Abnormal lateralization of functional connectivity between language and default mode regions in autism / Jared NIELSEN in Molecular Autism, (February 2014)  

Public ISBD [article]  inMolecular Autism > (February 2014) Titre : Abnormal lateralization of functional connectivity between language and default mode regions in autism Type de document : Texte imprimé et/ou numérique Auteurs : Jared NIELSEN, Auteur ; Brandon ZIELINSKI, Auteur ; P FLETCHER, Auteur ; Andrew A. ALEXANDER, Auteur ; Nicholas LANGE, Auteur ; Erin D. BIGLER, Auteur ; Janet E. LAINHART, Auteur ; Jeffrey S. ANDERSON, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Lateralization of brain structure and function occurs in typical development, and abnormal lateralization is present in various neuropsychiatric disorders. Autism is characterized by a lack of left lateralization in structure and function of regions involved in language, such as Broca and Wernicke areas. Using functional connectivity magnetic resonance imaging from a large publicly available sample (n=964), we tested whether abnormal functional lateralization in autism exists preferentially in language regions or in a more diffuse pattern across networks of lateralized brain regions. The autism group exhibited significantly reduced left lateralization in a few connections involving language regions and regions from the default mode network, but results were not significant throughout left- and right-lateralized networks. There is a trend that suggests the lack of left lateralization in a connection involving Wernicke area and the posterior cingulate cortex associates with more severe autism. Abnormal language lateralization in autism may be due to abnormal language development rather than to a deficit in hemispheric specialization of the entire brain. En ligne : http://dx.doi.org/10.1186/2040-2392-5-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227 [article] Abnormal lateralization of functional connectivity between language and default mode regions in autism [Texte imprimé et/ou numérique] / Jared NIELSEN, Auteur ; Brandon ZIELINSKI, Auteur ; P FLETCHER, Auteur ; Andrew A. ALEXANDER, Auteur ; Nicholas LANGE, Auteur ; Erin D. BIGLER, Auteur ; Janet E. LAINHART, Auteur ; Jeffrey S. ANDERSON, Auteur. Langues : Anglais (eng) in Molecular Autism > (February 2014) Index. décimale : PER Périodiques Résumé : Lateralization of brain structure and function occurs in typical development, and abnormal lateralization is present in various neuropsychiatric disorders. Autism is characterized by a lack of left lateralization in structure and function of regions involved in language, such as Broca and Wernicke areas. Using functional connectivity magnetic resonance imaging from a large publicly available sample (n=964), we tested whether abnormal functional lateralization in autism exists preferentially in language regions or in a more diffuse pattern across networks of lateralized brain regions. The autism group exhibited significantly reduced left lateralization in a few connections involving language regions and regions from the default mode network, but results were not significant throughout left- and right-lateralized networks. There is a trend that suggests the lack of left lateralization in a connection involving Wernicke area and the posterior cingulate cortex associates with more severe autism. Abnormal language lateralization in autism may be due to abnormal language development rather than to a deficit in hemispheric specialization of the entire brain. En ligne : http://dx.doi.org/10.1186/2040-2392-5-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227

Atypical diffusion tensor hemispheric asymmetry in autism / Nicholas LANGE in Autism Research, 3-6 (December 2010)  

