Dépouillements

Alterations of local spontaneous brain activity and connectivity in adults with high-functioning autism spectrum disorder / Takashi ITAHASHI in Molecular Autism, (May 2015)  

Public ISBD [article]  inMolecular Autism > (May 2015) . - p.1-14 Titre : Alterations of local spontaneous brain activity and connectivity in adults with high-functioning autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Takashi ITAHASHI, Auteur ; Takashi YAMADA, Auteur ; Hiromi WATANABE, Auteur ; Motoaki NAKAMURA, Auteur ; Haruhisa OHTA, Auteur ; Chieko KANAI, Auteur ; Akira IWANAMI, Auteur ; Nobumasa KATO, Auteur ; Ryu-ichiro HASHIMOTO, Auteur Article en page(s) : p.1-14 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Previous autism research has hypothesized that abnormalities of functional connectivity in autism spectrum disorder (ASD) may vary with the spatial distance between two brain regions. Although several resting-state functional magnetic resonance imaging (rsfMRI) studies have extensively examined long-range (or distant) connectivity in the adult ASD brain, short-range (or local) connectivity has been investigated in less depth. Furthermore, the possible relationship between functional connectivity and brain activity level during the resting state remains unclear. En ligne : http://dx.doi.org/10.1186/s13229-015-0026-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Alterations of local spontaneous brain activity and connectivity in adults with high-functioning autism spectrum disorder [Texte imprimé et/ou numérique] / Takashi ITAHASHI, Auteur ; Takashi YAMADA, Auteur ; Hiromi WATANABE, Auteur ; Motoaki NAKAMURA, Auteur ; Haruhisa OHTA, Auteur ; Chieko KANAI, Auteur ; Akira IWANAMI, Auteur ; Nobumasa KATO, Auteur ; Ryu-ichiro HASHIMOTO, Auteur . - p.1-14. Langues : Anglais (eng) in Molecular Autism > (May 2015) . - p.1-14 Index. décimale : PER Périodiques Résumé : Previous autism research has hypothesized that abnormalities of functional connectivity in autism spectrum disorder (ASD) may vary with the spatial distance between two brain regions. Although several resting-state functional magnetic resonance imaging (rsfMRI) studies have extensively examined long-range (or distant) connectivity in the adult ASD brain, short-range (or local) connectivity has been investigated in less depth. Furthermore, the possible relationship between functional connectivity and brain activity level during the resting state remains unclear. En ligne : http://dx.doi.org/10.1186/s13229-015-0026-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

NTRK2 expression levels are reduced in laser captured pyramidal neurons from the anterior cingulate cortex in males with autism spectrum disorder / Michelle J. CHANDLEY in Molecular Autism, (May 2015)  

Public ISBD [article]  inMolecular Autism > (May 2015) . - p.1-12 Titre : NTRK2 expression levels are reduced in laser captured pyramidal neurons from the anterior cingulate cortex in males with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Michelle J. CHANDLEY, Auteur ; Jessica D. CRAWFORD, Auteur ; Attila SZEBENI, Auteur ; Katalin SZEBENI, Auteur ; Gregory A. ORDWAY, Auteur Article en page(s) : p.1-12 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The anterior cingulate cortex (ACC) is a brain area involved in modulating behavior associated with social interaction, disruption of which is a core feature of autism spectrum disorder (ASD). Functional brain imaging studies demonstrate abnormalities of the ACC in ASD as compared to typically developing control patients. However, little is known regarding the cellular basis of these functional deficits in ASD. Pyramidal neurons in the ACC are excitatory glutamatergic neurons and key cellular mediators of the neural output of the ACC. This study was designed to investigate the potential role of ACC pyramidal neurons in ASD brain pathology. En ligne : http://dx.doi.org/10.1186/s13229-015-0023-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] NTRK2 expression levels are reduced in laser captured pyramidal neurons from the anterior cingulate cortex in males with autism spectrum disorder [Texte imprimé et/ou numérique] / Michelle J. CHANDLEY, Auteur ; Jessica D. CRAWFORD, Auteur ; Attila SZEBENI, Auteur ; Katalin SZEBENI, Auteur ; Gregory A. ORDWAY, Auteur . - p.1-12. Langues : Anglais (eng) in Molecular Autism > (May 2015) . - p.1-12 Index. décimale : PER Périodiques Résumé : The anterior cingulate cortex (ACC) is a brain area involved in modulating behavior associated with social interaction, disruption of which is a core feature of autism spectrum disorder (ASD). Functional brain imaging studies demonstrate abnormalities of the ACC in ASD as compared to typically developing control patients. However, little is known regarding the cellular basis of these functional deficits in ASD. Pyramidal neurons in the ACC are excitatory glutamatergic neurons and key cellular mediators of the neural output of the ACC. This study was designed to investigate the potential role of ACC pyramidal neurons in ASD brain pathology. En ligne : http://dx.doi.org/10.1186/s13229-015-0023-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Regional brain volume differences between males with and without autism spectrum disorder are highly age-dependent / Hsiang-Yuan LIN in Molecular Autism, (May 2015)  

