Commentary: Substance use and the brain: it is not straightforward to differentiate cause from consequence - a commentary on Kim-Spoon et al. (2020) / Sylia WILSON in Journal of Child Psychology and Psychiatry, 62-4 (April 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-4 (April 2021) . - p.437-440 Titre : Commentary: Substance use and the brain: it is not straightforward to differentiate cause from consequence - a commentary on Kim-Spoon et al. (2020) Type de document : Texte imprimé et/ou numérique Auteurs : Sylia WILSON, Auteur Article en page(s) : p.437-440 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : That substance abuse is associated with differences in brain structure and function, and related neurocognitive impairment is undisputed. Causally informative study designs, such as the prospective, longitudinal study leveraged by Kim-Spoon et al. (2020), as well as twin and family studies, are necessary for answering vexing but critical questions about substance use and the developing brain. Investigations that seek to differentiate cause from consequence and identify the factors that initiate the cycle of addiction have the potential to transform our understanding of the development of substance use and abuse, prompt revisions to current models of addiction, guide the most strategic preventive-intervention efforts, and ultimately improve the lives of millions of affected individuals and their families. En ligne : http://dx.doi.org/10.1111/jcpp.13311 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445 [article] Commentary: Substance use and the brain: it is not straightforward to differentiate cause from consequence - a commentary on Kim-Spoon et al. (2020) [Texte imprimé et/ou numérique] / Sylia WILSON, Auteur . - p.437-440. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-4 (April 2021) . - p.437-440 Index. décimale : PER Périodiques Résumé : That substance abuse is associated with differences in brain structure and function, and related neurocognitive impairment is undisputed. Causally informative study designs, such as the prospective, longitudinal study leveraged by Kim-Spoon et al. (2020), as well as twin and family studies, are necessary for answering vexing but critical questions about substance use and the developing brain. Investigations that seek to differentiate cause from consequence and identify the factors that initiate the cycle of addiction have the potential to transform our understanding of the development of substance use and abuse, prompt revisions to current models of addiction, guide the most strategic preventive-intervention efforts, and ultimately improve the lives of millions of affected individuals and their families. En ligne : http://dx.doi.org/10.1111/jcpp.13311 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445

Internalizing–externalizing comorbidity and regional brain volumes in the ABCD study / Elana SCHETTINI in Development and Psychopathology, 33-5 (December 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-5 (December 2021) . - p.1620-1633 Titre : Internalizing–externalizing comorbidity and regional brain volumes in the ABCD study Type de document : Texte imprimé et/ou numérique Auteurs : Elana SCHETTINI, Auteur ; Sylia WILSON, Auteur ; Theodore P. BEAUCHAINE, Auteur Article en page(s) : p.1620-1633 Langues : Anglais (eng) Mots-clés : amygdala  anterior cingulate  RDoC  heterotypic comorbidity  striatum Index. décimale : PER Périodiques Résumé : Despite nonoverlapping diagnostic criteria, internalizing and externalizing disorders show substantial comorbidity. This comorbidity is attributable, at least in part, to transdiagnostic neuroaffective mechanisms. Both unipolar depression and externalizing disorders are characterized by structural and functional compromises in the striatum and its projections to the anterior cingulate cortex (ACC) and other frontal regions. Smaller volumes and dampened reward responding in these regions are associated with anhedonia and irritability – mood states that cut across the internalizing and externalizing spectra. In contrast, smaller amygdala volumes and dampened amygdala function differentiate externalizing disorders from internalizing disorders. Little is known, however, about associations between internalizing–externalizing comorbidity and brain volumes in these regions, or whether such patterns differ by sex. Using a transdiagnostic, research domain criteria (RDoC)-informed approach, we evaluate associations between heterotypic (Internalizing × Externalizing) symptom interactions and striatal, amygdalar, and ACC volumes among participants in the Adolescent Brain Cognitive Development study (N = 6,971, mean age 9.9 years, 51.6% female). Heterotypic symptoms were associated with ACC volumes for both sexes, over and above the main effects of internalizing and externalizing alone. However, heterotypic comorbidity was associated with larger ACC volumes for girls, but with smaller ACC volumes for boys. These findings suggest a need for further studies and transdiagnostic assessment by sex. En ligne : http://dx.doi.org/10.1017/S0954579421000560 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] Internalizing–externalizing comorbidity and regional brain volumes in the ABCD study [Texte imprimé et/ou numérique] / Elana SCHETTINI, Auteur ; Sylia WILSON, Auteur ; Theodore P. BEAUCHAINE, Auteur . - p.1620-1633. Langues : Anglais (eng) in Development and Psychopathology > 33-5 (December 2021) . - p.1620-1633 Mots-clés : amygdala  anterior cingulate  RDoC  heterotypic comorbidity  striatum Index. décimale : PER Périodiques Résumé : Despite nonoverlapping diagnostic criteria, internalizing and externalizing disorders show substantial comorbidity. This comorbidity is attributable, at least in part, to transdiagnostic neuroaffective mechanisms. Both unipolar depression and externalizing disorders are characterized by structural and functional compromises in the striatum and its projections to the anterior cingulate cortex (ACC) and other frontal regions. Smaller volumes and dampened reward responding in these regions are associated with anhedonia and irritability – mood states that cut across the internalizing and externalizing spectra. In contrast, smaller amygdala volumes and dampened amygdala function differentiate externalizing disorders from internalizing disorders. Little is known, however, about associations between internalizing–externalizing comorbidity and brain volumes in these regions, or whether such patterns differ by sex. Using a transdiagnostic, research domain criteria (RDoC)-informed approach, we evaluate associations between heterotypic (Internalizing × Externalizing) symptom interactions and striatal, amygdalar, and ACC volumes among participants in the Adolescent Brain Cognitive Development study (N = 6,971, mean age 9.9 years, 51.6% female). Heterotypic symptoms were associated with ACC volumes for both sexes, over and above the main effects of internalizing and externalizing alone. However, heterotypic comorbidity was associated with larger ACC volumes for girls, but with smaller ACC volumes for boys. These findings suggest a need for further studies and transdiagnostic assessment by sex. En ligne : http://dx.doi.org/10.1017/S0954579421000560 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

