Childhood vaccination as a protective factor for developmental psychopathology / Bora KIM in Research in Autism Spectrum Disorders, 79 (November 2020)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 79 (November 2020) . - 101653 Titre : Childhood vaccination as a protective factor for developmental psychopathology Type de document : Texte imprimé et/ou numérique Auteurs : Bora KIM, Auteur ; Mina HA, Auteur ; Young Shin KIM, Auteur ; Yun-Joo KOH, Auteur ; Ho-Jang KWON, Auteur ; Myung-Ho LIM, Auteur ; Ki-Chung PAIK, Auteur ; Hosanna KIM, Auteur ; Patricia HONG, Auteur ; Bennett L. LEVENTHAL, Auteur Article en page(s) : 101653 Langues : Anglais (eng) Mots-clés : ASD  Developmental psychopathology  Vaccination  Protective effects Index. décimale : PER Périodiques Résumé : Backgrounds Despite multiple studies demonstrating no relationship between childhood vaccination and increasing Autism Spectrum Disorder (ASD) prevalence, parental fear for vaccination and subsequent refusal to vaccinate their children continue, resulting in recent outbreaks of childhood infections such as measles in the US. We examine the relationship between the completion of 6 recommended vaccinations in childhood and the likelihood for having developmental psychopathology. Methods Two large-scale South Korean epidemiologic samples were used to examine whether completion of childhood vaccinations decrease likelihood of having ASD as assessed by Autism Spectrum Screening Questionnaire (ASSQ) and behavioral problems scores. Parental reports on vaccination completion were categorized in groups: <3, 4?5, & 6. The primary outcome is the likelihood of having ASD and/or, internalizing, and externalizing behavioral symptoms. Likelihood of having ASD was categorized as: low (ASSQ < 10), intermediate (ASSQ = 10–14), and high (ASSQ ? 15). The risk for externalizing/internalizing symptoms was assessed with the Behavior Assessment System for Children-Parent Rating Scale. We examined the hypothesis in a Discovery Sample (DS) (N = 10,006) and verified findings in a Replication Sample (RS) (N = 29,381). Results 84.3 % of DS and 80.1 % of RS participants were fully vaccinated. In the DS, after adjusting for demographics and confounders, children with incomplete-vaccinations were at greater risk for ASD when compared to those fully vaccinated (adjusted odds ratio [aOR] = 1.42, 95 % Confidence Interval [CI] 1.17?1.73 with 4?5 vaccinations; aOR = 2.33, CI 1.53?3.56 with vaccination <3). The DS finding was confirmed in the RS (aOR = 1.44, CI 1.32?1.58 with 4?5 vaccinations and aOR = 2.19, CI 1.80?2.67 with < 3 vaccinations). In the DS, those with incomplete-vaccinations were at a greater risk for internalizing and externalizing symptoms. Conclusions We replicate our own and prior findings that vaccination does not increase ASD risk. Further, completing recommended vaccinations may offer protection against the risk of having ASD and other developmental psychopathology. En ligne : https://doi.org/10.1016/j.rasd.2020.101653 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 [article] Childhood vaccination as a protective factor for developmental psychopathology [Texte imprimé et/ou numérique] / Bora KIM, Auteur ; Mina HA, Auteur ; Young Shin KIM, Auteur ; Yun-Joo KOH, Auteur ; Ho-Jang KWON, Auteur ; Myung-Ho LIM, Auteur ; Ki-Chung PAIK, Auteur ; Hosanna KIM, Auteur ; Patricia HONG, Auteur ; Bennett L. LEVENTHAL, Auteur . - 101653. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 79 (November 2020) . - 101653 Mots-clés : ASD  Developmental psychopathology  Vaccination  Protective effects Index. décimale : PER Périodiques Résumé : Backgrounds Despite multiple studies demonstrating no relationship between childhood vaccination and increasing Autism Spectrum Disorder (ASD) prevalence, parental fear for vaccination and subsequent refusal to vaccinate their children continue, resulting in recent outbreaks of childhood infections such as measles in the US. We examine the relationship between the completion of 6 recommended vaccinations in childhood and the likelihood for having developmental psychopathology. Methods Two large-scale South Korean epidemiologic samples were used to examine whether completion of childhood vaccinations decrease likelihood of having ASD as assessed by Autism Spectrum Screening Questionnaire (ASSQ) and behavioral problems scores. Parental reports on vaccination completion were categorized in groups: <3, 4?5, & 6. The primary outcome is the likelihood of having ASD and/or, internalizing, and externalizing behavioral symptoms. Likelihood of having ASD was categorized as: low (ASSQ < 10), intermediate (ASSQ = 10–14), and high (ASSQ ? 