Early pragmatic language difficulties in siblings of children with autism: implications for DSM-5 social communication disorder? / Meghan MILLER in Journal of Child Psychology and Psychiatry, 56-7 (July 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-7 (July 2015) . - p.774-781 Titre : Early pragmatic language difficulties in siblings of children with autism: implications for DSM-5 social communication disorder? Type de document : Texte imprimé et/ou numérique Auteurs : Meghan MILLER, Auteur ; Gregory S. YOUNG, Auteur ; Ted HUTMAN, Auteur ; Scott JOHNSON, Auteur ; A. J. SCHWICHTENBERG, Auteur ; Sally OZONOFF, Auteur Article en page(s) : p.774-781 Langues : Anglais (eng) Mots-clés : Pragmatic language  social communication  autism spectrum disorder  social (pragmatic) communication disorder  siblings  high-risk Index. décimale : PER Périodiques Résumé : Background We evaluated early pragmatic language skills in preschool-age siblings of children with autism spectrum disorder (ASD), and examined correspondence between pragmatic language impairments and general language difficulties, autism symptomatology, and clinical outcomes. Methods Participants were younger siblings of children with ASD (high-risk, n = 188) or typical development (low-risk, n = 119) who were part of a prospective study of infants at risk for ASD; siblings without ASD outcomes were included in analyses. Pragmatic language skills were measured via the Language Use Inventory (LUI). Results At 36 months, the high-risk group had significantly lower parent-rated pragmatic language scores than the low-risk group. When defining pragmatic language impairment (PLI) as scores below the 10th percentile on the LUI, 35% of the high-risk group was identified with PLI versus 10% of the low-risk group. Children with PLI had higher rates of general language impairment (16%), defined as scores below the 10th percentile on the Receptive or Expressive Language subscales of the Mullen Scales of Early Learning, relative to those without PLI (3%), but most did not evidence general language impairments. Children with PLI had significantly higher ADOS scores than those without PLI and had higher rates of clinician-rated atypical clinical best estimate outcomes (49%) relative to those without PLI (15%). Conclusions Pragmatic language problems are present in some siblings of children with ASD as early as 36 months of age. As the new DSM-5 diagnosis of Social (Pragmatic) Communication Disorder (SCD) is thought to occur more frequently in family members of individuals with ASD, it is possible that some of these siblings will meet criteria for SCD as they get older. Close monitoring of early pragmatic language development in young children at familial risk for ASD is warranted. En ligne : http://dx.doi.org/10.1111/jcpp.12342 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 [article] Early pragmatic language difficulties in siblings of children with autism: implications for DSM-5 social communication disorder? [Texte imprimé et/ou numérique] / Meghan MILLER, Auteur ; Gregory S. YOUNG, Auteur ; Ted HUTMAN, Auteur ; Scott JOHNSON, Auteur ; A. J. SCHWICHTENBERG, Auteur ; Sally OZONOFF, Auteur . - p.774-781. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-7 (July 2015) . - p.774-781 Mots-clés : Pragmatic language  social communication  autism spectrum disorder  social (pragmatic) communication disorder  siblings  high-risk Index. décimale : PER Périodiques Résumé : Background We evaluated early pragmatic language skills in preschool-age siblings of children with autism spectrum disorder (ASD), and examined correspondence between pragmatic language impairments and general language difficulties, autism symptomatology, and clinical outcomes. Methods Participants were younger siblings of children with ASD (high-risk, n = 188) or typical development (low-risk, n = 119) who were part of a prospective study of infants at risk for ASD; siblings without ASD outcomes were included in analyses. Pragmatic language skills were measured via the Language Use Inventory (LUI). Results At 36 months, the high-risk group had significantly lower parent-rated pragmatic language scores than the low-risk group. When defining pragmatic language impairment (PLI) as scores below the 10th percentile on the LUI, 35% of the high-risk group was identified with PLI versus 10% of the low-risk group. Children with PLI had higher rates of general language impairment (16%), defined as scores below the 10th percentile on the Receptive or Expressive Language subscales of the Mullen Scales of Early