Public ISBD [article]  inMolecular Autism > (May 2015) . - p.1-18 Titre : Regional brain volume differences between males with and without autism spectrum disorder are highly age-dependent Type de document : Texte imprimé et/ou numérique Auteurs : Hsiang-Yuan LIN, Auteur ; Hsing-Chang NI, Auteur ; Meng-Chuan LAI, Auteur ; Wen-Yih Isaac TSENG, Auteur ; Susan Shur-Fen GAU, Auteur Article en page(s) : p.1-18 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Neuroanatomical differences between individuals with and without autism spectrum disorder (ASD) were inconsistent in the literature. Such heterogeneity may substantially originate from age-differential effects. En ligne : http://dx.doi.org/10.1186/s13229-015-0022-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Regional brain volume differences between males with and without autism spectrum disorder are highly age-dependent [Texte imprimé et/ou numérique] / Hsiang-Yuan LIN, Auteur ; Hsing-Chang NI, Auteur ; Meng-Chuan LAI, Auteur ; Wen-Yih Isaac TSENG, Auteur ; Susan Shur-Fen GAU, Auteur . - p.1-18. Langues : Anglais (eng) in Molecular Autism > (May 2015) . - p.1-18 Index. décimale : PER Périodiques Résumé : Neuroanatomical differences between individuals with and without autism spectrum disorder (ASD) were inconsistent in the literature. Such heterogeneity may substantially originate from age-differential effects. En ligne : http://dx.doi.org/10.1186/s13229-015-0022-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Understanding autism in the light of sex/gender / Meng-Chuan LAI in Molecular Autism, (May 2015)  

Public ISBD [article]  inMolecular Autism > (May 2015) . - p.1-5 Titre : Understanding autism in the light of sex/gender Type de document : Texte imprimé et/ou numérique Auteurs : Meng-Chuan LAI, Auteur ; Simon BARON-COHEN, Auteur ; Joseph D. BUXBAUM, Auteur Article en page(s) : p.1-5 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1186/s13229-015-0021-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Understanding autism in the light of sex/gender [Texte imprimé et/ou numérique] / Meng-Chuan LAI, Auteur ; Simon BARON-COHEN, Auteur ; Joseph D. BUXBAUM, Auteur . - p.1-5. Langues : Anglais (eng) in Molecular Autism > (May 2015) . - p.1-5 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1186/s13229-015-0021-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

The female protective effect in autism spectrum disorder is not mediated by a single genetic locus / Jake GOCKLEY in Molecular Autism, (May 2015)  

Public ISBD [article]  inMolecular Autism > (May 2015) . - p.1-10 Titre : The female protective effect in autism spectrum disorder is not mediated by a single genetic locus Type de document : Texte imprimé et/ou numérique Auteurs : Jake GOCKLEY, Auteur ; A. Jeremy WILLSEY, Auteur ; Shan DONG, Auteur ; Joseph D. DOUGHERTY, Auteur ; John N. CONSTANTINO, Auteur ; Stephan J. SANDERS, Auteur Article en page(s) : p.1-10 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : A 4:1 male to female sex bias has consistently been observed in autism spectrum disorder (ASD). Epidemiological and genetic studies suggest a female protective effect (FPE) may account for part of this bias; however, the mechanism of such protection is unknown. Quantitative assessment of ASD symptoms using the Social Responsiveness Scale (SRS) shows a bimodal distribution unique to females in multiplex families. This leads to the hypothesis that a single, common genetic locus on chromosome X might mediate the FPE and produce the ASD sex bias. Such a locus would represent a major therapeutic target and is likely to have been missed by conventional genome-wide association study (GWAS) analysis. En ligne : http://dx.doi.org/10.1186/s13229-015-0014-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] The female protective effect in autism spectrum disorder is not mediated by a single genetic locus [Texte imprimé et/ou numérique] / Jake GOCKLEY, Auteur ; A. Jeremy WILLSEY, Auteur ; Shan DONG, Auteur ; Joseph D. DOUGHERTY, Auteur ; John N. CONSTANTINO, Auteur ; Stephan J. SANDERS, Auteur . - p.1-10. Langues : Anglais (eng) in Molecular Autism > (May 2015) . - p.1-10 Index. décimale : PER Périodiques Résumé : A 4:1 male to female sex bias has consistently been observed in autism spectrum disorder (ASD). Epidemiological and genetic studies suggest a female protective effect (FPE) may account for part of this bias; however, the mechanism of such protection is unknown. Quantitative assessment of ASD symptoms using the Social Responsiveness Scale (SRS) shows a bimodal distribution unique to females in multiplex families. This leads to the hypothesis that a single, common genetic locus on chromosome X might mediate the FPE and produce the ASD sex bias. Such a locus would represent a major therapeutic target and is likely to have been missed by conventional genome-wide association study (GWAS) analysis. En ligne : http://dx.doi.org/10.1186/s13229-015-0014-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Sex differences in the corpus callosum in preschool-aged children with autism spectrum disorder / Christine W. NORDAHL in Molecular Autism, (May 2015)  