15). The risk for externalizing/internalizing symptoms was assessed with the Behavior Assessment System for Children-Parent Rating Scale. We examined the hypothesis in a Discovery Sample (DS) (N = 10,006) and verified findings in a Replication Sample (RS) (N = 29,381). Results 84.3 % of DS and 80.1 % of RS participants were fully vaccinated. In the DS, after adjusting for demographics and confounders, children with incomplete-vaccinations were at greater risk for ASD when compared to those fully vaccinated (adjusted odds ratio [aOR] = 1.42, 95 % Confidence Interval [CI] 1.17?1.73 with 4?5 vaccinations; aOR = 2.33, CI 1.53?3.56 with vaccination <3). The DS finding was confirmed in the RS (aOR = 1.44, CI 1.32?1.58 with 4?5 vaccinations and aOR = 2.19, CI 1.80?2.67 with < 3 vaccinations). In the DS, those with incomplete-vaccinations were at a greater risk for internalizing and externalizing symptoms. Conclusions We replicate our own and prior findings that vaccination does not increase ASD risk. Further, completing recommended vaccinations may offer protection against the risk of having ASD and other developmental psychopathology. En ligne : https://doi.org/10.1016/j.rasd.2020.101653 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434

CRISIS AFAR: an international collaborative study of the impact of the COVID-19 pandemic on mental health and service access in youth with autism and neurodevelopmental conditions / Patricia SEGURA ; Louise GALLAGHER ; Stelios GEORGIADES ; Panagiota PERVANIDOU ; Audrey THURM ; Lindsay ALEXANDER ; Evdokia ANAGNOSTOU ; Yuta AOKI ; Catherine S. BIRKEN ; Somer L. BISHOP ; Jessica BOI ; Carmela BRAVACCIO ; Helena BRENTANI ; Paola CANEVINI ; Alessandra CARTA ; Alice CHARACH ; Antonella COSTANTINO ; Katherine T. COST ; Elaine A. CRAVO ; Jennifer CROSBIE ; Chiara DAVICO ; Federica DONNO ; Junya FUJINO ; Alessandra GABELLONE ; Cristiane T. GEYER ; Tomoya HIROTA ; Stephen KANNE ; Makiko KAWASHIMA ; Elizabeth KELLEY ; Hosanna KIM ; Young Shin KIM ; So Hyun KIM ; Daphne J. KORCZAK ; Meng-Chuan LAI ; Lucia MARGARI ; Lucia MARZULLI ; Gabriele MASI ; Luigi MAZZONE ; Jane MCGRATH ; Suneeta MONGA ; Paola MOROSINI ; Shinichiro NAKAJIMA ; Antonio NARZISI ; Rob NICOLSON ; Aki NIKOLAIDIS ; Yoshihiro NODA ; Kerri NOWELL ; Miriam POLIZZI ; Joana PORTOLESE ; Maria Pia RICCIO ; Manabu SAITO ; Ida SCHWARTZ ; Anish K. SIMHAL ; Martina SIRACUSANO ; Stefano SOTGIU ; Jacob STROUD ; Fernando SUMIYA ; Yoshiyuki TACHIBANA ; Nicole TAKAHASHI ; Riina TAKAHASHI ; Hiroki TAMON ; Raffaella TANCREDI ; Benedetto VITIELLO ; Alessandro ZUDDAS ; Bennett LEVENTHAL ; Kathleen MERIKANGAS ; Michael P. MILHAM ; Adriana DI MARTINO in Molecular Autism, 14 (2023)  

Public ISBD [article]  inMolecular Autism > 14 (2023) . - 7 p. Titre : CRISIS AFAR: an international collaborative study of the impact of the COVID-19 pandemic on mental health and service access in youth with autism and neurodevelopmental conditions Type de document : Texte imprimé et/ou numérique Auteurs : Patricia SEGURA, Auteur ; Louise GALLAGHER, Auteur ; Stelios GEORGIADES, Auteur ; Panagiota PERVANIDOU, Auteur ; Audrey THURM, Auteur ; Lindsay ALEXANDER, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Yuta AOKI, Auteur ; Catherine S. BIRKEN, Auteur ; Somer L. BISHOP, Auteur ; Jessica BOI, Auteur ; Carmela BRAVACCIO, Auteur ; Helena BRENTANI, Auteur ; Paola CANEVINI, Auteur ; Alessandra CARTA, Auteur ; Alice CHARACH, Auteur ; Antonella COSTANTINO, Auteur ; Katherine T. COST, Auteur ; Elaine A. CRAVO, Auteur ; Jennifer CROSBIE, Auteur ; Chiara DAVICO, Auteur ; Federica DONNO, Auteur ; Junya