Public ISBD [article]  inAutism Research > 3-6 (December 2010) . - p.350-358 Titre : Atypical diffusion tensor hemispheric asymmetry in autism Type de document : Texte imprimé et/ou numérique Auteurs : Nicholas LANGE, Auteur ; Molly B. DUBRAY, Auteur ; Jee Eun LEE, Auteur ; Michael P. FROIMOWITZ, Auteur ; Alyson L. FROEHLICH, Auteur ; Nagesh ADLURU, Auteur ; Brad WRIGHT, Auteur ; Caitlin RAVICHANDRAN, Auteur ; P. Thomas FLETCHER, Auteur ; Erin D. BIGLER, Auteur ; Andrew A. ALEXANDER, Auteur ; Janet E. LAINHART, Auteur Année de publication : 2010 Article en page(s) : p.350-358 Langues : Anglais (eng) Mots-clés : adaptive functioning  classification  diffusion tensor imaging  hemispheric asymmetry  language functioning Index. décimale : PER Périodiques Résumé : Background: Biological measurements that distinguish individuals with autism from typically developing individuals and those with other developmental and neuropsychiatric disorders must demonstrate very high performance to have clinical value as potential imaging biomarkers. We hypothesized that further study of white matter microstructure (WMM) in the superior temporal gyrus (STG) and temporal stem (TS), two brain regions in the temporal lobe containing circuitry central to language, emotion, and social cognition, would identify a useful combination of classification features and further understand autism neuropathology. Methods: WMM measurements from the STG and TS were examined from 30 high-functioning males satisfying full criteria for idiopathic autism aged 7–28 years and 30 matched controls and a replication sample of 12 males with idiopathic autism and 7 matched controls who participated in a previous case–control diffusion tensor imaging (DTI) study. Language functioning, adaptive functioning, and psychotropic medication usage were also examined. Results: In the STG, we find reversed hemispheric asymmetry of two separable measures of directional diffusion coherence, tensor skewness, and fractional anisotropy. In autism, tensor skewness is greater on the right and fractional anisotropy is decreased on the left. We also find increased diffusion parallel to white matter fibers bilaterally. In the right not left TS, we find increased omnidirectional, parallel, and perpendicular diffusion. These six multivariate measurements possess very high ability to discriminate individuals with autism from individuals without autism with 94% sensitivity, 90% specificity, and 92% accuracy in our original and replication samples. We also report a near-significant association between the classifier and a quantitative trait index of autism and significant correlations between two classifier components and measures of language, IQ, and adaptive functioning in autism. En ligne : http://dx.doi.org/10.1002/aur.162 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115 [article] Atypical diffusion tensor hemispheric asymmetry in autism [Texte imprimé et/ou numérique] / Nicholas LANGE, Auteur ; Molly B. DUBRAY, Auteur ; Jee Eun LEE, Auteur ; Michael P. FROIMOWITZ, Auteur ; Alyson L. FROEHLICH, Auteur ; Nagesh ADLURU, Auteur ; Brad WRIGHT, Auteur ; Caitlin RAVICHANDRAN, Auteur ; P. Thomas FLETCHER, Auteur ; Erin D. BIGLER, Auteur ; Andrew A. ALEXANDER, Auteur ; Janet E. LAINHART, Auteur . - 2010 . - p.350-358. Langues : Anglais (eng) in Autism Research > 3-6 (December 2010) . - p.350-358 Mots-clés : adaptive functioning  classification  diffusion tensor imaging  hemispheric asymmetry  language functioning Index. décimale : PER Périodiques Résumé : Background: Biological measurements that distinguish individuals with autism from typically developing individuals and those with other developmental and neuropsychiatric disorders must demonstrate very high performance to have clinical value as potential imaging biomarkers. We hypothesized that further study of white matter microstructure (WMM) in the superior temporal gyrus (STG) and temporal stem (TS), two brain regions in the temporal lobe containing circuitry central to language, emotion, and social cognition, would identify a useful combination of classification features and further understand autism neuropathology. Methods: WMM measurements from the STG and TS were examined from 30 high-functioning males satisfying full criteria for idiopathic autism aged 7–28 years and 30 matched controls and a replication sample of 12 males with idiopathic autism and 7 matched controls who participated in a previous case–control diffusion tensor imaging (DTI) study. Language functioning, adaptive functioning, and psychotropic medication usage were also examined. Results: In the STG, we find reversed hemispheric asymmetry of two separable measures of directional diffusion coherence, tensor skewness, and fractional anisotropy. In autism, tensor skewness is greater on the right and fractional anisotropy is decreased on the left. We also find increased diffusion parallel to white matter fibers bilaterally. In the right not left TS, we find increased omnidirectional, parallel, and perpendicular diffusion. These six multivariate measurements possess very high ability to discriminate individuals with autism from individuals without autism with 94% sensitivity, 90% specificity, and 92% accuracy in our original and replication samples. We also report a near-significant association between the classifier and a quantitative trait index of autism and significant correlations between two classifier components and measures of language, IQ, and adaptive functioning in autism. En ligne : http://dx.doi.org/10.1002/aur.162 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115

