A cluster analysis exploration of autism spectrum disorder subgroups in children without intellectual disability / Felicity KLOPPER in Research in Autism Spectrum Disorders, 36 (April 2017)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 36 (April 2017) . - p.66-78 Titre : A cluster analysis exploration of autism spectrum disorder subgroups in children without intellectual disability Type de document : Texte imprimé et/ou numérique Auteurs : Felicity KLOPPER, Auteur ; Renee TESTA, Auteur ; Christos PANTELIS, Auteur ; Efstratios SKAFIDAS, Auteur Article en page(s) : p.66-78 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Asperger disorder  Autistic disorder  Classification  Subgroups Index. décimale : PER Périodiques Résumé : The heterogeneity in autism spectrum disorder (ASD) remains poorly understood, particularly in individuals without intellectual disability (ID), where phenotypic variability can be most pronounced. The presence of phenotypic subgroups continues to be questioned. This study investigated whether children with ASD without ID are differentiable into clinically meaningful subgroups. Method Data from the ‘gold standard’ ASD diagnostic instruments for 61 children (5–14 years) with ASD without ID were subjected to exploratory cluster analysis. Cognition, language, pragmatic communication, and behaviour were used to explore subgroups. Results Children with ASD without ID could be differentiated into Moderate and Severe Social Impairment subgroups when core ASD symptoms were more closely examined. The Moderate Social Impairment subgroup showed less severe social interaction and communication impairments but greater lifetime severity of restricted/repetitive behaviours. In contrast, the Severe Social Impairment subgroup, with poorer social interaction and communication skills, had lower lifetime severity of restricted/repetitive behaviours. This subgroup also had greater cognitive and language difficulties, and poorer adaptive functioning. Importantly, however, these neurocognitive and functional differences showed only small to moderate associations with the differentiated ASD clinical profiles. Conclusions Evidence of dissociated levels of severity across core ASD dimensions supports the idea that clinically meaningful subgroups within ASD without ID can be identified. The dissociated profiles of ASD features could represent different underlying neurobiological mechanisms for each subgroup. Identifying such subgroups in practice can improve the clinical utility of diagnostic labels in this population. Thus, both categorical and dimensional approaches may be useful in classifying ASD, with neither alone being adequate. En ligne : http://dx.doi.org/10.1016/j.rasd.2017.01.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] A cluster analysis exploration of autism spectrum disorder subgroups in children without intellectual disability [Texte imprimé et/ou numérique] / Felicity KLOPPER, Auteur ; Renee TESTA, Auteur ; Christos PANTELIS, Auteur ; Efstratios SKAFIDAS, Auteur . - p.66-78. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 36 (April 2017) . - p.66-78 Mots-clés : Autism spectrum disorders  Asperger disorder  Autistic disorder  Classification  Subgroups Index. décimale : PER Périodiques Résumé : The heterogeneity in autism spectrum disorder (ASD) remains poorly understood, particularly in individuals without intellectual disability (ID), where phenotypic variability can be most pronounced. The presence of phenotypic subgroups continues to be questioned. This study investigated whether children with ASD without ID are differentiable into clinically meaningful subgroups. Method Data from the ‘gold standard’ ASD diagnostic instruments for 61 children (5–14 years) with ASD without ID were subjected to exploratory cluster analysis. Cognition, language, pragmatic communication, and behaviour were used to explore subgroups. Results Children with ASD without ID could be differentiated into Moderate and Severe Social Impairment subgroups when core ASD symptoms were more closely examined. The Moderate Social Impairment subgroup showed less severe social interaction and communication impairments but greater lifetime severity of restricted/repetitive behaviours. In contrast, the Severe Social Impairment subgroup, with poorer social interaction and communication skills, had lower lifetime severity of restricted/repetitive behaviours. This subgroup also had greater cognitive and language difficulties, and poorer adaptive functioning. Importantly, however, these neurocognitive and functional differences showed only small to moderate associations with the differentiated ASD clinical profiles. Conclusions Evidence of dissociated levels of severity across core ASD dimensions supports the idea that clinically meaningful subgroups within ASD without ID can be identified. The dissociated profiles of ASD features could represent different underlying neurobiological mechanisms for each subgroup. Identifying such subgroups in practice can improve the clinical utility of diagnostic labels in this population. Thus, both categorical and dimensional approaches may be useful in classifying ASD, with neither alone being adequate. En ligne : http://dx.doi.org/10.1016/j.rasd.2017.01.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304