FUJINO, Auteur ; Alessandra GABELLONE, Auteur ; Cristiane T. GEYER, Auteur ; Tomoya HIROTA, Auteur ; Stephen KANNE, Auteur ; Makiko KAWASHIMA, Auteur ; Elizabeth KELLEY, Auteur ; Hosanna KIM, Auteur ; Young Shin KIM, Auteur ; So Hyun KIM, Auteur ; Daphne J. KORCZAK, Auteur ; Meng-Chuan LAI, Auteur ; Lucia MARGARI, Auteur ; Lucia MARZULLI, Auteur ; Gabriele MASI, Auteur ; Luigi MAZZONE, Auteur ; Jane MCGRATH, Auteur ; Suneeta MONGA, Auteur ; Paola MOROSINI, Auteur ; Shinichiro NAKAJIMA, Auteur ; Antonio NARZISI, Auteur ; Rob NICOLSON, Auteur ; Aki NIKOLAIDIS, Auteur ; Yoshihiro NODA, Auteur ; Kerri NOWELL, Auteur ; Miriam POLIZZI, Auteur ; Joana PORTOLESE, Auteur ; Maria Pia RICCIO, Auteur ; Manabu SAITO, Auteur ; Ida SCHWARTZ, Auteur ; Anish K. SIMHAL, Auteur ; Martina SIRACUSANO, Auteur ; Stefano SOTGIU, Auteur ; Jacob STROUD, Auteur ; Fernando SUMIYA, Auteur ; Yoshiyuki TACHIBANA, Auteur ; Nicole TAKAHASHI, Auteur ; Riina TAKAHASHI, Auteur ; Hiroki TAMON, Auteur ; Raffaella TANCREDI, Auteur ; Benedetto VITIELLO, Auteur ; Alessandro ZUDDAS, Auteur ; Bennett LEVENTHAL, Auteur ; Kathleen MERIKANGAS, Auteur ; Michael P. MILHAM, Auteur ; Adriana DI MARTINO, Auteur Article en page(s) : 7 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: Heterogeneous mental health outcomes during the COVID-19 pandemic are documented in the general population. Such heterogeneity has not been systematically assessed in youth with autism spectrum disorder (ASD) and related neurodevelopmental disorders (NDD). To identify distinct patterns of the pandemic impact and their predictors in ASD/NDD youth, we focused on pandemic-related changes in symptoms and access to services. METHODS: Using a naturalistic observational design, we assessed parent responses on the Coronavirus Health and Impact Survey Initiative (CRISIS) Adapted For Autism and Related neurodevelopmental conditions (AFAR). Cross-sectional AFAR data were aggregated across 14 European and North American sites yielding a clinically well-characterized sample of N=1275 individuals with ASD/NDD (age=11.0?+?3.6 years; n females=277). To identify subgroups with differential outcomes, we applied hierarchical clustering across eleven variables measuring changes in symptoms and access to services. Then, random forest classification assessed the importance of socio-demographics, pre-pandemic service rates, clinical severity of ASD-associated symptoms, and COVID-19 pandemic experiences/environments in predicting the outcome subgroups. RESULTS: Clustering revealed four subgroups. One subgroup-broad symptom worsening only (20%)-included youth with worsening across a range of symptoms but with service disruptions similar to the average of the aggregate sample. The other three subgroups were, relatively, clinically stable but differed in service access: primarily modified services (23%), primarily lost services (6%), and average services/symptom changes (53%). Distinct combinations of a set of pre-pandemic services, pandemic environment (e.g., COVID-19 new cases, restrictions), experiences (e.g., COVID-19 Worries), and age predicted each outcome subgroup. LIMITATIONS: Notable limitations of the study are its cross-sectional nature and focus on the first six months of the pandemic. CONCLUSIONS: Concomitantly assessing variation in changes of symptoms and service access during the first phase of the pandemic revealed differential outcome profiles in ASD/NDD youth. Subgroups were characterized by distinct prediction patterns across a set of pre- and pandemic-related experiences/contexts. Results may inform recovery efforts and preparedness in future crises; they also underscore the critical value of international data-sharing and collaborations to address the needs of those most vulnerable in times of crisis. En ligne : http://dx.doi.org/10.1186/s13229-022-00536-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513 [article] CRISIS AFAR: an international collaborative study of the impact of the COVID-19 pandemic on mental health and service access in youth with autism and neurodevelopmental conditions [Texte imprimé et/ou numérique] / Patricia SEGURA, Auteur ; Louise GALLAGHER, Auteur ; Stelios GEORGIADES, Auteur ; Panagiota PERVANIDOU, Auteur ; Audrey THURM, Auteur ; Lindsay ALEXANDER, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Yuta AOKI, Auteur ; Catherine S. BIRKEN, Auteur ; Somer L. BISHOP, Auteur ; Jessica BOI, Auteur ; Carmela BRAVACCIO, Auteur ; Helena BRENTANI, Auteur ; Paola CANEVINI, Auteur ; Alessandra CARTA, Auteur ; Alice CHARACH, Auteur ; Antonella COSTANTINO, Auteur ; Katherine T. COST, Auteur ; Elaine A. CRAVO, Auteur ; Jennifer CROSBIE, Auteur ; Chiara DAVICO, Auteur ; Federica DONNO, Auteur ; Junya FUJINO, Auteur ; Alessandra GABELLONE, Auteur ; Cristiane T. GEYER, Auteur ; Tomoya HIROTA, Auteur ; Stephen KANNE, Auteur ; Makiko KAWASHIMA, Auteur ; Elizabeth KELLEY, Auteur ; Hosanna KIM, Auteur ; Young Shin KIM, Auteur ; So Hyun KIM, Auteur ; Daphne J. KORCZAK, Auteur ; Meng-Chuan LAI, Auteur ; Lucia MARGARI, Auteur ; Lucia MARZULLI, Auteur ; Gabriele MASI, Auteur ; Luigi MAZZONE, Auteur ; Jane MCGRATH, Auteur ; Suneeta MONGA, Auteur ; Paola MOROSINI, Auteur ; Shinichiro NAKAJIMA, Auteur ; Antonio NARZISI, Auteur ; Rob NICOLSON, Auteur ; Aki NIKOLAIDIS, Auteur ; Yoshihiro NODA, Auteur ; Kerri NOWELL, Auteur ; Miriam POLIZZI, Auteur ; Joana PORTOLESE, Auteur ; Maria Pia RICCIO, Auteur ; Manabu SAITO, Auteur ; Ida SCHWARTZ, Auteur ; Anish K. SIMHAL, Auteur ; Martina SIRACUSANO, Auteur ; Stefano SOTGIU, Auteur ; Jacob STROUD, Auteur ; Fernando SUMIYA, Auteur ; Yoshiyuki TACHIBANA, Auteur ; Nicole TAKAHASHI, Auteur ; Riina TAKAHASHI, Auteur ; Hiroki TAMON, Auteur ; Raffaella TANCREDI, Auteur ; Benedetto VITIELLO, Auteur ; Alessandro ZUDDAS, Auteur ; Bennett LEVENTHAL, Auteur ; Kathleen MERIKANGAS, Auteur ; Michael P. MILHAM, Auteur ; Adriana DI MARTINO, Auteur . - 7 p. Langues : Anglais (eng) in Molecular Autism > 14 (2023) . - 7 p. Index. décimale : PER Périodiques Résumé : BACKGROUND: Heterogeneous mental health outcomes during the COVID-19 pandemic are documented in the general population. Such heterogeneity has not been systematically assessed in youth with autism spectrum disorder (ASD) and related neurodevelopmental disorders (NDD). To identify distinct patterns of the pandemic impact and their predictors in ASD/NDD youth, we focused on pandemic-related changes in symptoms and access to services. METHODS: Using a naturalistic observational design, we assessed parent responses on the Coronavirus Health and Impact Survey Initiative (CRISIS) Adapted For Autism and Related neurodevelopmental conditions (AFAR). Cross-sectional AFAR data were aggregated across 14 European and North American sites yielding a clinically well-characterized sample of N=1275 individuals with ASD/NDD (age=11.0?+?3.6 years; n females=277). To identify subgroups with differential outcomes, we applied hierarchical clustering across eleven variables measuring changes in symptoms and access to services. Then, random forest classification assessed the importance of socio-demographics, pre-pandemic service rates, clinical severity of ASD-associated symptoms, and COVID-19 pandemic experiences/environments in predicting the outcome subgroups. RESULTS: Clustering revealed four subgroups. One subgroup-broad symptom worsening only (20%)-included youth with worsening across a range of symptoms but with service disruptions similar to the average of the aggregate sample. The other three subgroups were, relatively, clinically stable but differed in service access: primarily modified services (23%), primarily lost services (6%), and average services/symptom changes (53%). Distinct combinations of a set of pre-pandemic services, pandemic environment (e.g., COVID-19 new cases, restrictions), experiences (e.g., COVID-19 Worries), and age predicted each outcome subgroup. LIMITATIONS: Notable limitations of the study are its cross-sectional nature and focus on the first six months of the pandemic. CONCLUSIONS: Concomitantly assessing variation in changes of symptoms and service access during the first phase of the pandemic revealed differential outcome profiles in ASD/NDD youth. Subgroups were characterized by distinct prediction patterns across a set of pre- and pandemic-related experiences/contexts. Results may inform recovery efforts and preparedness in future crises; they also underscore the critical value of international data-sharing and collaborations to address the needs of those most vulnerable in times of crisis. En ligne : http://dx.doi.org/10.1186/s13229-022-00536-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513