Premorbid risk factors for major depressive disorder: Are they associated with early onset and recurrent course? / Sylia WILSON in Development and Psychopathology, 26-4 (Part 2) (November 2014)  

Public ISBD [article]  inDevelopment and Psychopathology > 26-4 (Part 2) (November 2014) . - p.1477-1493 Titre : Premorbid risk factors for major depressive disorder: Are they associated with early onset and recurrent course? Type de document : Texte imprimé et/ou numérique Auteurs : Sylia WILSON, Auteur ; Uma VAIDYANATHAN, Auteur ; Michael B. MILLER, Auteur ; Matt MCGUE, Auteur ; William G. IACONO, Auteur Année de publication : 2014 Article en page(s) : p.1477-1493 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Premorbid risk for major depressive disorder (MDD) and predictors of an earlier onset and recurrent course were examined in two studies in a large, community-based sample of parents and offspring, prospectively assessed from late childhood into adulthood. In Study 1 (N = 2,764 offspring and their parents), parental psychiatric status, offspring personality at age 11, and age 11 offspring internalizing and externalizing symptoms predicted the subsequent development of MDD, as did poor quality parent–child relationships, poor academic functioning, early pubertal development, and childhood maltreatment by age 11. Parental MDD and adult antisocial behavior, offspring negative emotionality and disconstraint, externalizing symptoms, and childhood maltreatment predicted an earlier onset of MDD, after accounting for course; lower positive emotionality, trait anxiety, and childhood maltreatment predicted recurrent MDD, after accounting for age of onset. In Study 2 (N = 7,146), we examined molecular genetic risk for MDD by extending recent reports of associations with glutamatergic system genes. We failed to confirm associations with MDD using either individual single nucleotide polymorphism based tests or gene-based analyses. Overall, results speak to the pervasiveness of risk for MDD, as well as specific risk for early onset MDD; risk for recurrent MDD appears to be largely a function of its often earlier onset. En ligne : http://dx.doi.org/10.1017/S0954579414001151 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=245 [article] Premorbid risk factors for major depressive disorder: Are they associated with early onset and recurrent course? [Texte imprimé et/ou numérique] / Sylia WILSON, Auteur ; Uma VAIDYANATHAN, Auteur ; Michael B. MILLER, Auteur ; Matt MCGUE, Auteur ; William G. IACONO, Auteur . - 2014 . - p.1477-1493. Langues : Anglais (eng) in Development and Psychopathology > 26-4 (Part 2) (November 2014) . - p.1477-1493 Index. décimale : PER Périodiques Résumé : Premorbid risk for major depressive disorder (MDD) and predictors of an earlier onset and recurrent course were examined in two studies in a large, community-based sample of parents and offspring, prospectively assessed from late childhood into adulthood. In Study 1 (N = 2,764 offspring and their parents), parental psychiatric status, offspring personality at age 11, and age 11 offspring internalizing and externalizing symptoms predicted the subsequent development of MDD, as did poor quality parent–child relationships, poor academic functioning, early pubertal development, and childhood maltreatment by age 11. Parental MDD and adult antisocial behavior, offspring negative emotionality and disconstraint, externalizing symptoms, and childhood maltreatment predicted an earlier onset of MDD, after accounting for course; lower positive emotionality, trait anxiety, and childhood maltreatment predicted recurrent MDD, after accounting for age of onset. In Study 2 (N = 7,146), we examined molecular genetic risk for MDD by extending recent reports of associations with glutamatergic system genes. We failed to confirm associations with MDD using either individual single nucleotide polymorphism based tests or gene-based analyses. Overall, results speak to the pervasiveness of risk for MDD, as well as specific risk for early onset MDD; risk for recurrent MDD appears to be largely a function of its often earlier onset. En ligne : http://dx.doi.org/10.1017/S0954579414001151 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=245

