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Adverse childhood experiences and transcriptional response in school-age children / A. MARIE-MITCHELL in Development and Psychopathology, 34-3 (August 2022)
[article]
Titre : Adverse childhood experiences and transcriptional response in school-age children Type de document : Texte imprimé et/ou numérique Auteurs : A. MARIE-MITCHELL, Auteur ; S. W. COLE, Auteur Article en page(s) : p.875-881 Langues : Anglais (eng) Mots-clés : adverse childhood experiences adversity biomarkers immunology inflammation Index. décimale : PER Périodiques Résumé : This study evaluated whether children with higher adverse childhood experiences (ACE) scores had alterations in immune cell gene expression profiles. RNA sequencing was conducted on dried blood spot samples from 37 generally healthy English-speaking children (age 5 “11) who were recruited from well-child visits at a university-affiliated pediatric practice. The Whole Child Assessment was used to assess ACE exposure. Primary analyses examined an a priori-specified composite of 19 pro-inflammatory gene transcripts. Secondary analyses examined a 34-gene composite assessing Type I interferon response, and used Transcript Origin Analyses to identify cellular mechanisms. After controlling for age, body mass index percentile, sex, race/ethnicity, current insurance status, and household smoking exposure, pro-inflammatory gene expression was elevated by 0.094 log2 RNA expression units with each Child-ACE total score point (p = .019). Type I interferon gene expression was similarly upregulated (0.103; p = .008). Transcript origin analyses implicated CD8+ T cell as the primary sources of gene transcripts upregulated, and nonclassical (CD16+) monocytes as sources of downregulated transcripts. These preliminary analyses suggest that parent-reported ACE exposures are associated with increased expression of both inflammatory and interferon gene transcripts in children's circulating blood cells. En ligne : http://dx.doi.org/10.1017/S095457942000187X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484
in Development and Psychopathology > 34-3 (August 2022) . - p.875-881[article] Adverse childhood experiences and transcriptional response in school-age children [Texte imprimé et/ou numérique] / A. MARIE-MITCHELL, Auteur ; S. W. COLE, Auteur . - p.875-881.
Langues : Anglais (eng)
in Development and Psychopathology > 34-3 (August 2022) . - p.875-881
Mots-clés : adverse childhood experiences adversity biomarkers immunology inflammation Index. décimale : PER Périodiques Résumé : This study evaluated whether children with higher adverse childhood experiences (ACE) scores had alterations in immune cell gene expression profiles. RNA sequencing was conducted on dried blood spot samples from 37 generally healthy English-speaking children (age 5 “11) who were recruited from well-child visits at a university-affiliated pediatric practice. The Whole Child Assessment was used to assess ACE exposure. Primary analyses examined an a priori-specified composite of 19 pro-inflammatory gene transcripts. Secondary analyses examined a 34-gene composite assessing Type I interferon response, and used Transcript Origin Analyses to identify cellular mechanisms. After controlling for age, body mass index percentile, sex, race/ethnicity, current insurance status, and household smoking exposure, pro-inflammatory gene expression was elevated by 0.094 log2 RNA expression units with each Child-ACE total score point (p = .019). Type I interferon gene expression was similarly upregulated (0.103; p = .008). Transcript origin analyses implicated CD8+ T cell as the primary sources of gene transcripts upregulated, and nonclassical (CD16+) monocytes as sources of downregulated transcripts. These preliminary analyses suggest that parent-reported ACE exposures are associated with increased expression of both inflammatory and interferon gene transcripts in children's circulating blood cells. En ligne : http://dx.doi.org/10.1017/S095457942000187X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484 Annual Research Review: The neuroinflammation hypothesis for stress and psychopathology in children – developmental psychoneuroimmunology / Thomas G. O'CONNOR in Journal of Child Psychology and Psychiatry, 55-6 (June 2014)
[article]