Prenatal exposure to paternal smoking and likelihood for autism spectrum disorder / Bora KIM in Autism, 26-7 (October 2022)  

Public ISBD [article]  inAutism > 26-7 (October 2022) . - p.1946-1959 Titre : Prenatal exposure to paternal smoking and likelihood for autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Bora KIM, Auteur ; Mina HA, Auteur ; Young Shin KIM, Auteur ; Yun-Joo KOH, Auteur ; Shan DONG, Auteur ; Ho-Jang KWON, Auteur ; Young-Suk KIM, Auteur ; Myung-Ho LIM, Auteur ; Ki-Chung PAIK, Auteur ; Seung-Jin YOO, Auteur ; Hosanna KIM, Auteur ; Patricia S. HONG, Auteur ; Stephan J. SANDERS, Auteur ; Bennett L. LEVENTHAL, Auteur Article en page(s) : p.1946-1959 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/epidemiology/etiology  Causality  Family  Female  Humans  Pregnancy  Prenatal Exposure Delayed Effects/epidemiology/etiology  Risk Factors  Smoking/adverse effects  autism spectrum disorders  environmental factors  risk factor epidemiology  relation to the research presented in this manuscript. Index. décimale : PER Périodiques Résumé : What is Already Known about This Subject: Genetics, (including de novo mutations), environmental factors (including toxic exposures), and their interactions impact autism spectrum disorder etiology. Paternal smoking is a candidate risk for autism spectrum disorder due to biological plausibility, high prevalence, and potential intervention.What This Study Adds: This original study and its replication confirms that paternal factors can substantially contribute to autism spectrum disorder risk for their offspring. It specifically indicates that paternal smoking both before and during pregnancy contributes significantly to autism spectrum disorder risk.Implications for practice, research, or policy: Smoking prevention, especially in pregnancy planning, may decrease autism spectrum disorder risk in offspring. En ligne : http://dx.doi.org/10.1177/13623613211007319 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484 [article] Prenatal exposure to paternal smoking and likelihood for autism spectrum disorder [Texte imprimé et/ou numérique] / Bora KIM, Auteur ; Mina HA, Auteur ; Young Shin KIM, Auteur ; Yun-Joo KOH, Auteur ; Shan DONG, Auteur ; Ho-Jang KWON, Auteur ; Young-Suk KIM, Auteur ; Myung-Ho LIM, Auteur ; Ki-Chung PAIK, Auteur ; Seung-Jin YOO, Auteur ; Hosanna KIM, Auteur ; Patricia S. HONG, Auteur ; Stephan J. SANDERS, Auteur ; Bennett L. LEVENTHAL, Auteur . - p.1946-1959. Langues : Anglais (eng) in Autism > 26-7 (October 2022) . - p.1946-1959 Mots-clés : Autism Spectrum Disorder/epidemiology/etiology  Causality  Family  Female  Humans  Pregnancy  Prenatal Exposure Delayed Effects/epidemiology/etiology  Risk Factors  Smoking/adverse effects  autism spectrum disorders  environmental factors  risk factor epidemiology  relation to the research presented in this manuscript. Index. décimale : PER Périodiques Résumé : What is Already Known about This Subject: Genetics, (including de novo mutations), environmental factors (including toxic exposures), and their interactions impact autism spectrum disorder etiology. Paternal smoking is a candidate risk for autism spectrum disorder due to biological plausibility, high prevalence, and potential intervention.What This Study Adds: This original study and its replication confirms that paternal factors can substantially contribute to autism spectrum disorder risk for their offspring. It specifically indicates that paternal smoking both before and during pregnancy contributes significantly to autism spectrum disorder risk.Implications for practice, research, or policy: Smoking prevention, especially in pregnancy planning, may decrease autism spectrum disorder risk in offspring. En ligne : http://dx.doi.org/10.1177/13623613211007319 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484

