Characteristics of the autism spectrum disorder gastrointestinal and related behaviors inventory in children / Calliope HOLINGUE in Autism Research, 15-6 (June 2022)  

Public ISBD [article]  inAutism Research > 15-6 (June 2022) . - p.1142-1155 Titre : Characteristics of the autism spectrum disorder gastrointestinal and related behaviors inventory in children Type de document : texte imprimé Auteurs : Calliope HOLINGUE, Auteur ; Luther G. KALB, Auteur ; Rashelle J. MUSCI, Auteur ; Colleen LUKENS, Auteur ; Li-Ching LEE, Auteur ; Jamie KACZANIUK, Auteur ; Michelle LANDRUM, Auteur ; Timothy M. BUIE, Auteur ; M. Daniele FALLIN, Auteur Article en page(s) : p.1142-1155 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/complications/diagnosis/epidemiology  Child  Constipation/diagnosis/epidemiology  Gastrointestinal Diseases/diagnosis/epidemiology  Humans  Prevalence  Psychometrics  autism  co-morbid conditions  questionnaire Index. décimale : PER Périodiques Résumé : Gastrointestinal (GI) symptoms are one of the prevalent co-occurring issues in autism spectrum disorder (ASD), though the range of symptom frequency estimates varies dramatically across studies, which can limit the further research of GI issues in ASD as well as potential treatment strategies. The wide range of prevalence estimates is partly due to the lack of standardized, validated measures of GI symptoms among people with ASD. The goal of this study was to (1) develop a measure, which included non-verbal and mealtime behaviors, to assess for GI symptoms and (2) evaluate its psychometric characteristics. This was accomplished by drawing on two existing tools, Autism Treatment Network Gastrointestinal Inventory and the Brief Autism Mealtime Behavior Inventory, and deriving new items, to create the "ASD Gastrointestinal and Related Behaviors Inventory" (ASD-GIRBI). The ASD-GIRBI was piloted in an online registry of families with a child with ASD. A psychometric analysis was carried out in a sample of 334 children aged 6-17 years with ASD, resulting in a 36-item tool. The Cronbach's alpha for the overall scale was 0.88. Exploratory factor analysis identified a seven-factor model (1. Bowel movement pain; 2. Aggressive or disruptive during mealtimes; 3. Particular with foods; 4. Abdominal pain and upset stomach; 5. Refusing food; 6. Constipation and encopresis; 7. Motor or other behaviors). Following validation in an independent sample with clinical evaluation of GI symptoms, this tool will be helpful for both research and clinical purposes. En ligne : http://dx.doi.org/10.1002/aur.2707 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 [article] Characteristics of the autism spectrum disorder gastrointestinal and related behaviors inventory in children [texte imprimé] / Calliope HOLINGUE, Auteur ; Luther G. KALB, Auteur ; Rashelle J. MUSCI, Auteur ; Colleen LUKENS, Auteur ; Li-Ching LEE, Auteur ; Jamie KACZANIUK, Auteur ; Michelle LANDRUM, Auteur ; Timothy M. BUIE, Auteur ; M. Daniele FALLIN, Auteur . - p.1142-1155. Langues : Anglais (eng) in Autism Research > 15-6 (June 2022) . - p.1142-1155 Mots-clés : Autism Spectrum Disorder/complications/diagnosis/epidemiology  Child  Constipation/diagnosis/epidemiology  Gastrointestinal Diseases/diagnosis/epidemiology  Humans  Prevalence  Psychometrics  autism  co-morbid conditions  questionnaire Index. décimale : PER Périodiques Résumé : Gastrointestinal (GI) symptoms are one of the prevalent co-occurring issues in autism spectrum disorder (ASD), though the range of symptom frequency estimates varies dramatically across studies, which can limit the further research of GI issues in ASD as well as potential treatment strategies. The wide range of prevalence estimates is partly due to the lack of standardized, validated measures of GI symptoms among people with ASD. The goal of this study was to (1) develop a measure, which included non-verbal and mealtime behaviors, to assess for GI symptoms and (2) evaluate its psychometric characteristics. This was accomplished by drawing on two existing tools, Autism Treatment Network Gastrointestinal Inventory and the Brief