Titre : Annual Research Review: The neuroinflammation hypothesis for stress and psychopathology in children – developmental psychoneuroimmunology Type de document : Texte imprimé et/ou numérique Auteurs : Thomas G. O'CONNOR, Auteur ; Jan A. MOYNIHAN, Auteur ; Mary T. CASERTA, Auteur Année de publication : 2014 Article en page(s) : p.615-631 Langues : Anglais (eng) Mots-clés : Immunology psychoneuroimmunology neuroinflammation stress developmental psychopathology Index. décimale : PER Périodiques Résumé : Abstract Experimental animal and adult human data suggest that stress exposure is associated with alterations in immune system function that may underlie increased susceptibility to disease and behavioral disorders. The implications of these data for child psychology and psychiatry are not yet clear. The current review seeks to distil and translate the relevant animal and adult human work to children to advance a developmental model of psychoneuroimmunology. In addition to reviewing key specific findings, we consider biological/conceptual models and technical aspects of psychoneuroimmunology work in pediatric populations, and outline the rationales and advantages of integrating hypotheses concerning neuroinflammation in developmental studies of psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.12187 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=234
in Journal of Child Psychology and Psychiatry > 55-6 (June 2014) . - p.615-631[article] Annual Research Review: The neuroinflammation hypothesis for stress and psychopathology in children – developmental psychoneuroimmunology [Texte imprimé et/ou numérique] / Thomas G. O'CONNOR, Auteur ; Jan A. MOYNIHAN, Auteur ; Mary T. CASERTA, Auteur . - 2014 . - p.615-631.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 55-6 (June 2014) . - p.615-631
Mots-clés : Immunology psychoneuroimmunology neuroinflammation stress developmental psychopathology Index. décimale : PER Périodiques Résumé : Abstract Experimental animal and adult human data suggest that stress exposure is associated with alterations in immune system function that may underlie increased susceptibility to disease and behavioral disorders. The implications of these data for child psychology and psychiatry are not yet clear. The current review seeks to distil and translate the relevant animal and adult human work to children to advance a developmental model of psychoneuroimmunology. In addition to reviewing key specific findings, we consider biological/conceptual models and technical aspects of psychoneuroimmunology work in pediatric populations, and outline the rationales and advantages of integrating hypotheses concerning neuroinflammation in developmental studies of psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.12187 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=234 Autism spectrum disorders are associated with an elevated autoantibody response to tissue transglutaminase-2 / Allen J. ROSENSPIRE in Autism Research, 4-4 (August 2011)
[article]
Titre : Autism spectrum disorders are associated with an elevated autoantibody response to tissue transglutaminase-2 Type de document : Texte imprimé et/ou numérique Auteurs : Allen J. ROSENSPIRE, Auteur ; Wonsuk YOO, Auteur ; Sherri MENARD, Auteur ; Anthony R. TORRES, Auteur Année de publication : 2011 Article en page(s) : p.242-249 Langues : Anglais (eng) Mots-clés : immunology anti-transglutaminase antibody pediatrics Index. décimale : PER Périodiques Résumé : We report that a significant number of autistic children have serum levels of IgA antibodies above normal to the enzyme tissue transglutaminase II (TG2), and that expression of these antibodies to TG2 is linked to the (HLA)-DR3, DQ2 and DR7, DQ2 haplotypes. TG2 is expressed in the brain, where it has been shown to be important in cell adhesion and synaptic stabilization. Thus, these children appear to constitute a subpopulation of autistic children who fall within the autism disease spectrum, and for whom autoimmunity may represent a significant etiological component of their autism. En ligne : http://dx.doi.org/10.1002/aur.194 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141
in Autism Research > 4-4 (August 2011) . - p.242-249[article] Autism spectrum disorders are associated with an elevated autoantibody response to tissue transglutaminase-2 [Texte imprimé et/ou numérique] / Allen J. ROSENSPIRE, Auteur ; Wonsuk YOO, Auteur ; Sherri MENARD, Auteur ; Anthony R. TORRES, Auteur . - 2011 . - p.242-249.
