Association of subcortical gray-matter volumes with life-course-persistent antisocial behavior in a population-representative longitudinal birth cohort / Christina O. CARLISI in Development and Psychopathology, 34-5 (December 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-5 (December 2022) . - p.2012-2022 Titre : Association of subcortical gray-matter volumes with life-course-persistent antisocial behavior in a population-representative longitudinal birth cohort Type de document : texte imprimé Auteurs : Christina O. CARLISI, Auteur ; Terrie E. MOFFITT, Auteur ; Annchen R. KNODT, Auteur ; Honalee HARRINGTON, Auteur ; Stéphanie LANGEVIN, Auteur ; David IRELAND, Auteur ; Tracy R. MELZER, Auteur ; Richie POULTON, Auteur ; Sandhya RAMRAKHA, Auteur ; Avshalom CASPI, Auteur ; Ahmad R. HARIRI, Auteur ; Essi VIDING, Auteur Article en page(s) : p.2012-2022 Langues : Anglais (eng) Mots-clés : antisocial behavior  conduct disorder  development  longitudinal  structural MRI Index. décimale : PER Périodiques Résumé : Neuropsychological evidence supports the developmental taxonomy theory of antisocial behavior, suggesting that abnormal brain development distinguishes life-course-persistent from adolescence-limited antisocial behavior. Recent neuroimaging work confirmed that prospectively-measured life-course-persistent antisocial behavior is associated with differences in cortical brain structure. Whether this extends to subcortical brain structures remains uninvestigated. This study compared subcortical gray-matter volumes between 672 members of the Dunedin Study previously defined as exhibiting life-course-persistent, adolescence-limited or low-level antisocial behavior based on repeated assessments at ages 7 “26 years. Gray-matter volumes of 10 subcortical structures were compared across groups. The life-course-persistent group had lower volumes of amygdala, brain stem, cerebellum, hippocampus, pallidum, thalamus, and ventral diencephalon compared to the low-antisocial group. Differences between life-course-persistent and adolescence-limited individuals were comparable in effect size to differences between life-course-persistent and low-antisocial individuals, but were not statistically significant due to less statistical power. Gray-matter volumes in adolescence-limited individuals were near the norm in this population-representative cohort and similar to volumes in low-antisocial individuals. Although this study could not establish causal links between brain volume and antisocial behavior, it constitutes new biological evidence that all people with antisocial behavior are not the same, supporting a need for greater developmental and diagnostic precision in clinical, forensic, and policy-based interventions. En ligne : http://dx.doi.org/10.1017/S0954579421000377 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 [article] Association of subcortical gray-matter volumes with life-course-persistent antisocial behavior in a population-representative longitudinal birth cohort [texte imprimé] / Christina O. CARLISI, Auteur ; Terrie E. MOFFITT, Auteur ; Annchen R. KNODT, Auteur ; Honalee HARRINGTON, Auteur ; Stéphanie LANGEVIN, Auteur ; David IRELAND, Auteur ; Tracy R. MELZER, Auteur ; Richie POULTON, Auteur ; Sandhya RAMRAKHA, Auteur ; Avshalom CASPI, Auteur ; Ahmad R. HARIRI, Auteur ; Essi VIDING, Auteur . - p.2012-2022. Langues : Anglais (eng) in Development and Psychopathology > 34-5 (December 2022) . - p.2012-2022 Mots-clés : antisocial behavior  conduct disorder  development  longitudinal  structural MRI Index. décimale : PER Périodiques Résumé : Neuropsychological evidence supports the developmental taxonomy theory of antisocial behavior, suggesting that abnormal brain development distinguishes life-course-persistent from adolescence-limited antisocial behavior. Recent neuroimaging work confirmed that prospectively-measured life-course-persistent antisocial behavior is associated with differences in cortical brain structure. Whether this extends to subcortical brain structures remains uninvestigated. This study compared subcortical gray-matter volumes between 672 members of the Dunedin Study previously defined as exhibiting life-course-persistent, adolescence-limited or low-level antisocial behavior based on repeated assessments at ages 7 “26 years. Gray-matter volumes of 10 subcortical structures were compared across groups. The life-course-persistent group had lower volumes of amygdala, brain stem, cerebellum, hippocampus, pallidum, thalamus, and ventral diencephalon compared to the low-antisocial group. Differences between life-course-persistent and adolescence-limited individuals were comparable in effect