Developmental mediation of genetic variation in response to the Fast Track prevention program / Dustin ALBERT in Development and Psychopathology, 27-1 (February 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-1 (February 2015) . - p.81-95 Titre : Developmental mediation of genetic variation in response to the Fast Track prevention program Type de document : Texte imprimé et/ou numérique Auteurs : Dustin ALBERT, Auteur ; Daniel W. BELSKY, Auteur ; D. Max CROWLEY, Auteur ; John E. BATES, Auteur ; Gregory S. PETTIT, Auteur ; Jennifer E. LANSFORD, Auteur ; Danielle DICK, Auteur ; Kenneth A. DODGE, Auteur Article en page(s) : p.81-95 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We conducted a developmental analysis of genetic moderation of the effect of the Fast Track intervention on adult externalizing psychopathology. The Fast Track intervention enrolled 891 children at high risk to develop externalizing behavior problems when they were in kindergarten. Half of the enrolled children were randomly assigned to receive 10 years of treatment, with a range of services and resources provided to the children and their families, and the other half to usual care (controls). We previously showed that the effect of the Fast Track intervention on participants' risk of externalizing psychopathology at age 25 years was moderated by a variant in the glucocorticoid receptor gene. Children who carried copies of the A allele of the single nucleotide polymorphism rs10482672 had the highest risk of externalizing psychopathology if they were in the control arm of the trial and the lowest risk of externalizing psychopathology if they were in the treatment arm. In this study, we test a developmental hypothesis about the origins of this for better and for worse Gene × Intervention interaction (G × I): that the observed G × I effect on adult psychopathology is mediated by the proximal impact of intervention on childhood externalizing problems and adolescent substance use and delinquency. We analyzed longitudinal data tracking the 270 European American children in the Fast Track randomized control trial with available genetic information (129 intervention children, 141 control group peers, 69% male) from kindergarten through age 25 years. Results show that the same pattern of for better and for worse susceptibility to intervention observed at the age 25 follow-up was evident already during childhood. At the elementary school follow-ups and at the middle/high school follow-ups, rs10482672 predicted better adjustment among children receiving the Fast Track intervention and worse adjustment among children in the control condition. In turn, these proximal G × I effects early in development mediated the ultimate G × I effect on externalizing psychopathology at age 25 years. We discuss the contribution of these findings to the growing literature on genetic susceptibility to environmental intervention. En ligne : http://dx.doi.org/10.1017/S095457941400131X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257 [article] Developmental mediation of genetic variation in response to the Fast Track prevention program [Texte imprimé et/ou numérique] / Dustin ALBERT, Auteur ; Daniel W. BELSKY, Auteur ; D. Max CROWLEY, Auteur ; John E. BATES, Auteur ; Gregory S. PETTIT, Auteur ; Jennifer E. LANSFORD, Auteur ; Danielle DICK, Auteur ; Kenneth A. DODGE, Auteur . - p.81-95. Langues : Anglais (eng) in Development and Psychopathology > 27-1 (February 2015) . - p.81-95 Index. décimale : PER Périodiques Résumé : We conducted a developmental analysis of genetic moderation of the effect of the Fast Track intervention on adult externalizing psychopathology. The Fast Track intervention enrolled 891 children at high risk to develop externalizing behavior problems when they were in kindergarten. Half of the enrolled children were randomly assigned to receive 10 years of treatment, with a range of services and resources provided to the children and their families, and the other half to usual care (controls). We previously showed that the effect of the Fast Track intervention on participants' risk of externalizing psychopathology at age 25 years was moderated by a variant in the glucocorticoid receptor gene. Children who carried copies of the A allele of the single nucleotide polymorphism rs10482672 had the highest risk of externalizing psychopathology if they were in the control arm of the trial and the lowest risk of externalizing psychopathology if they were in the treatment arm. In this study, we test a developmental hypothesis about the origins of this for better and for worse Gene × Intervention interaction (G × I): that the observed G × I effect on adult psychopathology is mediated by the proximal impact of intervention on childhood externalizing problems and adolescent substance use and delinquency. We analyzed longitudinal data tracking the 270 European American children in the Fast Track