Annual Research Review: The neuroinflammation hypothesis for stress and psychopathology in children – developmental psychoneuroimmunology / Thomas G. O'CONNOR in Journal of Child Psychology and Psychiatry, 55-6 (June 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-6 (June 2014) . - p.615-631 Titre : Annual Research Review: The neuroinflammation hypothesis for stress and psychopathology in children – developmental psychoneuroimmunology Type de document : Texte imprimé et/ou numérique Auteurs : Thomas G. O'CONNOR, Auteur ; Jan A. MOYNIHAN, Auteur ; Mary T. CASERTA, Auteur Année de publication : 2014 Article en page(s) : p.615-631 Langues : Anglais (eng) Mots-clés : Immunology  psychoneuroimmunology  neuroinflammation  stress  developmental psychopathology Index. décimale : PER Périodiques Résumé : Abstract Experimental animal and adult human data suggest that stress exposure is associated with alterations in immune system function that may underlie increased susceptibility to disease and behavioral disorders. The implications of these data for child psychology and psychiatry are not yet clear. The current review seeks to distil and translate the relevant animal and adult human work to children to advance a developmental model of psychoneuroimmunology. In addition to reviewing key specific findings, we consider biological/conceptual models and technical aspects of psychoneuroimmunology work in pediatric populations, and outline the rationales and advantages of integrating hypotheses concerning neuroinflammation in developmental studies of psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.12187 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=234 [article] Annual Research Review: The neuroinflammation hypothesis for stress and psychopathology in children – developmental psychoneuroimmunology [Texte imprimé et/ou numérique] / Thomas G. O'CONNOR, Auteur ; Jan A. MOYNIHAN, Auteur ; Mary T. CASERTA, Auteur . - 2014 . - p.615-631. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-6 (June 2014) . - p.615-631 Mots-clés : Immunology  psychoneuroimmunology  neuroinflammation  stress  developmental psychopathology Index. décimale : PER Périodiques Résumé : Abstract Experimental animal and adult human data suggest that stress exposure is associated with alterations in immune system function that may underlie increased susceptibility to disease and behavioral disorders. The implications of these data for child psychology and psychiatry are not yet clear. The current review seeks to distil and translate the relevant animal and adult human work to children to advance a developmental model of psychoneuroimmunology. In addition to reviewing key specific findings, we consider biological/conceptual models and technical aspects of psychoneuroimmunology work in pediatric populations, and outline the rationales and advantages of integrating hypotheses concerning neuroinflammation in developmental studies of psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.12187 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=234

Associations among depression, perceived self-efficacy, and immune function and health in preadolescent children / Mary T. CASERTA in Development and Psychopathology, 23-4 (November 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-4 (November 2011) . - p.1139-1147 Titre : Associations among depression, perceived self-efficacy, and immune function and health in preadolescent children Type de document : Texte imprimé et/ou numérique Auteurs : Mary T. CASERTA, Auteur ; Peter A. WYMAN, Auteur ; Hongyue WANG, Auteur ; Jan MOYNIHAN, Auteur ; Thomas G. O'CONNOR, Auteur Année de publication : 2011 Article en page(s) : p.1139-1147 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Experimental animal studies and adult research consistently show that stress exposure and/or psychological symptoms are associated with poorer health and immune functioning. The application to children is not yet clear, however, and we lack developmental models for studies in this area. The objective of this paper was to test the hypothesis that self-reported self-efficacy and depression, two markers of psychological well-being in children, would predict immunity and rate of illnesses. The data are based on a prospective study of 141 healthy, normally developing children aged 7–13 years who were recruited from an ambulatory pediatric setting. Children completed self-efficacy and depression measures and had blood obtained for IL-6 plasma levels and natural killer cell functional assays on three occasions, 6 months apart. Parents maintained weekly child illness diaries over 1 year using a thermometer to record fever. Parent psychiatric symptoms and income were used as covariates. Results indicated that, across the three occasions of measurement collected over the 1-year period, higher perceived self-efficacy was significantly associated with lower plasma interleukin 6 concentrations. There was no overall main effect of depressive symptoms on immune measures; however, for older girls, higher depression was associated with elevated natural killer cell cytotoxicity and an increased rate of total illnesses and febrile illnesses. The findings provide some of the first evidence that psychological processes are associated with immunity and health in a normally developing sample of preadolescents. Furthermore, the pattern of results suggests a modified model of a link between psychological well-being and immunological processes in children. These results build on and expand research on the notion of allostatic load and develop a groundwork for developmental studies in this area. En ligne : http://dx.doi.org/10.1017/S0954579411000526 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146 [article] Associations among depression, perceived self-efficacy, and immune function and health in preadolescent children [Texte imprimé et/ou numérique] / Mary T. CASERTA, Auteur ; Peter A. WYMAN, Auteur ; Hongyue WANG, Auteur ; Jan MOYNIHAN, Auteur ; Thomas G. O'CONNOR, Auteur . - 2011 . - p.1139-1147. Langues : Anglais (eng) in Development and Psychopathology > 23-4 (November 2011) . - p.1139-1147 Index. décimale : PER Périodiques Résumé : Experimental animal studies and adult research consistently show that stress exposure and/or psychological symptoms are associated with poorer health and immune functioning. The application to children is not yet clear, however, and we lack developmental models for studies in this area. The objective of this paper was to test the hypothesis that self-reported self-efficacy and depression, two markers of psychological well-being in children, would predict immunity and rate of illnesses. The data are based on a prospective study of 141 healthy, normally developing children aged 7–13 years who were recruited from an ambulatory pediatric setting. Children completed self-efficacy and depression measures and had blood obtained for IL-6 plasma levels and natural killer cell functional assays on three occasions, 6 months apart. Parents maintained weekly child illness diaries over 1 year using a thermometer to record fever. Parent psychiatric symptoms and income were used as covariates. Results indicated that, across the three occasions of measurement collected over the 1-year period, higher perceived self-efficacy was significantly associated with lower plasma interleukin 6 concentrations. There was no overall main effect of depressive symptoms on immune measures; however, for older girls, higher depression was associated with elevated natural killer cell cytotoxicity and an increased rate of total illnesses and febrile illnesses. The findings provide some of the first evidence that psychological processes are associated with immunity and health in a normally developing sample of preadolescents. Furthermore, the pattern of results suggests a modified model of a link between psychological well-being and immunological processes in children. These results build on and expand research on the notion of allostatic load and develop a groundwork for developmental studies in this area. En ligne : http://dx.doi.org/10.1017/S0954579411000526 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146

