Guidelines and Best Practices for Electrophysiological Data Collection, Analysis and Reporting in Autism / Sara Jane WEBB in Journal of Autism and Developmental Disorders, 45-2 (February 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.425-443 Titre : Guidelines and Best Practices for Electrophysiological Data Collection, Analysis and Reporting in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Sara Jane WEBB, Auteur ; Raphael BERNIER, Auteur ; Heather A. HENDERSON, Auteur ; Mark H. JOHNSON, Auteur ; Emily J. H. JONES, Auteur ; Matthew D. LERNER, Auteur ; James C. MCPARTLAND, Auteur ; Charles A. NELSON, Auteur ; Donald C. ROJAS, Auteur ; Jeanne TOWNSEND, Auteur ; Marissa A. WESTERFIELD, Auteur Article en page(s) : p.425-443 Langues : Anglais (eng) Mots-clés : EEG  Electrophysiology  ERP  Event-related potentials  MEG  Magnetoencephalography  Autism  ASD  Guidelines Index. décimale : PER Périodiques Résumé : The EEG reflects the activation of large populations of neurons that act in synchrony and propagate to the scalp surface. This activity reflects both the brain’s background electrical activity and when the brain is being challenged by a task. Despite strong theoretical and methodological arguments for the use of EEG in understanding the neural correlates of autism, the practice of collecting, processing and evaluating EEG data is complex. Scientists should take into consideration both the nature of development in autism given the life-long, pervasive course of the disorder and the disability of altered or atypical social, communicative, and motor behaviors, all of which require accommodations to traditional EEG environments and paradigms. This paper presents guidelines for the recording, analyzing, and interpreting of EEG data with participants with autism. The goal is to articulate a set of scientific standards as well as methodological considerations that will increase the general field’s understanding of EEG methods, provide support for collaborative projects, and contribute to the evaluation of results and conclusions. En ligne : http://dx.doi.org/10.1007/s10803-013-1916-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 [article] Guidelines and Best Practices for Electrophysiological Data Collection, Analysis and Reporting in Autism [Texte imprimé et/ou numérique] / Sara Jane WEBB, Auteur ; Raphael BERNIER, Auteur ; Heather A. HENDERSON, Auteur ; Mark H. JOHNSON, Auteur ; Emily J. H. JONES, Auteur ; Matthew D. LERNER, Auteur ; James C. MCPARTLAND, Auteur ; Charles A. NELSON, Auteur ; Donald C. ROJAS, Auteur ; Jeanne TOWNSEND, Auteur ; Marissa A. WESTERFIELD, Auteur . - p.425-443. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.425-443 Mots-clés : EEG  Electrophysiology  ERP  Event-related potentials  MEG  Magnetoencephalography  Autism  ASD  Guidelines Index. décimale : PER Périodiques Résumé : The EEG reflects the activation of large populations of neurons that act in synchrony and propagate to the scalp surface. This activity reflects both the brain’s background electrical activity and when the brain is being challenged by a task. Despite strong theoretical and methodological arguments for the use of EEG in understanding the neural correlates of autism, the practice of collecting, processing and evaluating EEG data is complex. Scientists should take into consideration both the nature of development in autism given the life-long, pervasive course of the disorder and the disability of altered or atypical social, communicative, and motor behaviors, all of which require accommodations to traditional EEG environments and paradigms. This paper presents guidelines for the recording, analyzing, and interpreting of EEG data with participants with autism. The goal is to articulate a set of scientific standards as well as methodological considerations that will increase the general field’s understanding of EEG methods, provide support for collaborative projects, and contribute to the evaluation of results and conclusions. En ligne : http://dx.doi.org/10.1007/s10803-013-1916-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258

Increased Glutamate Concentration in the Auditory Cortex of Persons With Autism and First-Degree Relatives: A 1H-MRS Study / Mark S. BROWN in Autism Research, 6-1 (February 2013)  

