Consistency matters: Consistency in the timing and quality of daily interactions between parents and adolescents predicts production of proinflammatory cytokines in youths / Erika M. MANCZAK in Development and Psychopathology, 30-2 (May 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-2 (May 2018) . - p.373-382 Titre : Consistency matters: Consistency in the timing and quality of daily interactions between parents and adolescents predicts production of proinflammatory cytokines in youths Type de document : Texte imprimé et/ou numérique Auteurs : Erika M. MANCZAK, Auteur ; Adam K. K. LEIGH, Auteur ; Chia-Ping CHIN, Auteur ; Edith CHEN, Auteur Article en page(s) : p.373-382 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The current study examined whether consistency in day-to-day interactions between children and parents related to inflammatory cytokine production in youths. One hundred twenty-three parents recorded the daily quality of interactions and timing of leisure activities with their adolescent children for 2 weeks, and the degree of variability in those ratings was calculated. One year later, the production of proinflammatory cytokines in youths’ blood was measured in response to in vitro exposure to lipopolysaccharide (a bacterial product). The results indicate that greater variability in parent–child relationship quality related to greater stimulated proinflammatory cytokine production in youths, above and beyond overall relationship quality. Greater variability in the timing of parent–child leisure activities also predicted greater stimulated proinflammatory cytokine production in youths, regardless of the frequency of interactions. In sum, consistency in both the affective and temporal aspects of parent–child relationships may contribute to inflammatory processes in youth. En ligne : http://dx.doi.org/10.1017/S0954579417000918 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=358 [article] Consistency matters: Consistency in the timing and quality of daily interactions between parents and adolescents predicts production of proinflammatory cytokines in youths [Texte imprimé et/ou numérique] / Erika M. MANCZAK, Auteur ; Adam K. K. LEIGH, Auteur ; Chia-Ping CHIN, Auteur ; Edith CHEN, Auteur . - p.373-382. Langues : Anglais (eng) in Development and Psychopathology > 30-2 (May 2018) . - p.373-382 Index. décimale : PER Périodiques Résumé : The current study examined whether consistency in day-to-day interactions between children and parents related to inflammatory cytokine production in youths. One hundred twenty-three parents recorded the daily quality of interactions and timing of leisure activities with their adolescent children for 2 weeks, and the degree of variability in those ratings was calculated. One year later, the production of proinflammatory cytokines in youths’ blood was measured in response to in vitro exposure to lipopolysaccharide (a bacterial product). The results indicate that greater variability in parent–child relationship quality related to greater stimulated proinflammatory cytokine production in youths, above and beyond overall relationship quality. Greater variability in the timing of parent–child leisure activities also predicted greater stimulated proinflammatory cytokine production in youths, regardless of the frequency of interactions. In sum, consistency in both the affective and temporal aspects of parent–child relationships may contribute to inflammatory processes in youth. En ligne : http://dx.doi.org/10.1017/S0954579417000918 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=358

