Design and Subject Characteristics in the Federally-Funded Citalopram Trial in Children with Pervasive Developmental Disorders / Lawrence SCAHILL in Journal of Autism and Developmental Disorders, 42-3 (March 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-3 (March 2012) . - p.460-467 Titre : Design and Subject Characteristics in the Federally-Funded Citalopram Trial in Children with Pervasive Developmental Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Lawrence SCAHILL, Auteur ; James T. MCCRACKEN, Auteur ; Karen E. BEARSS, Auteur ; Fay ROBINSON, Auteur ; Eric HOLLANDER, Auteur ; Bryan H. KING, Auteur ; Joel D. BREGMAN, Auteur ; Lin SIKICH, Auteur ; Kimberly DUKES, Auteur ; Lisa SULLIVAN, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Craig DONNELLY, Auteur ; Young-Shin KIM, Auteur ; Louise RITZ, Auteur ; Deborah HIRTZ, Auteur ; Ann WAGNER, Auteur Année de publication : 2012 Article en page(s) : p.460-467 Langues : Anglais (eng) Mots-clés : Autism  Asperger syndrome  Life history  Neuropathology  Adult Index. décimale : PER Périodiques Résumé : Despite recent interest in the pathogenesis of the autism spectrum disorders (pervasive developmental disorders), neuropathological descriptions of brains of individuals with well documented clinical information and without potentially confounding symptomatology are exceptionally rare. Asperger syndrome differs from classic autism by lack of cognitive impairment or delay in expressive language acquisition. We examined the 1,570 g brain of a 63 year old otherwise healthy mathematician with an Autistic Spectrum Disorder of Asperger subtype. Except for an atypical gyral pattern and megalencephaly, we detected no specific neuropathologic abnormality. Taken together, the behavioral data and pathological findings in this case are compatible with an early neurodevelopmental process affecting multiple neuroanatomic networks, but without a convincing morphologic signature detectable with routine neuropathologic technology. En ligne : http://dx.doi.org/10.1007/s10803-011-1259-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152 [article] Design and Subject Characteristics in the Federally-Funded Citalopram Trial in Children with Pervasive Developmental Disorders [Texte imprimé et/ou numérique] / Lawrence SCAHILL, Auteur ; James T. MCCRACKEN, Auteur ; Karen E. BEARSS, Auteur ; Fay ROBINSON, Auteur ; Eric HOLLANDER, Auteur ; Bryan H. KING, Auteur ; Joel D. BREGMAN, Auteur ; Lin SIKICH, Auteur ; Kimberly DUKES, Auteur ; Lisa SULLIVAN, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Craig DONNELLY, Auteur ; Young-Shin KIM, Auteur ; Louise RITZ, Auteur ; Deborah HIRTZ, Auteur ; Ann WAGNER, Auteur . - 2012 . - p.460-467. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-3 (March 2012) . - p.460-467 Mots-clés : Autism  Asperger syndrome  Life history  Neuropathology  Adult Index. décimale : PER Périodiques Résumé : Despite recent interest in the pathogenesis of the autism spectrum disorders (pervasive developmental disorders), neuropathological descriptions of brains of individuals with well documented clinical information and without potentially confounding symptomatology are exceptionally rare. Asperger syndrome differs from classic autism by lack of cognitive impairment or delay in expressive language acquisition. We examined the 1,570 g brain of a 63 year old otherwise healthy mathematician with an Autistic Spectrum Disorder of Asperger subtype. Except for an atypical gyral pattern and megalencephaly, we detected no specific neuropathologic abnormality. Taken together, the behavioral data and pathological findings in this case are compatible with an early neurodevelopmental process affecting multiple neuroanatomic networks, but without a convincing morphologic signature detectable with routine neuropathologic technology. En ligne : http://dx.doi.org/10.1007/s10803-011-1259-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152