Learning, relative to those without PLI (3%), but most did not evidence general language impairments. Children with PLI had significantly higher ADOS scores than those without PLI and had higher rates of clinician-rated atypical clinical best estimate outcomes (49%) relative to those without PLI (15%). Conclusions Pragmatic language problems are present in some siblings of children with ASD as early as 36 months of age. As the new DSM-5 diagnosis of Social (Pragmatic) Communication Disorder (SCD) is thought to occur more frequently in family members of individuals with ASD, it is possible that some of these siblings will meet criteria for SCD as they get older. Close monitoring of early pragmatic language development in young children at familial risk for ASD is warranted. En ligne : http://dx.doi.org/10.1111/jcpp.12342 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260

Parent-Reported Temperament Trajectories Among Infant Siblings of Children with Autism / Mithi ROSARIO in Journal of Autism and Developmental Disorders, 44-2 (February 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-2 (February 2014) . - p.381-393 Titre : Parent-Reported Temperament Trajectories Among Infant Siblings of Children with Autism Type de document : Texte imprimé et/ou numérique Auteurs : Mithi ROSARIO, Auteur ; Kristen GILLESPIE-LYNCH, Auteur ; Scott JOHNSON, Auteur ; Marian SIGMAN, Auteur ; Ted HUTMAN, Auteur Article en page(s) : p.381-393 Langues : Anglais (eng) Mots-clés : Temperament  Autism  Parent perception  Infants  Toddlers Index. décimale : PER Périodiques Résumé : Temperament atypicalities have been documented in infancy and early development in children who develop autism spectrum disorders (ASD). The current study investigates whether there are differences in developmental trajectories of temperament between infants and toddlers with and without ASD. Parents of infant siblings of children with autism completed the Carey Temperament Scales about their child at 6, 12, 18, 24, and 36 months of age. Temperament trajectories of children with ASD reflected increases over time in activity level, and decreasing adaptability and approach behaviors relative to high-risk typically developing (TD) children. This study is the first to compare temperament trajectories between high-risk TD infants and infants subsequently diagnosed with ASD in the developmental window when overt symptoms of ASD first emerge. En ligne : http://dx.doi.org/10.1007/s10803-013-1876-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=223 [article] Parent-Reported Temperament Trajectories Among Infant Siblings of Children with Autism [Texte imprimé et/ou numérique] / Mithi ROSARIO, Auteur ; Kristen GILLESPIE-LYNCH, Auteur ; Scott JOHNSON, Auteur ; Marian SIGMAN, Auteur ; Ted HUTMAN, Auteur . - p.381-393. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-2 (February 2014) . - p.381-393 Mots-clés : Temperament  Autism  Parent perception  Infants  Toddlers Index. décimale : PER Périodiques Résumé : Temperament atypicalities have been documented in infancy and early development in children who develop autism spectrum disorders (ASD). The current study investigates whether there are differences in developmental trajectories of temperament between infants and toddlers with and without ASD. Parents of infant siblings of children with autism completed the Carey Temperament Scales about their child at 6, 12, 18, 24, and 36 months of age. Temperament trajectories of children with ASD reflected increases over time in activity level, and decreasing adaptability and approach behaviors relative to high-risk typically developing (TD) children. This study is the first to compare temperament trajectories between high-risk TD infants and infants subsequently diagnosed with ASD in the developmental window when overt symptoms of ASD first emerge. En ligne : http://dx.doi.org/10.1007/s10803-013-1876-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=223

School-age outcomes of infants at risk for autism spectrum disorder / Meghan MILLER in Autism Research, 9-6 (June 2016)  

