Childhood trauma, adolescent risk behaviours and cardiovascular health indices in the 2004 Pelotas Birth Cohort / Megan BAILEY in Journal of Child Psychology and Psychiatry, 66-11 (November 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-11 (November 2025) . - p.1653-1663 Titre : Childhood trauma, adolescent risk behaviours and cardiovascular health indices in the 2004 Pelotas Birth Cohort Type de document : texte imprimé Auteurs : Megan BAILEY, Auteur ; Graeme FAIRCHILD, Auteur ; Gemma HAMMERTON, Auteur ; Iná S. SANTOS, Auteur ; Luciana TOVO-RODRIGUES, Auteur ; Joseph MURRAY, Auteur ; Alicia MATIJASEVICH, Auteur ; Sarah L. HALLIGAN, Auteur Article en page(s) : p.1653-1663 Langues : Anglais (eng) Mots-clés : Childhood trauma  adolescent  substance use  psychophysiology  risk behaviours Index. décimale : PER Périodiques Résumé : Background Childhood trauma has been associated with increased risk of substance use and poor sleep, with these factors linked to subsequent poor cardiovascular health. However, there has been little longitudinal research exploring these associations in adolescence, especially in low- and middle-income countries (LMICs). To address this, we investigated longitudinal pathways from trauma to risk behaviours and cardiovascular health indices among adolescents in the 2004 Pelotas Birth Cohort, Brazil. Methods Lifetime cumulative trauma was assessed via caregiver reports up to age 11, and combined adolescent/caregiver reports at ages 15 and 18. At age 18, current problematic alcohol use, smoking, illicit drug use and sleep duration were measured via self-report and resting heart rate (HR) and blood pressure (BP) were assessed. We tested for trauma risk behaviour?HR/BP associations using multivariable regression, population attributable fractions and counterfactual mediation. Results Of 4,229 adolescents (51.9% boys), 81.9% were trauma-exposed by age 18. Cumulative trauma up to ages 15 and 18 increased the odds of age 18 alcohol, smoking and drug use (adjusted ORs: 1.25?1.44). Sleep duration was unrelated to childhood trauma. Population attributable fractions indicated that childhood trauma explained ≥28% of age 18 substance use. Unexpectedly, greater trauma exposure was associated with lower resting HR and BP. Substance use partially mediated the effect of trauma on cardiovascular health indices. Conclusions Trauma is associated with substance use in LMIC adolescents. Prevention and intervention strategies targeting trauma are critical given this significant burden. Our finding that trauma predicts lower HR/BP warrants further exploration given well-established associations between trauma and poorer cardiovascular health in adulthood. En ligne : https://doi.org/10.1111/jcpp.14173 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=570 [article] Childhood trauma, adolescent risk behaviours and cardiovascular health indices in the 2004 Pelotas Birth Cohort [texte imprimé] / Megan BAILEY, Auteur ; Graeme FAIRCHILD, Auteur ; Gemma HAMMERTON, Auteur ; Iná S. SANTOS, Auteur ; Luciana TOVO-RODRIGUES, Auteur ; Joseph MURRAY, Auteur ; Alicia MATIJASEVICH, Auteur ; Sarah L. HALLIGAN, Auteur . - p.1653-1663. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-11 (November 2025) . - p.1653-1663 Mots-clés : Childhood trauma  adolescent  substance use  psychophysiology  risk behaviours Index. décimale : PER Périodiques Résumé : Background Childhood trauma has been associated with increased risk of substance use and poor sleep, with these factors linked to subsequent poor cardiovascular health. However, there has been little longitudinal research exploring these associations in adolescence, especially in low- and middle-income countries (LMICs). To address this, we investigated longitudinal pathways from trauma to risk behaviours and cardiovascular health indices among adolescents in the 2004 Pelotas Birth Cohort, Brazil. Methods Lifetime cumulative trauma was assessed via caregiver reports up to age 11, and combined adolescent/caregiver reports at ages 15 and 18. At age 18, current problematic alcohol use, smoking, illicit drug use and sleep duration were measured via self-report and resting heart rate (HR) and blood pressure (BP) were assessed. We tested for trauma risk behaviour?HR/BP associations using multivariable regression, population attributable fractions and counterfactual mediation. Results Of 4,229 adolescents (51.9% boys), 81.9% were trauma-exposed by age 18. Cumulative trauma up to ages 15 