Exploring the Manifestations of Anxiety in Children with Autism Spectrum Disorders / Victoria HALLETT in Journal of Autism and Developmental Disorders, 43-10 (October 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-10 (October 2013) . - p.2341-2352 Titre : Exploring the Manifestations of Anxiety in Children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Victoria HALLETT, Auteur ; Luc LECAVALIER, Auteur ; Denis G. SUKHODOLSKY, Auteur ; Noreen CIPRIANO, Auteur ; Michael G. AMAN, Auteur ; James T. MCCRACKEN, Auteur ; Christopher J. MCDOUGLE, Auteur ; Elaine TIERNEY, Auteur ; Bryan H. KING, Auteur ; Eric HOLLANDER, Auteur ; Linmarie SIKICH, Auteur ; Joel D. BREGMAN, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Craig DONNELLY, Auteur ; Lily KATSOVICH, Auteur ; Kimberly DUKES, Auteur ; Benedetto VITIELLO, Auteur ; Kenneth D. GADOW, Auteur ; Lawrence SCAHILL, Auteur Article en page(s) : p.2341-2352 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Anxiety  Measurement  Clinical Trials Index. décimale : PER Périodiques Résumé : This study explores the manifestation and measurement of anxiety symptoms in 415 children with ASDs on a 20-item, parent-rated, DSM-IV referenced anxiety scale. In both high and low-functioning children (IQ above vs. below 70), commonly endorsed items assessed restlessness, tension and sleep difficulties. Items requiring verbal expression of worry by the child were rarely endorsed. Higher anxiety was associated with functional language, IQ above 70 and higher scores on several other behavioral measures. Four underlying factors emerged: Generalized Anxiety, Separation Anxiety, Social Anxiety and Over-arousal. Our findings extend our understanding of anxiety across IQ in ASD and provide guidance for improving anxiety outcome measurement. En ligne : http://dx.doi.org/10.1007/s10803-013-1775-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=215 [article] Exploring the Manifestations of Anxiety in Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Victoria HALLETT, Auteur ; Luc LECAVALIER, Auteur ; Denis G. SUKHODOLSKY, Auteur ; Noreen CIPRIANO, Auteur ; Michael G. AMAN, Auteur ; James T. MCCRACKEN, Auteur ; Christopher J. MCDOUGLE, Auteur ; Elaine TIERNEY, Auteur ; Bryan H. KING, Auteur ; Eric HOLLANDER, Auteur ; Linmarie SIKICH, Auteur ; Joel D. BREGMAN, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Craig DONNELLY, Auteur ; Lily KATSOVICH, Auteur ; Kimberly DUKES, Auteur ; Benedetto VITIELLO, Auteur ; Kenneth D. GADOW, Auteur ; Lawrence SCAHILL, Auteur . - p.2341-2352. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-10 (October 2013) . - p.2341-2352 Mots-clés : Autism spectrum disorders  Anxiety  Measurement  Clinical Trials Index. décimale : PER Périodiques Résumé : This study explores the manifestation and measurement of anxiety symptoms in 415 children with ASDs on a 20-item, parent-rated, DSM-IV referenced anxiety scale. In both high and low-functioning children (IQ above vs. below 70), commonly endorsed items assessed restlessness, tension and sleep difficulties. Items requiring verbal expression of worry by the child were rarely endorsed. Higher anxiety was associated with functional language, IQ above 70 and higher scores on several other behavioral measures. Four underlying factors emerged: Generalized Anxiety, Separation Anxiety, Social Anxiety and Over-arousal. Our findings extend our understanding of anxiety across IQ in ASD and provide guidance for improving anxiety outcome measurement. En ligne : http://dx.doi.org/10.1007/s10803-013-1775-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=215

Genetic and epigenetic signatures associated with plasma oxytocin levels in children and adolescents with autism spectrum disorder / Stephen K. SIECINSKI in Autism Research, 16-3 (March 2023)  