Public ISBD [article]  inMolecular Autism > (May 2015) . - p.1-11 Titre : Sex differences in the corpus callosum in preschool-aged children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Christine W. NORDAHL, Auteur ; Ana-Maria IOSIF, Auteur ; Gregory S. YOUNG, Auteur ; Lee Michael PERRY, Auteur ; Robert DOUGHERTY, Auteur ; Aaron LEE, Auteur ; Deana LI, Auteur ; Michael H. BUONOCORE, Auteur ; Tony SIMON, Auteur ; Sally J ROGERS, Auteur ; Brian WANDELL, Auteur ; David G. AMARAL, Auteur Article en page(s) : p.1-11 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abnormalities in the corpus callosum have been reported in individuals with autism spectrum disorder (ASD), but few studies have evaluated young children. Sex differences in callosal organization and diffusion characteristics have also not been evaluated fully in ASD. En ligne : http://dx.doi.org/10.1186/s13229-015-0005-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Sex differences in the corpus callosum in preschool-aged children with autism spectrum disorder [Texte imprimé et/ou numérique] / Christine W. NORDAHL, Auteur ; Ana-Maria IOSIF, Auteur ; Gregory S. YOUNG, Auteur ; Lee Michael PERRY, Auteur ; Robert DOUGHERTY, Auteur ; Aaron LEE, Auteur ; Deana LI, Auteur ; Michael H. BUONOCORE, Auteur ; Tony SIMON, Auteur ; Sally J ROGERS, Auteur ; Brian WANDELL, Auteur ; David G. AMARAL, Auteur . - p.1-11. Langues : Anglais (eng) in Molecular Autism > (May 2015) . - p.1-11 Index. décimale : PER Périodiques Résumé : Abnormalities in the corpus callosum have been reported in individuals with autism spectrum disorder (ASD), but few studies have evaluated young children. Sex differences in callosal organization and diffusion characteristics have also not been evaluated fully in ASD. En ligne : http://dx.doi.org/10.1186/s13229-015-0005-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Recurrence rates provide evidence for sex-differential, familial genetic liability for autism spectrum disorders in multiplex families and twins / Donna M. WERLING in Molecular Autism, (May 2015)  

Public ISBD [article]  inMolecular Autism > (May 2015) . - p.1-14 Titre : Recurrence rates provide evidence for sex-differential, familial genetic liability for autism spectrum disorders in multiplex families and twins Type de document : Texte imprimé et/ou numérique Auteurs : Donna M. WERLING, Auteur ; Daniel H. GESCHWIND, Auteur Article en page(s) : p.1-14 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) are more prevalent in males, suggesting a multiple threshold liability model in which females are, on average, protected by sex-differential mechanisms. Under this model, autistic females are predicted to carry a more penetrant risk variant load than males and to share this greater genetic liability with their siblings. However, reported ASD recurrence rates have not demonstrated significantly increased risk to siblings of affected girls. Here, we characterize recurrence patterns in multiplex families from the Autism Genetics Resource Exchange (AGRE) to determine if risk in these families follows a female protective model. En ligne : http://dx.doi.org/10.1186/s13229-015-0004-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Recurrence rates provide evidence for sex-differential, familial genetic liability for autism spectrum disorders in multiplex families and twins [Texte imprimé et/ou numérique] / Donna M. WERLING, Auteur ; Daniel H. GESCHWIND, Auteur . - p.1-14. Langues : Anglais (eng) in Molecular Autism > (May 2015) . - p.1-14 Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) are more prevalent in males, suggesting a multiple threshold liability model in which females are, on average, protected by sex-differential mechanisms. Under this model, autistic females are predicted to carry a more penetrant risk variant load than males and to share this greater genetic liability with their siblings. However, reported ASD recurrence rates have not demonstrated significantly increased risk to siblings of affected girls. Here, we characterize recurrence patterns in multiplex families from the Autism Genetics Resource Exchange (AGRE) to determine if risk in these families follows a female protective model. En ligne : http://dx.doi.org/10.1186/s13229-015-0004-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Investigation of sex differences in the expression of RORA and its transcriptional targets in the brain as a potential contributor to the sex bias in autism / Valerie W. HU in Molecular Autism, (May 2015)  