A family-centered prevention ameliorates the associations of low self-control during childhood with employment income and poverty status in young African American adults / Gene H. BRODY in Journal of Child Psychology and Psychiatry, 61-4 (April 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-4 (April 2020) . - p.425-435 Titre : A family-centered prevention ameliorates the associations of low self-control during childhood with employment income and poverty status in young African American adults Type de document : Texte imprimé et/ou numérique Auteurs : Gene H. BRODY, Auteur ; Tianyi YU, Auteur ; Gregory E. MILLER, Auteur ; Edith CHEN, Auteur Article en page(s) : p.425-435 Langues : Anglais (eng) Mots-clés : African American  Parent-child relations  preventive intervention  self-control Index. décimale : PER Périodiques Résumé : OBJECTIVE: Children with low self-control who grow up in poverty are at elevated risk for living in poverty when they are adults. The purpose of this study was to further understanding of the intergenerational continuity of poverty by (a) examining the likelihood that children with low levels of self-control at age 11 earn less employment income and are more likely to live in poverty 14 years later, at age 25; and (b) determining, via a preventive intervention, whether enhancing supportive parenting during childhood will ameliorate these associations. METHODS: Parents and their 11-year-old children from 381 families participated in the Strong African American Families (SAAF) program or a control condition. Teachers assessed children's self-control at 11 years; parents reported their use of supportive parenting when children were 11 and 13 years; emerging adults provided data on cognitive and emotional self-control at 19, 20, and 21 years; and young adults indicated their employment income at 25 years. RESULTS: Significant two-way interactions were detected between children's self-control and prevention condition for employment income (b = -183.18, 95% CI [-363.82, -2.53], p < .05) and poverty status (b = 0.257, 95% CI [0.018, 0.497], p < .05). Low self-control at age 11 forecast less employment income and a greater likelihood of living in poverty among children in the control condition, but not among low self-control SAAF participants. Mediated moderation analyses confirmed that enhanced supportive parenting accounted for SAAF's effects on employment income (indirect effect = 63.057, 95% BCA [19.385, 124.748]) and poverty status (indirect effect = -0.071, 95% BCA [-0.165, -0.016]). CONCLUSIONS: This study is unique in using a randomized controlled trial to show that preventive interventions designed to enhance parenting and strengthen families can buffer the long-term economic consequences of low self-control. En ligne : http://dx.doi.org/10.1111/jcpp.13139 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421 [article] A family-centered prevention ameliorates the associations of low self-control during childhood with employment income and poverty status in young African American adults [Texte imprimé et/ou numérique] / Gene H. BRODY, Auteur ; Tianyi YU, Auteur ; Gregory E. MILLER, Auteur ; Edith CHEN, Auteur . - p.425-435. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-4 (April 2020) . - p.425-435 Mots-clés : African American  Parent-child relations  preventive intervention  self-control Index. décimale : PER Périodiques Résumé : OBJECTIVE: Children with low self-control who grow up in poverty are at elevated risk for living in poverty when they are adults. The purpose of this study was to further understanding of the intergenerational continuity of poverty by (a) examining the likelihood that children with low levels of self-control at age 11 earn less employment income and are more likely to live in poverty 14 years later, at age 25; and (b) determining, via a preventive intervention, whether enhancing supportive parenting during childhood will ameliorate these associations. METHODS: Parents and their 11-year-old children from 381 families participated in the Strong African American Families (SAAF) program or a control condition. Teachers assessed children's self-control at 11 years; parents reported their use of supportive parenting when children were 11 and 13 years; emerging adults provided data on cognitive and emotional self-control at 19, 20, and 21 years; and young adults indicated their employment income at 25 years. RESULTS: Significant two-way interactions were detected between children's self-control and prevention condition for employment income (b = -183.18, 95% CI [-363.82, -2.53], p < .05) and poverty status (b = 0.257, 95% CI [0.018, 0.497], p < .05). Low self-control at age 11 forecast less employment income and a greater likelihood of living in poverty among children in the control condition, but not among low self-control SAAF participants. Mediated moderation analyses confirmed that enhanced supportive parenting accounted for SAAF's effects on employment income (indirect effect = 63.057, 95% BCA [19.385, 124.748]) and poverty status (indirect effect = -0.071, 95% BCA [-0.165, -0.016]). CONCLUSIONS: This study is unique in using a randomized controlled trial to show that preventive interventions designed to enhance parenting and strengthen families can buffer the long-term economic consequences of low self-control. En ligne : http://dx.doi.org/10.1111/jcpp.13139 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421

