Daytime Secretion of Salivary Cortisol and Alpha-Amylase in Preschool-Aged Children with Autism and Typically Developing Children / Sharon A. KIDD in Journal of Autism and Developmental Disorders, 42-12 (December 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-12 (December 2012) . - p.2648-2658 Titre : Daytime Secretion of Salivary Cortisol and Alpha-Amylase in Preschool-Aged Children with Autism and Typically Developing Children Type de document : texte imprimé Auteurs : Sharon A. KIDD, Auteur ; Blythe A. CORBETT, Auteur ; Douglas A. GRANGER, Auteur ; W. Thomas BOYCE, Auteur ; Thomas F. ANDERS, Auteur ; Ira B. TAGER, Auteur Année de publication : 2012 Article en page(s) : p.2648-2658 Langues : Anglais (eng) Mots-clés : Autism  Children  Salivary cortisol  Salivary alpha-amylase  Diurnal  Variability Index. décimale : PER Périodiques Résumé : We examined daytime salivary cortisol and salivary alpha-amylase (sAA) secretion levels and variability in preschool-aged children with autism (AUT) and typically developing children (TYP). Fifty-two subjects (26 AUT and 26 TYP) were enrolled. Salivary samples were obtained at waking, midday, and bedtime on two consecutive days at three phases (baseline, 3 months later, 6 months later). There were modest increases in waking cortisol and sAA levels in AUT relative to TYP, but the increases were not statistically significant. Important differences were observed in cortisol and sAA variability between AUT and TYP. There was also a graded response among AUT by functional status' cortisol and sAA secretion levels were higher when IQ was lower. En ligne : http://dx.doi.org/10.1007/s10803-012-1522-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=184 [article] Daytime Secretion of Salivary Cortisol and Alpha-Amylase in Preschool-Aged Children with Autism and Typically Developing Children [texte imprimé] / Sharon A. KIDD, Auteur ; Blythe A. CORBETT, Auteur ; Douglas A. GRANGER, Auteur ; W. Thomas BOYCE, Auteur ; Thomas F. ANDERS, Auteur ; Ira B. TAGER, Auteur . - 2012 . - p.2648-2658. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-12 (December 2012) . - p.2648-2658 Mots-clés : Autism  Children  Salivary cortisol  Salivary alpha-amylase  Diurnal  Variability Index. décimale : PER Périodiques Résumé : We examined daytime salivary cortisol and salivary alpha-amylase (sAA) secretion levels and variability in preschool-aged children with autism (AUT) and typically developing children (TYP). Fifty-two subjects (26 AUT and 26 TYP) were enrolled. Salivary samples were obtained at waking, midday, and bedtime on two consecutive days at three phases (baseline, 3 months later, 6 months later). There were modest increases in waking cortisol and sAA levels in AUT relative to TYP, but the increases were not statistically significant. Important differences were observed in cortisol and sAA variability between AUT and TYP. There was also a graded response among AUT by functional status' cortisol and sAA secretion levels were higher when IQ was lower. En ligne : http://dx.doi.org/10.1007/s10803-012-1522-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=184

Improving the Diagnosis of Autism Spectrum Disorder in Fragile X Syndrome by Adapting the Social Communication Questionnaire and the Social Responsiveness Scale-2 / Sharon A. KIDD in Journal of Autism and Developmental Disorders, 50-9 (September 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-9 (September 2020) . - p.3276-3295 Titre : Improving the Diagnosis of Autism Spectrum Disorder in Fragile X Syndrome by Adapting the Social Communication Questionnaire and the Social Responsiveness Scale-2 Type de document : texte imprimé Auteurs : Sharon A. KIDD, Auteur ; Elizabeth BERRY-KRAVIS, Auteur ; Tse-Hwei CHOO, Auteur ; Chen CHEN, Auteur ; Amy N. ESLER, Auteur ; Anne HOFFMANN, Auteur ; Howard F. ANDREWS, Auteur ; Walter E. KAUFMANN, Auteur Article en page(s) : p.3276-3295 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Exploratory factor analysis  Fragile X syndrome  Receiver operating characteristic curves  Social Communication Questionnaire  Social Responsiveness Scale-2 Index. décimale : PER Périodiques Résumé : We carried out a psychometric assessment of the Social Communication Questionnaire (SCQ) and the Social Responsiveness Scale (SRS-2) in fragile X syndrome (FXS), relative to clinician DSM5-based diagnosis of autism spectrum disorder (ASD) in FXS. This was followed by instrument revisions that included: removal of non-discriminating and/or low face validity items for FXS; use of receiver operating characteristic (ROC) curves to determine optimal cut points for the original and revised measures; an exploratory factor analysis to outline subscales better representing ASD in FXS; and creation of a "triple criteria" diagnosis to better delineate ASD subgroups in FXS. These methods improved the sensitivity and/or specificity of the SCQ and SRS-2, but diagnostic accuracy of ASD remains problematic in FXS. En ligne : http://dx.doi.org/10.1007/s10803-019-04148-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430 [article] Improving the Diagnosis of Autism Spectrum Disorder in Fragile X Syndrome by Adapting the Social Communication Questionnaire and the Social Responsiveness Scale-2 [texte imprimé] / Sharon A. KIDD, Auteur ; Elizabeth BERRY-KRAVIS, Auteur ; Tse-Hwei CHOO, Auteur ; Chen CHEN, Auteur ; Amy N. ESLER, Auteur ; Anne HOFFMANN, Auteur ; Howard F. ANDREWS, Auteur ; Walter E. KAUFMANN, Auteur . - p.3276-3295. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-9 (September 2020) . - p.3276-3295 Mots-clés : Autism spectrum disorder  Exploratory factor analysis  Fragile X syndrome  Receiver operating characteristic curves  Social Communication Questionnaire  Social Responsiveness Scale-2 Index. décimale : PER Périodiques Résumé : We carried out a psychometric assessment of the Social Communication Questionnaire (SCQ) and the Social Responsiveness Scale (SRS-2) in fragile X syndrome (FXS), relative to clinician DSM5-based diagnosis of autism spectrum disorder (ASD) in FXS. This was followed by instrument revisions that included: removal of non-discriminating and/or low face validity items for FXS; use of receiver operating characteristic (ROC) curves to determine optimal cut points for the original and revised measures; an exploratory factor analysis to outline subscales better representing ASD in FXS; and creation of a "triple criteria" diagnosis to better delineate ASD subgroups in FXS. These methods improved the sensitivity and/or specificity of the SCQ and SRS-2, but diagnostic accuracy of ASD remains problematic in FXS. En ligne : http://dx.doi.org/10.1007/s10803-019-04148-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430