Corpus callosum area in children and adults with autism / Molly B. D. PRIGGE in Research in Autism Spectrum Disorders, 7-2 (February 2013)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 7-2 (February 2013) . - p.221-234 Titre : Corpus callosum area in children and adults with autism Type de document : Texte imprimé et/ou numérique Auteurs : Molly B. D. PRIGGE, Auteur ; Nicholas LANGE, Auteur ; Erin D. BIGLER, Auteur ; Tricia L. MERKLEY, Auteur ; E. Shannon NEELEY, Auteur ; Tracy J. ABILDSKOV, Auteur ; Alyson L. FROEHLICH, Auteur ; Jared A. NIELSEN, Auteur ; Jason R. COOPERRIDER, Auteur ; Annahir N. CARIELLO, Auteur ; Caitlin RAVICHANDRAN, Auteur ; Andrew A. ALEXANDER, Auteur ; Janet E. LAINHART, Auteur Année de publication : 2013 Article en page(s) : p.221-234 Langues : Anglais (eng) Mots-clés : Autism  Corpus callosum area  Development  MRI Index. décimale : PER Périodiques Résumé : Despite repeated findings of abnormal corpus callosum structure in autism, the developmental trajectories of corpus callosum growth in the disorder have not yet been reported. In this study, we examined corpus callosum size from a developmental perspective across a 30-year age range in a large cross-sectional sample of individuals with autism compared to a typically developing sample. Midsagittal corpus callosum area and the 7 Witelson subregions were examined in 68 males with autism (mean age 14.1 years; range 3'36 years) and 47 males with typical development (mean age 15.3 years; range 4'29 years). Controlling for total brain volume, increased variability in total corpus callosum area was found in autism. In autism, increased midsagittal areas were associated with reduced severity of autism behaviors, higher intelligence, and faster speed of processing (p = 0.003, p = 0.011, p = 0.013, respectively). A trend toward group differences in isthmus development was found (p = 0.029, uncorrected). These results suggest that individuals with autism benefit functionally from increased corpus callosum area. Our cross-sectional examination also shows potential maturational abnormalities in autism, a finding that should be examined further with longitudinal datasets. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.09.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=186 [article] Corpus callosum area in children and adults with autism [Texte imprimé et/ou numérique] / Molly B. D. PRIGGE, Auteur ; Nicholas LANGE, Auteur ; Erin D. BIGLER, Auteur ; Tricia L. MERKLEY, Auteur ; E. Shannon NEELEY, Auteur ; Tracy J. ABILDSKOV, Auteur ; Alyson L. FROEHLICH, Auteur ; Jared A. NIELSEN, Auteur ; Jason R. COOPERRIDER, Auteur ; Annahir N. CARIELLO, Auteur ; Caitlin RAVICHANDRAN, Auteur ; Andrew A. ALEXANDER, Auteur ; Janet E. LAINHART, Auteur . - 2013 . - p.221-234. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 7-2 (February 2013) . - p.221-234 Mots-clés : Autism  Corpus callosum area  Development  MRI Index. décimale : PER Périodiques Résumé : Despite repeated findings of abnormal corpus callosum structure in autism, the developmental trajectories of corpus callosum growth in the disorder have not yet been reported. In this study, we examined corpus callosum size from a developmental perspective across a 30-year age range in a large cross-sectional sample of individuals with autism compared to a typically developing sample. Midsagittal corpus callosum area and the 7 Witelson subregions were examined in 68 males with autism (mean age 14.1 years; range 3'36 years) and 47 males with typical development (mean age 15.3 years; range 4'29 years). Controlling for total brain volume, increased variability in total corpus callosum area was found in autism. In autism, increased midsagittal areas were associated with reduced severity of autism behaviors, higher intelligence, and faster speed of processing (p = 0.003, p = 0.011, p = 0.013, respectively). A trend toward group differences in isthmus development was found (p = 0.029, uncorrected). These results suggest that individuals with autism benefit functionally from increased corpus callosum area. Our cross-sectional examination also shows potential maturational abnormalities in autism, a finding that should be examined further with longitudinal datasets. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.09.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=186

Diffusion Tensor Imaging in Autism Spectrum Disorder: A Review / Brittany G. TRAVERS in Autism Research, 5-5 (October 2012)  

