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Auteur Elinor L. SULLIVAN
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Documents disponibles écrits par cet auteur (6)
Faire une suggestion Affiner la rechercheCaregiver sensitivity moderates effects of gestational inflammation on child ADHD symptoms / Elinor L. SULLIVAN in Journal of Child Psychology and Psychiatry, 67-12 (December 2026)
Titre : Caregiver sensitivity moderates effects of gestational inflammation on child ADHD symptoms Type de document : texte imprimé Auteurs : Elinor L. SULLIVAN, Auteur ; Jessica M. TIPSORD, Auteur ; Elizabeth K. NOUSEN, Auteur ; Julia WILLIAMS, Auteur ; Sara SHAO, Auteur ; Diana Vazquez DUQUE, Auteur ; Jennifer M. LOFTIS, Auteur ; Sarah L. KARALUNAS, Auteur ; Joel T. NIGG, Auteur ; Hanna C. GUSTAFSSON, Auteur Article en page(s) : p.2112-2122 Langues : Anglais (eng) Mots-clés : Pregnancy inflammation attention-deficit/hyperactivity disorder preschool sensitive caregiving parenting Index. décimale : PER Périodiques Résumé : Background Increased inflammation during pregnancy may increase the risk for child psychopathology, though prospective data remain preliminary. Child symptoms of attention-deficit/hyperactivity disorder (ADHD) are particularly important due to ADHD's role as an early precursor of many later forms of externalizing and internalizing problems. Despite strong theories surrounding the ways in which pre- and postnatal environmental factors may interact in the prediction of child risk, few studies have examined how the postnatal social environment moderates prenatal effects. This study examined whether gestational inflammation was prospectively related to ADHD symptoms and whether this association was moderated by postnatal caregiving behaviors. Methods Data came from a prospective cohort of pregnant individuals and their offspring (N?=?302). Second trimester inflammation was assessed in maternal plasma using a comprehensive panel of cytokines. ADHD symptoms were assessed at 36?months of age using parent-report and clinician ratings. Observer ratings of maternal sensitive caregiving behaviors were assessed when infants were 6?months old. Results The effect of gestational inflammation on child ADHD symptoms was moderated by maternal sensitive caregiving during infancy. Increased inflammation during pregnancy was associated with greater child ADHD symptoms only when children experienced lower levels of maternal sensitivity. Conclusions Early sensitive caregiving appears to buffer children against the negative effects of gestational inflammation. Interventions that decrease gestational inflammation and those that support early caregiver?child relationships may both be effective at reducing child ADHD risk. En ligne : https://doi.org/10.1111/jcpp.70200 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=597
in Journal of Child Psychology and Psychiatry > 67-12 (December 2026) . - p.2112-2122[article] Caregiver sensitivity moderates effects of gestational inflammation on child ADHD symptoms [texte imprimé] / Elinor L. SULLIVAN, Auteur ; Jessica M. TIPSORD, Auteur ; Elizabeth K. NOUSEN, Auteur ; Julia WILLIAMS, Auteur ; Sara SHAO, Auteur ; Diana Vazquez DUQUE, Auteur ; Jennifer M. LOFTIS, Auteur ; Sarah L. KARALUNAS, Auteur ; Joel T. NIGG, Auteur ; Hanna C. GUSTAFSSON, Auteur . - p.2112-2122.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 67-12 (December 2026) . - p.2112-2122
Mots-clés : Pregnancy inflammation attention-deficit/hyperactivity disorder preschool sensitive caregiving parenting Index. décimale : PER Périodiques Résumé : Background Increased inflammation during pregnancy may increase the risk for child psychopathology, though prospective data remain preliminary. Child symptoms of attention-deficit/hyperactivity disorder (ADHD) are particularly important due to ADHD's role as an early precursor of many later forms of externalizing and internalizing problems. Despite strong theories surrounding the ways in which pre- and postnatal environmental factors may interact in the prediction of child risk, few studies have examined how the postnatal social environment moderates prenatal effects. This study examined whether gestational inflammation was prospectively related to ADHD symptoms and whether this association was moderated by postnatal caregiving behaviors. Methods Data came from a prospective cohort of pregnant individuals and their offspring (N?=?302). Second trimester inflammation was assessed in maternal plasma using a comprehensive panel of cytokines. ADHD symptoms were assessed at 36?months of age using parent-report and clinician ratings. Observer ratings of maternal sensitive caregiving behaviors were assessed when infants were 6?months old. Results The effect of gestational inflammation on child ADHD symptoms was moderated by maternal sensitive caregiving during infancy. Increased inflammation during pregnancy was associated with greater child ADHD symptoms only when children experienced lower levels of maternal sensitivity. Conclusions Early sensitive caregiving appears to buffer children against the negative effects of gestational inflammation. Interventions that decrease gestational inflammation and those that support early caregiver?child relationships may both be effective at reducing child ADHD risk. En ligne : https://doi.org/10.1111/jcpp.70200 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=597
