Predicting substance use in emerging adulthood: A genetically informed study of developmental transactions between impulsivity and family conflict / Kit K. ELAM in Development and Psychopathology, 28-3 (August 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-3 (August 2016) . - p.673-688 Titre : Predicting substance use in emerging adulthood: A genetically informed study of developmental transactions between impulsivity and family conflict Type de document : texte imprimé Auteurs : Kit K. ELAM, Auteur ; Frances L. WANG, Auteur ; Kaitlin BOUNTRESS, Auteur ; Laurie A. CHASSIN, Auteur ; Danielle PANDIKA, Auteur ; Kathryn LEMERY-CHALFANT, Auteur Article en page(s) : p.673-688 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Deviance proneness models propose a multilevel interplay in which transactions among genetic, individual, and family risk factors place children at increased risk for substance use. We examined bidirectional transactions between impulsivity and family conflict from middle childhood to adolescence and their contributions to substance use in adolescence and emerging adulthood (n = 380). Moreover, we examined children's, mothers’, and fathers’ polygenic risk scores for behavioral undercontrol, and mothers’ and fathers’ interparental conflict and substance disorder diagnoses as predictors of these transactions. The results support a developmental cascade model in which children's polygenic risk scores predicted greater impulsivity in middle childhood. Impulsivity in middle childhood predicted greater family conflict in late childhood, which in turn predicted greater impulsivity in late adolescence. Adolescent impulsivity subsequently predicted greater substance use in emerging adulthood. Results are discussed with respect to evocative genotype–environment correlations within developmental cascades and applications to prevention efforts. En ligne : http://dx.doi.org/10.1017/S0954579416000249 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291 [article] Predicting substance use in emerging adulthood: A genetically informed study of developmental transactions between impulsivity and family conflict [texte imprimé] / Kit K. ELAM, Auteur ; Frances L. WANG, Auteur ; Kaitlin BOUNTRESS, Auteur ; Laurie A. CHASSIN, Auteur ; Danielle PANDIKA, Auteur ; Kathryn LEMERY-CHALFANT, Auteur . - p.673-688. Langues : Anglais (eng) in Development and Psychopathology > 28-3 (August 2016) . - p.673-688 Index. décimale : PER Périodiques Résumé : Deviance proneness models propose a multilevel interplay in which transactions among genetic, individual, and family risk factors place children at increased risk for substance use. We examined bidirectional transactions between impulsivity and family conflict from middle childhood to adolescence and their contributions to substance use in adolescence and emerging adulthood (n = 380). Moreover, we examined children's, mothers’, and fathers’ polygenic risk scores for behavioral undercontrol, and mothers’ and fathers’ interparental conflict and substance disorder diagnoses as predictors of these transactions. The results support a developmental cascade model in which children's polygenic risk scores predicted greater impulsivity in middle childhood. Impulsivity in middle childhood predicted greater family conflict in late childhood, which in turn predicted greater impulsivity in late adolescence. Adolescent impulsivity subsequently predicted greater substance use in emerging adulthood. Results are discussed with respect to evocative genotype–environment correlations within developmental cascades and applications to prevention efforts. En ligne : http://dx.doi.org/10.1017/S0954579416000249 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291

Role of temperament in early adolescent pure and co-occurring internalizing and externalizing problems using a bifactor model: Moderation by parenting and gender / Frances L. WANG in Development and Psychopathology, 28-4 pt2 (November 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-4 pt2 (November 2016) . - p.1487-1504 Titre : Role of temperament in early adolescent pure and co-occurring internalizing and externalizing problems using a bifactor model: Moderation by parenting and gender Type de document : texte imprimé Auteurs : Frances L. WANG, Auteur ; Nancy EISENBERG, Auteur ; Carlos VALIENTE, Auteur ; Tracy L. SPINRAD, Auteur Article en page(s) : p.1487-1504 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We contribute to the literature on the relations of temperament to externalizing and internalizing problems by considering parental emotional expressivity and child gender as moderators of such relations and examining prediction of pure and co-occurring problem behaviors during early to middle adolescence using bifactor models (which provide unique and continuous factors for pure and co-occurring internalizing and externalizing problems). Parents and teachers reported on children's (4.5- to 8-year-olds; N = 214) and early adolescents’ (6 years later; N = 168) effortful control, impulsivity, anger, sadness, and problem behaviors. Parental emotional expressivity was measured observationally and with parents’ self-reports. Early-adolescents’ pure externalizing and co-occurring problems shared childhood and/or early-adolescent risk factors of low effortful control, high impulsivity, and high anger. Lower childhood and early-adolescent impulsivity and higher early-adolescent sadness predicted early-adolescents’ pure internalizing. Childhood