Aberrant brain network topology in youth with a familial risk for bipolar disorder: a task-based fMRI connectome study / Kun QIN ; Luis R. PATINO ; Maxwell J. TALLMAN ; Du LEI ; Lu LU ; Wenbin LI ; Thomas J. BLOM ; Kaitlyn M. BRUNS ; Jeffrey A. WELGE ; Jeffrey R. STRAWN ; Qiyong GONG ; John A. SWEENEY ; Manpreet K. SINGH ; Melissa P. DELBELLO in Journal of Child Psychology and Psychiatry, 65-8 (August 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-8 (August 2024) . - p.1072-1086 Titre : Aberrant brain network topology in youth with a familial risk for bipolar disorder: a task-based fMRI connectome study Type de document : Texte imprimé et/ou numérique Auteurs : Kun QIN, Auteur ; Luis R. PATINO, Auteur ; Maxwell J. TALLMAN, Auteur ; Du LEI, Auteur ; Lu LU, Auteur ; Wenbin LI, Auteur ; Thomas J. BLOM, Auteur ; Kaitlyn M. BRUNS, Auteur ; Jeffrey A. WELGE, Auteur ; Jeffrey R. STRAWN, Auteur ; Qiyong GONG, Auteur ; John A. SWEENEY, Auteur ; Manpreet K. SINGH, Auteur ; Melissa P. DELBELLO, Auteur Article en page(s) : p.1072-1086 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Youth with a family history of bipolar disorder (BD) may be at increased risk for mood disorders and for developing side effects after antidepressant exposure. The neurobiological basis of these risks remains poorly understood. We aimed to identify biomarkers underlying risk by characterizing abnormalities in the brain connectome of symptomatic youth at familial risk for BD. Methods Depressed and/or anxious youth (n = 119, age = 14.9?+?1.6?years) with a family history of BD but no prior antidepressant exposure and typically developing controls (n = 57, age = 14.8?+?1.7?years) received functional magnetic resonance imaging (fMRI) during an emotional continuous performance task. A generalized psychophysiological interaction (gPPI) analysis was performed to compare their brain connectome patterns, followed by machine learning of topological metrics. Results High-risk youth showed weaker connectivity patterns that were mainly located in the default mode network (DMN) (network weight = 50.1%) relative to controls, and connectivity patterns derived from the visual network (VN) constituted the largest proportion of aberrant stronger pairs (network weight = 54.9%). Global local efficiency (Elocal, p = .022) and clustering coefficient (Cp, p = .029) and nodal metrics of the right superior frontal gyrus (SFG) (Elocal: p < .001; Cp: p = .001) in the high-risk group were significantly higher than those in healthy subjects, and similar patterns were also found in the left insula (degree: p = .004; betweenness: p = .005; age-by-group interaction, p = .038) and right hippocampus (degree: p = .003; betweenness: p = .003). The case-control classifier achieved a cross-validation accuracy of 78.4%. Conclusions Our findings of abnormal connectome organization in the DMN and VN may advance mechanistic understanding of risk for BD. Neuroimaging biomarkers of increased network segregation in the SFG and altered topological centrality in the insula and hippocampus in broader limbic systems may be used to target interventions tailored to mitigate the underlying risk of brain abnormalities in these at-risk youth. En ligne : https://doi.org/10.1111/jcpp.13946 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532 [article] Aberrant brain network topology in youth with a familial risk for bipolar disorder: a task-based fMRI connectome study [Texte imprimé et/ou numérique] / Kun QIN, Auteur ; Luis R. PATINO, Auteur ; Maxwell J. TALLMAN, Auteur ; Du LEI, Auteur ; Lu LU, Auteur ; Wenbin LI, Auteur ; Thomas J. BLOM, Auteur ; Kaitlyn M. BRUNS, Auteur ; Jeffrey A. WELGE, Auteur ; Jeffrey R. STRAWN, Auteur ; Qiyong GONG, Auteur ; John A. SWEENEY, Auteur ; Manpreet K. SINGH, Auteur ; Melissa P. DELBELLO, Auteur . - p.1072-1086. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-8 (August 2024) . - p.1072-1086 Index. décimale : PER Périodiques Résumé : Background Youth with a family history of bipolar disorder (BD) may be at increased risk for mood disorders and for developing side effects after antidepressant exposure. The neurobiological basis of these risks remains poorly understood. We aimed to identify biomarkers underlying risk by characterizing abnormalities in the brain connectome of symptomatic youth at familial risk for BD. Methods Depressed and/or anxious youth (n = 119, age = 14.9?