Hippocampal volume and sensitivity to maternal aggressive behavior: A prospective study of adolescent depressive symptoms / Sarah WHITTLE in Development and Psychopathology, 23-1 (January 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-1 (January 2011) . - p.115-129 Titre : Hippocampal volume and sensitivity to maternal aggressive behavior: A prospective study of adolescent depressive symptoms Type de document : Texte imprimé et/ou numérique Auteurs : Sarah WHITTLE, Auteur ; Marie B.H. YAP, Auteur ; Lisa B. SHEEBER, Auteur ; Paul DUDGEON, Auteur ; Murat YUCEL, Auteur ; Christos PANTELIS, Auteur ; Julian G. SIMMONS, Auteur ; Nicholas B. ALLEN, Auteur Année de publication : 2011 Article en page(s) : p.115-129 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : It has been suggested that biological factors confer increased sensitivity to environmental influences on depressive symptoms during adolescence, a crucial time for the onset of depressive disorders. Given the critical role of the hippocampus in sensitivity to stress and processing of contextual aspects of the environment, investigation of its role in determining sensitivity to environmental context seems warranted. This study prospectively examined hippocampal volume as a measure of sensitivity to the influence of aggressive maternal behavior on change in depressive symptoms from early to midadolescence. The interaction between aggressive maternal behavior and hippocampal volume was found to predict change in depressive symptoms. Significant sex differences also emerged, whereby only for girls were larger bilateral hippocampal volumes more sensitive to the effects of maternal aggressive behavior, particularly with respect to experiencing the protective effects of low levels of maternal aggressiveness. These findings help elucidate the complex relationships between brain structure, environmental factors such as maternal parenting style, and sensitivity to (i.e., risk for, and protection from) the emergence of depression during this life stage. Given that family context risk factors are modifiable, our findings suggest the potential utility of targeted parenting interventions for the prevention and treatment of adolescent depressive disorder. En ligne : http://dx.doi.org/10.1017/S0954579410000684 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=117 [article] Hippocampal volume and sensitivity to maternal aggressive behavior: A prospective study of adolescent depressive symptoms [Texte imprimé et/ou numérique] / Sarah WHITTLE, Auteur ; Marie B.H. YAP, Auteur ; Lisa B. SHEEBER, Auteur ; Paul DUDGEON, Auteur ; Murat YUCEL, Auteur ; Christos PANTELIS, Auteur ; Julian G. SIMMONS, Auteur ; Nicholas B. ALLEN, Auteur . - 2011 . - p.115-129. Langues : Anglais (eng) in Development and Psychopathology > 23-1 (January 2011) . - p.115-129 Index. décimale : PER Périodiques Résumé : It has been suggested that biological factors confer increased sensitivity to environmental influences on depressive symptoms during adolescence, a crucial time for the onset of depressive disorders. Given the critical role of the hippocampus in sensitivity to stress and processing of contextual aspects of the environment, investigation of its role in determining sensitivity to environmental context seems warranted. This study prospectively examined hippocampal volume as a measure of sensitivity to the influence of aggressive maternal behavior on change in depressive symptoms from early to midadolescence. The interaction between aggressive maternal behavior and hippocampal volume was found to predict change in depressive symptoms. Significant sex differences also emerged, whereby only for girls were larger bilateral hippocampal volumes more sensitive to the effects of maternal aggressive behavior, particularly with respect to experiencing the protective effects of low levels of maternal aggressiveness. These findings help elucidate the complex relationships between brain structure, environmental factors such as maternal parenting style, and sensitivity to (i.e., risk for, and protection from) the emergence of depression during this life stage. Given that family context risk factors are modifiable, our findings suggest the potential utility of targeted parenting interventions for the prevention and treatment of adolescent depressive disorder. En ligne : http://dx.doi.org/10.1017/S0954579410000684 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=117