randomized control trial with available genetic information (129 intervention children, 141 control group peers, 69% male) from kindergarten through age 25 years. Results show that the same pattern of for better and for worse susceptibility to intervention observed at the age 25 follow-up was evident already during childhood. At the elementary school follow-ups and at the middle/high school follow-ups, rs10482672 predicted better adjustment among children receiving the Fast Track intervention and worse adjustment among children in the control condition. In turn, these proximal G × I effects early in development mediated the ultimate G × I effect on externalizing psychopathology at age 25 years. We discuss the contribution of these findings to the growing literature on genetic susceptibility to environmental intervention. En ligne : http://dx.doi.org/10.1017/S095457941400131X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257

Effect of housing relocation and neighborhood environment on adolescent mental and behavioral health / Gayle R. BYCK in Journal of Child Psychology and Psychiatry, 56-11 (November 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-11 (November 2015) . - p.1185-1193 Titre : Effect of housing relocation and neighborhood environment on adolescent mental and behavioral health Type de document : Texte imprimé et/ou numérique Auteurs : Gayle R. BYCK, Auteur ; John BOLLAND, Auteur ; Danielle DICK, Auteur ; Gregory SWANN, Auteur ; David HENRY, Auteur ; Brian MUSTANSKI, Auteur Article en page(s) : p.1185-1193 Langues : Anglais (eng) Mots-clés : Adolescent  housing relocation  sexual risk-taking  mental health  substance abuse Index. décimale : PER Périodiques Résumé : Background This study examined whether relocating from a high-poverty neighborhood to a lower poverty neighborhood as part of a federal housing relocation program (HOPE VI; Housing Opportunities for People Everywhere) had effects on adolescent mental and behavioral health compared to adolescents consistently living in lower poverty neighborhoods. Methods Sociodemographic, risk behavior, and neighborhood data were collected from 592 low-income, primarily African-American adolescents and their primary caregivers. Structured psychiatric interviews were conducted with adolescents. Prerelocation neighborhood, demographic, and risk behavior data were also included. Hierarchical Linear Modeling (HLM) was used to test associations between neighborhood variables and risk outcomes. HLM was used to test whether the effect of neighborhood relocation and neighborhood characteristics might explain differences in sexual risk taking, substance use, and mental health outcomes. Results Adolescents who relocated of HOPE VI neighborhoods (n = 158) fared worse than control group participants (n = 429) on most self-reported mental health outcomes. The addition of subjective neighborhood measures generally did not substantively change these results. Conclusions Our findings suggest that moving from a high-poverty neighborhood to a somewhat lower poverty neighborhood is not associated with better mental health and risk behavior outcomes in adolescents. The continued effects of having grown up in a high-poverty neighborhood, the small improvements in their new neighborhoods, the comparatively short length of time they lived in their new neighborhood, and/or the stress of moving appears to worsen most of the mental health outcomes of HOPE VI compared to control group participants who consistently lived in the lower poverty neighborhoods. En ligne : http://dx.doi.org/10.1111/jcpp.12386 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Effect of housing relocation and neighborhood environment on adolescent mental and behavioral health [Texte imprimé et/ou numérique] / Gayle R. BYCK, Auteur ; John BOLLAND, Auteur ; Danielle DICK, Auteur ; Gregory SWANN, Auteur ; David HENRY, Auteur ; Brian MUSTANSKI, Auteur . - p.1185-1193. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-11 (November 2015) . - p.1185-1193 Mots-clés : Adolescent  housing relocation  sexual risk-taking  mental health  substance abuse Index. décimale : PER Périodiques Résumé : Background This study examined whether relocating from a high-poverty neighborhood to a lower poverty neighborhood as part of a federal housing relocation program (HOPE VI; Housing Opportunities for People Everywhere) had effects on adolescent mental and behavioral health compared to adolescents consistently living in lower poverty neighborhoods. Methods Sociodemographic, risk behavior, and neighborhood data were collected from 592 low-income, primarily African-American adolescents and their primary caregivers. Structured psychiatric interviews were conducted with adolescents. Prerelocation neighborhood, demographic, and risk behavior data were also included. Hierarchical Linear Modeling (HLM) was used to test associations between neighborhood variables