Prevalence and cumulative incidence of autism spectrum disorders and the patterns of co-occurring neurodevelopmental disorders in a total population sample of 5-year-old children / Manabu SAITO in Molecular Autism, 11 (2020)  

Public ISBD [article]  inMolecular Autism > 11 (2020) . - 35 p. Titre : Prevalence and cumulative incidence of autism spectrum disorders and the patterns of co-occurring neurodevelopmental disorders in a total population sample of 5-year-old children Type de document : Texte imprimé et/ou numérique Auteurs : Manabu SAITO, Auteur ; Tomoya HIROTA, Auteur ; Yui SAKAMOTO, Auteur ; Masaki ADACHI, Auteur ; Michio TAKAHASHI, Auteur ; Ayako OSATO-KANEDA, Auteur ; Young Shin KIM, Auteur ; Bennett L. LEVENTHAL, Auteur ; Amy SHUI, Auteur ; Sumi KATO, Auteur ; Kazuhiko NAKAMURA, Auteur Article en page(s) : 35 p. Langues : Anglais (eng) Mots-clés : A total population study  Autism spectrum disorder  Co-existing neurodevelopmental disorders  Cumulative incidence  Prevalence Index. décimale : PER Périodiques Résumé : BACKGROUNDS: Whether there is a true increase in autism spectrum disorder (ASD) frequency or not remains unclear. Additionally, the rates of co-existing neurodevelopmental disorders (NDD) in a total population sample has not been fully examined before. Therefore, using a total population sample in Japan, we aimed to estimate the prevalence and cumulative incidence of autism spectrum disorder (ASD) annually, to determine whether there is a true increase in ASD prevalence by estimating the cumulative incidence of ASD annually, and to examine the rates of co-existing neurodevelopmental disorders (NDD). METHOD: In this cross-sectional sequential design study, all 5-year-old children in the catchment area underwent the screening annually from the year 2013-2016. Screen-positive children were invited to participate in a comprehensive assessment, including child and parent interview, behavioral observation, and cognitive and motor function testing. All cases were reviewed by a multidisciplinary research team. RESULTS: Caregivers of 3954 children returned the screening, among which 559 children underwent the assessment with 87 children receiving an ASD diagnosis. Adjusted ASD prevalence was 3.22% (95% confidence interval (CI) 2.66-3.76%). The male to female ratio of the crude prevalence was 2.2:1. The cumulative incidence of ASD up to 5?years of age for the total study years was 1.31% (95% CI 1.00-1.62%). A generalized linear model revealed no significant linear trends in 5-year cumulative incidence over the study years. Only 11.5% of children had ASD alone; the remaining 88.5% were found to have at least one co-existing NDD. LIMITATIONS: Modest sample size for a total population study. CONCLUSIONS: Our findings demonstrate the stability of the 5-year cumulative incidence of ASD, implying no true rise in ASD incident cases over the 4-year study period in the study catchment area. High rates of co-existing NDDs reflect the importance of investigating broad developmental challenges in children with ASD. En ligne : http://dx.doi.org/10.1186/s13229-020-00342-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 [article] Prevalence and cumulative incidence of autism spectrum disorders and the patterns of co-occurring neurodevelopmental disorders in a total population sample of 5-year-old children [Texte imprimé et/ou numérique] / Manabu SAITO, Auteur ; Tomoya HIROTA, Auteur ; Yui SAKAMOTO, Auteur ; Masaki ADACHI, Auteur ; Michio TAKAHASHI, Auteur ; Ayako OSATO-KANEDA, Auteur ; Young Shin KIM, Auteur ; Bennett L. LEVENTHAL, Auteur ; Amy SHUI, Auteur ; Sumi KATO, Auteur ; Kazuhiko NAKAMURA, Auteur . - 35 p. Langues : Anglais (eng) in Molecular Autism > 11 (2020) . - 35 p. Mots-clés : A total population study  Autism spectrum disorder  Co-existing neurodevelopmental disorders  Cumulative incidence  Prevalence Index. décimale : PER Périodiques Résumé : BACKGROUNDS: Whether there is a true increase in autism spectrum disorder (ASD) frequency or not remains unclear. Additionally, the