Titre : Early development of negative and positive affect: Implications for ADHD symptomatology across three birth cohorts Type de document : texte imprimé Auteurs : Hanna C. GUSTAFSSON, Auteur ; Saara NOLVI, Auteur ; Elinor L. SULLIVAN, Auteur ; Jerod M. RASMUSSEN, Auteur ; Lauren E. GYLLENHAMMER, Auteur ; Sonja ENTRINGER, Auteur ; Pathik D. WADHWA, Auteur ; Thomas G. O'CONNOR, Auteur ; Linnea KARLSSON, Auteur ; Hasse KARLSSON, Auteur ; Riikka KORJA, Auteur ; Claudia BUSS, Auteur ; Alice M. GRAHAM, Auteur ; Joel T. NIGG, Auteur Article en page(s) : p.1837-1848 Langues : Anglais (eng) Mots-clés : ADHD symptomatology infant temperament negative affect positive affect trajectory analysis Index. décimale : PER Périodiques Résumé : High levels of early emotionality (of either negative or positive valence) are hypothesized to be important precursors to early psychopathology, with attention-deficit/hyperactivity disorder (ADHD) a prime early target. The positive and negative affect domains are prime examples of Research Domain Criteria (RDoC) concepts that may enrich a multilevel mechanistic map of psychopathology risk. Utilizing both variable-centered and person-centered approaches, the current study examined whether levels and trajectories of infant negative and positive emotionality, considered either in isolation or together, predicted children's ADHD symptoms at 4 to 8 years of age. In variable-centered analyses, higher levels of infant negative affect (at as early as 3 months of age) were associated with childhood ADHD symptoms. Findings for positive affect failed to reach statistical threshold. Results from person-centered trajectory analyses suggest that additional information is gained by simultaneously considering the trajectories of positive and negative emotionality. Specifically, only when exhibiting moderate, stable or low levels of positive affect did negative affect and its trajectory relate to child ADHD symptoms. These findings add to a growing literature that suggests that infant negative emotionality is a promising early life marker of future ADHD risk and suggest secondarily that moderation by positive affectivity warrants more consideration. En ligne : http://dx.doi.org/10.1017/S0954579421001012 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458
in Development and Psychopathology > 33-5 (December 2021) . - p.1837-1848[article] Early development of negative and positive affect: Implications for ADHD symptomatology across three birth cohorts [texte imprimé] / Hanna C. GUSTAFSSON, Auteur ; Saara NOLVI, Auteur ; Elinor L. SULLIVAN, Auteur ; Jerod M. RASMUSSEN, Auteur ; Lauren E. GYLLENHAMMER, Auteur ; Sonja ENTRINGER, Auteur ; Pathik D. WADHWA, Auteur ; Thomas G. O'CONNOR, Auteur ; Linnea KARLSSON, Auteur ; Hasse KARLSSON, Auteur ; Riikka KORJA, Auteur ; Claudia BUSS, Auteur ; Alice M. GRAHAM, Auteur ; Joel T. NIGG, Auteur . - p.1837-1848.
Langues : Anglais (eng)
in Development and Psychopathology > 33-5 (December 2021) . - p.1837-1848
Mots-clés : ADHD symptomatology infant temperament negative affect positive affect trajectory analysis Index. décimale : PER Périodiques Résumé : High levels of early emotionality (of either negative or positive valence) are hypothesized to be important precursors to early psychopathology, with attention-deficit/hyperactivity disorder (ADHD) a prime early target. The positive and negative affect domains are prime examples of Research Domain Criteria (RDoC) concepts that may enrich a multilevel mechanistic map of psychopathology risk. Utilizing both variable-centered and person-centered approaches, the current study examined whether levels and trajectories of infant negative and positive emotionality, considered either in isolation or together, predicted children's ADHD symptoms at 4 to 8 years of age. In variable-centered analyses, higher levels of infant negative affect (at as early as 3 months of age) were associated with childhood ADHD symptoms. Findings for positive affect failed to reach statistical threshold. Results from person-centered trajectory analyses suggest that additional information is gained by simultaneously considering the trajectories of positive and negative emotionality. Specifically, only when exhibiting moderate, stable or low levels of positive affect did negative affect and its trajectory relate to child ADHD symptoms. These findings add to a growing literature that suggests that infant negative emotionality is a promising early life marker of future ADHD risk and suggest secondarily that moderation by positive affectivity warrants more consideration. En ligne : http://dx.doi.org/10.1017/S0954579421001012 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458