Autism Mealtime Behavior Inventory, and deriving new items, to create the "ASD Gastrointestinal and Related Behaviors Inventory" (ASD-GIRBI). The ASD-GIRBI was piloted in an online registry of families with a child with ASD. A psychometric analysis was carried out in a sample of 334 children aged 6-17 years with ASD, resulting in a 36-item tool. The Cronbach's alpha for the overall scale was 0.88. Exploratory factor analysis identified a seven-factor model (1. Bowel movement pain; 2. Aggressive or disruptive during mealtimes; 3. Particular with foods; 4. Abdominal pain and upset stomach; 5. Refusing food; 6. Constipation and encopresis; 7. Motor or other behaviors). Following validation in an independent sample with clinical evaluation of GI symptoms, this tool will be helpful for both research and clinical purposes. En ligne : http://dx.doi.org/10.1002/aur.2707 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476

How do collective student behavior and other classroom contextual factors relate to teachers' implementation of an evidence-based intervention? A multilevel structural equation model / Rashelle J. MUSCI in Development and Psychopathology, 31-5 (December 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-5 (December 2019) . - p.1827-1835 Titre : How do collective student behavior and other classroom contextual factors relate to teachers' implementation of an evidence-based intervention? A multilevel structural equation model Type de document : texte imprimé Auteurs : Rashelle J. MUSCI, Auteur ; Elise T. PAS, Auteur ; Amie F. BETTENCOURT, Auteur ; Katherine E. MASYN, Auteur ; Nicholas S. IALONGO, Auteur ; Catherine P. BRADSHAW, Auteur Année de publication : 2019 Article en page(s) : p.1827-1835 Langues : Anglais (eng) Mots-clés : aggression  multilevel  structural equation modeling Index. décimale : PER Périodiques Résumé : Building on prior work regarding the potential for peer contagion or deviance training in group delivered interventions (Dishion & Dodge, 2005, 2006; Dodge, Dishion, & Lansford, 2006), we leveraged data from a randomized trial, testing the integration of two preventive interventions (Promoting Alternative THinking Strategies and PAX Good Behavior Game), to explore the extent to which classroom contextual factors served as either a barrier to or a motivator for teachers to implement the evidence-based PAX Good Behavior Game with high frequency or dosage. We included students' baseline levels of behavior, measured with regard to both positive (i.e., engagement and social emotional skills) and negative (i.e., hyperactive and aggressive-disruptive) behaviors. Data were collected from 204 teachers in 18 urban elementary schools. A series of multilevel structural equation models were fit to the data. The analyses indicated that classrooms with higher classroom levels of aggressive behavior, on average, at baseline had teachers with lower implementation dosage (i.e., played fewer games) across the school year. In addition, teachers who reported higher baseline levels of emotional exhaustion, regardless of student behavior, also reported lower implementation dosage. Taken together, the results indicated that negative, but not positive, contextual factors at baseline were related to lower implementation dosage; this, in turn, suggests that negative contextual factors may serve as a barrier, rather than a motivator, of teachers' implementation dosage of classroom-based preventive interventions. En ligne : http://dx.doi.org/10.1017/s095457941900097x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=412 [article] How do collective student behavior and other classroom contextual factors relate to teachers' implementation of an evidence-based intervention? A multilevel structural equation model [texte imprimé] / Rashelle J. MUSCI, Auteur ; Elise T. PAS, Auteur ; Amie F. BETTENCOURT, Auteur ; Katherine E. MASYN, Auteur ; Nicholas S. IALONGO, Auteur ; Catherine P. BRADSHAW, Auteur . - 2019 . - p.1827-1835. Langues : Anglais (eng) in Development and Psychopathology > 31-5 (December 2019) . - p.1827-1835 Mots-clés : aggression  multilevel  