Public ISBD [article]  inAutism Research > 5-5 (October 2012) . - p.289-313 Titre : Diffusion Tensor Imaging in Autism Spectrum Disorder: A Review Type de document : Texte imprimé et/ou numérique Auteurs : Brittany G. TRAVERS, Auteur ; Nagesh ADLURU, Auteur ; Chad ENNIS, Auteur ; Do P. M. TROMP, Auteur ; Dan DESTICHE, Auteur ; Sam DORAN, Auteur ; Erin D. BIGLER, Auteur ; Nicholas LANGE, Auteur ; Janet E. LAINHART, Auteur ; Andrew A. ALEXANDER, Auteur Article en page(s) : p.289-313 Langues : Anglais (eng) Mots-clés : diffusion tensor imaging  neuroimaging  autism  white matter Index. décimale : PER Périodiques Résumé : White matter tracts of the brain allow neurons and neuronal networks to communicate and function with high efficiency. The aim of this review is to briefly introduce diffusion tensor imaging methods that examine white matter tracts and then to give an overview of the studies that have investigated white matter integrity in the brains of individuals with autism spectrum disorder (ASD). From the 48 studies we reviewed, persons with ASD tended to have decreased fractional anisotropy and increased mean diffusivity in white matter tracts spanning many regions of the brain but most consistently in regions such as the corpus callosum, cingulum, and aspects of the temporal lobe. This decrease in fractional anisotropy was often accompanied by increased radial diffusivity. Additionally, the review suggests possible atypical lateralization in some white matter tracts of the brain and a possible atypical developmental trajectory of white matter microstructure in persons with ASD. Clinical implications and future research directions are discussed. Autism Res 2012, 5: 289–313. © 2012 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1243 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=183 [article] Diffusion Tensor Imaging in Autism Spectrum Disorder: A Review [Texte imprimé et/ou numérique] / Brittany G. TRAVERS, Auteur ; Nagesh ADLURU, Auteur ; Chad ENNIS, Auteur ; Do P. M. TROMP, Auteur ; Dan DESTICHE, Auteur ; Sam DORAN, Auteur ; Erin D. BIGLER, Auteur ; Nicholas LANGE, Auteur ; Janet E. LAINHART, Auteur ; Andrew A. ALEXANDER, Auteur . - p.289-313. Langues : Anglais (eng) in Autism Research > 5-5 (October 2012) . - p.289-313 Mots-clés : diffusion tensor imaging  neuroimaging  autism  white matter Index. décimale : PER Périodiques Résumé : White matter tracts of the brain allow neurons and neuronal networks to communicate and function with high efficiency. The aim of this review is to briefly introduce diffusion tensor imaging methods that examine white matter tracts and then to give an overview of the studies that have investigated white matter integrity in the brains of individuals with autism spectrum disorder (ASD). From the 48 studies we reviewed, persons with ASD tended to have decreased fractional anisotropy and increased mean diffusivity in white matter tracts spanning many regions of the brain but most consistently in regions such as the corpus callosum, cingulum, and aspects of the temporal lobe. This decrease in fractional anisotropy was often accompanied by increased radial diffusivity. Additionally, the review suggests possible atypical lateralization in some white matter tracts of the brain and a possible atypical developmental trajectory of white matter microstructure in persons with ASD. Clinical implications and future research directions are discussed. Autism Res 2012, 5: 289–313. © 2012 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1243 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=183

Diffusion Tensor Magnetic Resonance Imaging in Autism / Brittany G. TRAVERS

Public ISBD in Imaging the Brain in Autism / Manuel F. CASANOVA Titre : Diffusion Tensor Magnetic Resonance Imaging in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Brittany G. TRAVERS, Auteur ; Andrew A. ALEXANDER, Auteur Année de publication : 2013 Importance : p.179-230 Langues : Anglais (eng) Mots-clés : Imagerie du tenseur de diffusion Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202 in Imaging the Brain in Autism / Manuel F. CASANOVA Diffusion Tensor Magnetic Resonance Imaging in Autism [Texte imprimé et/ou numérique] / Brittany G. TRAVERS, Auteur ; Andrew A. ALEXANDER, Auteur . - 2013 . - p.179-230. Langues : Anglais (eng) Mots-clés : Imagerie du tenseur de diffusion Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202

Exemplaires

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Longitudinal Heschl's Gyrus Growth During Childhood and Adolescence in Typical Development and Autism / Molly B. D. PRIGGE in Autism Research, 6-2 (April 2013)  

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Longitudinal Volumetric Brain Changes in Autism Spectrum Disorder Ages 6–35 Years / Nicholas LANGE in Autism Research, 8-1 (February 2015)  

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