and risk outcomes. HLM was used to test whether the effect of neighborhood relocation and neighborhood characteristics might explain differences in sexual risk taking, substance use, and mental health outcomes. Results Adolescents who relocated of HOPE VI neighborhoods (n = 158) fared worse than control group participants (n = 429) on most self-reported mental health outcomes. The addition of subjective neighborhood measures generally did not substantively change these results. Conclusions Our findings suggest that moving from a high-poverty neighborhood to a somewhat lower poverty neighborhood is not associated with better mental health and risk behavior outcomes in adolescents. The continued effects of having grown up in a high-poverty neighborhood, the small improvements in their new neighborhoods, the comparatively short length of time they lived in their new neighborhood, and/or the stress of moving appears to worsen most of the mental health outcomes of HOPE VI compared to control group participants who consistently lived in the lower poverty neighborhoods. En ligne : http://dx.doi.org/10.1111/jcpp.12386 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

Patterns and predictors of alcohol misuse trajectories from adolescence through early midlife / Mallory STEPHENSON in Development and Psychopathology, 37-2 (May 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-2 (May 2025) . - p.734-750 Titre : Patterns and predictors of alcohol misuse trajectories from adolescence through early midlife Type de document : Texte imprimé et/ou numérique Auteurs : Mallory STEPHENSON, Auteur ; Peter BARR, Auteur ; Nathaniel THOMAS, Auteur ; Megan COOKE, Auteur ; Antti LATVALA, Auteur ; Richard J. ROSE, Auteur ; Jaakko KAPRIO, Auteur ; Danielle DICK, Auteur ; Jessica E. SALVATORE, Auteur Article en page(s) : p.734-750 Langues : Anglais (eng) Mots-clés : alcohol  biometric  early midlife  genetic  growth curve  trajectories Index. décimale : PER Périodiques Résumé : We took a multilevel developmental contextual approach and characterized trajectories of alcohol misuse from adolescence through early midlife, examined genetic and environmental contributions to individual differences in those trajectories, and identified adolescent and young adult factors associated with change in alcohol misuse. Data were from two longitudinal population-based studies. FinnTwin16 is a study of Finnish twins assessed at 16, 17, 18, 25, and 35 years (N = 5659; 52% female; 32% monozygotic). The National Longitudinal Study of Adolescent to Adult Health (Add Health) is a study of adolescents from the United States, who were assessed at five time points from 1994 to 2018 (N = 18026; 50% female; 64% White, 21% Black, 4% Native American, 7% Asian, 9% Other race/ethnicity). Alcohol misuse was measured as frequency of intoxication in FinnTwin16 and frequency of binge drinking in Add Health. In both samples, trajectories of alcohol misuse were best described by a quadratic growth curve: Alcohol misuse increased across adolescence, peaked in young adulthood, and declined into early midlife. Individual differences in these trajectories were primarily explained by environmental factors. Several adolescent and young adult correlates were related to the course of alcohol misuse, including other substance use, physical and mental health, and parenthood. En ligne : https://dx.doi.org/10.1017/S0954579424000543 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=552 [article] Patterns and predictors of alcohol misuse trajectories from adolescence through early midlife [Texte imprimé et/ou numérique] / Mallory STEPHENSON, Auteur ; Peter BARR, Auteur ; Nathaniel THOMAS, Auteur ; Megan COOKE, Auteur ; Antti LATVALA, Auteur ; Richard J. ROSE, Auteur ; Jaakko KAPRIO, Auteur ; Danielle DICK, Auteur ; Jessica E. SALVATORE, Auteur . - p.734-750. Langues : Anglais (eng) in Development and Psychopathology > 37-2 (May 2025) . - p.734-750 Mots-clés : alcohol  biometric  early midlife  genetic  growth curve  trajectories Index. décimale : PER Périodiques Résumé : We took a multilevel developmental contextual approach and characterized trajectories of alcohol misuse from adolescence through early midlife, examined genetic and environmental contributions to individual differences in those trajectories, and identified adolescent and young adult factors associated with change in alcohol misuse. Data were from two longitudinal population-based studies. FinnTwin16 is a study of Finnish twins assessed at 16, 17, 18, 25, and 35 years (N = 5659; 52% female; 32% monozygotic). The National Longitudinal Study of Adolescent to Adult Health (Add Health) is a study of adolescents from the United States, who were assessed at five time points from 1994 to 2018 (N = 18026; 50% female; 64% White, 21% Black, 4% Native American, 7% Asian, 9% Other race/ethnicity). Alcohol misuse was measured as frequency of intoxication in FinnTwin16 and frequency of binge drinking in Add Health. In both samples, trajectories of alcohol misuse were best described by a quadratic growth curve: Alcohol misuse increased across adolescence, peaked in young adulthood, and declined into early midlife. Individual differences in these trajectories were primarily explained by environmental factors. Several adolescent and young adult correlates were related to the course of alcohol misuse, including other substance use, physical and mental health, and parenthood. En ligne : https://dx.doi.org/10.1017/S0954579424000543 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=552