structural equation modeling Index. décimale : PER Périodiques Résumé : Building on prior work regarding the potential for peer contagion or deviance training in group delivered interventions (Dishion & Dodge, 2005, 2006; Dodge, Dishion, & Lansford, 2006), we leveraged data from a randomized trial, testing the integration of two preventive interventions (Promoting Alternative THinking Strategies and PAX Good Behavior Game), to explore the extent to which classroom contextual factors served as either a barrier to or a motivator for teachers to implement the evidence-based PAX Good Behavior Game with high frequency or dosage. We included students' baseline levels of behavior, measured with regard to both positive (i.e., engagement and social emotional skills) and negative (i.e., hyperactive and aggressive-disruptive) behaviors. Data were collected from 204 teachers in 18 urban elementary schools. A series of multilevel structural equation models were fit to the data. The analyses indicated that classrooms with higher classroom levels of aggressive behavior, on average, at baseline had teachers with lower implementation dosage (i.e., played fewer games) across the school year. In addition, teachers who reported higher baseline levels of emotional exhaustion, regardless of student behavior, also reported lower implementation dosage. Taken together, the results indicated that negative, but not positive, contextual factors at baseline were related to lower implementation dosage; this, in turn, suggests that negative contextual factors may serve as a barrier, rather than a motivator, of teachers' implementation dosage of classroom-based preventive interventions. En ligne : http://dx.doi.org/10.1017/s095457941900097x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=412

Impulsivity profiles across five harmonized longitudinal childhood preventive interventions and associations with adult outcomes / Natalie GOULTER in Development and Psychopathology, 37-2 (May 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-2 (May 2025) . - p.990-1003 Titre : Impulsivity profiles across five harmonized longitudinal childhood preventive interventions and associations with adult outcomes Type de document : texte imprimé Auteurs : Natalie GOULTER, Auteur ; Masoumeh AMIN-ESMAEILI, Auteur ; Ryoko SUSUKIDA, Auteur ; Joseph M. KUSH, Auteur ; Jennifer GODWIN, Auteur ; Katherine E. MASYN, Auteur ; Robert J. MCMAHON, Auteur ; J. Mark EDDY, Auteur ; Nicholas S. IALONGO, Auteur ; Patrick H. TOLAN, Auteur ; Holly C. WILCOX, Auteur ; Rashelle J. MUSCI, Auteur Article en page(s) : p.990-1003 Langues : Anglais (eng) Mots-clés : Adolescence  adulthood  childhood  impulsivity  preventive interventions  psychopathology Index. décimale : PER Périodiques Résumé : This study aimed to parse between-person heterogeneity in growth of impulsivity across childhood and adolescence among participants enrolled in five childhood preventive intervention trials targeting conduct problems. In addition, we aimed to test profile membership in relation to adult psychopathologies. Measurement items representing impulsive behavior across grades 2, 4, 5, 7, 8, and 10, and aggression, substance use, suicidal ideation/attempts, and anxiety/depression in adulthood were integrated from the five trials (N = 4,975). We applied latent class growth analysis to this sample, as well as samples separated into nonintervention (n = 2,492) and intervention (n = 2,483) participants. Across all samples, profiles were characterized by high, moderate, low, and low-increasing impulsive levels. Regarding adult outcomes, in all samples, the high, moderate, and low profiles endorsed greater levels of aggression compared to the low-increasing profile. There were nuanced differences across samples and profiles on suicidal ideation/attempts and anxiety/depression. Across samples, there were no significant differences between profiles on substance use. Overall, our study helps to inform understanding of the developmental course and prognosis of impulsivity, as well as adding to collaborative efforts linking data across multiple studies