Gene variants associated with antisocial behaviour: a latent variable approach / Mary Jane BENTLEY in Journal of Child Psychology and Psychiatry, 54-10 (October 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-10 (October 2013) . - p.1074-1085 Titre : Gene variants associated with antisocial behaviour: a latent variable approach Type de document : Texte imprimé et/ou numérique Auteurs : Mary Jane BENTLEY, Auteur ; Haiqun LIN, Auteur ; Thomas V. FERNANDEZ, Auteur ; Maria LEE, Auteur ; Carolyn M. YRIGOLLEN, Auteur ; Andrew J. PAKSTIS, Auteur ; Liliya KATSOVICH, Auteur ; David L. OLDS, Auteur ; Elena L. GRIGORENKO, Auteur ; James F. LECKMAN, Auteur Article en page(s) : p.1074-1085 Langues : Anglais (eng) Mots-clés : Antisocial behaviour  latent variable analysis  shared variance  co-action of gene variants Index. décimale : PER Périodiques Résumé : Objective The aim of this study was to determine if a latent variable approach might be useful in identifying shared variance across genetic risk alleles that is associated with antisocial behaviour at age 15 years. Methods Using a conventional latent variable approach, we derived an antisocial phenotype in 328 adolescents utilizing data from a 15-year follow-up of a randomized trial of a prenatal and infancy nurse-home visitation programme in Elmira, New York. We then investigated, via a novel latent variable approach, 450 informative genetic polymorphisms in 71 genes previously associated with antisocial behaviour, drug use, affiliative behaviours and stress response in 241 consenting individuals for whom DNA was available. Haplotype and Pathway analyses were also performed. Results Eight single-nucleotide polymorphisms (SNPs) from eight genes contributed to the latent genetic variable that in turn accounted for 16.0% of the variance within the latent antisocial phenotype. The number of risk alleles was linearly related to the latent antisocial variable scores. Haplotypes that included the putative risk alleles for all eight genes were also associated with higher latent antisocial variable scores. In addition, 33 SNPs from 63 of the remaining genes were also significant when added to the final model. Many of these genes interact on a molecular level, forming molecular networks. The results support a role for genes related to dopamine, norepinephrine, serotonin, glutamate, opioid and cholinergic signalling as well as stress response pathways in mediating susceptibility to antisocial behaviour. Conclusions This preliminary study supports use of relevant behavioural indicators and latent variable approaches to study the potential ‘co-action’ of gene variants associated with antisocial behaviour. It also underscores the cumulative relevance of common genetic variants for understanding the aetiology of complex behaviour. If replicated in future studies, this approach may allow the identification of a ‘shared’ variance across genetic risk alleles associated with complex neuropsychiatric dimensional phenotypes using relatively small numbers of well-characterized research participants. En ligne : http://dx.doi.org/10.1111/jcpp.12109 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212 [article] Gene variants associated with antisocial behaviour: a latent variable approach [Texte imprimé et/ou numérique] / Mary Jane BENTLEY, Auteur ; Haiqun LIN, Auteur ; Thomas V. FERNANDEZ, Auteur ; Maria LEE, Auteur ; Carolyn M. YRIGOLLEN, Auteur ; Andrew J. PAKSTIS, Auteur ; Liliya KATSOVICH, Auteur ; David L. OLDS, Auteur ; Elena L. GRIGORENKO, Auteur ; James F. LECKMAN, Auteur . - p.1074-1085. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-10 (October 2013) . - p.1074-1085 Mots-clés : Antisocial behaviour  latent variable analysis  shared variance  co-action of gene variants Index. décimale : PER Périodiques Résumé : Objective The aim of this study was to determine if a latent variable approach might be useful in identifying shared variance across genetic risk alleles that is associated with antisocial behaviour at age 15 years. Methods Using a conventional latent variable approach, we derived an antisocial phenotype in 328 adolescents utilizing data from a 15-year follow-up of a randomized trial of a prenatal and infancy nurse-home visitation programme in Elmira, New York. We then investigated, via a novel latent variable approach, 450 informative genetic polymorphisms in 71 genes previously associated with antisocial behaviour, drug use, affiliative behaviours and stress response in 241 consenting individuals for whom DNA was available. Haplotype and Pathway analyses were also performed. Results Eight single-nucleotide polymorphisms (SNPs) from eight genes contributed to the latent genetic variable that in turn accounted for 16.0% of the variance within the latent antisocial phenotype. The number of risk alleles was linearly related to the latent antisocial variable scores. Haplotypes that included the putative risk alleles for all eight genes were also associated with higher latent antisocial variable scores. In addition, 33 SNPs from 63 of the remaining genes were also significant when added to the final model. Many of these genes interact on a molecular level, forming molecular networks. The results support a role for genes related to dopamine, norepinephrine, serotonin, glutamate, opioid and cholinergic signalling as well as stress response pathways in mediating susceptibility to antisocial behaviour. Conclusions This preliminary study supports use of relevant behavioural indicators and latent variable approaches to study the potential ‘co-action’ of gene variants associated with antisocial behaviour. It also underscores the cumulative relevance of common genetic variants for understanding the aetiology of complex behaviour. If replicated in future studies, this approach may allow the identification of a ‘shared’ variance across genetic risk alleles associated with complex neuropsychiatric dimensional phenotypes using relatively small numbers of well-characterized research participants. En ligne : http://dx.doi.org/10.1111/jcpp.12109 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212