Public ISBD [article]  inAutism Research > 6-1 (February 2013) . - p.1-10 Titre : Increased Glutamate Concentration in the Auditory Cortex of Persons With Autism and First-Degree Relatives: A 1H-MRS Study Type de document : Texte imprimé et/ou numérique Auteurs : Mark S. BROWN, Auteur ; Debra SINGEL, Auteur ; Susan HEPBURN, Auteur ; Donald C. ROJAS, Auteur Année de publication : 2013 Article en page(s) : p.1-10 Langues : Anglais (eng) Mots-clés : glutamate  n-acetyl-aspartate  creatine  spectroscopy  auditory cortex Index. décimale : PER Périodiques Résumé : Increased glutamate levels have been reported in the hippocampal and frontal regions of persons with autism using proton magnetic resonance spectroscopy (1H-MRS). Although autism spectrum disorders (ASDs) are highly heritable, MRS studies have not included relatives of persons with ASD. We therefore conducted a study to determine if glutamate levels are elevated in people with autism and parents of children with autism. Single-voxel, point-resolved spectroscopy data were acquired at 3T for left and right hemisphere auditory cortical voxels in 13 adults with autism, 15 parents of children with autism, and 15 adult control subjects. The primary measure was glutamate?+?glutamine (Glx). Additional measures included n-acetyl-aspartate (NAA), choline (Cho), myoinositol (mI), and creatine (Cr). The autism group had significantly higher Glx, NAA, and Cr concentrations than the control subjects. Parents did not differ from control subjects on any measures. No significant differences in Cho or mI levels were seen among groups. No reliable correlations between autism symptom measures, and MRS variables were seen after Bonferroni correction for multiple comparisons. The elevation in Glx in autism is consistent with prior MRS data in the hippocampus and frontal lobe and may suggest increased cortical excitability. Increased NAA and Cr may indicate brain metabolism disturbances in autism. In the current study, we found no reliable evidence of a familial effect for any spectroscopy measure. This may indicate that these metabolites have no heritable component in autism, the presence of a compensatory factor in parents, or sample-specific limitations such as the participation of singleton families. En ligne : http://dx.doi.org/10.1002/aur.1260 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=192 [article] Increased Glutamate Concentration in the Auditory Cortex of Persons With Autism and First-Degree Relatives: A 1H-MRS Study [Texte imprimé et/ou numérique] / Mark S. BROWN, Auteur ; Debra SINGEL, Auteur ; Susan HEPBURN, Auteur ; Donald C. ROJAS, Auteur . - 2013 . - p.1-10. Langues : Anglais (eng) in Autism Research > 6-1 (February 2013) . - p.1-10 Mots-clés : glutamate  n-acetyl-aspartate  creatine  spectroscopy  auditory cortex Index. décimale : PER Périodiques Résumé : Increased glutamate levels have been reported in the hippocampal and frontal regions of persons with autism using proton magnetic resonance spectroscopy (1H-MRS). Although autism spectrum disorders (ASDs) are highly heritable, MRS studies have not included relatives of persons with ASD. We therefore conducted a study to determine if glutamate levels are elevated in people with autism and parents of children with autism. Single-voxel, point-resolved spectroscopy data were acquired at 3T for left and right hemisphere auditory cortical voxels in 13 adults with autism, 15 parents of children with autism, and 15 adult control subjects. The primary measure was glutamate?+?glutamine (Glx). Additional measures included n-acetyl-aspartate (NAA), choline (Cho), myoinositol (mI), and creatine (Cr). The autism group had significantly higher Glx, NAA, and Cr concentrations than the control subjects. Parents did not differ from control subjects on any measures. No significant differences in Cho or mI levels were seen among groups. No reliable correlations between autism symptom measures, and MRS variables were seen after Bonferroni correction for multiple comparisons. The elevation in Glx in autism is consistent with prior MRS data in the hippocampus and frontal lobe and may suggest increased cortical excitability. Increased NAA and Cr may indicate brain metabolism disturbances in autism. In the current study, we found no reliable evidence of a familial effect for any spectroscopy measure. This may indicate that these metabolites have no heritable component in autism, the presence of a compensatory factor in parents, or sample-specific limitations such as the participation of singleton families. En ligne : http://dx.doi.org/10.1002/aur.1260 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=192

Transient and steady-state auditory gamma-band responses in first-degree relatives of people with autism spectrum disorder / Donald C. ROJAS in Molecular Autism, (July 2011)  