to better inform understanding of developmental processes. En ligne : https://dx.doi.org/10.1017/S0954579424000828 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=552 [article] Impulsivity profiles across five harmonized longitudinal childhood preventive interventions and associations with adult outcomes [texte imprimé] / Natalie GOULTER, Auteur ; Masoumeh AMIN-ESMAEILI, Auteur ; Ryoko SUSUKIDA, Auteur ; Joseph M. KUSH, Auteur ; Jennifer GODWIN, Auteur ; Katherine E. MASYN, Auteur ; Robert J. MCMAHON, Auteur ; J. Mark EDDY, Auteur ; Nicholas S. IALONGO, Auteur ; Patrick H. TOLAN, Auteur ; Holly C. WILCOX, Auteur ; Rashelle J. MUSCI, Auteur . - p.990-1003. Langues : Anglais (eng) in Development and Psychopathology > 37-2 (May 2025) . - p.990-1003 Mots-clés : Adolescence  adulthood  childhood  impulsivity  preventive interventions  psychopathology Index. décimale : PER Périodiques Résumé : This study aimed to parse between-person heterogeneity in growth of impulsivity across childhood and adolescence among participants enrolled in five childhood preventive intervention trials targeting conduct problems. In addition, we aimed to test profile membership in relation to adult psychopathologies. Measurement items representing impulsive behavior across grades 2, 4, 5, 7, 8, and 10, and aggression, substance use, suicidal ideation/attempts, and anxiety/depression in adulthood were integrated from the five trials (N = 4,975). We applied latent class growth analysis to this sample, as well as samples separated into nonintervention (n = 2,492) and intervention (n = 2,483) participants. Across all samples, profiles were characterized by high, moderate, low, and low-increasing impulsive levels. Regarding adult outcomes, in all samples, the high, moderate, and low profiles endorsed greater levels of aggression compared to the low-increasing profile. There were nuanced differences across samples and profiles on suicidal ideation/attempts and anxiety/depression. Across samples, there were no significant differences between profiles on substance use. Overall, our study helps to inform understanding of the developmental course and prognosis of impulsivity, as well as adding to collaborative efforts linking data across multiple studies to better inform understanding of developmental processes. En ligne : https://dx.doi.org/10.1017/S0954579424000828 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=552

A latent class approach to understanding patterns of emotional and behavioral problems among early adolescents across four low- and middle-income countries / Robert W. BLUM ; Judith K. BASS ; Aimée M. LULEBO ; Anggriyani W. PINANDARI ; William STONES ; Siswanto A. WILOPO ; Xiayun ZUO ; Rashelle J. MUSCI in Development and Psychopathology, 35-4 (October 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-4 (October 2023) . - p.1684-1700 Titre : A latent class approach to understanding patterns of emotional and behavioral problems among early adolescents across four low- and middle-income countries Type de document : texte imprimé Auteurs : Robert W. BLUM, Auteur ; Judith K. BASS, Auteur ; Aimée M. LULEBO, Auteur ; Anggriyani W. PINANDARI, Auteur ; William STONES, Auteur ; Siswanto A. WILOPO, Auteur ; Xiayun ZUO, Auteur ; Rashelle J. MUSCI, Auteur Article en page(s) : p.1684-1700 Langues : Anglais (eng) Mots-clés : behavioral problems  early adolescents  emotional problems  latent class analysis  low- and middle-income countries  psychosocial development Index. décimale : PER Périodiques Résumé : Early adolescents (ages 10-14) living in low- and middle-income countries have heightened vulnerability to psychosocial risks, but available evidence from these settings is limited. This study used data from the Global Early Adolescent Study to characterize prototypical patterns of emotional and behavioral problems among 10,437 early adolescents (51% female) living in the Democratic Republic of Congo (DRC), Malawi, Indonesia, and China, and explore the extent to which these patterns varied by country and sex. LCA was used to identify and classify patterns of emotional and behavioral