Titre : Early identification of ADHD risk via infant temperament and emotion regulation: a pilot study Type de document : texte imprimé Auteurs : Elinor L. SULLIVAN, Auteur ; Kathleen F. HOLTON, Auteur ; Elizabeth K. NOUSEN, Auteur ; Ashley N. BARLING, Auteur ; Ceri A. SULLIVAN, Auteur ; Cathi B. PROPPER, Auteur ; Joel T. NIGG, Auteur Article en page(s) : p.949-957 Langues : Anglais (eng) Mots-clés : ADHD risk markers early identification maternal precursors emotional dysregulation infant temperament Index. décimale : PER Périodiques Résumé : Background Attention deficit hyperactivity disorder (ADHD) is theorized to have temperamental precursors early in life. These are difficult to identify because many core features of ADHD, such as breakdowns in executive function and self-control, involve psychological and neural systems that are too immature to reliably show dysfunction in early life. ADHD also involves emotional dysregulation, and these temperamental features appear earlier as well. Here, we report a first attempt to utilize indices of emotional regulation to identify ADHD-related liability in infancy. Methods Fifty women were recruited in the 2nd trimester of pregnancy, with overselection for high parental ADHD symptoms. Measures of maternal body mass index, nutrition, substance use, stress, and mood were examined during pregnancy as potential confounds. Offspring were evaluated at 6 months of age using LABTAB procedures designed to elicit fear, anger, and regulatory behavior. Mothers completed the Infant Behavior Questionnaire about their child's temperament. Results After control for associated covariates, including maternal depression and prenatal stress, family history of ADHD was associated with measures of anger/irritability, including infant negative vocalizations during the arm restraint task (p = .004), and maternal ratings of infant distress to limitations (p = .036). In the regulation domain, familial ADHD was associated with less parent-oriented attention seeking during the still face procedure (p < .001), but this was not echoed in the maternal ratings of recovery from distress. Conclusions Affective response at 6 months of age may identify infants with familial history of ADHD, providing an early indicator of ADHD liability. These preliminary results provide a foundation for further studies and will be amplified by enlarging this cohort and following participants longitudinally to evaluate ADHD outcomes. En ligne : http://dx.doi.org/10.1111/jcpp.12426 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267
in Journal of Child Psychology and Psychiatry > 56-9 (September 2015) . - p.949-957[article] Early identification of ADHD risk via infant temperament and emotion regulation: a pilot study [texte imprimé] / Elinor L. SULLIVAN, Auteur ; Kathleen F. HOLTON, Auteur ; Elizabeth K. NOUSEN, Auteur ; Ashley N. BARLING, Auteur ; Ceri A. SULLIVAN, Auteur ; Cathi B. PROPPER, Auteur ; Joel T. NIGG, Auteur . - p.949-957.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 56-9 (September 2015) . - p.949-957
Mots-clés : ADHD risk markers early identification maternal precursors emotional dysregulation infant temperament Index. décimale : PER Périodiques Résumé : Background Attention deficit hyperactivity disorder (ADHD) is theorized to have temperamental precursors early in life. These are difficult to identify because many core features of ADHD, such as breakdowns in executive function and self-control, involve psychological and neural systems that are too immature to reliably show dysfunction in early life. ADHD also involves emotional dysregulation, and these temperamental features appear earlier as well. Here, we report a first attempt to utilize indices of emotional regulation to identify ADHD-related liability in infancy. Methods Fifty women were recruited in the 2nd trimester of pregnancy, with overselection for high parental ADHD symptoms. Measures of maternal body mass index, nutrition, substance use, stress, and mood were examined during pregnancy as potential confounds. Offspring were evaluated at 6 months of age using LABTAB procedures designed to elicit fear, anger, and regulatory behavior. Mothers completed the Infant Behavior Questionnaire about their child's temperament. Results After control for associated covariates, including maternal depression and prenatal stress, family history of ADHD was associated with measures of anger/irritability, including infant negative vocalizations during the arm restraint task (p = .004), and maternal ratings of infant distress to limitations (p = .036). In the regulation domain, familial ADHD was associated with less parent-oriented attention seeking during the still face procedure (p < .001), but this was not echoed in the maternal ratings of recovery from distress. Conclusions Affective response at 6 months of age may identify infants with familial history of ADHD, providing an early indicator of ADHD liability. These preliminary results provide a foundation for further studies and will be amplified by enlarging this cohort and following participants longitudinally to evaluate ADHD outcomes. En ligne : http://dx.doi.org/10.1111/jcpp.12426 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267
