Attentional bias toward threatening emotional faces in individuals with autism spectrum disorder: A meta-analysis on reaction time tasks / Xiao-Zhuang FAN in Research in Autism Spectrum Disorders, 78 (October 2020)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 78 (October 2020) . - 101646 Titre : Attentional bias toward threatening emotional faces in individuals with autism spectrum disorder: A meta-analysis on reaction time tasks Type de document : Texte imprimé et/ou numérique Auteurs : Xiao-Zhuang FAN, Auteur ; Yu-Wei DUAN, Auteur ; Li-Xin YI, Auteur ; Hui-Zhong HE, Auteur Article en page(s) : 101646 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Attentional bias  Threatening emotional faces  meta-analysis Index. décimale : PER Périodiques Résumé : Background Social differences for individuals with autism spectrum disorder (ASD) could be related to attentional bias toward threatening emotional faces. However, studies investigating this attentional bias in individuals with ASD vary in paradigms and results. Methods We conducted a meta-analysis across different reaction time tasks, including dot-probe, spatial cuing, visual search and emotional Stroop tasks, to examine the attentional bias toward threatening emotional faces in individuals with ASD. Narrative synthesis further summarized possible moderators affecting attentional bias. Results We used systematic searches to identify 21 empirical studies with 1,805 participants in total (ASD n = 909). Individuals with ASD showed a small but significant attentional bias toward threatening emotional faces over other faces (g = 0.162), which was similar to individuals with typical development (g = 0.203). Moderator analysis showed that adults with ASD showed a larger attentional bias than children with ASD. For the dot-probe and spatial cuing paradigms, attentional bias toward threatening emotional faces was observed when stimuli were presented for less than 500 ms, and bias away from threatening emotional faces was shown when stimuli were presented for over 500 ms. For the visual search paradigm, attentional bias was significant in button-press tasks, but not in touch-screen tasks. Furthermore, attentional bias was only observed when the stimuli were schematic faces and reference materials were happy faces. Conclusions Individuals with ASD showed a small but significant attentional bias toward threatening emotional faces. Furthermore, significant moderators included stimulus presentation, response type, reference face type, stimulus type, and age. Thus, more research is needed to further explore attentional bias toward threatening emotional faces in individuals with ASD. En ligne : https://doi.org/10.1016/j.rasd.2020.101646 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433 [article] Attentional bias toward threatening emotional faces in individuals with autism spectrum disorder: A meta-analysis on reaction time tasks [Texte imprimé et/ou numérique] / Xiao-Zhuang FAN, Auteur ; Yu-Wei DUAN, Auteur ; Li-Xin YI, Auteur ; Hui-Zhong HE, Auteur . - 101646. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 78 (October 2020) . - 101646 Mots-clés : Autism spectrum disorder  Attentional bias  Threatening emotional faces  meta-analysis Index. décimale : PER Périodiques Résumé : Background Social differences for individuals with autism spectrum disorder (ASD) could be related to attentional bias toward threatening emotional faces. However, studies investigating this attentional bias in individuals with ASD vary in paradigms and results. Methods We conducted a meta-analysis across different reaction time tasks, including dot-probe, spatial cuing, visual search and emotional Stroop tasks, to examine the attentional bias toward threatening emotional faces in individuals with ASD. Narrative synthesis further summarized possible moderators affecting attentional bias. Results We used systematic searches to identify 21 empirical studies with 1,805 participants in total (ASD n = 909). Individuals with ASD showed a small but significant attentional bias toward threatening emotional faces over other faces (g = 0.162), which was similar to individuals with typical development (g = 0.203). Moderator analysis showed that adults with ASD showed a larger attentional bias than children with ASD. For the dot-probe and spatial cuing paradigms, attentional bias toward threatening emotional faces was observed when stimuli were presented for less than 500 ms, and bias away from threatening emotional faces was shown when stimuli were presented for over 500 ms. For the visual search paradigm, attentional bias was significant in button-press tasks, but not in touch-screen tasks. Furthermore, attentional bias was only observed when the stimuli were schematic faces and reference materials were happy faces. Conclusions Individuals with ASD showed a small but significant attentional bias toward threatening emotional faces. Furthermore, significant moderators included stimulus presentation, response type, reference face type, stimulus type, and age. Thus, more research is needed to further explore attentional bias toward threatening emotional faces in individuals with ASD. En ligne : https://doi.org/10.1016/j.rasd.2020.101646 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433