Family-centered prevention ameliorates the longitudinal association between risky family processes and epigenetic aging / Gene H. BRODY in Journal of Child Psychology and Psychiatry, 57-5 (May 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-5 (May 2016) . - p.566-574 Titre : Family-centered prevention ameliorates the longitudinal association between risky family processes and epigenetic aging Type de document : Texte imprimé et/ou numérique Auteurs : Gene H. BRODY, Auteur ; Tianyi YU, Auteur ; Edith CHEN, Auteur ; Steven R. H. BEACH, Auteur ; Gregory E. MILLER, Auteur Article en page(s) : p.566-574 Langues : Anglais (eng) Mots-clés : Depression  epigenetics  epigenetic clock  health  intervention  parenting  prevention Index. décimale : PER Périodiques Résumé : Background Research has suggested that ‘risky’ family processes have unforeseen negative consequences for health later in life. The purpose of this study was to further understanding of risky family environments and development of health vulnerabilities by (a) examining the likelihood that elevated levels of parental depressive symptoms when children are age 11 forecast accelerated epigenetic aging 9 years later at age 20; (b) determining whether participation in an efficacious family-centered prevention program focused on enhancing supportive parenting and strengthening family relationships will ameliorate this association; and (c) testing a moderation-mediation hypothesis that prevention-induced reductions in harsh parenting across adolescence will account for prevention effects in reducing accelerated epigenetic aging. Methods In the rural southeastern United States, parents and 11-year-old children from 399 families participated in the Strong African American Families (SAAF) program or a control condition. Parents reported their own depressive symptoms when their children were 11, and both youths and parents reported youth exposure to harsh parenting at ages 11 and 16. Blood was drawn from youths at age 20 to measure accelerated epigenetic aging using a marker derived from the DNA methylation of cells. Results Elevated parental depressive symptoms forecast accelerated epigenetic aging among youths in the control condition, but not among SAAF participants. Moderated-mediation analyses confirmed that reductions in harsh parenting accounted for SAAF's protective effects on epigenetic aging. Subsequent exploratory analyses indicated that accelerated epigenetic aging forecast emotional distress among young adults in the control condition but not among those who participated in SAAF. Conclusions This study is unique in using a randomized prevention trial to test hypotheses about the ways risky family processes contribute to accelerated epigenetic aging. The results suggest that developmentally appropriate family-centered interventions designed to enhance parenting and strengthen families can buffer the biological residue of life in a risky family. En ligne : http://dx.doi.org/10.1111/jcpp.12495 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288 [article] Family-centered prevention ameliorates the longitudinal association between risky family processes and epigenetic aging [Texte imprimé et/ou numérique] / Gene H. BRODY, Auteur ; Tianyi YU, Auteur ; Edith CHEN, Auteur ; Steven R. H. BEACH, Auteur ; Gregory E. MILLER, Auteur . - p.566-574. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-5 (May 2016) . - p.566-574 Mots-clés : Depression  epigenetics  epigenetic clock  health  intervention  parenting  prevention Index. décimale : PER Périodiques Résumé : Background Research has suggested that ‘risky’ family processes have unforeseen negative consequences for health later in life. The purpose of this study was to further understanding of risky family environments and development of health vulnerabilities by (a) examining the likelihood that elevated levels of parental depressive symptoms when children are age 11 forecast accelerated epigenetic aging 9 years later at age 20; (b) determining whether participation in an efficacious family-centered prevention program focused on enhancing supportive parenting and strengthening family relationships will ameliorate this association; and (c) testing a moderation-mediation hypothesis that prevention-induced reductions in harsh parenting across adolescence will account for prevention effects in reducing accelerated epigenetic aging. Methods In the rural southeastern United States, parents and 11-year-old children from 399 families participated in the Strong African American Families (SAAF) program or a control condition. Parents reported their own depressive symptoms when their children were 11, and both youths and parents reported youth exposure to harsh parenting at ages 11 and 16. Blood was drawn from youths at age 20 to measure accelerated epigenetic aging using a marker derived from the DNA methylation of cells. Results Elevated parental depressive symptoms forecast accelerated epigenetic aging among youths in the control condition, but not among SAAF participants. Moderated-mediation analyses confirmed that reductions in harsh parenting accounted for SAAF's protective effects on epigenetic aging. Subsequent exploratory analyses indicated that accelerated epigenetic aging forecast emotional distress among young adults in the control condition but not among those who participated in SAAF. Conclusions This study is unique in using a randomized prevention trial to test hypotheses about the ways risky family processes contribute to accelerated epigenetic aging. The results suggest that developmentally appropriate family-centered interventions designed to enhance parenting and strengthen families can buffer the biological residue of life in a risky family. En ligne : http://dx.doi.org/10.1111/jcpp.12495 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288