Public ISBD [article]  inAutism Research > 16-3 (March 2023) . - p.502-523 Titre : Genetic and epigenetic signatures associated with plasma oxytocin levels in children and adolescents with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Stephen K. SIECINSKI, Auteur ; Stephanie N. GIAMBERARDINO, Auteur ; Marina SPANOS, Auteur ; Annalise C. HAUSER, Auteur ; Jason R. GIBSON, Auteur ; Tara CHANDRASEKHAR, Auteur ; Maria Del Pilar TRELLES, Auteur ; Carol M. ROCKHILL, Auteur ; Michelle L. PALUMBO, Auteur ; Allyson Witters CUNDIFF, Auteur ; Alicia MONTGOMERY, Auteur ; Paige SIPER, Auteur ; Mendy MINJAREZ, Auteur ; Lisa A. NOWINSKI, Auteur ; Sarah MARLER, Auteur ; Lydia C. KWEE, Auteur ; Lauren C. SHUFFREY, Auteur ; Cheryl ALDERMAN, Auteur ; Jordana WEISSMAN, Auteur ; Brooke ZAPPONE, Auteur ; Jennifer E. MULLETT, Auteur ; Hope CROSSON, Auteur ; Natalie HONG, Auteur ; Sheng LUO, Auteur ; Lilin SHE, Auteur ; Manjushri BHAPKAR, Auteur ; Russell DEAN, Auteur ; Abby SCHEER, Auteur ; Jacqueline L. JOHNSON, Auteur ; Bryan H. KING, Auteur ; Christopher J. MCDOUGLE, Auteur ; Kevin B. SANDERS, Auteur ; Soo-Jeong KIM, Auteur ; Alexander KOLEVZON, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur ; Elizabeth R. HAUSER, Auteur ; Linmarie SIKICH, Auteur ; Simon G. GREGORY, Auteur Article en page(s) : p.502-523 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Oxytocin (OT), the brain's most abundant neuropeptide, plays an important role in social salience and motivation. Clinical trials of the efficacy of OT in autism spectrum disorder (ASD) have reported mixed results due in part to ASD's complex etiology. We investigated whether genetic and epigenetic variation contribute to variable endogenous OT levels that modulate sensitivity to OT therapy. To carry out this analysis, we integrated genome-wide profiles of DNA-methylation, transcriptional activity, and genetic variation with plasma OT levels in 290 participants with ASD enrolled in a randomized controlled trial of OT. Our analysis identified genetic variants with novel association with plasma OT, several of which reside in known ASD risk genes. We also show subtle but statistically significant association of plasma OT levels with peripheral transcriptional activity and DNA-methylation profiles across several annotated gene sets. These findings broaden our understanding of the effects of the peripheral oxytocin system and provide novel genetic candidates for future studies to decode the complex etiology of ASD and its interaction with OT signaling and OT-based interventions. Lay Summary Oxytocin (OT) is an abundant chemical produced by neurons that plays an important role in social interaction and motivation. We investigated whether genetic and epigenetic factors contribute to variable OT levels in the blood. To this, we integrated genetic, gene expression, and non-DNA regulated (epigenetic) signatures with blood OT levels in 290 participants with autism enrolled in an OT clinical trial. We identified genetic association with plasma OT, several of which reside in known autism risk genes. We also show statistically significant association of plasma OT levels with gene expression and epigenetic across several gene pathways. These findings broaden our understanding of the factors that influence OT levels in the blood for future studies to decode the complex presentation of autism and its interaction with OT and OT-based treatment. En ligne : https://doi.org/10.1002/aur.2884 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498 [article] Genetic and epigenetic signatures associated with plasma oxytocin levels in children and adolescents with autism spectrum disorder [Texte imprimé et/ou numérique] / Stephen K. SIECINSKI, Auteur ; Stephanie N. GIAMBERARDINO, Auteur ; Marina SPANOS, Auteur ; Annalise C. HAUSER, Auteur ; Jason R. GIBSON, Auteur ; Tara CHANDRASEKHAR, Auteur ; Maria Del Pilar TRELLES, Auteur ; Carol M. ROCKHILL, Auteur ; Michelle L. PALUMBO, Auteur ; Allyson Witters CUNDIFF, Auteur ; Alicia MONTGOMERY, Auteur ; Paige SIPER, Auteur ; Mendy MINJAREZ, Auteur ; Lisa A. NOWINSKI, Auteur ; Sarah MARLER, Auteur ; Lydia C. KWEE, Auteur ; Lauren C. SHUFFREY, Auteur ; Cheryl ALDERMAN, Auteur ; Jordana WEISSMAN, Auteur ; Brooke ZAPPONE, Auteur ; Jennifer E. MULLETT, Auteur ; Hope CROSSON, Auteur ; Natalie HONG, Auteur ; Sheng LUO, Auteur ; Lilin SHE, Auteur ; Manjushri BHAPKAR, Auteur ; Russell DEAN, Auteur ; Abby SCHEER, Auteur ; Jacqueline L. JOHNSON, Auteur ; Bryan H. KING, Auteur ; Christopher J. MCDOUGLE, Auteur ; Kevin B. SANDERS, Auteur ; Soo-Jeong KIM, Auteur ; Alexander KOLEVZON, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur ; Elizabeth R. HAUSER, Auteur ; Linmarie SIKICH, Auteur ; Simon G. GREGORY, Auteur . - p.502-523. Langues : Anglais (eng) in Autism Research > 16-3 (March 2023) . - p.502-523 Index. décimale : PER Périodiques Résumé : Abstract Oxytocin (OT), the brain's most abundant neuropeptide, plays an important role in social salience and motivation. Clinical trials of the efficacy of OT in autism spectrum disorder (ASD) have reported mixed results due in part to ASD's complex etiology. We investigated whether genetic and epigenetic variation contribute to variable endogenous OT levels that modulate sensitivity to OT therapy. To carry out this analysis, we integrated genome-wide profiles of DNA-methylation, transcriptional activity, and genetic variation with plasma OT levels in 290 participants with ASD enrolled in a randomized controlled trial of OT. Our analysis identified genetic variants with novel association with plasma OT, several of which reside in known ASD risk genes. We also show subtle but statistically significant association of plasma OT levels with peripheral transcriptional activity and DNA-methylation profiles across several annotated gene sets. These findings broaden our understanding of the effects of the peripheral oxytocin system and provide novel genetic candidates for future studies to decode the complex etiology of ASD and its interaction with OT signaling and OT-based interventions. Lay Summary Oxytocin (OT) is an abundant chemical produced by neurons that plays an important role in social interaction and motivation. We investigated whether genetic and epigenetic factors contribute to variable OT levels in the blood. To this, we integrated genetic, gene expression, and non-DNA regulated (epigenetic) signatures with blood OT levels in 290 participants with autism enrolled in an OT clinical trial. We identified genetic association with plasma OT, several of which reside in known autism risk genes. We also show statistically significant association of plasma OT levels with gene expression and epigenetic across several gene pathways. These findings broaden our understanding of the factors that influence OT levels in the blood for future studies to decode the complex presentation of autism and its interaction with OT and OT-based treatment. En ligne : https://doi.org/10.1002/aur.2884 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498