Depressive symptoms and immune response to meningococcal conjugate vaccine in early adolescence / Thomas G. O'CONNOR in Development and Psychopathology, 26-4 (Part 2) (November 2014)  

Public ISBD [article]  inDevelopment and Psychopathology > 26-4 (Part 2) (November 2014) . - p.1567-1576 Titre : Depressive symptoms and immune response to meningococcal conjugate vaccine in early adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Thomas G. O'CONNOR, Auteur ; Jan A. MOYNIHAN, Auteur ; Peter A. WYMAN, Auteur ; Jennifer CARNAHAN, Auteur ; Gerry LOFTHUS, Auteur ; Sally A. QUATAERT, Auteur ; Melissa BOWMAN, Auteur ; Mary T. CASERTA, Auteur Année de publication : 2014 Article en page(s) : p.1567-1576 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Research findings in psychoneuroimmunology document reliable, bidirectional linkages among psychological processes, the nervous system, and the immune system. However, available data are based almost entirely on animal and adult human studies; the application to children and adolescents is uncertain. We capitalized on the experimental leverage provided by a routine vaccination to examine the link between mood symptoms and the immune response to a vaccine challenge in early adolescence. One hundred twenty-six 11-year-olds for whom vaccine response data were available were assessed at prevaccination and 4 weeks, 3 months, and 6 months following vaccination; self-report ratings of depression and anxiety as well as measures of psychosocial and somatic risk were assessed prior to vaccine response. Analyses indicated that children's internalizing mood symptoms were associated with elevated and persistently higher antibody responses, with evidence extending to two of the four serogroups. The associations remained after controlling for multiple possible confounders (social class, body mass index, sleep, psychosocial risk, and pubertal status). The observed enhanced vaccine response associated with depressive and anxious symptoms in early adolescence may reflect an important developmental difference in immune system–brain interplay between adults and children, and it underscores the need for further developmental studies of psychoneuroimmunology. En ligne : http://dx.doi.org/10.1017/S0954579414001242 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=245 [article] Depressive symptoms and immune response to meningococcal conjugate vaccine in early adolescence [Texte imprimé et/ou numérique] / Thomas G. O'CONNOR, Auteur ; Jan A. MOYNIHAN, Auteur ; Peter A. WYMAN, Auteur ; Jennifer CARNAHAN, Auteur ; Gerry LOFTHUS, Auteur ; Sally A. QUATAERT, Auteur ; Melissa BOWMAN, Auteur ; Mary T. CASERTA, Auteur . - 2014 . - p.1567-1576. Langues : Anglais (eng) in Development and Psychopathology > 26-4 (Part 2) (November 2014) . - p.1567-1576 Index. décimale : PER Périodiques Résumé : Research findings in psychoneuroimmunology document reliable, bidirectional linkages among psychological processes, the nervous system, and the immune system. However, available data are based almost entirely on animal and adult human studies; the application to children and adolescents is uncertain. We capitalized on the experimental leverage provided by a routine vaccination to examine the link between mood symptoms and the immune response to a vaccine challenge in early adolescence. One hundred twenty-six 11-year-olds for whom vaccine response data were available were assessed at prevaccination and 4 weeks, 3 months, and 6 months following vaccination; self-report ratings of depression and anxiety as well as measures of psychosocial and somatic risk were assessed prior to vaccine response. Analyses indicated that children's internalizing mood symptoms were associated with elevated and persistently higher antibody responses, with evidence extending to two of the four serogroups. The associations remained after controlling for multiple possible confounders (social class, body mass index, sleep, psychosocial risk, and pubertal status). The observed enhanced vaccine response associated with depressive and anxious symptoms in early adolescence may reflect an important developmental difference in immune system–brain interplay between adults and children, and it underscores the need for further developmental studies of psychoneuroimmunology. En ligne : http://dx.doi.org/10.1017/S0954579414001242 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=245