Psychosocial stress predicts future symptom severities in children and adolescents with Tourette syndrome and/or obsessive-compulsive disorder / Haiqun LIN in Journal of Child Psychology and Psychiatry, 48-2 (February 2007)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 48-2 (February 2007) . - p.157–166 Titre : Psychosocial stress predicts future symptom severities in children and adolescents with Tourette syndrome and/or obsessive-compulsive disorder Type de document : Texte imprimé et/ou numérique Auteurs : Haiqun LIN, Auteur ; James F. LECKMAN, Auteur ; Liliya KATSOVICH, Auteur ; Musie GHEBREMICHAEL, Auteur ; Diane B. FINDLEY, Auteur ; Heidi GRANTZ, Auteur ; Paul J. LOMBROSO, Auteur ; Robert A. KING, Auteur ; Heping ZHANG, Auteur Année de publication : 2007 Article en page(s) : p.157–166 Langues : Anglais (eng) Mots-clés : Tourette-syndrome obsessive-compulsive-disorder depression psychosocial-stress latent-variables longitudinal-study Index. décimale : PER Périodiques Résumé : The goals of this prospective longitudinal study were to monitor levels of psychosocial stress in children and adolescents with Tourette syndrome (TS) and/or obsessive-compulsive disorder (OCD) compared to healthy control subjects and to examine the relationship between measures of psychosocial stress and fluctuations in tic, obsessive-compulsive (OC), and depressive symptom severity. Methods: Consecutive ratings of tic, OC and depressive symptom severity were obtained for 45 cases and 41 matched healthy control subjects over a two-year period. Measures of psychosocial stress included youth self-report, parental report, and clinician ratings of long-term contextual threat. Structural equation modeling for unbalanced repeated measures was used to assess the temporal sequence of psychosocial stress with the severity of tic, OC and depressive symptoms. Results: Subjects with TS and OCD experienced significantly more psychosocial stress than did the controls. Estimates of psychosocial stress were predictive of future depressive symptoms. Current levels of psychosocial stress were also a significant predictor of future OC symptom severity, but not vice versa. Current OC symptom severity was a predictor of future depressive symptom severity, but not vice versa. Current levels of psychosocial stress and depression were independent predictors of future tic severity, even after controlling for the effect of advancing chronological age. Conclusions: The impact of antecedent psychosocial adversity is greater on future depressive symptoms than for tic and/or OC symptoms. Worsening OC symptoms are also a predictor of future depressive symptoms. Advancing chronological age is robustly associated with reductions in tic severity. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01687.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=940 [article] Psychosocial stress predicts future symptom severities in children and adolescents with Tourette syndrome and/or obsessive-compulsive disorder [Texte imprimé et/ou numérique] / Haiqun LIN, Auteur ; James F. LECKMAN, Auteur ; Liliya KATSOVICH, Auteur ; Musie GHEBREMICHAEL, Auteur ; Diane B. FINDLEY, Auteur ; Heidi GRANTZ, Auteur ; Paul J. LOMBROSO, Auteur ; Robert A. KING, Auteur ; Heping ZHANG, Auteur . - 2007 . - p.157–166. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 48-2 (February 2007) . - p.157–166 Mots-clés : Tourette-syndrome obsessive-compulsive-disorder depression psychosocial-stress latent-variables longitudinal-study Index. décimale : PER Périodiques Résumé : The goals of this prospective longitudinal study were to monitor levels of psychosocial stress in children and adolescents with Tourette syndrome (TS) and/or obsessive-compulsive disorder (OCD) compared to healthy control subjects and to examine the relationship between measures of psychosocial stress and fluctuations in tic, obsessive-compulsive (OC), and depressive symptom severity. Methods: Consecutive ratings of tic, OC and depressive symptom severity were obtained for 45 cases and 41 matched healthy control subjects over a two-year period. Measures of psychosocial stress included youth self-report, parental report, and clinician ratings of long-term contextual threat. Structural equation modeling for unbalanced repeated measures was used to assess the temporal sequence of psychosocial stress with the severity of tic, OC and depressive symptoms. Results: Subjects with TS and OCD experienced significantly more psychosocial stress than did the controls. Estimates of psychosocial stress were predictive of future depressive symptoms. Current levels of psychosocial stress were also a significant predictor of future OC symptom severity, but not vice versa. Current OC symptom severity was a predictor of future depressive symptom severity, but not vice versa. Current levels of psychosocial stress and depression were independent predictors of future tic severity, even after controlling for the effect of advancing chronological age. Conclusions: The impact of antecedent psychosocial adversity is greater on future depressive symptoms than for tic and/or OC symptoms. Worsening OC symptoms are also a predictor of future depressive symptoms. Advancing chronological age is robustly associated with reductions in tic severity. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01687.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=940

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