Measuring Anxiety as a Treatment Endpoint in Youth with Autism Spectrum Disorder / Luc LECAVALIER in Journal of Autism and Developmental Disorders, 44-5 (May 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-5 (May 2014) . - p.1128-1143 Titre : Measuring Anxiety as a Treatment Endpoint in Youth with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Luc LECAVALIER, Auteur ; Jeffrey J. WOOD, Auteur ; Alycia K. HALLADAY, Auteur ; Nancy E. JONES, Auteur ; Michael G. AMAN, Auteur ; Edwin H. Jr COOK, Auteur ; Benjamin L. HANDEN, Auteur ; Bryan H. KING, Auteur ; Deborah A. PEARSON, Auteur ; Victoria HALLETT, Auteur ; Katherine Anne SULLIVAN, Auteur ; Sabrina N. GRONDHUIS, Auteur ; Somer L. BISHOP, Auteur ; Joseph P. HORRIGAN, Auteur ; Geraldine DAWSON, Auteur ; Lawrence SCAHILL, Auteur Année de publication : 2014 Article en page(s) : p.1128-1143 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Anxiety  Instrument  Measure  Assessment  Treatment  Intervention Index. décimale : PER Périodiques Résumé : Despite the high rate of anxiety in individuals with autism spectrum disorder (ASD), measuring anxiety in ASD is fraught with uncertainty. This is due, in part, to incomplete consensus on the manifestations of anxiety in this population. Autism Speaks assembled a panel of experts to conduct a systematic review of available measures for anxiety in youth with ASD. To complete the review, the panel held monthly conference calls and two face-to-face meetings over a fourteen-month period. Thirty eight published studies were reviewed and ten assessment measures were examined: four were deemed appropriate for use in clinical trials, although with conditions; three were judged to be potentially appropriate, while three were considered not useful for clinical trials assessing anxiety. Despite recent advances, additional relevant, reliable and valid outcome measures are needed to evaluate treatments for anxiety in ASD. En ligne : http://dx.doi.org/10.1007/s10803-013-1974-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=232 [article] Measuring Anxiety as a Treatment Endpoint in Youth with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Luc LECAVALIER, Auteur ; Jeffrey J. WOOD, Auteur ; Alycia K. HALLADAY, Auteur ; Nancy E. JONES, Auteur ; Michael G. AMAN, Auteur ; Edwin H. Jr COOK, Auteur ; Benjamin L. HANDEN, Auteur ; Bryan H. KING, Auteur ; Deborah A. PEARSON, Auteur ; Victoria HALLETT, Auteur ; Katherine Anne SULLIVAN, Auteur ; Sabrina N. GRONDHUIS, Auteur ; Somer L. BISHOP, Auteur ; Joseph P. HORRIGAN, Auteur ; Geraldine DAWSON, Auteur ; Lawrence SCAHILL, Auteur . - 2014 . - p.1128-1143. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-5 (May 2014) . - p.1128-1143 Mots-clés : Autism spectrum disorder  Anxiety  Instrument  Measure  Assessment  Treatment  Intervention Index. décimale : PER Périodiques Résumé : Despite the high rate of anxiety in individuals with autism spectrum disorder (ASD), measuring anxiety in ASD is fraught with uncertainty. This is due, in part, to incomplete consensus on the manifestations of anxiety in this population. Autism Speaks assembled a panel of experts to conduct a systematic review of available measures for anxiety in youth with ASD. To complete the review, the panel held monthly conference calls and two face-to-face meetings over a fourteen-month period. Thirty eight published studies were reviewed and ten assessment measures were examined: four were deemed appropriate for use in clinical trials, although with conditions; three were judged to be potentially appropriate, while three were considered not useful for clinical trials assessing anxiety. Despite recent advances, additional relevant, reliable and valid outcome measures are needed to evaluate treatments for anxiety in ASD. En ligne : http://dx.doi.org/10.1007/s10803-013-1974-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=232