Pubertal timing and adolescent outcomes: investigating explanations for associations with a genetically informed design / Emily R. PADRUTT in Journal of Child Psychology and Psychiatry, 64-8 (August 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-8 (August 2023) . - p.1232-1241 Titre : Pubertal timing and adolescent outcomes: investigating explanations for associations with a genetically informed design Type de document : Texte imprimé et/ou numérique Auteurs : Emily R. PADRUTT, Auteur ; Jeremy HARPER, Auteur ; Jonathan D. SCHAEFER, Auteur ; Kayla M. NELSON, Auteur ; Matt MCGUE, Auteur ; William G. IACONO, Auteur ; Sylia WILSON, Auteur Article en page(s) : p.1232-1241 Langues : Anglais (eng) Mots-clés : Pubertal timing  substance use  risky behavior  peer problems  psychopathology Index. décimale : PER Périodiques Résumé : Background Psychopathology and risky behaviors increase during adolescence, and understanding which adolescents are most at risk informs prevention and intervention efforts. Pubertal timing relative to same-sex, same-age peers is a known correlate of adolescent outcomes among both boys and girls. However, it remains unclear whether this relation is better explained by a plausible causal process or unobserved familial liability. Methods We extended previous research by examining associations between pubertal timing in early adolescence (age 14) and outcomes in later adolescence (age 17) in a community sample of 2,510 twins (49% boys, 51% girls). Results Earlier pubertal timing was associated with more substance use, risk behavior, internalizing and externalizing problems, and peer problems in later adolescence; these effects were small, consistent with previous literature. Follow-up co-twin control analyses indicated that within-twin-pair differences in pubertal timing were not associated with within-twin-pair differences in most adolescent outcomes after accounting for shared familial liability, suggesting that earlier pubertal timing and adolescent outcomes both reflect familial risk factors. Biometric models indicated that associations between earlier pubertal timing and negative adolescent outcomes were largely attributable to shared genetic liability. Conclusions Although earlier pubertal timing was associated with negative adolescent outcomes, our results suggests that these associations did not appear to be caused by earlier pubertal timing but were likely caused by shared genetic influences. En ligne : https://doi.org/10.1111/jcpp.13808 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 [article] Pubertal timing and adolescent outcomes: investigating explanations for associations with a genetically informed design [Texte imprimé et/ou numérique] / Emily R. PADRUTT, Auteur ; Jeremy HARPER, Auteur ; Jonathan D. SCHAEFER, Auteur ; Kayla M. NELSON, Auteur ; Matt MCGUE, Auteur ; William G. IACONO, Auteur ; Sylia WILSON, Auteur . - p.1232-1241. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-8 (August 2023) . - p.1232-1241 Mots-clés : Pubertal timing  substance use  risky behavior  peer problems  psychopathology Index. décimale : PER Périodiques Résumé : Background Psychopathology and risky behaviors increase during adolescence, and understanding which adolescents are most at risk informs prevention and intervention efforts. Pubertal timing relative to same-sex, same-age peers is a known correlate of adolescent outcomes among both boys and girls. However, it remains unclear whether this relation is better explained by a plausible causal process or unobserved familial liability. Methods We extended previous research by examining associations between pubertal timing in early adolescence (age 14) and outcomes in later adolescence (age 17) in a community sample of 2,510 twins (49% boys, 51% girls). Results Earlier pubertal timing was associated with more substance use, risk behavior, internalizing and externalizing problems, and peer problems in later adolescence; these effects were small, consistent with previous literature. Follow-up co-twin control analyses indicated that within-twin-pair differences in pubertal timing were not associated with within-twin-pair differences in most adolescent outcomes after accounting for shared familial liability, suggesting that earlier pubertal timing and adolescent outcomes both reflect familial risk factors. Biometric models indicated that associations between earlier pubertal timing and negative adolescent outcomes were largely attributable to shared genetic liability. Conclusions Although earlier pubertal timing was associated with negative adolescent outcomes, our results suggests that these associations did not appear to be caused by earlier pubertal timing but were likely caused by shared genetic influences. En ligne : https://doi.org/10.1111/jcpp.13808 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508