Immune and neuroendocrine correlates of temperament in infancy / Thomas G. O'CONNOR in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1589-1600 Titre : Immune and neuroendocrine correlates of temperament in infancy Type de document : Texte imprimé et/ou numérique Auteurs : Thomas G. O'CONNOR, Auteur ; Kristin SCHEIBLE, Auteur ; Ana Vallejo SEFAIR, Auteur ; Michelle GILCHRIST, Auteur ; Emma Robertson BLACKMORE, Auteur ; Marcia A. WINTER, Auteur ; Megan R. GUNNAR, Auteur ; Claire WYMAN, Auteur ; Jennifer CARNAHAN, Auteur ; Jan A. MOYNIHAN, Auteur ; Mary T. CASERTA, Auteur Article en page(s) : p.1589-1600 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : There is now a clear focus on incorporating, and integrating, multiple levels of analysis in developmental science. The current study adds to research in this area by including markers of the immune and neuroendocrine systems in a longitudinal study of temperament in infants. Observational and parent-reported ratings of infant temperament, serum markers of the innate immune system, and cortisol reactivity from repeated salivary collections were examined in a sample of 123 infants who were assessed at 6 months and again when they were, on average, 17 months old. Blood from venipuncture was collected for analyses of nine select innate immune cytokines; salivary cortisol collected prior to and 15 min and 30 min following a physical exam including blood draw was used as an index of neuroendocrine functioning. Analyses indicated fairly minimal significant associations between biological markers and temperament at 6 months. However, by 17 months of age, we found reliable and nonoverlapping associations between observed fearful temperament and biological markers of the immune and neuroendocrine systems. The findings provide some of the earliest evidence of robust biological correlates of fear behavior with the immune system, and identify possible immune and neuroendocrine mechanisms for understanding the origins of behavioral development. En ligne : http://dx.doi.org/10.1017/S0954579417001250 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Immune and neuroendocrine correlates of temperament in infancy [Texte imprimé et/ou numérique] / Thomas G. O'CONNOR, Auteur ; Kristin SCHEIBLE, Auteur ; Ana Vallejo SEFAIR, Auteur ; Michelle GILCHRIST, Auteur ; Emma Robertson BLACKMORE, Auteur ; Marcia A. WINTER, Auteur ; Megan R. GUNNAR, Auteur ; Claire WYMAN, Auteur ; Jennifer CARNAHAN, Auteur ; Jan A. MOYNIHAN, Auteur ; Mary T. CASERTA, Auteur . - p.1589-1600. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1589-1600 Index. décimale : PER Périodiques Résumé : There is now a clear focus on incorporating, and integrating, multiple levels of analysis in developmental science. The current study adds to research in this area by including markers of the immune and neuroendocrine systems in a longitudinal study of temperament in infants. Observational and parent-reported ratings of infant temperament, serum markers of the innate immune system, and cortisol reactivity from repeated salivary collections were examined in a sample of 123 infants who were assessed at 6 months and again when they were, on average, 17 months old. Blood from venipuncture was collected for analyses of nine select innate immune cytokines; salivary cortisol collected prior to and 15 min and 30 min following a physical exam including blood draw was used as an index of neuroendocrine functioning. Analyses indicated fairly minimal significant associations between biological markers and temperament at 6 months. However, by 17 months of age, we found reliable and nonoverlapping associations between observed fearful temperament and biological markers of the immune and neuroendocrine systems. The findings provide some of the earliest evidence of robust biological correlates of fear behavior with the immune system, and identify possible immune and neuroendocrine mechanisms for understanding the origins of behavioral development. En ligne : http://dx.doi.org/10.1017/S0954579417001250 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

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