Association of subcortical gray-matter volumes with life-course-persistent antisocial behavior in a population-representative longitudinal birth cohort / Christina O. CARLISI in Development and Psychopathology, 34-5 (December 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-5 (December 2022) . - p.2012-2022 Titre : Association of subcortical gray-matter volumes with life-course-persistent antisocial behavior in a population-representative longitudinal birth cohort Type de document : Texte imprimé et/ou numérique Auteurs : Christina O. CARLISI, Auteur ; Terrie E. MOFFITT, Auteur ; Annchen R. KNODT, Auteur ; Honalee HARRINGTON, Auteur ; Stéphanie LANGEVIN, Auteur ; David IRELAND, Auteur ; Tracy R. MELZER, Auteur ; Richie POULTON, Auteur ; Sandhya RAMRAKHA, Auteur ; Avshalom CASPI, Auteur ; Ahmad R. HARIRI, Auteur ; Essi VIDING, Auteur Article en page(s) : p.2012-2022 Langues : Anglais (eng) Mots-clés : antisocial behavior  conduct disorder  development  longitudinal  structural MRI Index. décimale : PER Périodiques Résumé : Neuropsychological evidence supports the developmental taxonomy theory of antisocial behavior, suggesting that abnormal brain development distinguishes life-course-persistent from adolescence-limited antisocial behavior. Recent neuroimaging work confirmed that prospectively-measured life-course-persistent antisocial behavior is associated with differences in cortical brain structure. Whether this extends to subcortical brain structures remains uninvestigated. This study compared subcortical gray-matter volumes between 672 members of the Dunedin Study previously defined as exhibiting life-course-persistent, adolescence-limited or low-level antisocial behavior based on repeated assessments at ages 7 “26 years. Gray-matter volumes of 10 subcortical structures were compared across groups. The life-course-persistent group had lower volumes of amygdala, brain stem, cerebellum, hippocampus, pallidum, thalamus, and ventral diencephalon compared to the low-antisocial group. Differences between life-course-persistent and adolescence-limited individuals were comparable in effect size to differences between life-course-persistent and low-antisocial individuals, but were not statistically significant due to less statistical power. Gray-matter volumes in adolescence-limited individuals were near the norm in this population-representative cohort and similar to volumes in low-antisocial individuals. Although this study could not establish causal links between brain volume and antisocial behavior, it constitutes new biological evidence that all people with antisocial behavior are not the same, supporting a need for greater developmental and diagnostic precision in clinical, forensic, and policy-based interventions. En ligne : http://dx.doi.org/10.1017/S0954579421000377 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 [article] Association of subcortical gray-matter volumes with life-course-persistent antisocial behavior in a population-representative longitudinal birth cohort [Texte imprimé et/ou numérique] / Christina O. CARLISI, Auteur ; Terrie E. MOFFITT, Auteur ; Annchen R. KNODT, Auteur ; Honalee HARRINGTON, Auteur ; Stéphanie LANGEVIN, Auteur ; David IRELAND, Auteur ; Tracy R. MELZER, Auteur ; Richie POULTON, Auteur ; Sandhya RAMRAKHA, Auteur ; Avshalom CASPI, Auteur ; Ahmad R. HARIRI, Auteur ; Essi VIDING, Auteur . - p.2012-2022. Langues : Anglais (eng) in Development and Psychopathology > 34-5 (December 2022) . - p.2012-2022 Mots-clés : antisocial behavior  conduct disorder  development  longitudinal  structural MRI Index. décimale : PER Périodiques Résumé : Neuropsychological evidence supports the developmental taxonomy theory of antisocial behavior, suggesting that abnormal brain development distinguishes life-course-persistent from adolescence-limited antisocial behavior. Recent neuroimaging work confirmed that prospectively-measured life-course-persistent antisocial behavior is associated with differences in cortical brain structure. Whether this extends to subcortical brain structures remains uninvestigated. This study compared subcortical gray-matter volumes between 672 members of the Dunedin Study previously defined as exhibiting