Accelerating Motor Skill Acquisition for Bicycle Riding in Children with ASD: A Pilot Study / Zoe HAWKS in Journal of Autism and Developmental Disorders, 50-1 (January 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-1 (January 2020) . - p.342-348 Titre : Accelerating Motor Skill Acquisition for Bicycle Riding in Children with ASD: A Pilot Study Type de document : Texte imprimé et/ou numérique Auteurs : Zoe HAWKS, Auteur ; John N. CONSTANTINO, Auteur ; Claire WEICHSELBAUM, Auteur ; Natasha MARRUS, Auteur Article en page(s) : p.342-348 Langues : Anglais (eng) Mots-clés : Adaptive function  Autism spectrum disorder (ASD)  Bicycle riding  Motor coordination  Motor skill acquisition  Social communication Index. décimale : PER Périodiques Résumé : Motor impairment is common in autism spectrum disorder (ASD) and, as such, a potential target for interventions to improve adaptive functioning. This study investigated motor skill acquisition in children with ASD (n = 15, 12 males; ages 7-16 years) during iCan Bike Camp, a 1-week, community-based intervention (5 x 75-min sessions) to teach independent bicycle riding. After completing the camp's task-oriented, individualized training program, all participants demonstrated motor skill acquisition on the bicycle, and nine participants rode independently at least 70 feet. Exploratory analyses showed that motor coordination and social communication correlated with rates of skill acquisition. These findings indicate the feasibility and efficacy of brief, community-based motor interventions to teach bicycle riding-an important developmental skill supporting adaptive functioning-to children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-019-04224-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=414 [article] Accelerating Motor Skill Acquisition for Bicycle Riding in Children with ASD: A Pilot Study [Texte imprimé et/ou numérique] / Zoe HAWKS, Auteur ; John N. CONSTANTINO, Auteur ; Claire WEICHSELBAUM, Auteur ; Natasha MARRUS, Auteur . - p.342-348. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-1 (January 2020) . - p.342-348 Mots-clés : Adaptive function  Autism spectrum disorder (ASD)  Bicycle riding  Motor coordination  Motor skill acquisition  Social communication Index. décimale : PER Périodiques Résumé : Motor impairment is common in autism spectrum disorder (ASD) and, as such, a potential target for interventions to improve adaptive functioning. This study investigated motor skill acquisition in children with ASD (n = 15, 12 males; ages 7-16 years) during iCan Bike Camp, a 1-week, community-based intervention (5 x 75-min sessions) to teach independent bicycle riding. After completing the camp's task-oriented, individualized training program, all participants demonstrated motor skill acquisition on the bicycle, and nine participants rode independently at least 70 feet. Exploratory analyses showed that motor coordination and social communication correlated with rates of skill acquisition. These findings indicate the feasibility and efficacy of brief, community-based motor interventions to teach bicycle riding-an important developmental skill supporting adaptive functioning-to children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-019-04224-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=414