size to differences between life-course-persistent and low-antisocial individuals, but were not statistically significant due to less statistical power. Gray-matter volumes in adolescence-limited individuals were near the norm in this population-representative cohort and similar to volumes in low-antisocial individuals. Although this study could not establish causal links between brain volume and antisocial behavior, it constitutes new biological evidence that all people with antisocial behavior are not the same, supporting a need for greater developmental and diagnostic precision in clinical, forensic, and policy-based interventions. En ligne : http://dx.doi.org/10.1017/S0954579421000377 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492

Heightened amygdala reactivity and increased stress generation predict internalizing symptoms in adults following childhood maltreatment / Mattia I. GERIN in Journal of Child Psychology and Psychiatry, 60-7 (July 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-7 (July 2019) . - p.752-761 Titre : Heightened amygdala reactivity and increased stress generation predict internalizing symptoms in adults following childhood maltreatment Type de document : texte imprimé Auteurs : Mattia I. GERIN, Auteur ; Essi VIDING, Auteur ; Jean-Baptiste PINGAULT, Auteur ; Vanessa B. PUETZ, Auteur ; Annchen R. KNODT, Auteur ; Sarah R. RADTKE, Auteur ; Bartholomew D. BRIGIDI, Auteur ; Johnna R. SWARTZ, Auteur ; Ahmad R. HARIRI, Auteur ; Eamon J. MCCRORY, Auteur Article en page(s) : p.752-761 Langues : Anglais (eng) Mots-clés : Maltreatment  amygdala  child abuse  internalizing disorder  stress Index. décimale : PER Périodiques Résumé : BACKGROUND: Childhood maltreatment is one of the most potent predictors of future psychopathology, including internalizing disorders. It remains unclear whether heightened amygdala reactivity to threat and elevated stress exposure may be implicated in the pathogenesis and maintenance of internalizing disorders among individuals with a history of childhood maltreatment. METHODS: Using data from a sample of 1,144 young adults, we investigated the contribution of baseline threat-related amygdala reactivity and prospective major stressful life events to internalizing symptoms severity 1 year later (on average) in individuals with a history of maltreatment (n = 100) and propensity score matched nonmaltreated peers (n = 96). RESULTS: Even after stringently matching for several potentially confounding variables - including baseline internalizing symptoms, socioeconomic status and IQ - childhood maltreatment status predicted increased amygdala reactivity at baseline, elevated post-baseline exposure to major stressful life events and internalizing symptoms at follow-up. We also showed, for the first time, that amygdala reactivity at baseline and also post-baseline exposure to major stressful life events mediated the association between a history of maltreatment and future internalizing symptoms. CONCLUSIONS: These findings provide support for the view that maltreatment is a potent developmental insult leading to long-lasting neurocognitive recalibrations of the threat processing system. It is possible that such alterations, over time, may impact mental health functioning by compromising the ability to effectively negotiate everyday challenges (stress susceptibility). These alterations were not, however, found to sensitize an individual to the impact of major stressful life events. The results of this study also lend compelling support to the view that increased psychiatric risk, in the context of childhood maltreatment, follows from an increased propensity to experience major stressful life events (stress generation). En ligne : http://dx.doi.org/10.1111/jcpp.13041 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401 [article] Heightened amygdala reactivity and increased stress generation predict internalizing symptoms in adults following childhood maltreatment [texte imprimé] / Mattia I. GERIN, Auteur ; Essi VIDING, Auteur ; Jean-Baptiste PINGAULT, Auteur ; Vanessa B. PUETZ, Auteur ; Annchen R. KNODT, Auteur ; Sarah R. RADTKE, Auteur ; Bartholomew D. BRIGIDI, Auteur ; Johnna R. SWARTZ, Auteur ; Ahmad R. HARIRI, Auteur ; Eamon J. MCCRORY, Auteur . - p.752-761. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-7 (July 2019) . - p.752-761 Mots-clés : Maltreatment  amygdala  child abuse  internalizing disorder  stress Index. décimale : PER Périodiques Résumé : BACKGROUND: Childhood maltreatment is one of the most potent predictors of future psychopathology, including internalizing disorders. It remains unclear whether heightened amygdala reactivity to threat and elevated stress exposure may be implicated in the pathogenesis and maintenance of internalizing disorders among individuals with a history of childhood maltreatment. METHODS: Using data from a sample of 1,144 young adults, we investigated the contribution of baseline threat-related amygdala reactivity and prospective major stressful life events to internalizing symptoms severity 1 year later (on average) in individuals with a history of maltreatment (n = 100) and propensity score matched nonmaltreated peers (n = 96). RESULTS: Even after stringently matching for several potentially confounding variables - including baseline internalizing symptoms, socioeconomic status and IQ - childhood maltreatment status predicted increased amygdala reactivity at baseline, elevated post-baseline exposure to major stressful life events and internalizing symptoms at follow-up. We also showed, for the first time, that amygdala reactivity at baseline and also post-baseline exposure to major stressful life events mediated the association between a history of maltreatment and future internalizing symptoms. CONCLUSIONS: These findings provide support for the view that maltreatment is a potent developmental insult leading to long-lasting neurocognitive recalibrations of the threat processing system. It is possible that such alterations, over time, may impact mental health functioning by compromising the ability to effectively negotiate everyday challenges (stress susceptibility). These alterations were not, however, found to sensitize an individual to the impact of major stressful life events. The results of this study also lend compelling support to the view that increased psychiatric risk, in the context of childhood maltreatment, follows from an increased propensity to experience major stressful life events (stress generation). En ligne : http://dx.doi.org/10.1111/jcpp.13041 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401

Is low cognitive functioning a predictor or consequence of major depressive disorder? A test in two longitudinal birth cohorts / Jonathan D. SCHAEFER in Development and Psychopathology, 37-5 (December 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-5 (December 2025) . - p.2251-2265 Titre : Is low cognitive functioning a predictor or consequence of major depressive disorder? A test in two longitudinal birth cohorts Type de document : texte imprimé Auteurs : Jonathan D. SCHAEFER, Auteur ; Matthew A. SCULT, Auteur ; Avshalom CASPI, Auteur ; Louise ARSENEAULT, Auteur ; Daniel W. BELSKY, Auteur ; Ahmad R. HARIRI, Auteur ; Honalee HARRINGTON, Auteur ; Renate HOUTS, Auteur ; Sandhya RAMRAKHA, Auteur ; Richie POULTON, Auteur ; Terrie E. MOFFITT, Auteur Article en page(s) : p.2251-2265 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Cognitive impairment has been identified as an important aspect of major depressive disorder (MDD). We tested two theories regarding the association between MDD and cognitive functioning using data from longitudinal cohort studies. One theory, the cognitive reserve hypothesis, suggests that higher cognitive ability in childhood decreases risk of later MDD. The second, the scarring hypothesis, instead suggests that MDD leads to persistent cognitive deficits following disorder onset. We tested both theories in the Dunedin Study, a population-representative cohort followed from birth to midlife and assessed repeatedly for both cognitive functioning and psychopathology. We also used data from the Environmental Risk Longitudinal Twin Study to test whether childhood cognitive functioning predicts future MDD risk independent of family-wide and genetic risk using a discordant twin design. Contrary to both hypotheses, we found that childhood cognitive functioning did not predict future risk of MDD, nor did study members with a past history of MDD show evidence of greater cognitive decline unless MDD was accompanied by other comorbid psychiatric conditions. Our results thus suggest that low cognitive functioning is related to comorbidity, but is neither an antecedent nor an enduring consequence of MDD. Future research may benefit from considering cognitive deficits that occur during depressive episodes from a transdiagnostic perspective. En ligne : https://dx.doi.org/10.1017/S095457941700164X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572 [article] Is low cognitive functioning a predictor or consequence of major depressive disorder? A test in two longitudinal birth cohorts [texte imprimé] / Jonathan D. SCHAEFER, Auteur ; Matthew A. SCULT, Auteur ; Avshalom CASPI, Auteur ; Louise ARSENEAULT, Auteur ; Daniel W. BELSKY, Auteur ; Ahmad R. HARIRI, Auteur ; Honalee