Oxytocin therapy for core symptoms in autism spectrum disorder: An updated meta-analysis of randomized controlled trials / Yue WANG in Research in Autism Spectrum Disorders, 64 (August 2019)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 64 (August 2019) . - p.63-75 Titre : Oxytocin therapy for core symptoms in autism spectrum disorder: An updated meta-analysis of randomized controlled trials Type de document : Texte imprimé et/ou numérique Auteurs : Yue WANG, Auteur ; Meng-Jie WANG, Auteur ; Ying RONG, Auteur ; Hui-Zhong HE, Auteur ; Chang-Jiang YANG, Auteur Article en page(s) : p.63-75 Langues : Anglais (eng) Mots-clés : Oxytocin  Autism spectrum disorder  Social function  Repetitive behaviors  Meta-analysis  Randomized controlled trials Index. décimale : PER Périodiques Résumé : Background Evidence of oxytocin for treating core symptoms in autism spectrum disorder (ASD) across development remains mixed and establishing its role is critical for guiding therapy. Aim The current paper is aimed to include new studies and provide a stricter and updated meta-analysis to assess the oxytocin's effects on core symptoms in ASD. Method Computerized search was conducted in PubMed, EMBASE, Cochrane Library, PsycINFO, Web of Science Database and references in reviews from the earliest date available to September 2018. Randomized controlled trials (RCTs) were identified which evaluated the effectiveness of oxytocin on at least one of two domains in patients with ASD, namely social function and repetitive behaviors. Standardized mean difference (SMD) and 95% confidence intervals (CIs) were calculated, and heterogeneity was assessed using the I2 test. Results Sixteen studies comprising 520 individuals with ASD were included in this meta-analysis. Results suggested that oxytocin had a small and non-significant effect on social function [SMD?=?0.03, 95% CI (?0.19, 0.25), p?=?0.781] and repetitive behaviors [SMD?=?0.01, 95% CI (?0.26, 0.27), p?=?0.952] compared with placebo. Studies included had a low heterogeneity (I2?=?46.4%, p?=?0.025 in social function; I2?=?37.0%, p?=?0.123 in repetitive behaviors). Conclusions The current meta-analysis demonstrated that oxytocin had a small and non-significant effect on core symptoms in ASD population. With the limited number of included studies, more large-scale, rigorously and multi-site RCTs are needed to confirm the effectiveness of oxytocin as a treatment of ASD to acquire more convincing conclusions in the future. En ligne : https://doi.org/10.1016/j.rasd.2019.03.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=399 [article] Oxytocin therapy for core symptoms in autism spectrum disorder: An updated meta-analysis of randomized controlled trials [Texte imprimé et/ou numérique] / Yue WANG, Auteur ; Meng-Jie WANG, Auteur ; Ying RONG, Auteur ; Hui-Zhong HE, Auteur ; Chang-Jiang YANG, Auteur . - p.63-75. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 64 (August 2019) . - p.63-75 Mots-clés : Oxytocin  Autism spectrum disorder  Social function  Repetitive behaviors  Meta-analysis  Randomized controlled trials Index. décimale : PER Périodiques Résumé : Background Evidence of oxytocin for treating core symptoms in autism spectrum disorder (ASD) across development remains mixed and establishing its role is critical for guiding therapy. Aim The current paper is aimed to include new studies and provide a stricter and updated meta-analysis to assess the oxytocin's effects on core symptoms in ASD. Method Computerized search was conducted in PubMed, EMBASE, Cochrane Library, PsycINFO, Web of Science Database and references in reviews from the earliest date available to September 2018. Randomized controlled trials (RCTs) were identified which evaluated the effectiveness of oxytocin on at least one of two domains in patients with ASD, namely social function and repetitive behaviors. Standardized mean difference (SMD) and 95% confidence intervals (CIs) were calculated, and heterogeneity was assessed using the I2 test. Results Sixteen studies comprising 520 individuals with ASD were included in this meta-analysis. Results suggested that oxytocin had a small and non-significant effect on social function [SMD?=?0.03, 95% CI (?0.19, 0.25), p?=?0.781] and repetitive behaviors [SMD?=?0.01, 95% CI (?0.26, 0.27), p?=?0.952] compared with placebo. Studies included had a low heterogeneity (I2?=?46.4%, p?=?0.025 in social function; I2?=?37.0%, p?=?0.123 in repetitive behaviors). Conclusions The current meta-analysis demonstrated that oxytocin had a small and non-significant effect on core symptoms in ASD population. With the limited number of included studies, more large-scale, rigorously and multi-site RCTs are needed to confirm the effectiveness of oxytocin as a treatment of ASD to acquire more convincing conclusions in the future. En ligne : https://doi.org/10.1016/j.rasd.2019.03.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=399