A Meta-analysis of Mental Time Travel in Individuals with Autism Spectrum Disorders / Jun-yan YE in Journal of Autism and Developmental Disorders, 53-4 (April 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-4 (April 2023) . - p.1509-1528 Titre : A Meta-analysis of Mental Time Travel in Individuals with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Jun-yan YE, Auteur ; Xiao-jing QIN, Auteur ; Ji-fang CUI, Auteur ; Qian REN, Auteur ; Lu-xia JIA, Auteur ; Ya WANG, Auteur ; Christos PANTELIS, Auteur ; Raymond C. K. CHAN, Auteur Article en page(s) : p.1509-1528 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are associated with cognitive dysfunctions, including mental time travel (MTT). However, findings on diminished MTT ability may be confounded by a number of factors, including the individuals' language ability, factors related to the MTT task and the demographic factors of participants. The present study provided a meta-analysis of MTT ability in people with ASD. The results showed significant overall reductions in MTT ability in people with ASD. Moderator analyses revealed that the variables examined did not explain the reduction in MTT ability. These findings suggest that MTT ability is diminished in people with ASD and that the degree of this diminishment may not depend on the characteristics of measures or demographic variables of people with ASD. En ligne : https://doi.org/10.1007/s10803-021-05375-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=500 [article] A Meta-analysis of Mental Time Travel in Individuals with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Jun-yan YE, Auteur ; Xiao-jing QIN, Auteur ; Ji-fang CUI, Auteur ; Qian REN, Auteur ; Lu-xia JIA, Auteur ; Ya WANG, Auteur ; Christos PANTELIS, Auteur ; Raymond C. K. CHAN, Auteur . - p.1509-1528. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-4 (April 2023) . - p.1509-1528 Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are associated with cognitive dysfunctions, including mental time travel (MTT). However, findings on diminished MTT ability may be confounded by a number of factors, including the individuals' language ability, factors related to the MTT task and the demographic factors of participants. The present study provided a meta-analysis of MTT ability in people with ASD. The results showed significant overall reductions in MTT ability in people with ASD. Moderator analyses revealed that the variables examined did not explain the reduction in MTT ability. These findings suggest that MTT ability is diminished in people with ASD and that the degree of this diminishment may not depend on the characteristics of measures or demographic variables of people with ASD. En ligne : https://doi.org/10.1007/s10803-021-05375-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=500

Neural Correlates of Audiovisual Temporal Binding Window in Individuals With Schizotypal and Autistic Traits: Evidence From Resting-State Functional Connectivity / Han-Yu ZHOU in Autism Research, 14-4 (April 2021)  