Sensory Symptoms and Signs of Hyperarousal in Individuals with Fragile X Syndrome: Findings from the FORWARD Registry and Database Multisite Study / Ave M. LACHIEWICZ in Journal of Autism and Developmental Disorders, 54-11 (November)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-11 (November) . - p.4259-4277 Titre : Sensory Symptoms and Signs of Hyperarousal in Individuals with Fragile X Syndrome: Findings from the FORWARD Registry and Database Multisite Study Type de document : texte imprimé Auteurs : Ave M. LACHIEWICZ, Auteur ; Tracy M. STACKHOUSE, Auteur ; Kristin BURGESS, Auteur ; Debra BURGESS, Auteur ; Howard F. ANDREWS, Auteur ; Tse-Hwei CHOO, Auteur ; Walter E. KAUFMANN, Auteur ; Sharon A. KIDD, Auteur Article en page(s) : p.4259-4277 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study was designed to increase our understanding about characteristics and the impact of sensory symptoms (SS) and signs of hyperarousal (HA) in individuals with fragile X syndrome (FXS) from childhood through early adulthood and by gender. Data derived from the Fragile X Online Registry With Accessible Research Database (FORWARD), a natural history study of FXS, were analyzed using descriptive statistics and multivariate linear and logistic regression models to examine SS and signs of HA, their impact on behavioral regulation and limitations on the subject/family. The sample (N = 933) consisted of 720 males and 213 females. More males were affected with SS (87% vs. 68%) and signs of HA (92% vs. 79%). Subjects who were endorsed as having a strong sensory response had more comorbidities, including behavioral problems. The predominant SS was difficulty with eye gaze that increased with age in both genders. As individuals age, there was less use of non-medication therapies, such as occupational therapy (OT)/physical therapy (PT), but there was more use of psychopharmacological medications and investigational drugs for behaviors. Multiple regression models suggested that endorsing SS and signs of HA was associated with statistically significantly increased ABC-C-I subscale scores and limited participation in everyday activities. This study improves our understanding of SS and signs of HA as well as their impact in FXS. It supports the need for more research regarding these clinical symptoms, especially to understand how they contribute to well-known behavioral concerns. En ligne : https://doi.org/10.1007/s10803-023-06135-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=537 [article] Sensory Symptoms and Signs of Hyperarousal in Individuals with Fragile X Syndrome: Findings from the FORWARD Registry and Database Multisite Study [texte imprimé] / Ave M. LACHIEWICZ, Auteur ; Tracy M. STACKHOUSE, Auteur ; Kristin BURGESS, Auteur ; Debra BURGESS, Auteur ; Howard F. ANDREWS, Auteur ; Tse-Hwei CHOO, Auteur ; Walter E. KAUFMANN, Auteur ; Sharon A. KIDD, Auteur . - p.4259-4277. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-11 (November) . - p.4259-4277 Index. décimale : PER Périodiques Résumé : This study was designed to increase our understanding about characteristics and the impact of sensory symptoms (SS) and signs of hyperarousal (HA) in individuals with fragile X syndrome (FXS) from childhood through early adulthood and by gender. Data derived from the Fragile X Online Registry With Accessible Research Database (FORWARD), a natural history study of FXS, were analyzed using descriptive statistics and multivariate linear and logistic regression models to examine SS and signs of HA, their impact on behavioral regulation and limitations on the subject/family. The sample (N = 933) consisted of 720 males and 213 females. More males were affected with SS (87% vs. 68%) and signs of HA (92% vs. 79%). Subjects who were endorsed as having a strong sensory response had more comorbidities, including behavioral problems. The predominant SS was difficulty with eye gaze that increased with age in both genders. As individuals age, there was less use of non-medication therapies, such as occupational therapy (OT)/physical therapy (PT), but there was more use of psychopharmacological medications and investigational drugs for behaviors. Multiple regression models suggested that endorsing SS and signs of HA was associated with statistically significantly increased ABC-C-I subscale scores and limited participation in everyday activities. This study improves our understanding of SS and signs of HA as well as their impact in FXS. It supports the need for more research regarding these clinical symptoms, especially to understand how they contribute to well-known behavioral concerns. En ligne : https://doi.org/10.1007/s10803-023-06135-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=537

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