Affording autism an early brain development re-definition / Ami KLIN in Development and Psychopathology, 32-4 (October 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-4 (October 2020) . - p.1175-1189 Titre : Affording autism an early brain development re-definition Type de document : Texte imprimé et/ou numérique Auteurs : Ami KLIN, Auteur ; Megan MICHELETTI, Auteur ; Cheryl KLAIMAN, Auteur ; Sarah SHULTZ, Auteur ; John N. CONSTANTINO, Auteur ; Warren JONES, Auteur Article en page(s) : p.1175-1189 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  brain development  definition  early diagnosis  early intervention Index. décimale : PER Périodiques Résumé : The national priority to advance early detection and intervention for children with autism spectrum disorder (ASD) has not reduced the late age of ASD diagnosis in the US over several consecutive Centers for Disease Control and Prevention (CDC) surveillance cohorts, with traditionally under-served populations accessing diagnosis later still. In this review, we explore a potential perceptual barrier to this enterprise which views ASD in terms that are contradicted by current science, and which may have its origins in the current definition of the condition and in its historical associations. To address this perceptual barrier, we propose a re-definition of ASD in early brain development terms, with a view to revisit the world of opportunities afforded by current science to optimize children's outcomes despite the risks that they are born with. This view is presented here to counter outdated notions that potentially devastating disability is determined the moment a child is born, and that these burdens are inevitable, with opportunities for improvement being constrained to only alleviation of symptoms or limited improvements in adaptive skills. The impetus for this piece is the concern that such views of complex neurodevelopmental conditions, such as ASD, can become self-fulfilling science and policy, in ways that are diametrically opposed to what we currently know, and are learning every day, of how genetic risk becomes, or not, instantiated as lifetime disabilities. En ligne : http://dx.doi.org/10.1017/s0954579420000802 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433 [article] Affording autism an early brain development re-definition [Texte imprimé et/ou numérique] / Ami KLIN, Auteur ; Megan MICHELETTI, Auteur ; Cheryl KLAIMAN, Auteur ; Sarah SHULTZ, Auteur ; John N. CONSTANTINO, Auteur ; Warren JONES, Auteur . - p.1175-1189. Langues : Anglais (eng) in Development and Psychopathology > 32-4 (October 2020) . - p.1175-1189 Mots-clés : autism spectrum disorder  brain development  definition  early diagnosis  early intervention Index. décimale : PER Périodiques Résumé : The national priority to advance early detection and intervention for children with autism spectrum disorder (ASD) has not reduced the late age of ASD diagnosis in the US over several consecutive Centers for Disease Control and Prevention (CDC) surveillance cohorts, with traditionally under-served populations accessing diagnosis later still. In this review, we explore a potential perceptual barrier to this enterprise which views ASD in terms that are contradicted by current science, and which may have its origins in the current definition of the condition and in its historical associations. To address this perceptual barrier, we propose a re-definition of ASD in early brain development terms, with a view to revisit the world of opportunities afforded by current science to optimize children's outcomes despite the risks that they are born with. This view is presented here to counter outdated notions that potentially devastating disability is determined the moment a child is born, and that these burdens are inevitable, with opportunities for improvement being constrained to only alleviation of symptoms or limited improvements in adaptive skills. The impetus for this piece is the concern that such views of complex neurodevelopmental conditions, such as ASD, can become self-fulfilling science and policy, in ways that are diametrically opposed to what we currently know, and are learning every day, of how genetic risk becomes, or not, instantiated as lifetime disabilities. En ligne : http://dx.doi.org/10.1017/s0954579420000802 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433

Assessing autistic traits: cross-cultural validation of the social responsiveness scale (SRS) / Sven BÖLTE in Autism Research, 1-6 (December 2008)  

Public ISBD [article]  inAutism Research > 1-6 (December 2008) . - p.354-363 Titre : Assessing autistic traits: cross-cultural validation of the social responsiveness scale (SRS) Type de document : Texte imprimé et/ou numérique Auteurs : Sven BÖLTE, Auteur ; Fritz POUSTKA, Auteur ; John N. CONSTANTINO, Auteur Année de publication : 2008 Article en page(s) : p.354-363 Langues : Anglais (eng) Mots-clés : autism PDD psychometrics ADI-R ADOS SCQ TCI CBCL Index. décimale : PER Périodiques Résumé : The Social Responsiveness Scale (SRS) is a quantitative measure of autistic traits in 4- to 18-year-olds, which has been used in behavior-genetic, epidemiological and intervention studies. The US standardization demonstrated a single-factor structure and good to excellent psychometric properties. The cross-cultural validity of the German adaptation of the parent-report SRS in a sample of N=1,436 children and adolescents: 838 typically developing and 527 clinical participants (160 with autism spectrum disorders (ASDs)) was examined. Internal consistency (0.91-0.97), test-retest reliability (0.84-0.97), interrater reliability (0.76 and 0.95) and convergent validity with the Autism Diagnostic Observation Schedule as well as the Autism Diagnostic Interview - Revised and Social Communication Questionnaire (0.35-0.58) were satisfactory to good. The SRS total score discriminated between ASD and other mental disorders. SRS scores proved to be sufficiently independent of general psychopathology. Principal component analyses yielded single-factor solutions for the normative and clinical subsamples. In addition, construct validity was ensured by consistent correlations with the Vineland Adaptive Behavior Scales, the Child Behavior Checklist and the Junior Temperament and Character Inventory. Normative SRS total scores for girls and boys as well as values for ASD were lower in the German sample, while scores for conduct disorder and attention deficit hyperactivity/conduct disorder combined were higher. Generally, cross-cultural validity of the SRS seems to be sufficiently assured for a large European sample. However, some discrepancies regarding SRS normative and clinical raw score distributions, reliability and validity findings are critically discussed. En ligne : http://dx.doi.org/10.1002/aur.49 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=934 [article] Assessing autistic traits: cross-cultural validation of the social responsiveness scale (SRS) [Texte imprimé et/ou numérique] / Sven BÖLTE, Auteur ; Fritz POUSTKA, Auteur ; John N. CONSTANTINO, Auteur . - 2008 . - p.354-363. Langues : Anglais (eng) in Autism Research > 1-6 (December 2008) . - p.354-363 Mots-clés : autism PDD psychometrics ADI-R ADOS SCQ TCI CBCL Index. décimale : PER Périodiques Résumé : The Social Responsiveness Scale (SRS) is a quantitative measure of autistic traits in 4- to 18-year-olds, which has been used in behavior-genetic, epidemiological and intervention studies. The US standardization demonstrated a single-factor structure and good to excellent psychometric properties. The cross-cultural validity of the German adaptation of the parent-report SRS in a sample of N=1,436 children and adolescents: 838 typically developing and 527 clinical participants (160 with autism spectrum disorders (ASDs)) was examined. Internal consistency (0.91-0.97), test-retest reliability (0.84-0.97), interrater reliability (0.76 and 0.95) and convergent validity with the Autism Diagnostic Observation Schedule as well as the Autism Diagnostic Interview - Revised and Social Communication Questionnaire (0.35-0.58) were satisfactory to good. The SRS total score discriminated between ASD and other mental disorders. SRS scores proved to be sufficiently independent of general psychopathology. Principal component analyses yielded single-factor solutions for the normative and clinical subsamples. In addition, construct validity was ensured by consistent correlations with the Vineland Adaptive Behavior Scales, the Child Behavior Checklist and the Junior Temperament and Character Inventory. Normative SRS total scores for girls and boys as well as values for ASD were lower in the German sample, while scores for conduct disorder and attention deficit hyperactivity/conduct disorder combined were higher. Generally, cross-cultural validity of the SRS seems to be sufficiently assured for a large European sample. However, some discrepancies regarding SRS normative and clinical raw score distributions, reliability and validity findings are critically discussed. En ligne : http://dx.doi.org/10.1002/aur.49 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=934