+?1.6?years) with a family history of BD but no prior antidepressant exposure and typically developing controls (n = 57, age = 14.8?+?1.7?years) received functional magnetic resonance imaging (fMRI) during an emotional continuous performance task. A generalized psychophysiological interaction (gPPI) analysis was performed to compare their brain connectome patterns, followed by machine learning of topological metrics. Results High-risk youth showed weaker connectivity patterns that were mainly located in the default mode network (DMN) (network weight = 50.1%) relative to controls, and connectivity patterns derived from the visual network (VN) constituted the largest proportion of aberrant stronger pairs (network weight = 54.9%). Global local efficiency (Elocal, p = .022) and clustering coefficient (Cp, p = .029) and nodal metrics of the right superior frontal gyrus (SFG) (Elocal: p < .001; Cp: p = .001) in the high-risk group were significantly higher than those in healthy subjects, and similar patterns were also found in the left insula (degree: p = .004; betweenness: p = .005; age-by-group interaction, p = .038) and right hippocampus (degree: p = .003; betweenness: p = .003). The case-control classifier achieved a cross-validation accuracy of 78.4%. Conclusions Our findings of abnormal connectome organization in the DMN and VN may advance mechanistic understanding of risk for BD. Neuroimaging biomarkers of increased network segregation in the SFG and altered topological centrality in the insula and hippocampus in broader limbic systems may be used to target interventions tailored to mitigate the underlying risk of brain abnormalities in these at-risk youth. En ligne : https://doi.org/10.1111/jcpp.13946 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532

Emotional and behavioral problems in preschool children with autism: Relationship with sensory processing dysfunction / Mei-Hui TSENG in Research in Autism Spectrum Disorders, 5-4 (October-December 2011)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 5-4 (October-December 2011) . - p.1441-1450 Titre : Emotional and behavioral problems in preschool children with autism: Relationship with sensory processing dysfunction Type de document : Texte imprimé et/ou numérique Auteurs : Mei-Hui TSENG, Auteur ; Chung-Pei FU, Auteur ; Sharon A. CERMAK, Auteur ; Lu LU, Auteur ; Jeng-Yi SHIEH, Auteur Année de publication : 2011 Article en page(s) : p.1441-1450 Langues : Anglais (eng) Mots-clés : Sensory processing patterns  Internalizing problems  Externalizing problems  Preschool children with autism Index. décimale : PER Périodiques Résumé : This study aimed to investigate the sensory processing (SP) dysfunction and emotional and behavioral problems in preschool children with autism and then examine the relationship between the SP dysfunction and emotional and behavioral problems. The parents of 112 children aged 48–84 months (67 with autism; 45 age-matched typically developing) completed a demographic questionnaire, the Child Behavior Checklist-Chinese version (CBCL-C), and the Sensory Profile-Chinese version (SP-C). We found that 95.8% of children with autism who showed significant internalizing problems had at least one SP quadrant in the definite difference range, while 81.8% with significant externalizing problems had at least one SP quadrant in the definite difference range. Typically developing children showed lower percentages of 66.7% and 40.0%. Stepwise linear regression analysis revealed that in children with autism, avoiding and male gender were significant predictors of internalizing problems and sensitivity was a significant predictor of externalizing problems. In contrast, in typically developing children, avoiding was a significant predictor of internalizing problems and seeking was a significant predictor of externalizing problems. This study provided further understanding of the factors influencing emotional and behavioral problems in autism. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.02.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=125 [article] Emotional and behavioral problems in preschool children with autism: Relationship with sensory processing dysfunction [Texte imprimé et/ou numérique] / Mei-Hui TSENG, Auteur ; Chung-Pei FU, Auteur ; Sharon A. CERMAK, Auteur ; Lu LU, Auteur ; Jeng-Yi SHIEH, Auteur . - 2011 . - p.1441-1450. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 5-4 (October-December 2011) . - p.1441-1450 Mots-clés : Sensory processing patterns  Internalizing problems  Externalizing problems  Preschool children with autism Index. décimale : PER Périodiques Résumé : This study aimed to investigate the sensory processing (SP) dysfunction and emotional and behavioral problems in preschool children with autism and then examine the relationship between the SP dysfunction and emotional and behavioral problems. The parents of 112 children aged 48–84 months (67 with autism; 45 age-matched typically developing) completed a demographic questionnaire, the Child Behavior Checklist-Chinese version (CBCL-C), and the Sensory Profile-Chinese version (SP-C). We found that 95.8% of children with autism who showed significant internalizing problems had at least one SP quadrant in the definite difference range, while 81.8% with significant externalizing problems had at least one SP quadrant in the definite difference range. Typically developing children showed lower percentages of 66.7% and 40.0%. Stepwise linear regression analysis revealed that in children with autism, avoiding and male gender were significant predictors of internalizing problems and sensitivity was a significant predictor of externalizing problems. In contrast, in typically developing children, avoiding was a significant predictor of internalizing problems and seeking was a significant predictor of externalizing problems. This study provided further understanding of the factors influencing emotional and behavioral problems in autism. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.02.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=125

Predictors of the health-related quality of life in preschool children with Autism spectrum disorders / I. Ching CHUANG in Research in Autism Spectrum Disorders, 8-9 (September 2014)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 8-9 (September 2014) . - p.1062-1070 Titre : Predictors of the health-related quality of life in preschool children with Autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : I. Ching CHUANG, Auteur ; Mei-Hui TSENG, Auteur ; Lu LU, Auteur ; Jeng-Yi SHIEH, Auteur ; Sharon A. CERMAK, Auteur Article en page(s) : p.1062-1070 Langues : Anglais (eng) Mots-clés : Health-related quality of life  Caregiver's mental health  Parenting stress  Preschool children with Autism spectrum disorders Index. décimale : PER Périodiques Résumé : Abstract This study was aimed to identify the predictors of health-related quality of life (HRQOL) by considering the caregiver's characteristics such as mental health and parenting stress as well as child characteristics in preschool children with Autism spectrum disorders (ASD). A total of 106 children aged 36–70 months participated in this study. The study indicated that the predictors of HRQOL in children with ASD encompassed not only child but also caregiver characteristics. In particular, good HRQOL on the domains of social and emotional functioning in children with ASD depended upon the caregiver's mental well-being. In summary, the present findings highlight the need for assessment of caregivers’ parenting stress and their mental status as well as the predictors of HRQOL in children with ASD. Furthermore, the findings of the study could serve as a guide for clinicians to target at the predictors when providing assessment and intervention for children with ASD to improve their HRQOL. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.05.015 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238 [article] Predictors of the health-related quality of life in preschool children with Autism spectrum disorders [Texte imprimé et/ou numérique] / I. Ching CHUANG, Auteur ; Mei-Hui TSENG, Auteur ; Lu LU, Auteur ; Jeng-Yi SHIEH, Auteur ; Sharon A. CERMAK, Auteur . - p.1062-1070. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 8-9 (September 2014) . - p.1062-1070 Mots-clés : Health-related quality of life  Caregiver's mental health  Parenting stress  Preschool children with Autism spectrum disorders Index. décimale : PER Périodiques Résumé : Abstract This study was aimed to identify the predictors of health-related quality of life (HRQOL) by considering the caregiver's characteristics such as mental health and parenting stress as well as child characteristics in preschool children with Autism spectrum disorders (ASD). A total of 106 children aged 36–70 months participated in this study. The study indicated that the predictors of HRQOL in children with ASD encompassed not only child but also caregiver characteristics. In particular, good HRQOL on the domains of social and emotional functioning in children with ASD depended upon the caregiver's mental well-being. In summary, the present findings highlight the need for assessment of caregivers’ parenting stress and their mental status as well as the predictors of HRQOL in children with ASD. Furthermore, the findings of the study could serve as a guide for clinicians to target at the predictors when providing assessment and intervention for children with ASD to improve their HRQOL. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.05.015 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238

Research Review: Pediatric anxiety disorders - what have we learnt in the last 10 years? / Jeffrey R. STRAWN in Journal of Child Psychology and Psychiatry, 62-2 (February 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-2 (February 2021) . - p.114-139 Titre : Research Review: Pediatric anxiety disorders - what have we learnt in the last 10 years? Type de document : Texte imprimé et/ou numérique Auteurs : Jeffrey R. STRAWN, Auteur ; Lu LU, Auteur ; Tara S. PERIS, Auteur ; Amir LEVINE, Auteur ; John T. WALKUP, Auteur Année de publication : 2021 Article en page(s) : p.114-139 Langues : Anglais (eng) Mots-clés : Generalized anxiety disorder  Sri)  fMRI  pharmacogenomics  selective serotonin reuptake inhibitor (SSRI  separation anxiety disorder Index. décimale : PER Périodiques Résumé : BACKGROUND: Anxiety disorders first emerge during the critical developmental periods of childhood and adolescence. This review synthesizes recent findings on the prevalence, risk factors, and course of the anxiety disorders; and their neurobiology and treatment. METHODS: For this review, searches were conducted using PubMed, PsycINFO, and clinicaltrials.gov. Findings related to the epidemiology, neurobiology, risk factors, and treatment of pediatric anxiety disorders were then summarized. FINDINGS: Anxiety disorders are high prevalence, and early-onset conditions associated with multiple risk factors including early inhibited temperament, environment stress, and structural and functional abnormalities in the prefrontal-amygdala circuitry as well as the default mode and salience networks. The anxiety disorders are effectively treated with cognitive behavioral therapy (CBT), selective serotonin reuptake inhibitors (SSRIs), and serotonin-norepinephrine reuptake inhibitors (SNRIs). CONCLUSIONS: Anxiety disorders are high prevalence, early-onset conditions associated with a distinct neurobiological fingerprint, and are consistently responsive to treatment. Questions remain regarding who is at risk of developing anxiety disorders as well as the way in which neurobiology predicts treatment response. En ligne : http://dx.doi.org/10.1111/jcpp.13262 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=440 [article] Research Review: Pediatric anxiety disorders - what have we learnt in the last 10 years? [Texte imprimé et/ou numérique] / Jeffrey R. STRAWN, Auteur ; Lu LU, Auteur ; Tara S. PERIS, Auteur ; Amir LEVINE, Auteur ; John T. WALKUP, Auteur . - 2021 . - p.114-139. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-2 (February 2021) . - p.114-139 Mots-clés : Generalized anxiety disorder  Sri)  fMRI  pharmacogenomics  selective serotonin reuptake inhibitor (SSRI  separation anxiety disorder Index. décimale : PER Périodiques Résumé : BACKGROUND: Anxiety disorders first emerge during the critical developmental periods of childhood and adolescence. This review synthesizes recent findings on the prevalence, risk factors, and course of the anxiety disorders; and their neurobiology and treatment. METHODS: For this review, searches were conducted using PubMed, PsycINFO, and clinicaltrials.gov. Findings related to the epidemiology, neurobiology, risk factors, and treatment of pediatric anxiety disorders were then summarized. FINDINGS: Anxiety disorders are high prevalence, and early-onset conditions associated with multiple risk factors including early inhibited temperament, environment stress, and structural and functional abnormalities in the prefrontal-amygdala circuitry as well as the default mode and salience networks. The anxiety disorders are effectively treated with cognitive behavioral therapy (CBT), selective serotonin reuptake inhibitors (SSRIs), and serotonin-norepinephrine reuptake inhibitors (SNRIs). CONCLUSIONS: Anxiety disorders are high prevalence, early-onset conditions associated with a distinct neurobiological fingerprint, and are consistently responsive to treatment. Questions remain regarding who is at risk of developing anxiety disorders as well as the way in which neurobiology predicts treatment response. En ligne : http://dx.doi.org/10.1111/jcpp.13262 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=440