and 18 increased the odds of age 18 alcohol, smoking and drug use (adjusted ORs: 1.25?1.44). Sleep duration was unrelated to childhood trauma. Population attributable fractions indicated that childhood trauma explained ≥28% of age 18 substance use. Unexpectedly, greater trauma exposure was associated with lower resting HR and BP. Substance use partially mediated the effect of trauma on cardiovascular health indices. Conclusions Trauma is associated with substance use in LMIC adolescents. Prevention and intervention strategies targeting trauma are critical given this significant burden. Our finding that trauma predicts lower HR/BP warrants further exploration given well-established associations between trauma and poorer cardiovascular health in adulthood. En ligne : https://doi.org/10.1111/jcpp.14173 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=570

Identifying biomarkers and trajectories of executive functions and language development in the first 3 years of life: Design, methods, and findings of the Germina cohort study / Daniel FATORI in Development and Psychopathology, 37-5 (December 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-5 (December 2025) . - p.2457-2467 Titre : Identifying biomarkers and trajectories of executive functions and language development in the first 3 years of life: Design, methods, and findings of the Germina cohort study Type de document : texte imprimé Auteurs : Daniel FATORI, Auteur ; Elizabeth SHEPHARD, Auteur ; Danilo BENETTE, Auteur ; Nathalia Ferrazzo NASPOLINI, Auteur ; Grover Castro GUZMAN, Auteur ; Jaqueline Yu Ting WANG, Auteur ; Pedro TÓTOLO, Auteur ; Anthonieta Looman MAFRA, Auteur ; Caio ISAIAS, Auteur ; Davi Pereira DOS SANTOS, Auteur ; Fabiele Baldino RUSSO, Auteur ; Gerson KOBAYASHI, Auteur ; Adriana ARGEU, Auteur ; Monike TEIXEIRA, Auteur ; Ana Claudia MATTIELLO-SVERZUT, Auteur ; Maria Teresa Bechere FERNANDES, Auteur ; Danila Cristina PETIAN-ALONSO, Auteur ; Helena BRENTANI, Auteur ; Marilia SCLIAR, Auteur ; Paulo Alfonso SCHÃœROFF, Auteur ; Pedro ZUCCOLO, Auteur ; Rogério LERNER, Auteur ; Stephania GERALDINI, Auteur ; Veronica Luiza Vale EUCLYDES, Auteur ; Alicia MATIJASEVICH, Auteur ; Alline Cristina DE CAMPOS, Auteur ; André Carlos Ponce DE CARVALHO, Auteur ; André FUJITA, Auteur ; Carla R. TADDEI, Auteur ; Maria Rita PASSOS-BUENO, Auteur ; Patricia BELTRÃO-BRAGA, Auteur ; Guilherme Vanoni POLANCZYK, Auteur Article en page(s) : p.2457-2467 Langues : Anglais (eng) Mots-clés : child development  cohort study  electroencephalography  genetics  gut microbiome Index. décimale : PER Périodiques Résumé : This paper reports the methods and preliminary findings of Germina, an ongoing cohort study to identify biomarkers and trajectories of executive functions and language development in the first 3 years of life. 557 mother-infant dyads (mean age of mothers 33.7 years, 65.2% white, 48.7% male infants) have undergone baseline and are currently collecting data for other timepoints. A linear regression was used to predict baseline Bayley-III using scores derived from data-driven sparse partial least squares utilizing a multiple holdout framework of 15 domains. Significant associations were found between socioeconomic/demographic characteristics (B = 0.29), epigenetics (B = 0.11), EEG theta (B = 0.14) and beta activity (B = 0.11), and microbiome functional pathways (B = 0.08) domains, and infant development measured by the Bayley-III at T1, suggesting potential interventions to prevent impairments. En ligne : https://dx.doi.org/10.1017/S0954579425000069 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572 [article] Identifying biomarkers and trajectories of executive functions and language development in the first 3 years of life: Design, methods, and findings of the Germina cohort study [texte imprimé] / Daniel FATORI, Auteur ; Elizabeth SHEPHARD, Auteur ; Danilo BENETTE, Auteur ; Nathalia Ferrazzo NASPOLINI, Auteur ; Grover Castro GUZMAN, Auteur ; Jaqueline Yu Ting WANG, Auteur ; Pedro TÓTOLO, Auteur ; Anthonieta Looman MAFRA, Auteur ; Caio ISAIAS, Auteur ; Davi Pereira DOS SANTOS, Auteur ; Fabiele Baldino RUSSO, Auteur ; Gerson KOBAYASHI, Auteur ; Adriana ARGEU, Auteur ; Monike TEIXEIRA, Auteur ; Ana Claudia MATTIELLO-SVERZUT, Auteur ; Maria Teresa Bechere FERNANDES, Auteur ; Danila Cristina PETIAN-ALONSO, Auteur ; Helena BRENTANI, Auteur ; Marilia SCLIAR, Auteur ; Paulo Alfonso SCHÃœROFF, Auteur ; Pedro ZUCCOLO, Auteur ; Rogério LERNER, Auteur ; Stephania