[article]
| Titre : |
Design and Subject Characteristics in the Federally-Funded Citalopram Trial in Children with Pervasive Developmental Disorders |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Lawrence SCAHILL, Auteur ; James T. MCCRACKEN, Auteur ; Karen E. BEARSS, Auteur ; Fay ROBINSON, Auteur ; Eric HOLLANDER, Auteur ; Bryan H. KING, Auteur ; Joel D. BREGMAN, Auteur ; Lin SIKICH, Auteur ; Kimberly DUKES, Auteur ; Lisa SULLIVAN, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Craig DONNELLY, Auteur ; Young-Shin KIM, Auteur ; Louise RITZ, Auteur ; Deborah HIRTZ, Auteur ; Ann WAGNER, Auteur |
| Année de publication : |
2012 |
| Article en page(s) : |
p.460-467 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Autism Asperger syndrome Life history Neuropathology Adult |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Despite recent interest in the pathogenesis of the autism spectrum disorders (pervasive developmental disorders), neuropathological descriptions of brains of individuals with well documented clinical information and without potentially confounding symptomatology are exceptionally rare. Asperger syndrome differs from classic autism by lack of cognitive impairment or delay in expressive language acquisition. We examined the 1,570 g brain of a 63 year old otherwise healthy mathematician with an Autistic Spectrum Disorder of Asperger subtype. Except for an atypical gyral pattern and megalencephaly, we detected no specific neuropathologic abnormality. Taken together, the behavioral data and pathological findings in this case are compatible with an early neurodevelopmental process affecting multiple neuroanatomic networks, but without a convincing morphologic signature detectable with routine neuropathologic technology. |
| En ligne : |
http://dx.doi.org/10.1007/s10803-011-1259-0 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152 |
in Journal of Autism and Developmental Disorders > 42-3 (March 2012) . - p.460-467
[article] Design and Subject Characteristics in the Federally-Funded Citalopram Trial in Children with Pervasive Developmental Disorders [Texte imprimé et/ou numérique] / Lawrence SCAHILL, Auteur ; James T. MCCRACKEN, Auteur ; Karen E. BEARSS, Auteur ; Fay ROBINSON, Auteur ; Eric HOLLANDER, Auteur ; Bryan H. KING, Auteur ; Joel D. BREGMAN, Auteur ; Lin SIKICH, Auteur ; Kimberly DUKES, Auteur ; Lisa SULLIVAN, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Craig DONNELLY, Auteur ; Young-Shin KIM, Auteur ; Louise RITZ, Auteur ; Deborah HIRTZ, Auteur ; Ann WAGNER, Auteur . - 2012 . - p.460-467. Langues : Anglais ( eng) in Journal of Autism and Developmental Disorders > 42-3 (March 2012) . - p.460-467
| Mots-clés : |
Autism Asperger syndrome Life history Neuropathology Adult |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Despite recent interest in the pathogenesis of the autism spectrum disorders (pervasive developmental disorders), neuropathological descriptions of brains of individuals with well documented clinical information and without potentially confounding symptomatology are exceptionally rare. Asperger syndrome differs from classic autism by lack of cognitive impairment or delay in expressive language acquisition. We examined the 1,570 g brain of a 63 year old otherwise healthy mathematician with an Autistic Spectrum Disorder of Asperger subtype. Except for an atypical gyral pattern and megalencephaly, we detected no specific neuropathologic abnormality. Taken together, the behavioral data and pathological findings in this case are compatible with an early neurodevelopmental process affecting multiple neuroanatomic networks, but without a convincing morphologic signature detectable with routine neuropathologic technology. |
| En ligne : |
http://dx.doi.org/10.1007/s10803-011-1259-0 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152 |
|  |
Design and Subject Characteristics in the Federally-Funded Citalopram Trial in Children with Pervasive Developmental Disorders in Journal of Autism and Developmental Disorders, 42-3 (March 2012)