Langues : Anglais (eng)
in Autism Research > 4-4 (August 2011) . - p.242-249
Mots-clés : immunology anti-transglutaminase antibody pediatrics Index. décimale : PER Périodiques Résumé : We report that a significant number of autistic children have serum levels of IgA antibodies above normal to the enzyme tissue transglutaminase II (TG2), and that expression of these antibodies to TG2 is linked to the (HLA)-DR3, DQ2 and DR7, DQ2 haplotypes. TG2 is expressed in the brain, where it has been shown to be important in cell adhesion and synaptic stabilization. Thus, these children appear to constitute a subpopulation of autistic children who fall within the autism disease spectrum, and for whom autoimmunity may represent a significant etiological component of their autism. En ligne : http://dx.doi.org/10.1002/aur.194 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141 Fever during pregnancy as a risk factor for neurodevelopmental disorders: results from a systematic review and meta-analysis / S. ANTOUN in Molecular Autism, 12 (2021)
[article]
Titre : Fever during pregnancy as a risk factor for neurodevelopmental disorders: results from a systematic review and meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : S. ANTOUN, Auteur ; P. ELLUL, Auteur ; H. PEYRE, Auteur ; M. ROSENZWAJG, Auteur ; P. GRESSENS, Auteur ; D. KLATZMANN, Auteur ; R. DELORME, Auteur Article en page(s) : 60 p. Langues : Anglais (eng) Mots-clés : Autism Children Immunology Maternal immune activation Index. décimale : PER Périodiques Résumé : BACKGROUND: Fever during pregnancy is a relatively common and most often trivial event. However, under specific conditions, it could affect significantly fetal brain development. Few studies, with inconsistent results, investigated whether fever, regardless the pathogen, could represent a risk factor for neurodevelopmental disorders (NDD) in the offspring. We aimed to explore further this question by performing a systematic review and meta-analysis. METHODS: Peer-reviewed studies exploring the occurrence of NDD in offspring after a fetal exposure to maternal fever were included. We specifically considered the impact of fever severity and duration, taking into consideration some confounding variables such as the use of antipyretic during pregnancy, the trimester in which the fever arose, the maternal age or smoking at time of gestation. MEDLINE, EMBASE, PsycINFO, Cochrane and Web of Science were searched without language restriction. PRISMA recommendations were followed. Odds ratio (OR) were pooled using random-effects meta-analysis. Heterogeneity in effect size across studies was studied using random-effects meta-regression analysis. (PROSPERO CRD42020182801). RESULTS: We finally considered ten studies gathering a total of 10,304 children with NDD. Among them, 1394 were exposed to fever during pregnancy. The selected studies were divided into 5 case-control studies and 5 cohort studies. Maternal exposure to fever during pregnancy increased the risk of NDD in offspring with an OR of 1.24 [95% CI: 1.12-1.38]. Secondary analysis revealed an increased risk for NDD when fever occurred during the first trimester of gestation [OR 1.13-95% CI: 1.02-1.26]. LIMITATIONS: We excluded studies that considered infections with no evidence of fever. Another potential limitation may be the possible heterogeneity between study designs (cohorts and case-control). CONCLUSION: Additional evidence supported the association between fever during pregnancy and increased risk for NDD in offspring. Careful monitoring should be considered for children born from mothers with a febrile episode during pregnancy (specifically during the first trimester). En ligne : http://dx.doi.org/10.1186/s13229-021-00464-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459
in Molecular Autism > 12 (2021) . - 60 p.[article] Fever during pregnancy as a risk factor for neurodevelopmental disorders: results from a systematic review and meta-analysis [Texte imprimé et/ou numérique] / S. ANTOUN, Auteur ; P. ELLUL, Auteur ; H. PEYRE, Auteur ; M. ROSENZWAJG, Auteur ; P. GRESSENS, Auteur ; D. KLATZMANN, Auteur ; R. DELORME, Auteur . - 60 p.
Langues : Anglais (eng)
in Molecular Autism > 12 (2021) . - 60 p.