HARRINGTON, Auteur ; Renate HOUTS, Auteur ; Sandhya RAMRAKHA, Auteur ; Richie POULTON, Auteur ; Terrie E. MOFFITT, Auteur . - p.2251-2265. Langues : Anglais (eng) in Development and Psychopathology > 37-5 (December 2025) . - p.2251-2265 Index. décimale : PER Périodiques Résumé : Cognitive impairment has been identified as an important aspect of major depressive disorder (MDD). We tested two theories regarding the association between MDD and cognitive functioning using data from longitudinal cohort studies. One theory, the cognitive reserve hypothesis, suggests that higher cognitive ability in childhood decreases risk of later MDD. The second, the scarring hypothesis, instead suggests that MDD leads to persistent cognitive deficits following disorder onset. We tested both theories in the Dunedin Study, a population-representative cohort followed from birth to midlife and assessed repeatedly for both cognitive functioning and psychopathology. We also used data from the Environmental Risk Longitudinal Twin Study to test whether childhood cognitive functioning predicts future MDD risk independent of family-wide and genetic risk using a discordant twin design. Contrary to both hypotheses, we found that childhood cognitive functioning did not predict future risk of MDD, nor did study members with a past history of MDD show evidence of greater cognitive decline unless MDD was accompanied by other comorbid psychiatric conditions. Our results thus suggest that low cognitive functioning is related to comorbidity, but is neither an antecedent nor an enduring consequence of MDD. Future research may benefit from considering cognitive deficits that occur during depressive episodes from a transdiagnostic perspective. En ligne : https://dx.doi.org/10.1017/S095457941700164X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572

Lower structural integrity of the uncinate fasciculus is associated with a history of child maltreatment and future psychological vulnerability to stress / Jamie L. HANSON in Development and Psychopathology, 27-4 (Part 2) (November 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-4 (Part 2) (November 2015) . - p.1611-1619 Titre : Lower structural integrity of the uncinate fasciculus is associated with a history of child maltreatment and future psychological vulnerability to stress Type de document : texte imprimé Auteurs : Jamie L. HANSON, Auteur ; Annchen R. KNODT, Auteur ; Bartholomew D. BRIGIDI, Auteur ; Ahmad R. HARIRI, Auteur Article en page(s) : p.1611-1619 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The experience of child maltreatment is a significant risk factor for the development of later internalizing disorders such as depression and anxiety. This risk is particularly heightened after exposure to additional, more contemporaneous stress. While behavioral evidence exists for such “stress sensitization,” little is known about the mechanisms mediating such relationships, particularly within the brain. Here we report that the experience of child maltreatment independent of recent life stress, gender, and age is associated with reduced structural integrity of the uncinate fasciculus, a major white matter pathway between the amygdala and ventromedial prefrontal cortex, in young adults. We further demonstrate that individuals with lower uncinate fasciculus integrity at baseline who subsequently experience stressful life events report higher levels of internalizing symptomatology at follow-up. Our findings suggest a novel neurobiological mechanism linking child maltreatment with later internalizing symptoms, specifically altered structural connectivity within the brain's threat-detection and emotion-regulation circuitry. En ligne : http://dx.doi.org/10.1017/S0954579415000978 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273 [article] Lower structural integrity of the uncinate fasciculus is associated with a history of child maltreatment and future psychological vulnerability to stress [texte imprimé] / Jamie L. HANSON, Auteur ; Annchen R. KNODT, Auteur ; Bartholomew D. BRIGIDI, Auteur ; Ahmad R. HARIRI, Auteur . - p.1611-1619. Langues : Anglais (eng) in Development and Psychopathology > 27-4 (Part 2) (November 2015) . - p.1611-1619 Index. décimale : PER Périodiques Résumé : The experience of child maltreatment is a significant risk factor for the development of later internalizing disorders such as depression and anxiety. This risk is particularly heightened after exposure to additional, more contemporaneous stress. While behavioral evidence exists for such “stress sensitization,” little is known about the mechanisms mediating such relationships, particularly within the brain. Here we