Harsh parent–child conflict is associated with decreased anti-inflammatory gene expression and increased symptom severity in children with asthma / Katherine B. EHRLICH in Development and Psychopathology, 27-4 (Part 2) (November 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-4 (Part 2) (November 2015) . - p.1547-1554 Titre : Harsh parent–child conflict is associated with decreased anti-inflammatory gene expression and increased symptom severity in children with asthma Type de document : Texte imprimé et/ou numérique Auteurs : Katherine B. EHRLICH, Auteur ; Gregory E. MILLER, Auteur ; Edith CHEN, Auteur Article en page(s) : p.1547-1554 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Asthma is a chronic respiratory disorder that affects over 7 million children in the United States. Evidence indicates that family stressors are associated with worsening of asthma symptoms, and some research suggests that these stressful experiences engender changes in children's immune systems in ways that exacerbate airway inflammation and contribute to both acute and chronic asthma symptoms. We examined the association between observed experiences of parent–child conflict and the expression of signaling molecules involved in the transduction of anti-inflammatory signals that regulate airway inflammation and obstruction. Fifty-seven children and their parents participated in a conflict task, and coders rated interactions for evidence of harsh and supportive behaviors. Children reported on their perceptions of parental support and reported on their daily asthma symptoms for 2 weeks. We collected peripheral blood in children to measure leukocyte expression of messenger RNA for the glucocorticoid receptor and the ?2-adrenergic receptor. Analyses revealed that harsh conflict behaviors were associated with decreased expression of both messenger RNAs and more severe asthma symptoms. Neither supportive behaviors nor perceived parental support was associated with gene expression or asthma symptoms. These findings suggest that harsh interactions with parents are associated with downregulation of key anti-inflammatory signaling molecules and difficulties breathing in children with asthma. Children with asthma who are also victims of maltreatment may be particularly susceptible to transcriptional changes in immune cells that could worsen asthma over time. En ligne : http://dx.doi.org/10.1017/S0954579415000930 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273 [article] Harsh parent–child conflict is associated with decreased anti-inflammatory gene expression and increased symptom severity in children with asthma [Texte imprimé et/ou numérique] / Katherine B. EHRLICH, Auteur ; Gregory E. MILLER, Auteur ; Edith CHEN, Auteur . - p.1547-1554. Langues : Anglais (eng) in Development and Psychopathology > 27-4 (Part 2) (November 2015) . - p.1547-1554 Index. décimale : PER Périodiques Résumé : Asthma is a chronic respiratory disorder that affects over 7 million children in the United States. Evidence indicates that family stressors are associated with worsening of asthma symptoms, and some research suggests that these stressful experiences engender changes in children's immune systems in ways that exacerbate airway inflammation and contribute to both acute and chronic asthma symptoms. We examined the association between observed experiences of parent–child conflict and the expression of signaling molecules involved in the transduction of anti-inflammatory signals that regulate airway inflammation and obstruction. Fifty-seven children and their parents participated in a conflict task, and coders rated interactions for evidence of harsh and supportive behaviors. Children reported on their perceptions of parental support and reported on their daily asthma symptoms for 2 weeks. We collected peripheral blood in children to measure leukocyte expression of messenger RNA for the glucocorticoid receptor and the ?2-adrenergic receptor. Analyses revealed that harsh conflict behaviors were associated with decreased expression of both messenger RNAs and more severe asthma symptoms. Neither supportive behaviors nor perceived parental support was associated with gene expression or asthma symptoms. These findings suggest that harsh interactions with parents are associated with downregulation of key anti-inflammatory signaling molecules and difficulties breathing in children with asthma. Children with asthma who are also victims of maltreatment may be particularly susceptible to transcriptional changes in immune cells that could worsen asthma over time. En ligne : http://dx.doi.org/10.1017/S0954579415000930 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273