Shifting goalposts: widening discrepancies between girls' actual and ideal bodies predict disordered eating from preadolescence to adulthood / Chantelle A. MAGEL in Development and Psychopathology, 37-2 (May 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-2 (May 2025) . - p.1054-1067 Titre : Shifting goalposts: widening discrepancies between girls' actual and ideal bodies predict disordered eating from preadolescence to adulthood Type de document : Texte imprimé et/ou numérique Auteurs : Chantelle A. MAGEL, Auteur ; Emilie LACROIX, Auteur ; Sylia WILSON, Auteur ; William G. IACONO, Auteur ; Kristin M. VON RANSON, Auteur Article en page(s) : p.1054-1067 Langues : Anglais (eng) Mots-clés : body image  body size perception  development  disordered eating  females Index. décimale : PER Périodiques Résumé : Background:Little is known regarding how disordered eating (DE) relates to perceived actual body size, ideal body size, and their discrepancy. This study examined changes in perceived actual body size, ideal body size, and actual-ideal discrepancies over time, and their relationship with subsequent DE.Methods:Participants were 759 female twins from the Minnesota Twin Family Study who reported on body image and DE every three to five years between approximately ages 11 to 29. We used multilevel modeling to examine developmental trajectories of body mass index (BMI) and Body Rating Scale Actual, Ideal, and Actual-Ideal discrepancy scores and compared the degree to which BMI, BRS body size perceptions, and body dissatisfaction predicted DE behaviors and attitudes over time. Participants were treated as singletons in analyses.Results:Perceived Actual body sizes and BMIs increased from age 10 to 33, whereas Ideal body sizes remained largely stable across time, resulting in growing Actual-Ideal discrepancies. Body size perceptions and Actual-Ideal discrepancies predicted subsequent DE behaviors and attitudes more strongly than did body dissatisfaction as measured by self-report questionnaires.Conclusions:This research advances understanding of how female body size perceptions and ideals change across development and highlights their relationship with subsequent DE. En ligne : https://dx.doi.org/10.1017/S0954579424000907 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=552 [article] Shifting goalposts: widening discrepancies between girls' actual and ideal bodies predict disordered eating from preadolescence to adulthood [Texte imprimé et/ou numérique] / Chantelle A. MAGEL, Auteur ; Emilie LACROIX, Auteur ; Sylia WILSON, Auteur ; William G. IACONO, Auteur ; Kristin M. VON RANSON, Auteur . - p.1054-1067. Langues : Anglais (eng) in Development and Psychopathology > 37-2 (May 2025) . - p.1054-1067 Mots-clés : body image  body size perception  development  disordered eating  females Index. décimale : PER Périodiques Résumé : Background:Little is known regarding how disordered eating (DE) relates to perceived actual body size, ideal body size, and their discrepancy. This study examined changes in perceived actual body size, ideal body size, and actual-ideal discrepancies over time, and their relationship with subsequent DE.Methods:Participants were 759 female twins from the Minnesota Twin Family Study who reported on body image and DE every three to five years between approximately ages 11 to 29. We used multilevel modeling to examine developmental trajectories of body mass index (BMI) and Body Rating Scale Actual, Ideal, and Actual-Ideal discrepancy scores and compared the degree to which BMI, BRS body size perceptions, and body dissatisfaction predicted DE behaviors and attitudes over time. Participants were treated as singletons in analyses.Results:Perceived Actual body sizes and BMIs increased from age 10 to 33, whereas Ideal body sizes remained largely stable across time, resulting in growing Actual-Ideal discrepancies. Body size perceptions and Actual-Ideal discrepancies predicted subsequent DE behaviors and attitudes more strongly than did body dissatisfaction as measured by self-report questionnaires.Conclusions:This research advances understanding of how female body size perceptions and ideals change across development and highlights their relationship with subsequent DE. En ligne : https://dx.doi.org/10.1017/S0954579424000907 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=552

Special Issue editorial: Leveraging genetically informative study designs to understand the development and familial transmission of psychopathology / Sylia WILSON in Development and Psychopathology, 34-5 (December 2022)  

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Trait neuroticism and emotion neurocircuitry: Functional magnetic resonance imaging evidence for a failure in emotion regulation / Merav H. SILVERMAN in Development and Psychopathology, 31-3 (August 2019)  

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