Titre : Gestational kynurenine metabolites mediate effects of pregnancy adiposity on child negative affect Type de document : texte imprimé Auteurs : Hanna C. GUSTAFSSON, Auteur ; Hanna R. WRIGHT, Auteur ; Jorden E. Jacinto SCHREEDER, Auteur ; Joel T. NIGG, Auteur ; Elinor L. SULLIVAN, Auteur Article en page(s) : p.816-831 Langues : Anglais (eng) Mots-clés : Kynurenine pathway picolinic acid kynurenic acid quinolinic acid infant toddler temperament inflammation serotonin mental health Index. décimale : PER Périodiques Résumé : Background Mounting evidence links increased adiposity during pregnancy and offspring risk for mental health disorders. Yet the mechanisms underlying this association remain poorly understood, limiting our ability to design effective interventions. We hypothesize that alterations in the kynurenine system of the pregnant woman help to explain this association. Methods Participants were recruited during pregnancy with repeated assessments through 24?months postpartum. Maternal adiposity was assessed using air displacement plethysmography. Liquid chromatography tandem mass spectrometry was used to measure kynurenine system metabolites in maternal plasma. Child negative affect was assessed via maternal report at 6, 12, and 24 months. Results Participants (N?=?302) included mother?child dyads (70% non-Hispanic White, 51% female). The ratio of picolinic to quinolinic acid (PA:QA) predicted child fear (??=??.15, 95% CI ?0.27, ?0.03, p?=?.02) and sadness (??=??.14, 95% CI ?0.28, 0.003, p?=?.045) at 6?months. PA:QA mediated the effect of pregnancy adiposity on child fear (??=?.03, bootstrapped 95% CI 0.009, 0.07) and sadness (??=?.04, bootstrapped 95% CI 0.006, 0.08). Similar associations were observed when children were 12 and 24?months old, suggesting enduring effects. The ratio of kynurenic to quinolinic acid (KA:QA) was not associated with child negative affect. Conclusions This is the first evidence reporting that alterations in the kynurenine system during pregnancy are associated with increased child negative affectivity, an early life risk factor for psychopathology. Results further suggest that these kynurenine metabolites are a mechanistic link between pregnancy adiposity and child negative affect. Though observed effect sizes were small, results suggest that picolinic and quinolinic acid during pregnancy may be novel biomarkers for offspring behavioral risk. En ligne : https://doi.org/10.1111/jcpp.70071 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=587
in Journal of Child Psychology and Psychiatry > 67-6 (June 2026) . - p.816-831[article] Gestational kynurenine metabolites mediate effects of pregnancy adiposity on child negative affect [texte imprimé] / Hanna C. GUSTAFSSON, Auteur ; Hanna R. WRIGHT, Auteur ; Jorden E. Jacinto SCHREEDER, Auteur ; Joel T. NIGG, Auteur ; Elinor L. SULLIVAN, Auteur . - p.816-831.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 67-6 (June 2026) . - p.816-831
Mots-clés : Kynurenine pathway picolinic acid kynurenic acid quinolinic acid infant toddler temperament inflammation serotonin mental health Index. décimale : PER Périodiques Résumé : Background Mounting evidence links increased adiposity during pregnancy and offspring risk for mental health disorders. Yet the mechanisms underlying this association remain poorly understood, limiting our ability to design effective interventions. We hypothesize that alterations in the kynurenine system of the pregnant woman help to explain this association. Methods Participants were recruited during pregnancy with repeated assessments through 24?months postpartum. Maternal adiposity was assessed using air displacement plethysmography. Liquid chromatography tandem mass spectrometry was used to measure kynurenine system metabolites in maternal plasma. Child negative affect was assessed via maternal report at 6, 12, and 24 months. Results Participants (N?=?302) included mother?child dyads (70% non-Hispanic White, 51% female). The ratio of picolinic to quinolinic acid (PA:QA) predicted child fear (??=??.15, 95% CI ?0.27, ?0.03, p?=?.02) and sadness (??=??.14, 95% CI ?0.28, 0.003, p?=?.045) at 6?months. PA:QA mediated the effect of pregnancy adiposity on child fear (??=?.03, bootstrapped 95% CI 0.009, 0.07) and sadness (??=?.04, bootstrapped 95% CI 0.006, 0.08). Similar associations were observed when children were 12 and 24?months old, suggesting enduring effects. The ratio of kynurenic to quinolinic acid (KA:QA) was not associated with child negative affect. Conclusions This is the first evidence reporting that alterations in the kynurenine system during pregnancy are associated with increased child negative affectivity, an early life risk factor for psychopathology. Results further suggest that these kynurenine metabolites are a mechanistic link between pregnancy adiposity and child negative affect. Though observed effect sizes were small, results suggest that picolinic and quinolinic acid during pregnancy may be novel biomarkers for offspring behavioral risk. En ligne : https://doi.org/10.1111/jcpp.70071 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=587
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