Attention and motor deficits index non-specific background liabilities that predict autism recurrence in siblings / S. E. MOUS in Journal of Neurodevelopmental Disorders, 9-1 (December 2017)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.32 Titre : Attention and motor deficits index non-specific background liabilities that predict autism recurrence in siblings Type de document : Texte imprimé et/ou numérique Auteurs : S. E. MOUS, Auteur ; A. JIANG, Auteur ; Arpana AGRAWAL, Auteur ; John N. CONSTANTINO, Auteur Article en page(s) : p.32 Langues : Anglais (eng) Mots-clés : Adhd  Autism  Family studies  Motor coordination  Sibling recurrence Index. décimale : PER Périodiques Résumé : BACKGROUND: Recent research has demonstrated that subclinical autistic traits of parents amplify the effects of deleterious mutations in the causation of autism spectrum disorder (ASD) in their offspring. Here, we examined the extent to which two neurodevelopmental traits that are non-specific to ASD-inattention/hyperactivity and motor coordination-might contribute to ASD recurrence in siblings of ASD probands. METHODS: Data from a quantitative trait study of 114 ASD probands and their brothers, 26% of whom also had ASD, were analyzed. Autistic trait severity was ascertained using the Social Responsiveness Scale-2, attention/hyperactivity problems using the Achenbach System of Empirically Based Assessment, and motor coordination (in a subset of participants) using the Developmental Coordination Disorder Questionnaire. RESULTS: Among siblings (affected and unaffected), both categorical recurrence of ASD (Nagelkerke R (2) = 0.53) and quantitative ASD trait burden (R (2) = 0.55) were predicted by sibling ADHD and motor coordination impairment scores, even though these traits, on average, were not elevated among the unaffected siblings. CONCLUSIONS: These findings in a clinical family cohort confirm observations from general population studies that inattention/hyperactivity and motor impairment-axes of behavioral development that are non-specific to ASD, and often appreciable before ASD is typically diagnosed-jointly account for over 50% of the variation in autistic impairment of siblings, whether ascertained quantitatively or categorically. This finding within a sibling design suggests that background ASD susceptibilities that are inherited but non-specific ("BASINS") may contribute to additive genetic liability in the same manner that ASD-specific susceptibilities (such as parental subclinical ASD traits and deleterious mutations) engender ASD risk. En ligne : http://dx.doi.org/10.1186/s11689-017-9212-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=350 [article] Attention and motor deficits index non-specific background liabilities that predict autism recurrence in siblings [Texte imprimé et/ou numérique] / S. E. MOUS, Auteur ; A. JIANG, Auteur ; Arpana AGRAWAL, Auteur ; John N. CONSTANTINO, Auteur . - p.32. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.32 Mots-clés : Adhd  Autism  Family studies  Motor coordination  Sibling recurrence Index. décimale : PER Périodiques Résumé : BACKGROUND: Recent research has demonstrated that subclinical autistic traits of parents amplify the effects of deleterious mutations in the causation of autism spectrum disorder (ASD) in their offspring. Here, we examined the extent to which two neurodevelopmental traits that are non-specific to ASD-inattention/hyperactivity and motor coordination-might contribute to ASD recurrence in siblings of ASD probands. METHODS: Data from a quantitative trait study of 114 ASD probands and their brothers, 26% of whom also had ASD, were analyzed. Autistic trait severity was ascertained using the Social Responsiveness Scale-2, attention/hyperactivity problems using the Achenbach System of Empirically Based Assessment, and motor coordination (in a subset of participants) using the Developmental Coordination Disorder Questionnaire. RESULTS: Among siblings (affected and unaffected), both categorical recurrence of ASD (Nagelkerke R (2) = 0.53) and quantitative ASD trait burden (R (2) = 0.55) were predicted by sibling ADHD and motor coordination impairment scores, even though these traits, on average, were not elevated among the unaffected siblings. CONCLUSIONS: These findings in a clinical family cohort confirm observations from general population studies that inattention/hyperactivity and motor impairment-axes of behavioral development that are non-specific to ASD, and often appreciable before ASD is typically diagnosed-jointly account for over 50% of the variation in autistic impairment of siblings, whether ascertained quantitatively or categorically. This finding within a sibling design suggests that background ASD susceptibilities that are inherited but non-specific ("BASINS") may contribute to additive genetic liability in the same manner that ASD-specific susceptibilities (such as parental subclinical ASD traits and deleterious mutations) engender ASD risk. En ligne : http://dx.doi.org/10.1186/s11689-017-9212-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=350