Public ISBD [article]  inAutism Research > 14-4 (April 2021) . - p.668-680 Titre : Neural Correlates of Audiovisual Temporal Binding Window in Individuals With Schizotypal and Autistic Traits: Evidence From Resting-State Functional Connectivity Type de document : Texte imprimé et/ou numérique Auteurs : Han-Yu ZHOU, Auteur ; Yong-Ming WANG, Auteur ; Rui-Ting ZHANG, Auteur ; Eric F. C. CHEUNG, Auteur ; Christos PANTELIS, Auteur ; Raymond C. K. CHAN, Auteur Article en page(s) : p.668-680 Langues : Anglais (eng) Mots-clés : audiovisual  autistic traits  resting-state functional connectivity  schizotypal traits  temporal binding window Index. décimale : PER Périodiques Résumé : Temporal proximity is an important clue for multisensory integration. Previous evidence indicates that individuals with autism and schizophrenia are more likely to integrate multisensory inputs over a longer temporal binding window (TBW). However, whether such deficits in audiovisual temporal integration extend to subclinical populations with high schizotypal and autistic traits are unclear. Using audiovisual simultaneity judgment (SJ) tasks for nonspeech and speech stimuli, our results suggested that the width of the audiovisual TBW was not significantly correlated with self-reported schizotypal and autistic traits in a group of young adults. Functional magnetic resonance imaging (fMRI) resting-state activity was also acquired to explore the neural correlates underlying inter-individual variability of TBW width. Across the entire sample, stronger resting-state functional connectivity (rsFC) between the left superior temporal cortex and the left precuneus, and weaker rsFC between the left cerebellum and the right dorsal lateral prefrontal cortex were correlated with a narrower TBW for speech stimuli. Meanwhile, stronger rsFC between the left anterior superior temporal gyrus and the right inferior temporal gyrus was correlated with a wider audiovisual TBW for non-speech stimuli. The TBW-related rsFC was not affected by levels of subclinical traits. In conclusion, this study indicates that audiovisual temporal processing may not be affected by autistic and schizotypal traits and rsFC between brain regions responding to multisensory information and timing may account for the inter-individual difference in TBW width. LAY SUMMARY: Individuals with ASD and schizophrenia are more likely to perceive asynchronous auditory and visual events as occurring simultaneously even if they are well separated in time. We investigated whether similar difficulties in audiovisual temporal processing were present in subclinical populations with high autistic and schizotypal traits. We found that the ability to detect audiovisual asynchrony was not affected by different levels of autistic and schizotypal traits. We also found that connectivity of some brain regions engaging in multisensory and timing tasks might explain an individual's tendency to bind multisensory information within a wide or narrow time window. Autism Res 2021, 14: 668-680. © 2020 International Society for Autism Research and Wiley Periodicals LLC. En ligne : http://dx.doi.org/10.1002/aur.2456 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443 [article] Neural Correlates of Audiovisual Temporal Binding Window in Individuals With Schizotypal and Autistic Traits: Evidence From Resting-State Functional Connectivity [Texte imprimé et/ou numérique] / Han-Yu ZHOU, Auteur ; Yong-Ming WANG, Auteur ; Rui-Ting ZHANG, Auteur ; Eric F. C. CHEUNG, Auteur ; Christos PANTELIS, Auteur ; Raymond C. K. CHAN, Auteur . - p.668-680. Langues : Anglais (eng) in Autism Research > 14-4 (April 2021) . - p.668-680 Mots-clés : audiovisual  autistic traits  resting-state functional connectivity  schizotypal traits  temporal binding window Index. décimale : PER Périodiques Résumé : Temporal proximity is an important clue for multisensory integration. Previous evidence indicates that individuals with autism and schizophrenia are more likely to integrate multisensory inputs over a longer temporal binding window (TBW). However, whether such deficits in audiovisual temporal integration extend to subclinical populations with high schizotypal and autistic traits are unclear. Using audiovisual simultaneity judgment (SJ) tasks for nonspeech and speech stimuli, our results suggested that the width of the audiovisual TBW was not significantly correlated with self-reported schizotypal and autistic traits in a group of young adults. Functional magnetic resonance imaging (fMRI) resting-state activity was also acquired to explore the neural correlates underlying inter-individual variability of TBW width. Across the entire sample, stronger resting-state functional connectivity (rsFC) between the left superior temporal cortex and the left precuneus, and weaker rsFC between the left cerebellum and the right dorsal lateral prefrontal cortex were correlated with a narrower TBW for speech stimuli. Meanwhile, stronger rsFC between the left anterior superior temporal gyrus and the right inferior temporal gyrus was correlated with a wider audiovisual TBW for non-speech stimuli. The TBW-related rsFC was not affected by levels of subclinical traits. In conclusion, this study indicates that audiovisual temporal processing may not be affected by autistic and schizotypal traits and rsFC between brain regions responding to multisensory information and timing may account for the inter-individual difference in TBW width. LAY SUMMARY: Individuals with ASD and schizophrenia are more likely to perceive asynchronous auditory and visual events as occurring simultaneously even if they are well separated in time. We investigated whether similar difficulties in audiovisual temporal processing were present in subclinical populations with high autistic and schizotypal traits. We found that the ability to detect audiovisual asynchrony was not affected by different levels of autistic and schizotypal traits. We also found that connectivity of some brain regions engaging in multisensory and timing tasks might explain an individual's tendency to bind multisensory information within a wide or narrow time window. Autism Res 2021, 14: 668-680. © 2020 International Society for Autism Research and Wiley Periodicals LLC. En ligne : http://dx.doi.org/10.1002/aur.2456 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443

No preliminary evidence of differences in astrocyte density within the white matter of the dorsolateral prefrontal cortex in autism / T. T. LEE in Molecular Autism, 8 (2017)  