rates of co-existing neurodevelopmental disorders (NDD) in a total population sample has not been fully examined before. Therefore, using a total population sample in Japan, we aimed to estimate the prevalence and cumulative incidence of autism spectrum disorder (ASD) annually, to determine whether there is a true increase in ASD prevalence by estimating the cumulative incidence of ASD annually, and to examine the rates of co-existing neurodevelopmental disorders (NDD). METHOD: In this cross-sectional sequential design study, all 5-year-old children in the catchment area underwent the screening annually from the year 2013-2016. Screen-positive children were invited to participate in a comprehensive assessment, including child and parent interview, behavioral observation, and cognitive and motor function testing. All cases were reviewed by a multidisciplinary research team. RESULTS: Caregivers of 3954 children returned the screening, among which 559 children underwent the assessment with 87 children receiving an ASD diagnosis. Adjusted ASD prevalence was 3.22% (95% confidence interval (CI) 2.66-3.76%). The male to female ratio of the crude prevalence was 2.2:1. The cumulative incidence of ASD up to 5?years of age for the total study years was 1.31% (95% CI 1.00-1.62%). A generalized linear model revealed no significant linear trends in 5-year cumulative incidence over the study years. Only 11.5% of children had ASD alone; the remaining 88.5% were found to have at least one co-existing NDD. LIMITATIONS: Modest sample size for a total population study. CONCLUSIONS: Our findings demonstrate the stability of the 5-year cumulative incidence of ASD, implying no true rise in ASD incident cases over the 4-year study period in the study catchment area. High rates of co-existing NDDs reflect the importance of investigating broad developmental challenges in children with ASD. En ligne : http://dx.doi.org/10.1186/s13229-020-00342-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427

Sex differences in scores on standardized measures of autism symptoms: a multisite integrative data analysis / Aaron J. KAAT in Journal of Child Psychology and Psychiatry, 62-1 (January 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-1 (January 2021) . - p.97-106 Titre : Sex differences in scores on standardized measures of autism symptoms: a multisite integrative data analysis Type de document : Texte imprimé et/ou numérique Auteurs : Aaron J. KAAT, Auteur ; Amy M. SHUI, Auteur ; Sheila S. GHODS, Auteur ; Cristan A. FARMER, Auteur ; Amy N. ESLER, Auteur ; Audrey THURM, Auteur ; Stelios GEORGIADES, Auteur ; Stephen M. KANNE, Auteur ; Catherine LORD, Auteur ; Young Shin KIM, Auteur ; Somer L. BISHOP, Auteur Article en page(s) : p.97-106 Langues : Anglais (eng) Mots-clés : Sex differences  autism spectrum disorder  restricted and repetitive behavior  social impairment Index. décimale : PER Périodiques Résumé : BACKGROUND: Concerns have been raised that scores on standard measures of autism spectrum disorder (ASD) symptoms may differ as a function of sex. However, these findings are hindered by small female samples studied thus far. The current study evaluated if, after accounting for age, IQ, and language level, sex affects ASD severity estimates from diagnostic measures among children with ASD. METHODS: Data were obtained from eight sources comprising 27 sites. Linear mixed-effects models, including a random effect for site, were fit for 10 outcomes (Autism Diagnostic Observation Schedule [ADOS] domain-level calibrated severity scores, Autism Diagnostic Interview-Revised [ADI-R] raw scores by age-based algorithm, and raw scores from the two indices on the Social Responsiveness Scale [SRS]). Sex was added to the models after controlling for age, NVIQ, and an indicator for language level. RESULTS: Sex significantly improved model fit for half of the outcomes, but least square mean differences were generally negligible (effect sizes [ES] < 0.20), increasing to small to moderate in adolescence (ES < 0.40). Boys received more severe RRB scores than girls on both the ADOS and ADI-R (age 4 + algorithm), and