Empathic responsiveness in amygdala and anterior cingulate cortex in youths with psychopathic traits / Abigail A. MARSH in Journal of Child Psychology and Psychiatry, 54-8 (August 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-8 (August 2013) . - p.900-910 Titre : Empathic responsiveness in amygdala and anterior cingulate cortex in youths with psychopathic traits Type de document : Texte imprimé et/ou numérique Auteurs : Abigail A. MARSH, Auteur ; Elizabeth C. FINGER, Auteur ; Katherine A. FOWLER, Auteur ; Christopher J. ADALIO, Auteur ; Ilana T.N. JURKOWITZ, Auteur ; Julia C. SCHECHTER, Auteur ; Daniel S. PINE, Auteur ; Jean DECETY, Auteur ; James R. BLAIR, Auteur Article en page(s) : p.900-910 Langues : Anglais (eng) Mots-clés : Psychopathy  adolescents  empathy  pain  amygdala  conduct disorder Index. décimale : PER Périodiques Résumé : Background Psychopathic traits are associated with increases in antisocial behaviors such as aggression and are characterized by reduced empathy for others' distress. This suggests that psychopathic traits may also impair empathic pain sensitivity. However, whether psychopathic traits affect responses to the pain of others versus the self has not been previously assessed. Method We used whole-brain functional magnetic resonance imaging to measure neural activation in 14 adolescents with oppositional defiant disorder or conduct disorder and psychopathic traits, as well as 21 healthy controls matched on age, gender, and intelligence. Activation in structures associated with empathic pain perception was assessed as adolescents viewed photographs of pain-inducing injuries. Adolescents imagined either that the body in each photograph was their own or that it belonged to another person. Behavioral and neuroimaging data were analyzed using random-effects analysis of variance. Results Youths with psychopathic traits showed reduced activity within regions associated with empathic pain as the depicted pain increased. These regions included rostral anterior cingulate cortex, ventral striatum (putamen), and amygdala. Reductions in amygdala activity particularly occurred when the injury was perceived as occurring to another. Empathic pain responses within both amygdala and rostral anterior cingulate cortex were negatively correlated with the severity of psychopathic traits as indexed by PCL:YV scores. Conclusions Youths with psychopathic traits show less responsiveness in regions implicated in the affective response to another's pain as the perceived intensity of this pain increases. Moreover, this reduced responsiveness appears to predict symptom severity. En ligne : http://dx.doi.org/10.1111/jcpp.12063 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=210 [article] Empathic responsiveness in amygdala and anterior cingulate cortex in youths with psychopathic traits [Texte imprimé et/ou numérique] / Abigail A. MARSH, Auteur ; Elizabeth C. FINGER, Auteur ; Katherine A. FOWLER, Auteur ; Christopher J. ADALIO, Auteur ; Ilana T.N. JURKOWITZ, Auteur ; Julia C. SCHECHTER, Auteur ; Daniel S. PINE, Auteur ; Jean DECETY, Auteur ; James R. BLAIR, Auteur . - p.900-910. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-8 (August 2013) . - p.900-910 Mots-clés : Psychopathy  adolescents  empathy  pain  amygdala  conduct disorder Index. décimale : PER Périodiques Résumé : Background Psychopathic traits are associated with increases in antisocial behaviors such as aggression and are characterized by reduced empathy for others' distress. This suggests that psychopathic traits may also impair empathic pain sensitivity. However, whether psychopathic traits affect responses to the pain of others versus the self has not been previously assessed. Method We used whole-brain functional magnetic resonance imaging to measure neural activation in 14 adolescents with oppositional defiant disorder or conduct disorder and psychopathic traits, as well as 21 healthy controls matched on age, gender, and intelligence. Activation in structures associated with empathic pain perception was assessed as adolescents viewed photographs of pain-inducing injuries. Adolescents imagined either that the body in each photograph was their own or that it belonged to another person. Behavioral and neuroimaging data were analyzed using random-effects analysis of variance. Results Youths with psychopathic traits showed reduced activity within regions associated with empathic pain as the depicted pain increased. These regions included rostral anterior cingulate cortex, ventral striatum (putamen), and amygdala. Reductions in amygdala activity particularly occurred when the injury was perceived as occurring to another. Empathic pain responses within both amygdala and rostral anterior cingulate cortex were negatively correlated with the severity of psychopathic traits as indexed by PCL:YV scores. Conclusions Youths with psychopathic traits show less responsiveness in regions implicated in the affective response to another's pain as the perceived intensity of this pain increases. Moreover, this reduced responsiveness appears to predict symptom severity. En ligne : http://dx.doi.org/10.1111/jcpp.12063 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=210

