourinary infections or flu and the risk of ASD in a nested sample of 116 ASD cases and 988 typically developing controls in crude or adjusted analyses. Prenatal exposure to fever was associated with increased ASD risk (aOR 2.02 [1.04–3.92]) after adjustment for educational attainment, marital status, race, child sex, maternal age, birth year, gestational age, and maternal smoking. This effect may be specific to fever during the third trimester (aOR 2.70 [1.00–7.29]). Our findings provide a focus for future research efforts and ASD prevention strategies across diverse populations. Autism Res 2017, 10: 1878–1890. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary We looked at whether activation of the immune system during pregnancy increases the chance a child will develop ASD. We examined 116 children with ASD and 988 children without ASD that came from a predominantly low income, urban, minority population. We found that having the flu or genitourinary tract infections during pregnancy is not related to the child being diagnosed with ASD. However, we did find children were at increased risk for ASD when their mothers had a fever during pregnancy. En ligne : http://dx.doi.org/10.1002/aur.1841 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322 [article] Prenatal exposure to fever is associated with autism spectrum disorder in the boston birth cohort [Texte imprimé et/ou numérique] / Martha BRUCATO, Auteur ; Christine LADD-ACOSTA, Auteur ; Mengying LI, Auteur ; Deanna CARUSO, Auteur ; Xiumei HONG, Auteur ; Jamie KACZANIUK, Auteur ; Elizabeth A. STUART, Auteur ; M. Daniele FALLIN, Auteur ; Xiaobin WANG, Auteur . - p.1878-1890. Langues : Anglais (eng) in Autism Research > 10-11 (November 2017) . - p.1878-1890 Mots-clés : autism spectrum disorder (ASD)  environmental exposure  maternal exposure  fever  epidemiology  risk factors  minority health Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is phenotypically and etiologically heterogeneous, with evidence for genetic and environmental contributions to disease risk. Research has focused on the prenatal period as a time where environmental exposures are likely to influence risk for ASD. Epidemiological studies have shown significant associations between prenatal exposure to maternal immune activation (MIA), caused by infections and fever, and ASD. However, due to differences in study design and exposure measurements no consistent patterns have emerged revealing specific times or type of MIA exposure that are most important to ASD risk. No prior studies have examined prenatal MIA exposure and ASD risk in an under-represented minority population of African ancestry. To overcome these limitations, we estimated the association between prenatal exposure to fever and maternal infections and ASD in a prospective birth cohort of an understudied minority population in a city in the United States. No association was found between prenatal exposure to genitourinary infections or flu and the risk of ASD in a nested sample of 116 ASD cases and 988 typically developing controls in crude or adjusted analyses. Prenatal exposure to fever was associated with increased ASD risk (aOR 2.02 [1.04–3.92]) after adjustment for educational attainment, marital status, race, child sex, maternal age, birth year, gestational age, and maternal smoking. This effect may be specific to fever during the third trimester (aOR 2.70 [1.00–7.29]). Our findings provide a focus for future research efforts and ASD prevention strategies across diverse populations. Autism Res 2017, 10: 1878–1890. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary We looked at whether activation of the immune system during pregnancy increases the chance a child will develop ASD. We examined 116 children with ASD and 988 children without ASD that came from a predominantly low income, urban, minority population. We found that having the flu or genitourinary tract infections during pregnancy is not related to the child being diagnosed with ASD. However, we did find children were at increased risk for ASD when their mothers had a fever during pregnancy. En ligne : http://dx.doi.org/10.1002/aur.1841 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322

Relationship Status Among Parents of Children with Autism Spectrum Disorders: A Population-Based Study / Brian FREEDMAN in Journal of Autism and Developmental Disorders, 42-4 (April 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-4 (April 2012) . - p.539-548 Titre : Relationship Status Among Parents of Children with Autism Spectrum Disorders: A Population-Based Study Type de document : Texte imprimé et/ou numérique Auteurs : Brian FREEDMAN, Auteur ; Luther G. KALB, Auteur ; Benjamin ZABLOTSKY, Auteur ; Elizabeth A. STUART, Auteur Année de publication : 2012 Article en page(s) : p.539-548 Langues : Anglais (eng) Mots-clés : Autism  Pervasive developmental disorders  Family  Divorce  Marriage  National Survey Index. décimale : PER Périodiques Résumé : Despite speculation about an 80% divorce rate among parents of children with an Autism Spectrum Disorder (ASD), very little empirical and no epidemiological research has addressed the issue of separation and divorce among this population. Data for this study was taken from the 2007 National Survey of Children’s Health, a population-based, cross-sectional survey. A total of 77,911 parent interviews were completed on children aged 3–17 years, of which 913 reported an ASD diagnosis. After controlling for relevant covariates, results from multivariate analyses revealed no evidence to suggest that children with ASD are at an increased risk for living in a household not comprised of their two biological or adoptive parents compared to children without ASD in the United States. En ligne : http://dx.doi.org/10.1007/s10803-011-1269-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153 [article] Relationship Status Among Parents of Children with Autism Spectrum Disorders: A Population-Based Study [Texte imprimé et/ou numérique] / Brian FREEDMAN, Auteur ; Luther G. KALB, Auteur ; Benjamin ZABLOTSKY, Auteur ; Elizabeth A. STUART, Auteur . - 2012 . - p.539-548. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-4 (April 2012) . - p.539-548 Mots-clés : Autism  Pervasive developmental disorders  Family  Divorce  Marriage  National Survey Index. décimale : PER Périodiques Résumé : Despite speculation about an 80% divorce rate among parents of children with an Autism Spectrum Disorder (ASD), very little empirical and no epidemiological research has addressed the issue of separation and divorce among this population. Data for this study was taken from the 2007 National Survey of Children’s Health, a population-based, cross-sectional survey. A total of 77,911 parent interviews were completed on children aged 3–17 years, of which 913 reported an ASD diagnosis. After controlling for relevant covariates, results from multivariate analyses revealed no evidence to suggest that children with ASD are at an increased risk for living in a household not comprised of their two biological or adoptive parents compared to children without ASD in the United States. En ligne : http://dx.doi.org/10.1007/s10803-011-1269-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153

The Association Between Mental Health, Stress, and Coping Supports in Mothers of Children with Autism Spectrum Disorders / Benjamin ZABLOTSKY in Journal of Autism and Developmental Disorders, 43-6 (June 2013)  

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