Harshness and unpredictability: Childhood environmental links with immune and asthma outcomes / Phoebe H. LAM in Development and Psychopathology, 34-2 (May 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-2 (May 2022) . - 587-596 Titre : Harshness and unpredictability: Childhood environmental links with immune and asthma outcomes Type de document : Texte imprimé et/ou numérique Auteurs : Phoebe H. LAM, Auteur ; Gregory E. MILLER, Auteur ; Lauren HOFFER, Auteur ; Rebekah SILIEZAR, Auteur ; Johanna DEZIL, Auteur ; Amanda MCDONALD, Auteur ; Edith CHEN, Auteur Article en page(s) : 587-596 Langues : Anglais (eng) Mots-clés : asthma  harshness  inflammation  unpredictability Index. décimale : PER Périodiques Résumé : The environment has pervasive impacts on human development, and two key environmental conditions ? harshness and unpredictability ? are proposed to be instrumental in tuning development. This study examined (1) how harsh and unpredictable environments related to immune and clinical outcomes in the context of childhood asthma, and (2) whether there were independent associations of harshness and unpredictability with these outcomes. Participants were 290 youth physician-diagnosed with asthma. Harshness was assessed with youth-reported exposure to violence and neighborhood-level murder rate. Unpredictability was assessed with parent reports of family structural changes. Youth also completed measures of asthma control as well as asthma quality of life and provided blood samples to assess immune profiles, including in vitro cytokine responses to challenge and sensitivity to inhibitory signals from glucocorticoids. Results indicated that harshness was associated with more pronounced pro-inflammatory cytokine production following challenge and less sensitivity to the inhibitory properties of glucocorticoids. Furthermore, youth exposed to harsher environments reported less asthma control and poorer quality of life. All associations with harshness persisted when controlling for unpredictability. No associations between unpredictability and outcomes were found. These findings suggest that relative to unpredictability, harshness may be a more consistent correlate of asthma-relevant immune and clinical outcomes. En ligne : http://dx.doi.org/10.1017/s0954579421001577 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 [article] Harshness and unpredictability: Childhood environmental links with immune and asthma outcomes [Texte imprimé et/ou numérique] / Phoebe H. LAM, Auteur ; Gregory E. MILLER, Auteur ; Lauren HOFFER, Auteur ; Rebekah SILIEZAR, Auteur ; Johanna DEZIL, Auteur ; Amanda MCDONALD, Auteur ; Edith CHEN, Auteur . - 587-596. Langues : Anglais (eng) in Development and Psychopathology > 34-2 (May 2022) . - 587-596 Mots-clés : asthma  harshness  inflammation  unpredictability Index. décimale : PER Périodiques Résumé : The environment has pervasive impacts on human development, and two key environmental conditions ? harshness and unpredictability ? are proposed to be instrumental in tuning development. This study examined (1) how harsh and unpredictable environments related to immune and clinical outcomes in the context of childhood asthma, and (2) whether there were independent associations of harshness and unpredictability with these outcomes. Participants were 290 youth physician-diagnosed with asthma. Harshness was assessed with youth-reported exposure to violence and neighborhood-level murder rate. Unpredictability was assessed with parent reports of family structural changes. Youth also completed measures of asthma control as well as asthma quality of life and provided blood samples to assess immune profiles, including in vitro cytokine responses to challenge and sensitivity to inhibitory signals from glucocorticoids. Results indicated that harshness was associated with more pronounced pro-inflammatory cytokine production following challenge and less sensitivity to the inhibitory properties of glucocorticoids. Furthermore, youth exposed to harsher environments reported less asthma control and poorer quality of life. All associations with harshness persisted when controlling for unpredictability. No associations between unpredictability and outcomes were found. These findings suggest that relative to unpredictability, harshness may be a more consistent correlate of asthma-relevant immune and clinical outcomes. En ligne : http://dx.doi.org/10.1017/s0954579421001577 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474

One size does not fit all: Links between shift-and-persist and asthma in youth are moderated by perceived social status and experience of unfair treatment / Phoebe H. LAM in Development and Psychopathology, 30-5 (December 2018)  

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Preventive parenting intervention during childhood and young black adults' unhealthful behaviors: a randomized controlled trial / Gene H. BRODY in Journal of Child Psychology and Psychiatry, 60-1 (January 2019)  

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Reflections on resilience / Edith CHEN ; Tao JIANG ; Michelle A. CHEN ; Gregory E. MILLER in Development and Psychopathology, 36-5 (December 2024)  

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Smoking in young adulthood among African Americans: Interconnected effects of supportive parenting in early adolescence, proinflammatory epitype, and young adult stress / Steven R. H. BEACH in Development and Psychopathology, 29-3 (August 2017)  

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Social encounters in daily life and 2-year changes in metabolic risk factors in young women / Kharah ROSS in Development and Psychopathology, 23-3 (August 2011)  

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Socioeconomic disadvantage and high-effort coping in childhood: evidence of skin-deep resilience / Sarah M. LYLE ; Kelsey L. CORALLO ; Julie M. BRISSON ; Elizabeth R. WIGGINS ; Tianyi YU ; Edith CHEN ; Gregory E. MILLER ; Gene H. BRODY in Journal of Child Psychology and Psychiatry, 65-3 (March 2023)  

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Testing the biological embedding hypothesis: Is early life adversity associated with a later proinflammatory phenotype? / Katherine B. EHRLICH in Development and Psychopathology, 28-4 pt2 (November 2016)  

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Threat vigilance and socioeconomic disparities in metabolic health / Camelia E. HOSTINAR in Development and Psychopathology, 29-5 (December 2017)  

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Youth temperament, harsh parenting, and variation in the oxytocin receptor gene forecast allostatic load during emerging adulthood / Gene H. BRODY in Development and Psychopathology, 29-3 (August 2017)  

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