Public ISBD [article]  inMolecular Autism > (July 2011) . - 13 p. Titre : Transient and steady-state auditory gamma-band responses in first-degree relatives of people with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Donald C. ROJAS, Auteur ; Peter D. TEALE, Auteur ; Keeran MAHARAJH, Auteur ; Eugene KRONBERG, Auteur ; Katie YOUNGPETER, Auteur ; Lisa B. WILSON, Auteur ; Alissa WALLACE, Auteur ; Susan HEPBURN, Auteur Année de publication : 2011 Article en page(s) : 13 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Stimulus-related γ-band oscillations, which may be related to perceptual binding, are reduced in people with autism spectrum disorders (ASD). The purpose of this study was to examine auditory transient and steady-state γ-band findings in first-degree relatives of people with ASD to assess the potential familiality of these findings in ASD. Methods Magnetoencephalography (MEG) recordings in 21 parents who had a child with an autism spectrum disorder (pASD) and 20 healthy adult control subjects (HC) were obtained. Gamma-band phase locking factor (PLF), and evoked and induced power to 32, 40 and 48 Hz amplitude-modulated sounds were measured for transient and steady-state responses. Participants were also tested on a number of behavioral and cognitive assessments related to the broad autism phenotype (BAP). Results Reliable group differences were seen primarily for steady-state responses. In the left hemisphere, pASD subjects exhibited lower phase-locked steady-state power in all three conditions. Total γ-band power, including the non-phase-locked component, was also reduced in the pASD group. In addition, pASD subjects had significantly lower PLF than the HC group. Correlations were seen between MEG measures and BAP measures. Conclusions The reduction in steady-state γ-band responses in the pASD group is consistent with previous results for children with ASD. Steady-state responses may be more sensitive than transient responses to phase-locking errors in ASD. Together with the lower PLF and phase-locked power in first-degree relatives, correlations between γ-band measures and behavioral measures relevant to the BAP highlight the potential of γ-band deficits as a potential new autism endophenotype. En ligne : http://dx.doi.org/10.1186/2040-2392-2-11 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141 [article] Transient and steady-state auditory gamma-band responses in first-degree relatives of people with autism spectrum disorder [Texte imprimé et/ou numérique] / Donald C. ROJAS, Auteur ; Peter D. TEALE, Auteur ; Keeran MAHARAJH, Auteur ; Eugene KRONBERG, Auteur ; Katie YOUNGPETER, Auteur ; Lisa B. WILSON, Auteur ; Alissa WALLACE, Auteur ; Susan HEPBURN, Auteur . - 2011 . - 13 p. Langues : Anglais (eng) in Molecular Autism > (July 2011) . - 13 p. Index. décimale : PER Périodiques Résumé : Background Stimulus-related γ-band oscillations, which may be related to perceptual binding, are reduced in people with autism spectrum disorders (ASD). The purpose of this study was to examine auditory transient and steady-state γ-band findings in first-degree relatives of people with ASD to assess the potential familiality of these findings in ASD. Methods Magnetoencephalography (MEG) recordings in 21 parents who had a child with an autism spectrum disorder (pASD) and 20 healthy adult control subjects (HC) were obtained. Gamma-band phase locking factor (PLF), and evoked and induced power to 32, 40 and 48 Hz amplitude-modulated sounds were measured for transient and steady-state responses. Participants were also tested on a number of behavioral and cognitive assessments related to the broad autism phenotype (BAP). Results Reliable group differences were seen primarily for steady-state responses. In the left hemisphere, pASD subjects exhibited lower phase-locked steady-state power in all three conditions. Total γ-band power, including the non-phase-locked component, was also reduced in the pASD group. In addition, pASD subjects had significantly lower PLF than the HC group. Correlations were seen between MEG measures and BAP measures. Conclusions The reduction in steady-state γ-band responses in the pASD group is consistent with previous results for children with ASD. Steady-state responses may be more sensitive than transient responses to phase-locking errors in ASD. Together with the lower PLF and phase-locked power in first-degree relatives, correlations between γ-band measures and behavioral measures relevant to the BAP highlight the potential of γ-band deficits as a potential new autism endophenotype. En ligne : http://dx.doi.org/10.1186/2040-2392-2-11 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141

---

1 (1 - 3 / 3)