Risk and protective factors for comorbid internalizing and externalizing problems among economically disadvantaged African American youth / Jingwen LIU in Development and Psychopathology, 29-3 (August 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-3 (August 2017) . - p.1043-1056 Titre : Risk and protective factors for comorbid internalizing and externalizing problems among economically disadvantaged African American youth Type de document : Texte imprimé et/ou numérique Auteurs : Jingwen LIU, Auteur ; Brian MUSTANSKI, Auteur ; Danielle DICK, Auteur ; John BOLLAND, Auteur ; Darlene A. KERTES, Auteur Article en page(s) : p.1043-1056 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Comorbidity of internalizing and externalizing problems and its risk and protective factors have not been well incorporated into developmental research, especially among racial minority youth from high-poverty neighborhoods. The present study identified a latent comorbid factor as well as specific factors underlying internalizing and externalizing problems among 592 African American adolescents living in economically disadvantaged neighborhoods (291 male; M age = 15.9 years, SD = 1.43 years). Stressful life events and racial discrimination were associated with higher comorbid problems, whereas stressful life events and exposure to violence were associated with higher specific externalizing problems. Collective efficacy was associated with both lower specific externalizing problems and lower comorbid problems. Moreover, high collective efficacy buffered the risk effects of stressful life events and racial discrimination on comorbid problems. Our results demonstrated the advantages of latent variable modeling to understanding comorbidity by articulating impacts of risk factors on comorbid and specific components underlying internalizing and externalizing problems. They also highlighted the protective effect of collective efficacy in mitigating risks for these problems. These findings broadly call for more studies on comorbidities in developmental psychopathology among youth from diverse sociocultural backgrounds. En ligne : http://dx.doi.org/10.1017/s0954579416001012 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=312 [article] Risk and protective factors for comorbid internalizing and externalizing problems among economically disadvantaged African American youth [Texte imprimé et/ou numérique] / Jingwen LIU, Auteur ; Brian MUSTANSKI, Auteur ; Danielle DICK, Auteur ; John BOLLAND, Auteur ; Darlene A. KERTES, Auteur . - p.1043-1056. Langues : Anglais (eng) in Development and Psychopathology > 29-3 (August 2017) . - p.1043-1056 Index. décimale : PER Périodiques Résumé : Abstract Comorbidity of internalizing and externalizing problems and its risk and protective factors have not been well incorporated into developmental research, especially among racial minority youth from high-poverty neighborhoods. The present study identified a latent comorbid factor as well as specific factors underlying internalizing and externalizing problems among 592 African American adolescents living in economically disadvantaged neighborhoods (291 male; M age = 15.9 years, SD = 1.43 years). Stressful life events and racial discrimination were associated with higher comorbid problems, whereas stressful life events and exposure to violence were associated with higher specific externalizing problems. Collective efficacy was associated with both lower specific externalizing problems and lower comorbid problems. Moreover, high collective efficacy buffered the risk effects of stressful life events and racial discrimination on comorbid problems. Our results demonstrated the advantages of latent variable modeling to understanding comorbidity by articulating impacts of risk factors on comorbid and specific components underlying internalizing and externalizing problems. They also highlighted the protective effect of collective efficacy in mitigating risks for these problems. These findings broadly call for more studies on comorbidities in developmental psychopathology among youth from diverse sociocultural backgrounds. En ligne : http://dx.doi.org/10.1017/s0954579416001012 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=312