Public ISBD [article]  inMolecular Autism > (May 2015) . - p.1-19 Titre : Investigation of sex differences in the expression of RORA and its transcriptional targets in the brain as a potential contributor to the sex bias in autism Type de document : Texte imprimé et/ou numérique Auteurs : Valerie W. HU, Auteur ; Tewarit SARACHANA, Auteur ; Rachel M. SHERRARD, Auteur ; Kristen M. KOCHER, Auteur Article en page(s) : p.1-19 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by significant impairment in reciprocal social interactions and communication coupled with stereotyped, repetitive behaviors and restricted interests. Although genomic and functional studies are beginning to reveal some of the genetic complexity and underlying pathobiology of ASD, the consistently reported male bias of ASD remains an enigma. We have recently proposed that retinoic acid-related orphan receptor alpha (RORA), which is reduced in the brain and lymphoblastoid cell lines of multiple cohorts of individuals with ASD and oppositely regulated by male and female hormones, might contribute to the sex bias in autism by differentially regulating target genes, including CYP19A1 (aromatase), in a sex-dependent manner that can also lead to elevated testosterone levels, a proposed risk factor for autism. En ligne : http://dx.doi.org/10.1186/2040-2392-6-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Investigation of sex differences in the expression of RORA and its transcriptional targets in the brain as a potential contributor to the sex bias in autism [Texte imprimé et/ou numérique] / Valerie W. HU, Auteur ; Tewarit SARACHANA, Auteur ; Rachel M. SHERRARD, Auteur ; Kristen M. KOCHER, Auteur . - p.1-19. Langues : Anglais (eng) in Molecular Autism > (May 2015) . - p.1-19 Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by significant impairment in reciprocal social interactions and communication coupled with stereotyped, repetitive behaviors and restricted interests. Although genomic and functional studies are beginning to reveal some of the genetic complexity and underlying pathobiology of ASD, the consistently reported male bias of ASD remains an enigma. We have recently proposed that retinoic acid-related orphan receptor alpha (RORA), which is reduced in the brain and lymphoblastoid cell lines of multiple cohorts of individuals with ASD and oppositely regulated by male and female hormones, might contribute to the sex bias in autism by differentially regulating target genes, including CYP19A1 (aromatase), in a sex-dependent manner that can also lead to elevated testosterone levels, a proposed risk factor for autism. En ligne : http://dx.doi.org/10.1186/2040-2392-6-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Do women with eating disorders who have social and flexibility difficulties really have autism? A case series / Will MANDY in Molecular Autism, (May 2015)  

Public ISBD [article]  inMolecular Autism > (May 2015) . - p.1-10 Titre : Do women with eating disorders who have social and flexibility difficulties really have autism? A case series Type de document : Texte imprimé et/ou numérique Auteurs : Will MANDY, Auteur ; Kate TCHANTURIA, Auteur Article en page(s) : p.1-10 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Many women with eating disorders (EDs) have social impairments and difficulties with flexibility. It is unclear to what extent these are manifestations of an underlying autism spectrum disorder (ASD); or whether they are instead the consequence of starvation, anxiety, low mood or obsessive compulsive disorder, all of which are highly prevalent in EDs. The resolution of this clinically and theoretically important uncertainty will require the use of gold-standard ASD assessment measures. To date these have not been employed in ED research. This case series is the first report of a well-validated, direct-observational measure of ASD, the Autism Diagnostic Observation Schedule (ADOS), being administered to women with EDs. We aimed to learn about the feasibility of the ADOS in this population, and to contribute to debates about whether a sub-group with EDs really have ASD. En ligne : http://dx.doi.org/10.1186/2040-2392-6-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Do women with eating disorders who have social and flexibility difficulties really have autism? A case series [Texte imprimé et/ou numérique] / Will MANDY, Auteur ; Kate TCHANTURIA, Auteur . - p.1-10. Langues : Anglais (eng) in Molecular Autism > (May 2015) . - p.1-10 Index. décimale : PER Périodiques Résumé : Many women with eating disorders (EDs) have social impairments and difficulties with flexibility. It is unclear to what extent these are manifestations of an underlying autism spectrum disorder (ASD); or whether they are instead the consequence of starvation, anxiety, low mood or obsessive compulsive disorder, all of which are highly prevalent in EDs. The resolution of this clinically and theoretically important uncertainty will require the use of gold-standard ASD assessment measures. To date these have not been employed in ED research. This case series is the first report of a well-validated, direct-observational measure of ASD, the Autism Diagnostic Observation Schedule (ADOS), being administered to women with EDs. We aimed to learn about the feasibility of the ADOS in this population, and to contribute to debates about whether a sub-group with EDs really have ASD. En ligne : http://dx.doi.org/10.1186/2040-2392-6-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277