GERALDINI, Auteur ; Veronica Luiza Vale EUCLYDES, Auteur ; Alicia MATIJASEVICH, Auteur ; Alline Cristina DE CAMPOS, Auteur ; André Carlos Ponce DE CARVALHO, Auteur ; André FUJITA, Auteur ; Carla R. TADDEI, Auteur ; Maria Rita PASSOS-BUENO, Auteur ; Patricia BELTRÃO-BRAGA, Auteur ; Guilherme Vanoni POLANCZYK, Auteur . - p.2457-2467. Langues : Anglais (eng) in Development and Psychopathology > 37-5 (December 2025) . - p.2457-2467 Mots-clés : child development  cohort study  electroencephalography  genetics  gut microbiome Index. décimale : PER Périodiques Résumé : This paper reports the methods and preliminary findings of Germina, an ongoing cohort study to identify biomarkers and trajectories of executive functions and language development in the first 3 years of life. 557 mother-infant dyads (mean age of mothers 33.7 years, 65.2% white, 48.7% male infants) have undergone baseline and are currently collecting data for other timepoints. A linear regression was used to predict baseline Bayley-III using scores derived from data-driven sparse partial least squares utilizing a multiple holdout framework of 15 domains. Significant associations were found between socioeconomic/demographic characteristics (B = 0.29), epigenetics (B = 0.11), EEG theta (B = 0.14) and beta activity (B = 0.11), and microbiome functional pathways (B = 0.08) domains, and infant development measured by the Bayley-III at T1, suggesting potential interventions to prevent impairments. En ligne : https://dx.doi.org/10.1017/S0954579425000069 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572

Increase in child behavior problems among urban Brazilian 4-year olds: 1993 and 2004 Pelotas birth cohorts / Alicia MATIJASEVICH in Journal of Child Psychology and Psychiatry, 55-10 (October 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-10 (October 2014) . - p.1125-1134 Titre : Increase in child behavior problems among urban Brazilian 4-year olds: 1993 and 2004 Pelotas birth cohorts Type de document : texte imprimé Auteurs : Alicia MATIJASEVICH, Auteur ; Elizabeth MURRAY, Auteur ; Alan STEIN, Auteur ; Luciana ANSELMI, Auteur ; Ana Maria B. MENEZES, Auteur ; Iná S. SANTOS, Auteur ; Aluísio J.D. BARROS, Auteur ; Denise P. GIGANTE, Auteur ; Fernando C. BARROS, Auteur ; Cesar G. VICTORA, Auteur Article en page(s) : p.1125-1134 Langues : Anglais (eng) Mots-clés : Mental health  behavior problems  child behavior check list  longitudinal studies Index. décimale : PER Périodiques Résumé : Background There are an increasing number of reports on time trends in child and adolescent psychological problems but none from low- and middle-income countries, and very few covering the preschool period. The aim was to investigate changes in preschool behavioral/emotional problems in two birth cohorts from a middle-income country born 11 years apart. Methods We analyzed data from the 1993 and 2004 Pelotas birth cohort studies from Brazil. A subsample of 4-year olds from the 1993 cohort (634) and all 4-year olds from the 2004 cohort (3750) were assessed for behavioral/emotional problems through maternal report using the Child Behavior Checklist (CBCL). Response rates in these two population-based cohorts were above 90%. Results We found a significant increase in CBCL total problems, internalizing and externalizing mean scores over the 11-year period. For 1993 and 2004 Pelotas cohorts, respectively, CBCL mean values (SE) total problems scores were 27.9 (0.8) and 34.7 (0.3); for internalizing scores, 5.7 (0.2) and 6.3 (0.1) and for externalizing scores, 12.4 (0.4) and 15.5 (0.1). After adjusting for confounding variables, the largest increase from 1993 to 2004 was identified in the aggressive behavior syndrome score (Cohen's d = .50), followed by the externalizing problem score (Cohen's d = .40) and CBCL total problem score (Cohen's d = .36), respectively. The rise in child psychological problems was more marked in children from families with fewer assets and with less educated mothers. Conclusions Our findings provide evidence for a substantial increase in preschool behavioral problems among children in Brazil over an 11-year period. En ligne : http://dx.doi.org/10.1111/jcpp.12236 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=239 [article] Increase in child behavior problems among urban Brazilian 4-year olds: 1993 and 2004 Pelotas birth cohorts [texte imprimé] / Alicia MATIJASEVICH, Auteur ; Elizabeth MURRAY, Auteur ; Alan STEIN, Auteur ; Luciana ANSELMI, Auteur ; Ana Maria B. MENEZES, Auteur ; Iná S. SANTOS, Auteur ; Aluísio J.D. BARROS, Auteur ; Denise P. GIGANTE, Auteur ; Fernando C. BARROS, Auteur ; Cesar G. VICTORA, Auteur . - p.1125-1134. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-10 (October 2014) . - p.1125-1134 Mots-clés : Mental health  behavior problems  child behavior check list  longitudinal studies Index. décimale : PER Périodiques Résumé : Background There are an increasing number of reports on time trends in child and adolescent psychological problems but none from low- and middle-income countries, and very few covering the preschool period. The aim was to investigate changes in preschool behavioral/emotional problems in two birth cohorts from a middle-income country born 11 years apart. Methods We analyzed data from the 1993 and 2004 Pelotas birth cohort studies from Brazil. A subsample of 4-year olds from the 1993 cohort (634) and all 4-year olds from the 2004 cohort (3750) were assessed for behavioral/emotional problems through maternal report using the Child Behavior Checklist (CBCL). Response rates in these two population-based cohorts were above 90%. Results We found a significant increase in CBCL total problems, internalizing and externalizing mean scores over the 11-year period. For 1993 and 2004 Pelotas cohorts, respectively, CBCL mean values (SE) total problems scores were 27.9 (0.8) and 34.7 (0.3); for internalizing scores, 5.7 (0.2) and 6.3 (0.1) and for externalizing scores, 12.4 (0.4) and 15.5 (0.1). After adjusting for confounding variables, the largest increase from 1993 to 2004 was identified in the aggressive behavior syndrome score (Cohen's d = .50), followed by the externalizing problem score (Cohen's d = .40) and CBCL total problem score (Cohen's d = .36), respectively. The rise in child psychological problems was more marked in children from families with fewer assets and with less educated mothers. Conclusions Our findings provide evidence for a substantial increase in preschool behavioral problems among children in Brazil over an 11-year period. En ligne : http://dx.doi.org/10.1111/jcpp.12236 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=239

Perinatal and sociodemographic factors at birth predicting conduct problems and violence to age 18 years: comparison of Brazilian and British birth cohorts / Joseph MURRAY in Journal of Child Psychology and Psychiatry, 56-8 (August 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-8 (August 2015) . - p.914-922 Titre : Perinatal and sociodemographic factors at birth predicting conduct problems and violence to age 18 years: comparison of Brazilian and British birth cohorts Type de document : texte imprimé Auteurs : Joseph MURRAY, Auteur ; Barbara MAUGHAN, Auteur ; Ana Maria B. MENEZES, Auteur ; Matthew HICKMAN, Auteur ; John MACLEOD, Auteur ; Alicia MATIJASEVICH, Auteur ; Helen GONÇALVES, Auteur ; Luciana ANSELMI, Auteur ; Erika A.G. GALLO, Auteur ; Fernando C. BARROS, Auteur Article en page(s) : p.914-922 Langues : Anglais (eng) Mots-clés : Conduct problems  violence  risk factors  cohort study  middle-income country  ALSPAC Index. décimale : PER Périodiques Résumé : Background Many low- and middle-income countries have high levels of violence. Research in high-income countries shows that risk factors in the perinatal period are significant precursors of conduct problems which can develop into violence. It is not known whether the same early influences are important in lower income settings with higher rates of violence. This study compared perinatal and sociodemographic risk factors between Brazil and Britain, and their role in explaining higher rates of conduct problems and violence in Brazil. Methods Prospective population-based birth cohort studies were conducted in Pelotas, Brazil (N = 3,618) and Avon, Britain (N = 4,103). Eleven perinatal and sociodemographic risk factors were measured in questionnaires completed by mothers during the perinatal period. Conduct problems were measured in questionnaires completed by mothers at age 11, and violence in self-report questionnaires completed by adolescents at age 18. Results Conduct problems were predicted by similar risk factors in Brazil and Britain. Female violence was predicted by several of the same risk factors in both countries. However, male violence in Brazil was associated with only one risk factor, and several risk factor associations were weaker in Brazil than in Britain for both females and males. Almost 20% of the higher risk