positive parental emotional expressivity more consistently related to early-adolescents’ lower pure externalizing compared to co-occurring problems and pure internalizing. Lower effortful control predicted changes in externalizing (pure and co-occurring) over 6 years, but only when parental positive expressivity was low. Higher impulsivity predicted co-occurring problems only for boys. Findings highlight the probable complex developmental pathways to adolescent pure and co-occurring externalizing and internalizing problems. En ligne : http://dx.doi.org/10.1017/s0954579415001224 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Role of temperament in early adolescent pure and co-occurring internalizing and externalizing problems using a bifactor model: Moderation by parenting and gender [texte imprimé] / Frances L. WANG, Auteur ; Nancy EISENBERG, Auteur ; Carlos VALIENTE, Auteur ; Tracy L. SPINRAD, Auteur . - p.1487-1504. Langues : Anglais (eng) in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1487-1504 Index. décimale : PER Périodiques Résumé : We contribute to the literature on the relations of temperament to externalizing and internalizing problems by considering parental emotional expressivity and child gender as moderators of such relations and examining prediction of pure and co-occurring problem behaviors during early to middle adolescence using bifactor models (which provide unique and continuous factors for pure and co-occurring internalizing and externalizing problems). Parents and teachers reported on children's (4.5- to 8-year-olds; N = 214) and early adolescents’ (6 years later; N = 168) effortful control, impulsivity, anger, sadness, and problem behaviors. Parental emotional expressivity was measured observationally and with parents’ self-reports. Early-adolescents’ pure externalizing and co-occurring problems shared childhood and/or early-adolescent risk factors of low effortful control, high impulsivity, and high anger. Lower childhood and early-adolescent impulsivity and higher early-adolescent sadness predicted early-adolescents’ pure internalizing. Childhood positive parental emotional expressivity more consistently related to early-adolescents’ lower pure externalizing compared to co-occurring problems and pure internalizing. Lower effortful control predicted changes in externalizing (pure and co-occurring) over 6 years, but only when parental positive expressivity was low. Higher impulsivity predicted co-occurring problems only for boys. Findings highlight the probable complex developmental pathways to adolescent pure and co-occurring externalizing and internalizing problems. En ligne : http://dx.doi.org/10.1017/s0954579415001224 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

Serotonin functioning and adolescents' alcohol use: A genetically informed study examining mechanisms of risk / Frances L. WANG in Development and Psychopathology, 30-1 (February 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-1 (February 2018) . - p.213-233 Titre : Serotonin functioning and adolescents' alcohol use: A genetically informed study examining mechanisms of risk Type de document : texte imprimé Auteurs : Frances L. WANG, Auteur ; Laurie A. CHASSIN, Auteur ; John E. BATES, Auteur ; Danielle M. DICK, Auteur ; Jennifer E. LANSFORD, Auteur ; Gregory S. PETTIT, Auteur ; Kenneth A. DODGE, Auteur Article en page(s) : p.213-233 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The current study used data from two longitudinal samples to test whether self-regulation, depressive symptoms, and aggression/antisociality were mediators in the relation between a polygenic score indexing serotonin (5-HT) functioning and alcohol use in adolescence. The results from an independent genome-wide association study of 5-hydroxyindoleacetic acid in the cerebrospinal fluid were used to create 5-HT polygenic risk scores. Adolescents and/or parents reported on adolescents’ self-regulation (Time 1), depressive symptoms (Time 2), aggression/antisociality (Time 2), and alcohol use (Time 3). The results showed that 5-HT polygenic risk did not predict self-regulation. However, adolescents with higher levels of 5-HT polygenic risk showed greater depression and aggression/antisociality. Adolescents’ aggression/antisociality mediated the relation between 5-HT polygenic risk and later alcohol use. Deficits in self-regulation also predicted depression and aggression/antisociality, and indirectly predicted alcohol use through aggression/antisociality. Pathways to alcohol use were especially salient for males from families with low parental education in one of the two samples. The results provide insights into the longitudinal mechanisms underlying the relation between 5-HT functioning and alcohol use (i.e., earlier aggression/antisociality). There was no evidence that genetically based variation in 5-HT functioning predisposed individuals to deficits in self-regulation. Genetically based variation in 5-HT functioning and self-regulation might be separate, transdiagnostic risk factors for several types of psychopathology. En ligne : https://doi.org/10.1017/S095457941700058X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=336 [article] Serotonin functioning and adolescents' alcohol use: A genetically informed study examining mechanisms of risk [texte imprimé] / Frances L. WANG, Auteur ; Laurie A. CHASSIN, Auteur ; John E. BATES, Auteur ; Danielle M. DICK, Auteur ; Jennifer E. LANSFORD, Auteur ; Gregory S. PETTIT, Auteur ; Kenneth A. DODGE, Auteur . - p.213-233. Langues : Anglais (eng) in Development and Psychopathology > 30-1 (February 2018) . - p.213-233 Index. décimale : PER Périodiques Résumé : The current study used data from two longitudinal samples to test whether self-regulation, depressive symptoms, and aggression/antisociality were mediators in the relation between a polygenic score indexing serotonin (5-HT) functioning and alcohol use in adolescence. The results from an independent genome-wide association study of 5-hydroxyindoleacetic acid in the cerebrospinal fluid were used to create 5-HT polygenic risk scores. Adolescents and/or parents reported on adolescents’ self-regulation (Time 1), depressive symptoms (Time 2), aggression/antisociality (Time 2), and alcohol use (Time 3). The results showed that 5-HT polygenic risk did not predict self-regulation. However, adolescents with higher levels of 5-HT polygenic risk showed greater depression and aggression/antisociality. Adolescents’ aggression/antisociality mediated the relation between 5-HT polygenic risk and later alcohol use. Deficits in self-regulation also predicted depression and aggression/antisociality, and indirectly predicted alcohol use through aggression/antisociality. Pathways to alcohol use were especially salient for males from families with low parental education in one of the two samples. The results provide insights into the longitudinal mechanisms underlying the relation between 5-HT functioning and alcohol use (i.e., earlier aggression/antisociality). There was no evidence that genetically based variation in 5-HT functioning predisposed individuals to deficits in self-regulation. Genetically based variation in 5-HT functioning and self-regulation might be separate, transdiagnostic risk factors for several types of psychopathology. En ligne : https://doi.org/10.1017/S095457941700058X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=336

Temperament multi-trajectory groups across adolescence: Associations with adulthood psychopathology and polygenic scores in TRAILS / Frances L. WANG in Development and Psychopathology, 38-2 (May 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-2 (May 2026) . - p.704-718 Titre : Temperament multi-trajectory groups across adolescence: Associations with adulthood psychopathology and polygenic scores in TRAILS Type de document : texte imprimé Auteurs : Frances L. WANG, Auteur ; Shirley DUONG, Auteur ; Heather M. JOSEPH, Auteur ; Traci M. KENNEDY, Auteur ; Catharina HARTMAN, Auteur Article en page(s) : p.704-718 Langues : Anglais (eng) Mots-clés : Externalizing  internalizing  polygenic risk score  temperament multi-trajectory groups Index. décimale : PER Périodiques Résumé : It is well-established that adolescents’ temperament trajectories predict future psychopathology. Less well understood is how temperament traits co-develop from adolescence to young adulthood. We characterized how youths’ trajectories of effortful control, frustration, affiliation, and shyness formed multi-trajectory groups and examined their associations with adulthood psychopathology and polygenic risk scores (PRS). Participants were drawn from a larger longitudinal cohort (N = 1412). Effortful control, frustration, affiliation, and shyness were measured four times from ages 10-23. Adulthood internalizing and externalizing problems were measured at ages 24–27. PRS for externalizing problems and major depressive disorder were calculated. Group-based multi-trajectory analyses showed that a five-group model fit best, including “high-risk” on all temperament traits, “undercontrolled” and exuberant, “low-risk” on all traits, “overcontrolled” and inhibited, and “low affiliation” groups that differed on both the levels and slopes of temperament traits over time. The undercontrolled group showed the highest, and overcontrolled the lowest, externalizing PRS scores. The high-risk group showed heightened scores on the depression PRS. We found specific linkages between the high-risk group and withdrawn/depressed symptoms and the high-risk and undercontrolled groups with externalizing problems. Findings shed light on developmental patterns of temperament in adolescence-to-adulthood and unique combinations of temperament trajectories with specific linkages to etiologic factors and psychopathology. En ligne : https://dx.doi.org/10.1017/S0954579425100680 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] Temperament multi-trajectory groups across adolescence: Associations with adulthood psychopathology and polygenic scores in TRAILS [texte imprimé] / Frances L. WANG, Auteur ; Shirley DUONG, Auteur ; Heather M. JOSEPH, Auteur ; Traci M. KENNEDY, Auteur ; Catharina HARTMAN, Auteur . - p.704-718. Langues : Anglais (eng) in Development and Psychopathology > 38-2 (May 2026) . - p.704-718 Mots-clés : Externalizing  internalizing  polygenic risk score  temperament multi-trajectory groups Index. décimale : PER Périodiques Résumé : It is well-established that adolescents’ temperament trajectories predict future psychopathology. Less well understood is how temperament traits co-develop from adolescence to young adulthood. We characterized how youths’ trajectories of effortful control, frustration, affiliation, and shyness formed multi-trajectory groups and examined their associations with adulthood psychopathology and polygenic risk scores (PRS). Participants were drawn from a larger longitudinal cohort (N = 1412). Effortful control, frustration, affiliation, and shyness were