Spatial and identity cues differentially affect implicit learning in Chinese autistic children in the contextual cueing task with human stimuli / Yu XIE in Research in Autism Spectrum Disorders, 112 (April 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 112 (April 2024) . - p.102349 Titre : Spatial and identity cues differentially affect implicit learning in Chinese autistic children in the contextual cueing task with human stimuli Type de document : Texte imprimé et/ou numérique Auteurs : Yu XIE, Auteur ; Hui-Zhong HE, Auteur ; Linda R. WATSON, Auteur ; Zhi-Han DONG, Auteur Article en page(s) : p.102349 Langues : Anglais (eng) Mots-clés : Autism  Children  Implicit learning  Identity cues  Spatial cues  Visual attention Index. décimale : PER Périodiques Résumé : Background Autistic children cannot adjust their behaviors in response to environmental social cues as readily as typically developing children. The development of adaptive social behaviors is mainly dependent on the ability to implicitly learn associations or probabilities that are embedded in the environmental cues. Mounting evidence has suggested that autistic individuals have intact implicit learning in contextual cueing (CC) tasks with simple arrays of letters or numbers. However, it remains unclear whether autistic individuals have intact implicit learning in CC tasks with human stimuli. Spatial cues and stimulus-identity cues in CC tasks are thought to rely on distinct neural networks. It is also unknown whether these different types of cues will have different effects on implicit learning in autistic children if human photographs are used in CC tasks. This study examined the implicit learning performance of autistic children under different cue conditions in CC tasks that used photographs of children. Results Autistic children showed similar implicit learning performance to the comparison group, using only stimulus-identity cues. When both stimulus-identity and spatial cues were provided, implicit contextual learning was only observed in the comparison children, but not in the autistic group. Conclusions The results suggest that spatial cues and stimulus-identity cues have different effects on the implicit learning performance of autistic children. The atypical performance of autistic children on implicit learning when spatial cues combined with identity cues may result in divergent social behaviors and serve as an intrinsic mechanistic contributor to social interaction differences associated with autism. En ligne : https://doi.org/10.1016/j.rasd.2024.102349 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524 [article] Spatial and identity cues differentially affect implicit learning in Chinese autistic children in the contextual cueing task with human stimuli [Texte imprimé et/ou numérique] / Yu XIE, Auteur ; Hui-Zhong HE, Auteur ; Linda R. WATSON, Auteur ; Zhi-Han DONG, Auteur . - p.102349. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 112 (April 2024) . - p.102349 Mots-clés : Autism  Children  Implicit learning  Identity cues  Spatial cues  Visual attention Index. décimale : PER Périodiques Résumé : Background Autistic children cannot adjust their behaviors in response to environmental social cues as readily as typically developing children. The development of adaptive social behaviors is mainly dependent on the ability to implicitly learn associations or probabilities that are embedded in the environmental cues. Mounting evidence has suggested that autistic individuals have intact implicit learning in contextual cueing (CC) tasks with simple arrays of letters or numbers. However, it remains unclear whether autistic individuals have intact implicit learning in CC tasks with human stimuli. Spatial cues and stimulus-identity cues in CC tasks are thought to rely on distinct neural networks. It is also unknown whether these different types of cues will have different effects on implicit learning in autistic children if human photographs are used in CC tasks. This study examined the implicit learning performance of autistic children under different cue conditions in CC tasks that used photographs of children. Results Autistic children showed similar implicit learning performance to the comparison group, using only stimulus-identity cues. When both stimulus-identity and spatial cues were provided, implicit contextual learning was only observed in the comparison children, but not in the autistic group. Conclusions The results suggest that spatial cues and stimulus-identity cues have different effects on the implicit learning performance of autistic children. The atypical performance of autistic children on implicit learning when spatial cues combined with identity cues may result in divergent social behaviors and serve as an intrinsic mechanistic contributor to social interaction differences associated with autism. En ligne : https://doi.org/10.1016/j.rasd.2024.102349 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524