Public ISBD [article]  inAutism Research > 9-6 (June 2016) . - p.632-642 Titre : School-age outcomes of infants at risk for autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Meghan MILLER, Auteur ; Ana-Maria IOSIF, Auteur ; Gregory S. YOUNG, Auteur ; Monique HILL, Auteur ; Elise PHELPS HANZEL, Auteur ; Ted HUTMAN, Auteur ; Scott JOHNSON, Auteur ; Sally OZONOFF, Auteur Article en page(s) : p.632-642 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  broader autism phenotype  psychopathology  siblings  school-age Index. décimale : PER Périodiques Résumé : Studies of infants at risk for autism spectrum disorder (ASD) have proliferated, but few of these samples have been followed longer-term. We conducted a follow-up study, at age 5.5–9 years, of younger siblings of children with ASD (high-risk group, n?=?79) or typical development (low-risk group, n?=?60), originally recruited as infants. Children with ASD were excluded because of the focus on understanding the range of non-ASD outcomes among high-risk siblings. Using examiner ratings, parent ratings, and standardized assessments, we evaluated differences in clinical outcomes, psychopathology symptoms, autism symptoms, language skills, and nonverbal cognitive abilities. After adjusting for covariates, the high-risk group had increased odds of any clinically elevated/impaired score across measures relative to the low-risk group (43% vs. 12%, respectively). The high-risk group also had increased odds of examiner-rated Clinical Concerns (CC) outcomes (e.g., ADHD concerns, broader autism phenotype, speech-language difficulties, anxiety/mood problems, learning problems) relative to the low-risk group (38% vs. 13%, respectively). The high-risk group with CC outcomes had higher parent-reported psychopathology and autism symptoms, and lower directly-assessed language skills, than the Low-Risk Typically Developing (TD) and High-Risk TD groups, which did not differ. There were no differences in nonverbal cognitive skills. For some in the high-risk group, clinical concerns persisted from early childhood, whereas for others clinical concerns were first evident at school-age. Results suggest continued vulnerability in at least a subgroup of school-age children with a family history of ASD and suggest that this population may benefit from continued screening and monitoring into the school-age years. Autism Res 2016, 9: 632–642. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1572 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290 [article] School-age outcomes of infants at risk for autism spectrum disorder [Texte imprimé et/ou numérique] / Meghan MILLER, Auteur ; Ana-Maria IOSIF, Auteur ; Gregory S. YOUNG, Auteur ; Monique HILL, Auteur ; Elise PHELPS HANZEL, Auteur ; Ted HUTMAN, Auteur ; Scott JOHNSON, Auteur ; Sally OZONOFF, Auteur . - p.632-642. Langues : Anglais (eng) in Autism Research > 9-6 (June 2016) . - p.632-642 Mots-clés : autism spectrum disorder  broader autism phenotype  psychopathology  siblings  school-age Index. décimale : PER Périodiques Résumé : Studies of infants at risk for autism spectrum disorder (ASD) have proliferated, but few of these samples have been followed longer-term. We conducted a follow-up study, at age 5.5–9 years, of younger siblings of children with ASD (high-risk group, n?=?79) or typical development (low-risk group, n?=?60), originally recruited as infants. Children with ASD were excluded because of the focus on understanding the range of non-ASD outcomes among high-risk siblings. Using examiner ratings, parent ratings, and standardized assessments, we evaluated differences in clinical outcomes, psychopathology symptoms, autism symptoms, language skills, and nonverbal cognitive abilities. After adjusting for covariates, the high-risk group had increased odds of any clinically elevated/impaired score across measures relative to the low-risk group (43% vs. 12%, respectively). The high-risk group also had increased odds of examiner-rated Clinical Concerns (CC) outcomes (e.g., ADHD concerns, broader autism phenotype, speech-language difficulties, anxiety/mood problems, learning problems) relative to the low-risk group (38% vs. 13%, respectively). The high-risk group with CC outcomes had higher parent-reported psychopathology and autism symptoms, and lower directly-assessed language skills, than the Low-Risk Typically Developing (TD) and High-Risk TD groups, which did not differ. There were no differences in nonverbal cognitive skills. For some in the high-risk group, clinical concerns persisted from early childhood, whereas for others clinical concerns were first evident at school-age. Results suggest continued vulnerability in at least a subgroup of school-age children with a family history of ASD and suggest that this population may benefit from continued screening and monitoring into the school-age years. Autism Res 2016, 9: 632–642. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1572 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290

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