measured four times from ages 10-23. Adulthood internalizing and externalizing problems were measured at ages 24–27. PRS for externalizing problems and major depressive disorder were calculated. Group-based multi-trajectory analyses showed that a five-group model fit best, including “high-risk” on all temperament traits, “undercontrolled” and exuberant, “low-risk” on all traits, “overcontrolled” and inhibited, and “low affiliation” groups that differed on both the levels and slopes of temperament traits over time. The undercontrolled group showed the highest, and overcontrolled the lowest, externalizing PRS scores. The high-risk group showed heightened scores on the depression PRS. We found specific linkages between the high-risk group and withdrawn/depressed symptoms and the high-risk and undercontrolled groups with externalizing problems. Findings shed light on developmental patterns of temperament in adolescence-to-adulthood and unique combinations of temperament trajectories with specific linkages to etiologic factors and psychopathology. En ligne : https://dx.doi.org/10.1017/S0954579425100680 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586

Testing multiple levels of influence in the intergenerational transmission of alcohol disorders from a developmental perspective: The example of alcohol use promoting peers and μ-opioid receptor M1 variation / Laurie A. CHASSIN in Development and Psychopathology, 24-3 (August 2012)  

Public ISBD [article]  inDevelopment and Psychopathology > 24-3 (August 2012) . - p.953-67 Titre : Testing multiple levels of influence in the intergenerational transmission of alcohol disorders from a developmental perspective: The example of alcohol use promoting peers and μ-opioid receptor M1 variation Type de document : texte imprimé Auteurs : Laurie A. CHASSIN, Auteur ; Matthew R. LEE, Auteur ; Young Il CHO, Auteur ; Frances L. WANG, Auteur ; Arpana AGRAWAL, Auteur ; Kenneth J. SHER, Auteur ; Michael T. LYNSKEY, Auteur Année de publication : 2012 Article en page(s) : p.953-67 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study examined the interplay between the influence of peers who promote alcohol use and μ-opioid receptor M1 (OPRM1) genetic variation in the intergenerational transmission of alcohol use disorder (AUD) symptoms while separating the “traitlike” components of AUD symptoms from their age-specific manifestations at three ages from emerging adulthood (17–23 years) to adulthood (29–40 years). The results for males were consistent with genetically influenced peer selection mechanisms as mediators of parent alcoholism effects. Male children of alcoholics were less likely to be carriers of the G allele in single nucleotide polymorphism A118G (rs1799971), and those who were homozygous for the A allele were more likely to affiliate with alcohol use promoting peers who increased the risk for AUD symptoms at all ages. There was evidence for women of an interaction between OPRM1 variation and peer affiliations but only at the earliest age band. Peer influences had stronger effects among women who were G-carriers. These results illustrate the complex ways in which the interplay between influences at multiple levels of analysis can underlie the intergenerational transmission of alcohol disorders as well as the importance of considering age and gender differences in these pathways. En ligne : http://dx.doi.org/10.1017/S0954579412000478 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178 [article] Testing multiple levels of influence in the intergenerational transmission of alcohol disorders from a developmental perspective: The example of alcohol use promoting peers and μ-opioid receptor M1 variation [texte imprimé] / Laurie A. CHASSIN, Auteur ; Matthew R. LEE, Auteur ; Young Il CHO, Auteur ; Frances L. WANG, Auteur ; Arpana AGRAWAL, Auteur ; Kenneth J. SHER, Auteur ; Michael T. LYNSKEY, Auteur . - 2012 . - p.953-67. Langues : Anglais (eng) in Development and Psychopathology > 24-3 (August 2012) . - p.953-67 Index. décimale : PER Périodiques Résumé : This study examined the interplay between the influence of peers who promote alcohol use and μ-opioid receptor M1 (OPRM1) genetic variation in the intergenerational transmission of alcohol use disorder (AUD) symptoms while separating the “traitlike” components of AUD symptoms from their age-specific manifestations at three ages from emerging adulthood (17–23 years) to adulthood (29–40 years). The results for males were consistent with genetically influenced peer selection mechanisms as mediators of parent alcoholism effects. Male children of alcoholics were less likely to be carriers of the G allele in single nucleotide polymorphism A118G (rs1799971), and those who were homozygous for the A allele were more likely to affiliate with alcohol use promoting peers who increased the risk for AUD symptoms at all ages. There was evidence for women of an interaction between OPRM1 variation and peer affiliations but only at the earliest age band. Peer influences had stronger effects among women who were G-carriers. These results illustrate the complex ways in which the interplay between influences at multiple levels of analysis can underlie the intergenerational transmission of alcohol disorders as well as the importance of considering age and gender differences in these pathways. En ligne : http://dx.doi.org/10.1017/S0954579412000478 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178

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