Serotonin functioning and adolescents' alcohol use: A genetically informed study examining mechanisms of risk / Frances L. WANG in Development and Psychopathology, 30-1 (February 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-1 (February 2018) . - p.213-233 Titre : Serotonin functioning and adolescents' alcohol use: A genetically informed study examining mechanisms of risk Type de document : Texte imprimé et/ou numérique Auteurs : Frances L. WANG, Auteur ; Laurie A. CHASSIN, Auteur ; John E. BATES, Auteur ; Danielle DICK, Auteur ; Jennifer E. LANSFORD, Auteur ; Gregory S. PETTIT, Auteur ; Kenneth A. DODGE, Auteur Article en page(s) : p.213-233 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The current study used data from two longitudinal samples to test whether self-regulation, depressive symptoms, and aggression/antisociality were mediators in the relation between a polygenic score indexing serotonin (5-HT) functioning and alcohol use in adolescence. The results from an independent genome-wide association study of 5-hydroxyindoleacetic acid in the cerebrospinal fluid were used to create 5-HT polygenic risk scores. Adolescents and/or parents reported on adolescents’ self-regulation (Time 1), depressive symptoms (Time 2), aggression/antisociality (Time 2), and alcohol use (Time 3). The results showed that 5-HT polygenic risk did not predict self-regulation. However, adolescents with higher levels of 5-HT polygenic risk showed greater depression and aggression/antisociality. Adolescents’ aggression/antisociality mediated the relation between 5-HT polygenic risk and later alcohol use. Deficits in self-regulation also predicted depression and aggression/antisociality, and indirectly predicted alcohol use through aggression/antisociality. Pathways to alcohol use were especially salient for males from families with low parental education in one of the two samples. The results provide insights into the longitudinal mechanisms underlying the relation between 5-HT functioning and alcohol use (i.e., earlier aggression/antisociality). There was no evidence that genetically based variation in 5-HT functioning predisposed individuals to deficits in self-regulation. Genetically based variation in 5-HT functioning and self-regulation might be separate, transdiagnostic risk factors for several types of psychopathology. En ligne : https://doi.org/10.1017/S095457941700058X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=336 [article] Serotonin functioning and adolescents' alcohol use: A genetically informed study examining mechanisms of risk [Texte imprimé et/ou numérique] / Frances L. WANG, Auteur ; Laurie A. CHASSIN, Auteur ; John E. BATES, Auteur ; Danielle DICK, Auteur ; Jennifer E. LANSFORD, Auteur ; Gregory S. PETTIT, Auteur ; Kenneth A. DODGE, Auteur . - p.213-233. Langues : Anglais (eng) in Development and Psychopathology > 30-1 (February 2018) . - p.213-233 Index. décimale : PER Périodiques Résumé : The current study used data from two longitudinal samples to test whether self-regulation, depressive symptoms, and aggression/antisociality were mediators in the relation between a polygenic score indexing serotonin (5-HT) functioning and alcohol use in adolescence. The results from an independent genome-wide association study of 5-hydroxyindoleacetic acid in the cerebrospinal fluid were used to create 5-HT polygenic risk scores. Adolescents and/or parents reported on adolescents’ self-regulation (Time 1), depressive symptoms (Time 2), aggression/antisociality (Time 2), and alcohol use (Time 3). The results showed that 5-HT polygenic risk did not predict self-regulation. However, adolescents with higher levels of 5-HT polygenic risk showed greater depression and aggression/antisociality. Adolescents’ aggression/antisociality mediated the relation between 5-HT polygenic risk and later alcohol use. Deficits in self-regulation also predicted depression and aggression/antisociality, and indirectly predicted alcohol use through aggression/antisociality. Pathways to alcohol use were especially salient for males from families with low parental education in one of the two samples. The results provide insights into the longitudinal mechanisms underlying the relation between 5-HT functioning and alcohol use (i.e., earlier aggression/antisociality). There was no evidence that genetically based variation in 5-HT functioning predisposed individuals to deficits in self-regulation. Genetically based variation in 5-HT functioning and self-regulation might be separate, transdiagnostic risk factors for several types of psychopathology. En ligne : https://doi.org/10.1017/S095457941700058X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=336

The role of adolescent social relationships in promoting alcohol resistance: Interrupting the intergenerational transmission of alcohol misuse / Mallory STEPHENSON in Development and Psychopathology, 34-5 (December 2022)  

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