girls received more severe scores than boys on both SRS indices, which emerged in adolescence. CONCLUSIONS: This study combined several available databases to create the largest sample of girls with ASD diagnoses. We found minimal differences due to sex beyond other known influences on ASD severity indicators. This may suggest that, among children who ultimately receive a clinical ASD diagnosis, severity estimates do not systematically differ to such an extent that sex-specific scoring procedures would be necessary. However, given the limitations inherent in clinically ascertained samples, future research must address questions about systematic sex differences among children or adults who do not receive clinical diagnoses of ASD. Moreover, while the current study helps resolve questions about widely used diagnostic instruments, we could not address sex differences in phenotypic aspects outside of these scores. En ligne : http://dx.doi.org/10.1111/jcpp.13242 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=435 [article] Sex differences in scores on standardized measures of autism symptoms: a multisite integrative data analysis [Texte imprimé et/ou numérique] / Aaron J. KAAT, Auteur ; Amy M. SHUI, Auteur ; Sheila S. GHODS, Auteur ; Cristan A. FARMER, Auteur ; Amy N. ESLER, Auteur ; Audrey THURM, Auteur ; Stelios GEORGIADES, Auteur ; Stephen M. KANNE, Auteur ; Catherine LORD, Auteur ; Young Shin KIM, Auteur ; Somer L. BISHOP, Auteur . - p.97-106. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-1 (January 2021) . - p.97-106 Mots-clés : Sex differences  autism spectrum disorder  restricted and repetitive behavior  social impairment Index. décimale : PER Périodiques Résumé : BACKGROUND: Concerns have been raised that scores on standard measures of autism spectrum disorder (ASD) symptoms may differ as a function of sex. However, these findings are hindered by small female samples studied thus far. The current study evaluated if, after accounting for age, IQ, and language level, sex affects ASD severity estimates from diagnostic measures among children with ASD. METHODS: Data were obtained from eight sources comprising 27 sites. Linear mixed-effects models, including a random effect for site, were fit for 10 outcomes (Autism Diagnostic Observation Schedule [ADOS] domain-level calibrated severity scores, Autism Diagnostic Interview-Revised [ADI-R] raw scores by age-based algorithm, and raw scores from the two indices on the Social Responsiveness Scale [SRS]). Sex was added to the models after controlling for age, NVIQ, and an indicator for language level. RESULTS: Sex significantly improved model fit for half of the outcomes, but least square mean differences were generally negligible (effect sizes [ES] < 0.20), increasing to small to moderate in adolescence (ES < 0.40). Boys received more severe RRB scores than girls on both the ADOS and ADI-R (age 4 + algorithm), and girls received more severe scores than boys on both SRS indices, which emerged in adolescence. CONCLUSIONS: This study combined several available databases to create the largest sample of girls with ASD diagnoses. We found minimal differences due to sex beyond other known influences on ASD severity indicators. This may suggest that, among children who ultimately receive a clinical ASD diagnosis, severity estimates do not systematically differ to such an extent that sex-specific scoring procedures would be necessary. However, given the limitations inherent in clinically ascertained samples, future research must address questions about systematic sex differences among children or adults who do not receive clinical diagnoses of ASD. Moreover, while the current study helps resolve questions about widely used diagnostic instruments, we could not address sex differences in phenotypic aspects outside of these scores. En ligne : http://dx.doi.org/10.1111/jcpp.13242 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=435

The social responsiveness scale in relation to DSM IV and DSM5 ASD in Korean children / Keun-Ah CHEON in Autism Research, 9-9 (September 2016)  

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