report that the experience of child maltreatment independent of recent life stress, gender, and age is associated with reduced structural integrity of the uncinate fasciculus, a major white matter pathway between the amygdala and ventromedial prefrontal cortex, in young adults. We further demonstrate that individuals with lower uncinate fasciculus integrity at baseline who subsequently experience stressful life events report higher levels of internalizing symptomatology at follow-up. Our findings suggest a novel neurobiological mechanism linking child maltreatment with later internalizing symptoms, specifically altered structural connectivity within the brain's threat-detection and emotion-regulation circuitry. En ligne : http://dx.doi.org/10.1017/S0954579415000978 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273

A neuroscience perspective on sexual risk behavior in adolescence and emerging adulthood / Elizabeth C. VICTOR in Development and Psychopathology, 28-2 (May 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-2 (May 2016) . - p.471-487 Titre : A neuroscience perspective on sexual risk behavior in adolescence and emerging adulthood Type de document : texte imprimé Auteurs : Elizabeth C. VICTOR, Auteur ; Ahmad R. HARIRI, Auteur Article en page(s) : p.471-487 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Late adolescence and emerging adulthood (specifically ages 15–24) represent a period of heightened sexual risk taking resulting in the greatest annual rates of sexually transmitted infections and unplanned pregnancies in the US population. Ongoing efforts to prevent such negative consequences are likely to benefit from a deepening of our understanding of biological mechanisms through which sexual risk taking emerges and biases decision making during this critical window. Here we present a neuroscience framework from which a mechanistic examination of sexual risk taking can be advanced. Specifically, we adapt the neurodevelopmental triadic model, which outlines how motivated behavior is governed by three systems: approach, avoidance, and regulation, to sexual decision making and subsequent risk behavior. We further propose a testable hypothesis of the triadic model, wherein relatively decreased threat-related amygdala reactivity and increased reward-related ventral striatum reactivity leads to sexual risk taking, which is particularly exaggerated during adolescence and young adulthood when there is an overexpression of dopaminergic neurons coupled with immature top-down prefrontal cortex regulation. We conclude by discussing how future research based on our adapted triadic model can inform ongoing efforts to improve intervention and prevention efforts. En ligne : http://dx.doi.org/10.1017/S0954579415001042 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288 [article] A neuroscience perspective on sexual risk behavior in adolescence and emerging adulthood [texte imprimé] / Elizabeth C. VICTOR, Auteur ; Ahmad R. HARIRI, Auteur . - p.471-487. Langues : Anglais (eng) in Development and Psychopathology > 28-2 (May 2016) . - p.471-487 Index. décimale : PER Périodiques Résumé : Late adolescence and emerging adulthood (specifically ages 15–24) represent a period of heightened sexual risk taking resulting in the greatest annual rates of sexually transmitted infections and unplanned pregnancies in the US population. Ongoing efforts to prevent such negative consequences are likely to benefit from a deepening of our understanding of biological mechanisms through which sexual risk taking emerges and biases decision making during this critical window. Here we present a neuroscience framework from which a mechanistic examination of sexual risk taking can be advanced. Specifically, we adapt the neurodevelopmental triadic model, which outlines how motivated behavior is governed by three systems: approach, avoidance, and regulation, to sexual decision making and subsequent risk behavior. We further propose a testable hypothesis of the triadic model, wherein relatively decreased threat-related amygdala reactivity and increased reward-related ventral striatum reactivity leads to sexual risk taking, which is particularly exaggerated during adolescence and young adulthood when there is an overexpression of dopaminergic neurons coupled with immature top-down prefrontal cortex regulation. We conclude by discussing how future research based on our adapted triadic model can inform ongoing efforts to improve intervention and prevention efforts. En ligne : http://dx.doi.org/10.1017/S0954579415001042 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288

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