Analysis of Fmr1 Deletion in a Subpopulation of Post-Mitotic Neurons in Mouse Cortex and Hippocampus / Anahita AMIRI in Autism Research, 7-1 (February 2014)  

Public ISBD [article]  inAutism Research > 7-1 (February 2014) . - p.60-71 Titre : Analysis of Fmr1 Deletion in a Subpopulation of Post-Mitotic Neurons in Mouse Cortex and Hippocampus Type de document : texte imprimé Auteurs : Anahita AMIRI, Auteur ; Efrain SANCHEZ-ORTIZ, Auteur ; Woosung CHO, Auteur ; Shari G. BIRNBAUM, Auteur ; Jing XU, Auteur ; Renée M. MCKAY, Auteur ; Luis F. PARADA, Auteur Article en page(s) : p.60-71 Langues : Anglais (eng) Mots-clés : Fragile X Syndrome  Fmr1  autism  mental retardation  Nse-Cre  synaptic plasticity Index. décimale : PER Périodiques Résumé : Fragile X syndrome (FXS) is the most common form of inherited mental retardation and the leading cause of autism. FXS is caused by mutation in a single gene, FMR1, which encodes an RNA-binding protein FMRP. FMRP is highly expressed in neurons and is hypothesized to have a role in synaptic structure, function, and plasticity by regulating mRNAs that encode pre- and post-synaptic proteins. Fmr1 knockout (KO) mice have been used as a model to study FXS. These mice have been reported to show a great degree of phenotypic variability based on the genetic background, environmental signals, and experimental methods. In this study, we sought to restrict FMRP deletion to two brain regions that have been implicated in FXS and autism. We show that ablating Fmr1 in differentiated neurons of hippocampus and cortex results in dendritic alterations and changes in synaptic marker intensity that are brain region specific. In our conditional mutant mice, FMRP-deleted neurons have activated AKT-mTOR pathway signaling in hippocampus but display no apparent behavioral phenotypes. These results highlight the importance of identifying additional factors that interact with Fmr1 to develop FXS. En ligne : http://dx.doi.org/10.1002/aur.1342 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227 [article] Analysis of Fmr1 Deletion in a Subpopulation of Post-Mitotic Neurons in Mouse Cortex and Hippocampus [texte imprimé] / Anahita AMIRI, Auteur ; Efrain SANCHEZ-ORTIZ, Auteur ; Woosung CHO, Auteur ; Shari G. BIRNBAUM, Auteur ; Jing XU, Auteur ; Renée M. MCKAY, Auteur ; Luis F. PARADA, Auteur . - p.60-71. Langues : Anglais (eng) in Autism Research > 7-1 (February 2014) . - p.60-71 Mots-clés : Fragile X Syndrome  Fmr1  autism  mental retardation  Nse-Cre  synaptic plasticity Index. décimale : PER Périodiques Résumé : Fragile X syndrome (FXS) is the most common form of inherited mental retardation and the leading cause of autism. FXS is caused by mutation in a single gene, FMR1, which encodes an RNA-binding protein FMRP. FMRP is highly expressed in neurons and is hypothesized to have a role in synaptic structure, function, and plasticity by regulating mRNAs that encode pre- and post-synaptic proteins. Fmr1 knockout (KO) mice have been used as a model to study FXS. These mice have been reported to show a great degree of phenotypic variability based on the genetic background, environmental signals, and experimental methods. In this study, we sought to restrict FMRP deletion to two brain regions that have been implicated in FXS and autism. We show that ablating Fmr1 in differentiated neurons of hippocampus and cortex results in dendritic alterations and changes in synaptic marker intensity that are brain region specific. In our conditional mutant mice, FMRP-deleted neurons have activated AKT-mTOR pathway signaling in hippocampus but display no apparent behavioral phenotypes. These results highlight the importance of identifying additional factors that interact with Fmr1 to develop FXS. En ligne : http://dx.doi.org/10.1002/aur.1342 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227

Examining the Efficacy of a Family Peer Advocate Model for Black and Hispanic Caregivers of Children with Autism Spectrum Disorder / J.M. JAMISON in Journal of Autism and Developmental Disorders, 47-5 (May 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-5 (May 2017) . - p.1314-1322 Titre : Examining the Efficacy of a Family Peer Advocate Model for Black and Hispanic Caregivers of Children with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : J.M. JAMISON, Auteur ; Emily FOURIE, Auteur ; Paige M. SIPER, Auteur ; Maria Del Pilar TRELLES, Auteur ; Julia GEORGE-JONES, Auteur ; A. BUXBAUM GRICE, Auteur ; J. KRATA, Auteur ; E. HOLL, Auteur ; J. SHAOUL, Auteur ; B. HERNANDEZ, Auteur ; L. MITCHELL, Auteur ; Renée M. MCKAY, Auteur ; Joseph D. BUXBAUM, Auteur ; Alexander KOLEVZON, Auteur Article en page(s) : p.1314-1322 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Family peer advocate  Minority  Caregiver stress Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) affects individuals across all racial and ethnic groups, yet rates of diagnosis are disproportionately higher for Black and Hispanic children. Caregivers of children with ASD experience significant stressors, which have been associated with parental strain, inadequate utilization of mental health services and lower quality of life. The family peer advocate (FPA) model has been utilized across service delivery systems to provide family-to-family support, facilitate engagement, and increase access to care. This study used a randomized controlled design to examine the efficacy of FPAs in a racially and ethnically diverse sample. Results demonstrate significantly increased knowledge of ASD and reduced levels of stress for caregivers who received the FPA intervention as compared to treatment as usual. En ligne : http://dx.doi.org/10.1007/s10803-017-3045-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305 [article] Examining the Efficacy of a Family Peer Advocate Model for Black and Hispanic Caregivers of Children with Autism Spectrum Disorder [texte imprimé] / J.M. JAMISON, Auteur ; Emily FOURIE, Auteur ; Paige M. SIPER, Auteur ; Maria Del Pilar TRELLES, Auteur ; Julia GEORGE-JONES, Auteur ; A. BUXBAUM GRICE, Auteur ; J. KRATA, Auteur ; E. HOLL, Auteur ; J. SHAOUL, Auteur ; B. HERNANDEZ, Auteur ; L. MITCHELL, Auteur ; Renée M. MCKAY, Auteur ; Joseph D. BUXBAUM, Auteur ; Alexander KOLEVZON, Auteur . - p.1314-1322. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-5 (May 2017) . - p.1314-1322 Mots-clés : Autism spectrum disorder  Family peer advocate  Minority  Caregiver stress Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) affects individuals across all racial and ethnic groups, yet rates of diagnosis are disproportionately higher for Black and Hispanic children. Caregivers of children with ASD experience significant stressors, which have been associated with parental strain, inadequate utilization of mental health services and lower quality of life. The family peer advocate (FPA) model has been utilized across service delivery systems to provide family-to-family support, facilitate engagement, and increase access to care. This study used a randomized controlled design to examine the efficacy of FPAs in a racially and ethnically diverse sample. Results demonstrate significantly increased knowledge of ASD and reduced levels of stress for caregivers who received the FPA intervention as compared to treatment as usual. En ligne : http://dx.doi.org/10.1007/s10803-017-3045-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305

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