for conduct problems in Brazil compared to Britain was explained by differential exposure to risk factors. The percentage of the cross-national difference in violence explained by early risk factors was 15% for females and 8% for males. Conclusions A nontrivial proportion of cross-national differences in antisocial behaviour are related to perinatal and sociodemographic conditions at the start of life. However, risk factor associations are weaker in Brazil than in Britain, and influences in other developmental periods are probably of particular importance for understanding male youth violence in Brazil. En ligne : http://dx.doi.org/10.1111/jcpp.12369 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263 [article] Perinatal and sociodemographic factors at birth predicting conduct problems and violence to age 18 years: comparison of Brazilian and British birth cohorts [texte imprimé] / Joseph MURRAY, Auteur ; Barbara MAUGHAN, Auteur ; Ana Maria B. MENEZES, Auteur ; Matthew HICKMAN, Auteur ; John MACLEOD, Auteur ; Alicia MATIJASEVICH, Auteur ; Helen GONÇALVES, Auteur ; Luciana ANSELMI, Auteur ; Erika A.G. GALLO, Auteur ; Fernando C. BARROS, Auteur . - p.914-922. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-8 (August 2015) . - p.914-922 Mots-clés : Conduct problems  violence  risk factors  cohort study  middle-income country  ALSPAC Index. décimale : PER Périodiques Résumé : Background Many low- and middle-income countries have high levels of violence. Research in high-income countries shows that risk factors in the perinatal period are significant precursors of conduct problems which can develop into violence. It is not known whether the same early influences are important in lower income settings with higher rates of violence. This study compared perinatal and sociodemographic risk factors between Brazil and Britain, and their role in explaining higher rates of conduct problems and violence in Brazil. Methods Prospective population-based birth cohort studies were conducted in Pelotas, Brazil (N = 3,618) and Avon, Britain (N = 4,103). Eleven perinatal and sociodemographic risk factors were measured in questionnaires completed by mothers during the perinatal period. Conduct problems were measured in questionnaires completed by mothers at age 11, and violence in self-report questionnaires completed by adolescents at age 18. Results Conduct problems were predicted by similar risk factors in Brazil and Britain. Female violence was predicted by several of the same risk factors in both countries. However, male violence in Brazil was associated with only one risk factor, and several risk factor associations were weaker in Brazil than in Britain for both females and males. Almost 20% of the higher risk for conduct problems in Brazil compared to Britain was explained by differential exposure to risk factors. The percentage of the cross-national difference in violence explained by early risk factors was 15% for females and 8% for males. Conclusions A nontrivial proportion of cross-national differences in antisocial behaviour are related to perinatal and sociodemographic conditions at the start of life. However, risk factor associations are weaker in Brazil than in Britain, and influences in other developmental periods are probably of particular importance for understanding male youth violence in Brazil. En ligne : http://dx.doi.org/10.1111/jcpp.12369 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263

Sex differences in the association between foetal growth and child attention at age four: specific vulnerability of girls / Elizabeth MURRAY in Journal of Child Psychology and Psychiatry, 56-12 (December 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-12 (December 2015) . - p.1380-1388 Titre : Sex differences in the association between foetal growth and child attention at age four: specific vulnerability of girls Type de document : texte imprimé Auteurs : Elizabeth MURRAY, Auteur ; Alicia MATIJASEVICH, Auteur ; Iná S. SANTOS, Auteur ; Aluísio J.D. BARROS, Auteur ; Luciana ANSELMI, Auteur ; Fernando C. BARROS, Auteur ; Alan STEIN, Auteur Article en page(s) : p.1380-1388 Langues : Anglais (eng) Mots-clés : Gender  head circumference  low birth weight  ponderal index  small-for-gestational age  pelotas birth cohort Index. décimale : PER Périodiques Résumé : Background Recent evidence suggests that impaired foetal growth may provide an early indication of increased risk of child attention problems. However, despite