Sensory correlates of difficult temperament characteristics in preschool children with autism / Ching CHUANG I. in Research in Autism Spectrum Disorders, 6-3 (July-September 2012)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 6-3 (July-September 2012) . - p.988-995 Titre : Sensory correlates of difficult temperament characteristics in preschool children with autism Type de document : Texte imprimé et/ou numérique Auteurs : Ching CHUANG I., Auteur ; Mei-Hui TSENG, Auteur ; Lu LU, Auteur ; Jeng-Yi SHIEH, Auteur Année de publication : 2012 Article en page(s) : p.988-995 Langues : Anglais (eng) Mots-clés : Sensory processing patterns  Temperament  Preschool children with autism Index. décimale : PER Périodiques Résumé : This study was aimed to investigate the rate of co-occurring sensory processing (SP) dysfunction in children with autism who had a difficult temperament characteristics, and the relationship between SP dysfunction and temperament characteristics in preschool children with autism. A total of 111 children aged 48–84 months, 67 children with autism and 44 age-matched typically developing children, participated in this study. Results of the study indicated that SP dysfunction was prevalent in children with autism who had difficult temperament characteristics, and that different SP patterns were associated with different temperament characteristics in preschool children with autism. In summary, the present findings highlight the importance of evaluating SP patterns in addition to assessing temperament in children with autism in order for clinicians to plan appropriate intervention programs and support children's participation in their daily lives. Furthermore, the knowledge of the relationship between difficult temperament characteristics and SP dysfunction of the child can foster parental appreciation of individual differences in children, provide parents effective strategies to manage children's behaviors, and promote adaptive parent–child interaction. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.01.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153 [article] Sensory correlates of difficult temperament characteristics in preschool children with autism [Texte imprimé et/ou numérique] / Ching CHUANG I., Auteur ; Mei-Hui TSENG, Auteur ; Lu LU, Auteur ; Jeng-Yi SHIEH, Auteur . - 2012 . - p.988-995. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 6-3 (July-September 2012) . - p.988-995 Mots-clés : Sensory processing patterns  Temperament  Preschool children with autism Index. décimale : PER Périodiques Résumé : This study was aimed to investigate the rate of co-occurring sensory processing (SP) dysfunction in children with autism who had a difficult temperament characteristics, and the relationship between SP dysfunction and temperament characteristics in preschool children with autism. A total of 111 children aged 48–84 months, 67 children with autism and 44 age-matched typically developing children, participated in this study. Results of the study indicated that SP dysfunction was prevalent in children with autism who had difficult temperament characteristics, and that different SP patterns were associated with different temperament characteristics in preschool children with autism. In summary, the present findings highlight the importance of evaluating SP patterns in addition to assessing temperament in children with autism in order for clinicians to plan appropriate intervention programs and support children's participation in their daily lives. Furthermore, the knowledge of the relationship between difficult temperament characteristics and SP dysfunction of the child can foster parental appreciation of individual differences in children, provide parents effective strategies to manage children's behaviors, and promote adaptive parent–child interaction. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.01.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153

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