Reduced activity within the dorsal endogenous orienting of attention network to fearful expressions in youth with disruptive behavior disorders and psychopathic traits / Stuart F. WHITE in Development and Psychopathology, 24-3 (August 2012)  

Public ISBD [article]  inDevelopment and Psychopathology > 24-3 (August 2012) . - p.1105-16. Titre : Reduced activity within the dorsal endogenous orienting of attention network to fearful expressions in youth with disruptive behavior disorders and psychopathic traits Type de document : Texte imprimé et/ou numérique Auteurs : Stuart F. WHITE, Auteur ; Craig WILLIAMS W., Auteur ; Sarah J., BRISLIN, Auteur ; Stephen SINCLAIR, Auteur ; Karina S. BLAIR, Auteur ; Katherine A. FOWLER, Auteur ; Daniel Samuel PINE, Auteur ; Kayla POPE, Auteur ; James R. BLAIR, Auteur Année de publication : 2012 Article en page(s) : p.1105-16. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Using behavioral and blood oxygen level dependent (BOLD) response indices through functional magnetic resonance imaging (fMRI), the current study investigated whether youths with disruptive behavior disorders (conduct disorder and oppositional defiant disorder) plus psychopathic traits (DBD + PT) show aberrant sensitivity to eye gaze information generally and/or whether they show particular insensitivity to eye gaze information in the context of fearful expressions. The participants were 36 children and adolescents (ages 10–17 years); 17 had DBD + PT and 19 were healthy comparison subjects. Participants performed a spatial attention paradigm where spatial attention was cued by eye gaze in faces displaying fearful, angry, or neutral affect. Eye gaze sensitivity was indexed both behaviorally and as BOLD response. There were no group differences in behavioral response: both groups showed significantly faster responses if the target was in the congruent spatial direction indicated by eye gaze. Neither group showed a Congruence × Emotion interaction; neither group showed an advantage from the displayer's emotional expression behaviorally. However, the BOLD response revealed a significant Group × Congruence × Emotion interaction. The comparison youth showed increased activity within the dorsal endogenous orienting network (superior parietal lobule and inferior parietal sulcus) for fearful congruent relative to incongruent trials relative to the youth with DBD + PT. The results are discussed with reference to current models of DBD + PT and possible treatment innovations. En ligne : http://dx.doi.org/10.1017/S0954579412000569 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178 [article] Reduced activity within the dorsal endogenous orienting of attention network to fearful expressions in youth with disruptive behavior disorders and psychopathic traits [Texte imprimé et/ou numérique] / Stuart F. WHITE, Auteur ; Craig WILLIAMS W., Auteur ; Sarah J., BRISLIN, Auteur ; Stephen SINCLAIR, Auteur ; Karina S. BLAIR, Auteur ; Katherine A. FOWLER, Auteur ; Daniel Samuel PINE, Auteur ; Kayla POPE, Auteur ; James R. BLAIR, Auteur . - 2012 . - p.1105-16. Langues : Anglais (eng) in Development and Psychopathology > 24-3 (August 2012) . - p.1105-16. Index. décimale : PER Périodiques Résumé : Using behavioral and blood oxygen level dependent (BOLD) response indices through functional magnetic resonance imaging (fMRI), the current study investigated whether youths with disruptive behavior disorders (conduct disorder and oppositional defiant disorder) plus psychopathic traits (DBD + PT) show aberrant sensitivity to eye gaze information generally and/or whether they show particular insensitivity to eye gaze information in the context of fearful expressions. The participants were 36 children and adolescents (ages 10–17 years); 17 had DBD + PT and 19 were healthy comparison subjects. Participants performed a spatial attention paradigm where spatial attention was