both foetal growth and child attention problems differing by sex, few studies have examined sex differences in this association. Furthermore, no studies have been conducted in low- and middle-income countries, where there are higher rates of perinatal problems. This study aimed to test for sex differences in the association between foetal growth indices and attention problems at age four, in a large, prospective birth cohort from a middle-income country. Methods A total of 3,749 neonates from the 2004 Pelotas birth cohort (Brazil) with foetal growth indices collected at birth [low birthweight (LBW), small-for-gestational age (SGA), head circumference (HC), head circumference-to-abdominal circumference ratio (HC/AC) and ponderal index (PI)], were assessed for attention problems using the Child Behaviour Checklist at age four. Ordinal logistic regression with successive adjustment for maternal, demographic, gestational, perinatal and child nutrition/mother–child morbidity, was conducted separately for girls and boys. Results In girls, attention difficulties were associated with being born SGA (OR = 1.40, CI = 1.08–1.82, p = .012), with a small HC (OR = 1.52, CI = 1.11–2.08, p = .009), or with a low PI (OR = 1.29, CI = 1.08–1.54, p = .005). There were no associations identified between attention difficulties and any foetal growth indices in boys. Conclusions Our results show that girls with impaired foetal growth may be particularly at risk of attention difficulties in childhood. This is consistent with emerging research that female foetuses may be more vulnerable to certain suboptimal intrauterine environments, inducing epigenetic changes that lead to disturbed growth and long-term developmental impairment. En ligne : http://dx.doi.org/10.1111/jcpp.12422 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273 [article] Sex differences in the association between foetal growth and child attention at age four: specific vulnerability of girls [texte imprimé] / Elizabeth MURRAY, Auteur ; Alicia MATIJASEVICH, Auteur ; Iná S. SANTOS, Auteur ; Aluísio J.D. BARROS, Auteur ; Luciana ANSELMI, Auteur ; Fernando C. BARROS, Auteur ; Alan STEIN, Auteur . - p.1380-1388. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-12 (December 2015) . - p.1380-1388 Mots-clés : Gender  head circumference  low birth weight  ponderal index  small-for-gestational age  pelotas birth cohort Index. décimale : PER Périodiques Résumé : Background Recent evidence suggests that impaired foetal growth may provide an early indication of increased risk of child attention problems. However, despite both foetal growth and child attention problems differing by sex, few studies have examined sex differences in this association. Furthermore, no studies have been conducted in low- and middle-income countries, where there are higher rates of perinatal problems. This study aimed to test for sex differences in the association between foetal growth indices and attention problems at age four, in a large, prospective birth cohort from a middle-income country. Methods A total of 3,749 neonates from the 2004 Pelotas birth cohort (Brazil) with foetal growth indices collected at birth [low birthweight (LBW), small-for-gestational age (SGA), head circumference (HC), head circumference-to-abdominal circumference ratio (HC/AC) and ponderal index (PI)], were assessed for attention problems using the Child Behaviour Checklist at age four. Ordinal logistic regression with successive adjustment for maternal, demographic, gestational, perinatal and child nutrition/mother–child morbidity, was conducted separately for girls and boys. Results In girls, attention difficulties were associated with being born SGA (OR = 1.40, CI = 1.08–1.82, p = .012), with a small HC (OR = 1.52, CI = 1.11–2.08, p = .009), or with a low PI (OR = 1.29, CI = 1.08–1.54, p = .005). There were no associations identified between attention difficulties and any foetal growth indices in boys. Conclusions Our results show that girls with impaired foetal growth may be particularly at risk of attention difficulties in childhood. This is consistent with emerging research that female foetuses may be more vulnerable to certain suboptimal intrauterine environments, inducing epigenetic changes that lead to disturbed growth and long-term developmental impairment. En ligne : http://dx.doi.org/10.1111/jcpp.12422 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273

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