The cortisol, serotonin and oxytocin are associated with repetitive behavior in autism spectrum disorder / Chang-Jiang YANG in Research in Autism Spectrum Disorders, 18 (October 2015)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 18 (October 2015) . - p.12-20 Titre : The cortisol, serotonin and oxytocin are associated with repetitive behavior in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Chang-Jiang YANG, Auteur ; He-Ping TAN, Auteur ; Fu-Yi YANG, Auteur ; He-Ping WANG, Auteur ; Chun-Ling LIU, Auteur ; Hui-Zhong HE, Auteur ; Biao SANG, Auteur ; Xiao-Mei ZHU, Auteur ; Yi-Jie DU, Auteur Article en page(s) : p.12-20 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Repetitive behaviors  Cortisol  Serotonin  Oxytocin Index. décimale : PER Périodiques Résumé : Abstract Repetitive behaviors (RBs) are a core feature of autism spectrum disorders (ASD). They constitute a major barrier to learning and social adaptation. Research on potential causes of RBs is still at an early stage. However, promising new ideas and evidence are emerging from neurobiology. Instead of testing single neurotransmitter or hormone, the present study examined the associations of cortisol, serotonin, and oxytocin on subscales of repetitive behavior scales-revised (RBS-R). The results demonstrated that the individuals with ASD showed higher levels of cortisol areas under curve (cortisol AUC), higher levels of serotonin, and lower level of oxytocin compared with the typically developing (TD) individuals. For individuals with ASD, the levels of cortisol AUC, serotonin and oxytocin were all significantly associated with total scores measured by RBS-R. In addition, the cortisol AUC was positively associated with the stereotyped and restricted behavior subscales scores. The level of serotonin was positively associated with the stereotyped and self-injurious behavior subscales scores. The level of oxytocin was negatively associated with compulsive, sameness and restricted behavior subscales scores. Therefore, cortisol, serotonin and oxytocin may all be involved in the occurrence of RBs in ASD. The occurrence of RBs in ASD may due to a variety of pathological factors, not just one factor. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.07.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268 [article] The cortisol, serotonin and oxytocin are associated with repetitive behavior in autism spectrum disorder [Texte imprimé et/ou numérique] / Chang-Jiang YANG, Auteur ; He-Ping TAN, Auteur ; Fu-Yi YANG, Auteur ; He-Ping WANG, Auteur ; Chun-Ling LIU, Auteur ; Hui-Zhong HE, Auteur ; Biao SANG, Auteur ; Xiao-Mei ZHU, Auteur ; Yi-Jie DU, Auteur . - p.12-20. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 18 (October 2015) . - p.12-20 Mots-clés : Autism spectrum disorders  Repetitive behaviors  Cortisol  Serotonin  Oxytocin Index. décimale : PER Périodiques Résumé : Abstract Repetitive behaviors (RBs) are a core feature of autism spectrum disorders (ASD). They constitute a major barrier to learning and social adaptation. Research on potential causes of RBs is still at an early stage. However, promising new ideas and evidence are emerging from neurobiology. Instead of testing single neurotransmitter or hormone, the present study examined the associations of cortisol, serotonin, and oxytocin on subscales of repetitive behavior scales-revised (RBS-R). The results demonstrated that the individuals with ASD showed higher levels of cortisol areas under curve (cortisol AUC), higher levels of serotonin, and lower level of oxytocin compared with the typically developing (TD) individuals. For individuals with ASD, the levels of cortisol AUC, serotonin and oxytocin were all significantly associated with total scores measured by RBS-R. In addition, the cortisol AUC was positively associated with the stereotyped and restricted behavior subscales scores. The level of serotonin was positively associated with the stereotyped and self-injurious behavior subscales scores. The level of oxytocin was negatively associated with compulsive, sameness and restricted behavior subscales scores. Therefore, cortisol, serotonin and oxytocin may all be involved in the occurrence of RBs in ASD. The occurrence of RBs in ASD may due to a variety of pathological factors, not just one factor. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.07.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268

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