Autism as a Quantitative Trait / John N. CONSTANTINO

Public ISBD in Autism Spectrum Disorders / David G. AMARAL Titre : Autism as a Quantitative Trait Type de document : Texte imprimé et/ou numérique Auteurs : John N. CONSTANTINO, Auteur Année de publication : 2011 Importance : p.510-520 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139 in Autism Spectrum Disorders / David G. AMARAL Autism as a Quantitative Trait [Texte imprimé et/ou numérique] / John N. CONSTANTINO, Auteur . - 2011 . - p.510-520. Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139

Exemplaires

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Autistic traits in a population-based ADHD twin sample / Angela M. REIERSEN in Journal of Child Psychology and Psychiatry, 48-5 (May 2007)  

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Brain function distinguishes female carriers and non-carriers of familial risk for autism / Adam T. EGGEBRECHT in Molecular Autism, 11 (2020)  

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Brief Report: Chimpanzee Social Responsiveness Scale (CSRS) Detects Individual Variation in Social Responsiveness for Captive Chimpanzees / Carley FAUGHN in Journal of Autism and Developmental Disorders, 45-5 (May 2015)  

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Brief Report: Under-Representation of African Americans in Autism Genetic Research: A Rationale for Inclusion of Subjects Representing Diverse Family Structures / Claudia HILTON in Journal of Autism and Developmental Disorders, 40-5 (May 2010)  

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Cellular and molecular characterization of multiplex autism in human induced pluripotent stem cell-derived neurons / E. M. A. LEWIS in Molecular Autism, 10 (2019)  

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Clarifying the Associations Between Language and Social Development in Autism: A Study of Non-native Phoneme Recognition / John N. CONSTANTINO in Journal of Autism and Developmental Disorders, 37-7 (August 2007)  

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Commentary: The observed association between autistic severity measured by the Social Responsiveness Scale (SRS) and general psychopathology – a response to Hus et al.() / John N. CONSTANTINO in Journal of Child Psychology and Psychiatry, 54-6 (June 2013)  

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Complexities of X chromosome inactivation status in female human induced pluripotent stem cells-a brief review and scientific update for autism research / M. G. DANDULAKIS in Journal of Neurodevelopmental Disorders, 8-1 (December 2016)  

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Confirmatory factor analytic structure and measurement invariance of quantitative autistic traits measured by the Social Responsiveness Scale-2 / Thomas W. FRAZIER in Autism, 18-1 (January 2014)  

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Data from the Baby Siblings Research Consortium confirm and specify the nature of the female protective effect in autism: A commentary on Messinger et al / John N. CONSTANTINO in Molecular Autism, 7 (2016)  

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