cued by eye gaze in faces displaying fearful, angry, or neutral affect. Eye gaze sensitivity was indexed both behaviorally and as BOLD response. There were no group differences in behavioral response: both groups showed significantly faster responses if the target was in the congruent spatial direction indicated by eye gaze. Neither group showed a Congruence × Emotion interaction; neither group showed an advantage from the displayer's emotional expression behaviorally. However, the BOLD response revealed a significant Group × Congruence × Emotion interaction. The comparison youth showed increased activity within the dorsal endogenous orienting network (superior parietal lobule and inferior parietal sulcus) for fearful congruent relative to incongruent trials relative to the youth with DBD + PT. The results are discussed with reference to current models of DBD + PT and possible treatment innovations. En ligne : http://dx.doi.org/10.1017/S0954579412000569 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178

The relationship between large cavum septum pellucidum and antisocial behavior, callous-unemotional traits and psychopathy in adolescents / Stuart F. WHITE in Journal of Child Psychology and Psychiatry, 54-5 (May 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-5 (May 2013) . - p.575-581 Titre : The relationship between large cavum septum pellucidum and antisocial behavior, callous-unemotional traits and psychopathy in adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Stuart F. WHITE, Auteur ; Sarah J., BRISLIN, Auteur ; Stephen SINCLAIR, Auteur ; Katherine A. FOWLER, Auteur ; Kayla POPE, Auteur ; James R. BLAIR, Auteur Article en page(s) : p.575-581 Langues : Anglais (eng) Mots-clés : Conduct disorder  development Index. décimale : PER Périodiques Résumé : Background: The presence of a large cavum septum pellucidum (CSP) has been previously associated with antisocial behavior/psychopathic traits in an adult community sample. Aims: The current study investigated the relationship between a large CSP and symptom severity in disruptive behavior disorders (DBD; conduct disorder and oppositional defiant disorder). Method: Structural MRI scans of youth with DBDs (N = 32) and healthy comparison youth (N = 27) were examined for the presence of a large CSP and if this was related to symptom severity. Results: Replicating previous results, a large CSP was associated with DBD diagnosis, proactive aggression, and level of psychopathic traits in youth. However, the presence of a large CSP was unrelated to aggression or psychopathic traits within the DBD sample. Conclusions: Early brain mal-development may increase the risk of a DBD diagnosis, but does not mark a particularly severe form of DBD within patients receiving these diagnoses. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02603.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=196 [article] The relationship between large cavum septum pellucidum and antisocial behavior, callous-unemotional traits and psychopathy in adolescents [Texte imprimé et/ou numérique] / Stuart F. WHITE, Auteur ; Sarah J., BRISLIN, Auteur ; Stephen SINCLAIR, Auteur ; Katherine A. FOWLER, Auteur ; Kayla POPE, Auteur ; James R. BLAIR, Auteur . - p.575-581. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-5 (May 2013) . - p.575-581 Mots-clés : Conduct disorder  development Index. décimale : PER Périodiques Résumé : Background: The presence of a large cavum septum pellucidum (CSP) has been previously associated with antisocial behavior/psychopathic traits in an adult community sample. Aims: The current study investigated the relationship between a large CSP and symptom severity in disruptive behavior disorders (DBD; conduct disorder and oppositional defiant disorder). Method: Structural MRI scans of youth with DBDs (N = 32) and healthy comparison youth (N = 27) were examined for the presence of a large CSP and if this was related to symptom severity. Results: Replicating previous results, a large CSP was associated with DBD diagnosis, proactive aggression, and level of psychopathic traits in youth. However, the presence of a large CSP was unrelated to aggression or psychopathic traits within the DBD sample. Conclusions: Early brain mal-development may increase the risk of a DBD diagnosis, but does not mark a particularly severe form of DBD within patients receiving these diagnoses. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02603.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=196

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