problems separately by country. Within each country, measurement invariance by sex was evaluated. LCA supported a four-class solution in DRC, Malawi, and Indonesia, and a three-class solution in China. Across countries, early adolescents fell into the following subgroups: Well-Adjusted (40-62%), Emotional Problems (14-29%), Behavioral Problems (15-22%; not present in China), and Maladjusted (4-15%). Despite the consistency of these patterns, there were notable contextual differences. Further, tests of measurement invariance indicated that the prevalence and nature of these classes differed by sex. Findings can be used to support the tailoring of interventions targeting psychosocial adjustment, and suggest that such programs may have utility across diverse cross-national settings. En ligne : https://dx.doi.org/10.1017/S0954579422000384 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=515 [article] A latent class approach to understanding patterns of emotional and behavioral problems among early adolescents across four low- and middle-income countries [texte imprimé] / Robert W. BLUM, Auteur ; Judith K. BASS, Auteur ; Aimée M. LULEBO, Auteur ; Anggriyani W. PINANDARI, Auteur ; William STONES, Auteur ; Siswanto A. WILOPO, Auteur ; Xiayun ZUO, Auteur ; Rashelle J. MUSCI, Auteur . - p.1684-1700. Langues : Anglais (eng) in Development and Psychopathology > 35-4 (October 2023) . - p.1684-1700 Mots-clés : behavioral problems  early adolescents  emotional problems  latent class analysis  low- and middle-income countries  psychosocial development Index. décimale : PER Périodiques Résumé : Early adolescents (ages 10-14) living in low- and middle-income countries have heightened vulnerability to psychosocial risks, but available evidence from these settings is limited. This study used data from the Global Early Adolescent Study to characterize prototypical patterns of emotional and behavioral problems among 10,437 early adolescents (51% female) living in the Democratic Republic of Congo (DRC), Malawi, Indonesia, and China, and explore the extent to which these patterns varied by country and sex. LCA was used to identify and classify patterns of emotional and behavioral problems separately by country. Within each country, measurement invariance by sex was evaluated. LCA supported a four-class solution in DRC, Malawi, and Indonesia, and a three-class solution in China. Across countries, early adolescents fell into the following subgroups: Well-Adjusted (40-62%), Emotional Problems (14-29%), Behavioral Problems (15-22%; not present in China), and Maladjusted (4-15%). Despite the consistency of these patterns, there were notable contextual differences. Further, tests of measurement invariance indicated that the prevalence and nature of these classes differed by sex. Findings can be used to support the tailoring of interventions targeting psychosocial adjustment, and suggest that such programs may have utility across diverse cross-national settings. En ligne : https://dx.doi.org/10.1017/S0954579422000384 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=515

Maternal tobacco smoking and offspring autism spectrum disorder or traits in ECHO cohorts / Irva HERTZ-PICCIOTTO in Autism Research, 15-3 (March 2022)  

Public ISBD [article]  inAutism Research > 15-3 (March 2022) . - p.551-569 Titre : Maternal tobacco smoking and offspring autism spectrum disorder or traits in ECHO cohorts Type de document : texte imprimé Auteurs : Irva HERTZ-PICCIOTTO, Auteur ; Susan A. KORRICK, Auteur ; Christine LADD-ACOSTA, Auteur ; Margaret R. KARAGAS, Auteur ; Kristen LYALL, Auteur ; Rebecca J. SCHMIDT, Auteur ; Anne L. DUNLOP, Auteur ; Lisa A. CROEN, Auteur ; Dana DABELEA, Auteur ; Julie L. DANIELS, Auteur ; Cristiane S. DUARTE, Auteur ; M. Daniele FALLIN, Auteur ; Catherine J. KARR, Auteur ; Barry M. LESTER, Auteur ; Leslie D. LEVE, Auteur ; Yijun LI, Auteur ; Monica MCGRATH, Auteur ; Xuejuan NING, Auteur ; Emily OKEN, Auteur ; Sharon K. SAGIV, Auteur ; Sheela SATHYANARAYA, Auteur ; Frances TYLAVSKY, Auteur ; Heather E. VOLK, Auteur ; Lauren S. WAKSCHLAG, Auteur ; Mingyu ZHANG, Auteur ; T. Michael O'SHEA, Auteur ; Rashelle J. MUSCI, Auteur ; program collaborators for Environmental influences on Child Health OUTCOMES, Auteur Article en page(s) : p.551-569 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Given inconsistent evidence on preconception or prenatal tobacco use and offspring autism spectrum disorder (ASD), this study assessed associations of maternal smoking with ASD and ASD-related traits. Among 72 cohorts in the Environmental Influences on Child Health Outcomes consortium, 11 had ASD diagnosis and prenatal tobaccosmoking (n = 8648). and 7 had Social Responsiveness Scale (SRS) scores of ASD traits (n = 2399). Cohorts had diagnoses alone (6), traits alone (2), or both (5). Diagnoses drew from parent/caregiver report, review of records, or standardized instruments. Regression models estimated smoking-related odds ratios (ORs) for diagnoses and standardized mean differences for SRS scores. Cohort-specific ORs were meta-analyzed. Overall, maternal smoking was unassociated with child ASD (adjusted OR, 1.08; 95% confidence interval [CI], 0.72 1.61). However, heterogeneity across studies was strong: preterm cohorts showed reduced ASD risk for exposed children. After excluding preterm cohorts (biased by restrictions on causal intermediate and exposure opportunity) and small cohorts (very few ASD cases in either smoking category), the adjusted OR for ASD from maternal smoking was 1.44 (95% CI, 1.02 2.03). Children of smoking (versus non-smoking) mothers had more ASD traits (SRS T-score+2.37 points, 95% CI, 0.73 4.01 points), with results homogeneous across cohorts. Maternal preconception/prenatal smoking was consistently associated with quantitative ASD traits and modestly associated with ASD diagnosis among sufficiently powered United States cohorts of non-preterm children. Limitations resulting from self-reported smoking and unmeasured confounders preclude definitive conclusions. Nevertheless, counseling on potential and known risks to the child from maternal smoking is warranted for pregnant women and pregnancy planners. Lay Summary Evidence on the association between maternal prenatal smoking and the child's risk for autism spectrum disorder has been conflicting, with some studies reporting harmful effects, and others finding reduced risks. Our analysis of children in the ECHO consortium found that maternal prenatal tobacco smoking is consistently associated with an increase in autism-related symptoms in the general population and modestly associated with elevated risk for a diagnosis of autism spectrum disorder when looking at a combined analysis from multiple studies that each included both pre- and full-term births. However, this study is not proof of a causal connection. Future studies to clarify the role of smoking in autism-like behaviors or autism diagnoses should collect more reliable data on smoking and measure other exposures or lifestyle factors that might have confounded our results. En ligne : https://doi.org/10.1002/aur.2665 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473 [article] Maternal tobacco smoking and offspring autism spectrum disorder or traits in ECHO cohorts [texte imprimé] / Irva HERTZ-PICCIOTTO, Auteur ; Susan A. KORRICK, Auteur ; Christine LADD-ACOSTA, Auteur ; Margaret R. KARAGAS, Auteur ; Kristen LYALL, Auteur ; Rebecca J. SCHMIDT, Auteur ; Anne L. DUNLOP, Auteur ; Lisa A. CROEN, Auteur ; Dana DABELEA, Auteur ; Julie L. DANIELS, Auteur ; Cristiane S. DUARTE, Auteur ; M. Daniele FALLIN, Auteur ; Catherine J. KARR, Auteur ; Barry M. LESTER, Auteur ; Leslie D. LEVE, Auteur ; Yijun LI, Auteur ; Monica MCGRATH, Auteur ; Xuejuan NING, Auteur ; Emily OKEN, Auteur ; Sharon K. SAGIV, Auteur ; Sheela SATHYANARAYA, Auteur ; Frances TYLAVSKY, Auteur ; Heather E. VOLK, Auteur ; Lauren S. WAKSCHLAG, Auteur ; Mingyu ZHANG, Auteur ; T. Michael O'SHEA, Auteur ; Rashelle J. MUSCI, Auteur ; program collaborators for Environmental influences on Child Health OUTCOMES, Auteur . - p.551-569. Langues : Anglais (eng) in Autism Research > 15-3 (March 2022) . - p.551-569 Index. décimale : PER Périodiques Résumé : Abstract Given inconsistent evidence on preconception or prenatal tobacco use and offspring autism spectrum disorder (ASD), this study assessed associations of maternal smoking with ASD and ASD-related traits. Among 72 cohorts in the Environmental Influences on Child Health Outcomes consortium, 11 had ASD diagnosis and prenatal tobaccosmoking (n = 8648). and 7 had Social Responsiveness Scale (SRS) scores of ASD traits (n = 2399). Cohorts had diagnoses alone (6), traits alone (2), or both (5). Diagnoses drew from parent/caregiver report, review of records, or standardized instruments. Regression models estimated smoking-related odds ratios (ORs) for diagnoses and standardized mean differences for SRS scores. Cohort-specific ORs were meta-analyzed. Overall, maternal smoking was unassociated with child ASD (adjusted OR, 1.08; 95% confidence interval [CI], 0.72 1.61). However, heterogeneity across studies was strong: preterm cohorts showed reduced ASD risk for exposed children. After excluding preterm cohorts (biased by restrictions on causal intermediate and exposure opportunity) and small cohorts (very few ASD cases in either smoking category), the adjusted OR for ASD from maternal smoking was 1.44 (95% CI, 1.02 2.03). Children of smoking (versus non-smoking) mothers had more ASD traits (SRS T-score+2.37 points, 95% CI, 0.73 4.01 points), with results homogeneous across cohorts. Maternal preconception/prenatal smoking was consistently associated with quantitative ASD traits and modestly associated with ASD diagnosis among sufficiently powered United States cohorts of non-preterm children. Limitations resulting from self-reported smoking and unmeasured confounders preclude definitive conclusions. Nevertheless, counseling on potential and known risks to the child from maternal smoking is warranted for pregnant women and pregnancy planners. Lay Summary Evidence on the association between maternal prenatal smoking and the child's risk for autism spectrum disorder has been conflicting, with some studies reporting harmful effects, and others finding reduced risks. Our analysis of children in the ECHO consortium found that maternal prenatal tobacco smoking is consistently associated with an increase in autism-related symptoms in the general population and modestly associated with elevated risk for a diagnosis of autism spectrum disorder when looking at a combined analysis from multiple studies that each included both pre- and full-term births. However, this study is not proof of a causal connection. Future studies to clarify the role of smoking in autism-like behaviors or autism diagnoses should collect more reliable data on smoking and measure other exposures or lifestyle factors that might have confounded our results. En ligne : https://doi.org/10.1002/aur.2665 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473

Polygenic and environmental influences on the course of African Americans' alcohol use from early adolescence through young adulthood / Jill A. RABINOWITZ in Development and Psychopathology, 32-2 (May 2020)  

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Polygenic Score × Intervention Moderation: An application of discrete-time survival analysis to modeling the timing of first tobacco use among urban youth / Rashelle J. MUSCI in Development and Psychopathology, 27-1 (February 2015)  

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Self-control in first grade predicts success in the transition to adulthood / Sara B. JOHNSON in Development and Psychopathology, 35-3 (August 2023)  

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The effects of the interplay of genetics and early environmental risk on the course of internalizing symptoms from late childhood through adolescence / Rashelle J. MUSCI in Development and Psychopathology, 28-1 (February 2016)  

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Violence exposure in an urban city: A GxE interaction with aggressive and impulsive behaviors / Rashelle J. MUSCI in Journal of Child Psychology and Psychiatry, 60-1 (January 2019)  

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