Measuring repetitive behaviors as a treatment endpoint in youth with autism spectrum disorder / Lawrence SCAHILL in Autism, 19-1 (January 2015)  

Public ISBD [article]  inAutism > 19-1 (January 2015) . - p.38-52 Titre : Measuring repetitive behaviors as a treatment endpoint in youth with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Lawrence SCAHILL, Auteur ; Michael G. AMAN, Auteur ; Luc LECAVALIER, Auteur ; Alycia K. HALLADAY, Auteur ; Somer L. BISHOP, Auteur ; James W. BODFISH, Auteur ; Sabrina GRONDHUIS, Auteur ; Nancy JONES, Auteur ; Joseph P. HORRIGAN, Auteur ; Edwin H. Jr COOK, Auteur ; Benjamin L. HANDEN, Auteur ; Bryan H. KING, Auteur ; Deborah A. PEARSON, Auteur ; James T. MCCRACKEN, Auteur ; Katherine Anne SULLIVAN, Auteur ; Geraldine DAWSON, Auteur Année de publication : 2015 Article en page(s) : p.38-52 Langues : Anglais (eng) Mots-clés : Assessment  autism spectrum disorders  instrument  intervention  repetitive behavior  restricted interests  measure  treatment; Index. décimale : PER Périodiques Résumé : Restricted interests and repetitive behaviors vary widely in type, frequency, and intensity among children and adolescents with autism spectrum disorder. They can be stigmatizing and interfere with more constructive activities. Accordingly, restricted interests and repetitive behaviors may be a target of intervention. Several standardized instruments have been developed to assess restricted interests and repetitive behaviors in the autism spectrum disorder population, but the rigor of psychometric assessment is variable. This article evaluated the readiness of available measures for use as outcome measures in clinical trials. The Autism Speaks Foundation assembled a panel of experts to examine available instruments used to measure restricted interests and repetitive behaviors in youth with autism spectrum disorder. The panel held monthly conference calls and two face-to-face meetings over 14 months to develop and apply evaluative criteria for available instruments. Twenty-four instruments were evaluated and five were considered “appropriate with conditions” for use as outcome measures in clinical trials. Ideally, primary outcome measures should be relevant to the clinical target, be reliable and valid, and cover the symptom domain without being burdensome to subjects. The goal of the report was to promote consensus across funding agencies, pharmaceutical companies, and clinical investigators about advantages and disadvantages of existing outcome measures. En ligne : http://dx.doi.org/10.1177/1362361313510069 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=245 [article] Measuring repetitive behaviors as a treatment endpoint in youth with autism spectrum disorder [Texte imprimé et/ou numérique] / Lawrence SCAHILL, Auteur ; Michael G. AMAN, Auteur ; Luc LECAVALIER, Auteur ; Alycia K. HALLADAY, Auteur ; Somer L. BISHOP, Auteur ; James W. BODFISH, Auteur ; Sabrina GRONDHUIS, Auteur ; Nancy JONES, Auteur ; Joseph P. HORRIGAN, Auteur ; Edwin H. Jr COOK, Auteur ; Benjamin L. HANDEN, Auteur ; Bryan H. KING, Auteur ; Deborah A. PEARSON, Auteur ; James T. MCCRACKEN, Auteur ; Katherine Anne SULLIVAN, Auteur ; Geraldine DAWSON, Auteur . - 2015 . - p.38-52. Langues : Anglais (eng) in Autism > 19-1 (January 2015) . - p.38-52 Mots-clés : Assessment  autism spectrum disorders  instrument  intervention  repetitive behavior  restricted interests  measure  treatment; Index. décimale : PER Périodiques Résumé : Restricted interests and repetitive behaviors vary widely in type, frequency, and intensity among children and adolescents with autism spectrum disorder. They can be stigmatizing and interfere with more constructive activities. Accordingly, restricted interests and repetitive behaviors may be a target of intervention. Several standardized instruments have been developed to assess restricted interests and repetitive behaviors in the autism spectrum disorder population, but the rigor of psychometric assessment is variable. This article evaluated the readiness of available measures for use as outcome measures in clinical trials. The Autism Speaks Foundation assembled a panel of experts to examine available instruments used to measure restricted interests and repetitive behaviors in youth with autism spectrum disorder. The panel held monthly conference calls and two face-to-face meetings over 14 months to develop and apply evaluative criteria for available instruments. Twenty-four instruments were evaluated and five were considered “appropriate with conditions” for use as outcome measures in clinical trials. Ideally, primary outcome measures should be relevant to the clinical target, be reliable and valid, and cover the symptom domain without being burdensome to subjects. The goal of the report was to promote consensus across funding agencies, pharmaceutical companies, and clinical investigators about advantages and disadvantages of existing outcome measures. En ligne : http://dx.doi.org/10.1177/1362361313510069 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=245

Mice Exposed to Diagnostic Ultrasound In Utero Are Less Social and More Active in Social Situations Relative to Controls / Abbi M. MCCLINTIC in Autism Research, 7-3 (June 2014)  

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Severity of ASD symptoms and their correlation with the presence of copy number variations and exposure to first trimester ultrasound / Sara Jane WEBB in Autism Research, 10-3 (March 2017)  

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Stereotypy and Self-Injury / Lindsey STERLING

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STX209 (Arbaclofen) for Autism Spectrum Disorders: An 8-Week Open-Label Study / Craig ERICKSON in Journal of Autism and Developmental Disorders, 44-4 (April 2014)  

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Training of child and adolescent psychiatry fellows in autism and intellectual disability / Natasha MARRUS in Autism, 18-4 (May 2014)  

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