Public ISBD [article]  inMolecular Autism > 8 (2017) . - 64p. Titre : No preliminary evidence of differences in astrocyte density within the white matter of the dorsolateral prefrontal cortex in autism Type de document : Texte imprimé et/ou numérique Auteurs : T. T. LEE, Auteur ; E. SKAFIDAS, Auteur ; M. DOTTORI, Auteur ; D. ZANTOMIO, Auteur ; Christos PANTELIS, Auteur ; I. EVERALL, Auteur ; G. CHANA, Auteur Article en page(s) : 64p. Langues : Anglais (eng) Mots-clés : Astrocytes  Autism  Cell density  Dorsolateral prefrontal cortex (DLPFC)  Glia  White matter Index. décimale : PER Périodiques Résumé : Background: While evidence for white matter and astrocytic abnormalities exist in autism, a detailed investigation of astrocytes has not been conducted. Such an investigation is further warranted by an increasing role for neuroinflammation in autism pathogenesis, with astrocytes being key players in this process. We present the first study of astrocyte density and morphology within the white matter of the dorsolateral prefrontal cortex (DLPFC) in individuals with autism. Methods: DLPFC formalin-fixed sections containing white matter from individuals with autism (n = 8, age = 4-51 years) and age-matched controls (n = 7, age = 4-46 years) were immunostained for glial fibrillary acidic protein (GFAP). Density of astrocytes and other glia were estimated via the optical fractionator, astrocyte somal size estimated via the nucleator, and astrocyte process length via the spaceballs probe. Results: We found no evidence for alteration in astrocyte density within DLPFC white matter of individuals with autism versus controls, together with no differences in astrocyte somal size and process length. Conclusion: Our results suggest that astrocyte abnormalities within the white matter in the DLPFC in autism may be less pronounced than previously thought. However, astrocytic dysregulation may still exist in autism, even in the absence of gross morphological changes. Our lack of evidence for astrocyte abnormalities could have been confounded to an extent by having a small sample size and wide age range, with pathological features potentially restricted to early stages of autism. Nonetheless, future investigations would benefit from assessing functional markers of astrocytes in light of the underlying pathophysiology of autism. En ligne : http://dx.doi.org/10.1186/s13229-017-0181-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330 [article] No preliminary evidence of differences in astrocyte density within the white matter of the dorsolateral prefrontal cortex in autism [Texte imprimé et/ou numérique] / T. T. LEE, Auteur ; E. SKAFIDAS, Auteur ; M. DOTTORI, Auteur ; D. ZANTOMIO, Auteur ; Christos PANTELIS, Auteur ; I. EVERALL, Auteur ; G. CHANA, Auteur . - 64p. Langues : Anglais (eng) in Molecular Autism > 8 (2017) . - 64p. Mots-clés : Astrocytes  Autism  Cell density  Dorsolateral prefrontal cortex (DLPFC)  Glia  White matter Index. décimale : PER Périodiques Résumé : Background: While evidence for white matter and astrocytic abnormalities exist in autism, a detailed investigation of astrocytes has not been conducted. Such an investigation is further warranted by an increasing role for neuroinflammation in autism pathogenesis, with astrocytes being key players in this process. We present the first study of astrocyte density and morphology within the white matter of the dorsolateral prefrontal cortex (DLPFC) in individuals with autism. Methods: DLPFC formalin-fixed sections containing white matter from individuals with autism (n = 8, age = 4-51 years) and age-matched controls (n = 7, age = 4-46 years) were immunostained for glial fibrillary acidic protein (GFAP). Density of astrocytes and other glia were estimated via the optical fractionator, astrocyte somal size estimated via the nucleator, and astrocyte process length via the spaceballs probe. Results: We found no evidence for alteration in astrocyte density within DLPFC white matter of individuals with autism versus controls, together with no differences in astrocyte somal size and process length. Conclusion: Our results suggest that astrocyte abnormalities within the white matter in the DLPFC in autism may be less pronounced than previously thought. However, astrocytic dysregulation may still exist in autism, even in the absence of gross morphological changes. Our lack of evidence for astrocyte abnormalities could have been confounded to an extent by having a small sample size and wide age range, with pathological features potentially restricted to early stages of autism. Nonetheless, future investigations would benefit from assessing functional markers of astrocytes in light of the underlying pathophysiology of autism. En ligne : http://dx.doi.org/10.1186/s13229-017-0181-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330

Parenting x Brain Development interactions as predictors of adolescent depressive symptoms and well-being: Differential susceptibility or diathesis-stress? / Camille DEANE in Development and Psychopathology, 32-1 (February 2020)  

Permalink

---

1 (1 - 6 / 6)