Mots-clés : Autism Children Immunology Maternal immune activation Index. décimale : PER Périodiques Résumé : BACKGROUND: Fever during pregnancy is a relatively common and most often trivial event. However, under specific conditions, it could affect significantly fetal brain development. Few studies, with inconsistent results, investigated whether fever, regardless the pathogen, could represent a risk factor for neurodevelopmental disorders (NDD) in the offspring. We aimed to explore further this question by performing a systematic review and meta-analysis. METHODS: Peer-reviewed studies exploring the occurrence of NDD in offspring after a fetal exposure to maternal fever were included. We specifically considered the impact of fever severity and duration, taking into consideration some confounding variables such as the use of antipyretic during pregnancy, the trimester in which the fever arose, the maternal age or smoking at time of gestation. MEDLINE, EMBASE, PsycINFO, Cochrane and Web of Science were searched without language restriction. PRISMA recommendations were followed. Odds ratio (OR) were pooled using random-effects meta-analysis. Heterogeneity in effect size across studies was studied using random-effects meta-regression analysis. (PROSPERO CRD42020182801). RESULTS: We finally considered ten studies gathering a total of 10,304 children with NDD. Among them, 1394 were exposed to fever during pregnancy. The selected studies were divided into 5 case-control studies and 5 cohort studies. Maternal exposure to fever during pregnancy increased the risk of NDD in offspring with an OR of 1.24 [95% CI: 1.12-1.38]. Secondary analysis revealed an increased risk for NDD when fever occurred during the first trimester of gestation [OR 1.13-95% CI: 1.02-1.26]. LIMITATIONS: We excluded studies that considered infections with no evidence of fever. Another potential limitation may be the possible heterogeneity between study designs (cohorts and case-control). CONCLUSION: Additional evidence supported the association between fever during pregnancy and increased risk for NDD in offspring. Careful monitoring should be considered for children born from mothers with a febrile episode during pregnancy (specifically during the first trimester). En ligne : http://dx.doi.org/10.1186/s13229-021-00464-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 Male Gender Bias in Autism and Pediatric Autoimmunity / Kevin G. BECKER in Autism Research, 5-2 (April 2012)
[article]
Titre : Male Gender Bias in Autism and Pediatric Autoimmunity Type de document : Texte imprimé et/ou numérique Auteurs : Kevin G. BECKER, Auteur Année de publication : 2012 Article en page(s) : p.77-83 Langues : Anglais (eng) Mots-clés : autoimmune immunology molecular genetics pediatrics developmental neurobiology Index. décimale : PER Périodiques Résumé : Male bias in both autism and pediatric autoimmune disease is thought to involve hormonal perturbations in pregnancy or early childhood in the context of genetic control. These early molecular events, at a time of rapid development, are intimately linked to concurrent development in the brain and immune system. It is suggested here that these early regulatory events may overlap between autism and autoimmunity in determining male sex bias and may provide evidence of an etiological link among autism, immune dysregulation, and autoimmune disease. En ligne : http://dx.doi.org/10.1002/aur.1227 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155
in Autism Research > 5-2 (April 2012) . - p.77-83[article] Male Gender Bias in Autism and Pediatric Autoimmunity [Texte imprimé et/ou numérique] / Kevin G. BECKER, Auteur . - 2012 . - p.77-83.
Langues : Anglais (eng)
in Autism Research > 5-2 (April 2012) . - p.77-83
Mots-clés : autoimmune immunology molecular genetics pediatrics developmental neurobiology Index. décimale : PER Périodiques Résumé : Male bias in both autism and pediatric autoimmune disease is thought to involve hormonal perturbations in pregnancy or early childhood in the context of genetic control. These early molecular events, at a time of rapid development, are intimately linked to concurrent development in the brain and immune system. It is suggested here that these early regulatory events may overlap between autism and autoimmunity in determining male sex bias and may provide evidence of an etiological link among autism, immune dysregulation, and autoimmune disease. En ligne : http://dx.doi.org/10.1002/aur.1227 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155 Regulatory T lymphocytes/Th17 lymphocytes imbalance in autism spectrum disorders: evidence from a meta-analysis / P. ELLUL in Molecular Autism, 12 (2021)
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