life-course-persistent, adolescence-limited or low-level antisocial behavior based on repeated assessments at ages 7 “26 years. Gray-matter volumes of 10 subcortical structures were compared across groups. The life-course-persistent group had lower volumes of amygdala, brain stem, cerebellum, hippocampus, pallidum, thalamus, and ventral diencephalon compared to the low-antisocial group. Differences between life-course-persistent and adolescence-limited individuals were comparable in effect size to differences between life-course-persistent and low-antisocial individuals, but were not statistically significant due to less statistical power. Gray-matter volumes in adolescence-limited individuals were near the norm in this population-representative cohort and similar to volumes in low-antisocial individuals. Although this study could not establish causal links between brain volume and antisocial behavior, it constitutes new biological evidence that all people with antisocial behavior are not the same, supporting a need for greater developmental and diagnostic precision in clinical, forensic, and policy-based interventions. En ligne : http://dx.doi.org/10.1017/S0954579421000377 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492

Childhood sexual abuse and pervasive problems across multiple life domains: Findings from a five-decade study / Hayley GUINEY in Development and Psychopathology, 36-1 (February 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-1 (February 2024) . - p.219-235 Titre : Childhood sexual abuse and pervasive problems across multiple life domains: Findings from a five-decade study Type de document : Texte imprimé et/ou numérique Auteurs : Hayley GUINEY, Auteur ; Avshalom CASPI, Auteur ; Antony AMBLER, Auteur ; Jay BELSKY, Auteur ; Jesse KOKAUA, Auteur ; Jonathan BROADBENT, Auteur ; Kirsten CHEYNE, Auteur ; Nigel DICKSON, Auteur ; Robert J. HANCOX, Auteur ; Honalee HARRINGTON, Auteur ; Sean HOGAN, Auteur ; Sandhya RAMRAKHA, Auteur ; Antoinette RIGHARTS, Auteur ; W. Murray THOMSON, Auteur ; Terrie E. MOFFITT, Auteur ; Richie POULTON, Auteur Article en page(s) : p.219-235 Langues : Anglais (eng) Mots-clés : child sexual abuseconsequences  long-term outcomes  longitudinal  multi-morbidity Index. décimale : PER Périodiques Résumé : The aim of this study was to use longitudinal population-based data to examine the associations between childhood sexual abuse (CSA) and risk for adverse outcomes in multiple life domains across adulthood. In 937 individuals followed from birth to age 45y, we assessed associations between CSA (retrospectively reported at age 26y) and the experience of 22 adverse outcomes in seven domains (physical, mental, sexual, interpersonal, economic, antisocial, multi-domain) from young adulthood to midlife (26 to 45y). Analyses controlled for sex, socioeconomic status, prospectively reported child harm and household dysfunction adverse childhood experiences, and adult sexual assault, and considered different definitions of CSA. After adjusting for confounders, CSA survivors were more likely than their peers to experience internalizing, externalizing, and thought disorders, suicide attempts, health risk behaviors, systemic inflammation, poor oral health, sexually transmitted diseases, high-conflict relationships, benefit use, financial difficulties, antisocial behavior, and cumulative problems across multiple domains in adulthood. In sum, CSA was associated with multiple persistent problems across adulthood, even after adjusting for confounding life stressors, and the risk for particular problems incremented with CSA severity. The higher risk for most specific problems was small to moderate, but the cumulative long-term effects across multiple domains reflect considerable individual and societal burden. En ligne : https://dx.doi.org/10.1017/S0954579422001146 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523 [article] Childhood sexual abuse and pervasive problems across multiple life domains: Findings from a five-decade study [Texte imprimé et/ou numérique] / Hayley GUINEY, Auteur ; Avshalom CASPI, Auteur ; Antony AMBLER, Auteur ; Jay BELSKY, Auteur ; Jesse KOKAUA, Auteur ; Jonathan BROADBENT, Auteur ; Kirsten CHEYNE, Auteur ; Nigel DICKSON, Auteur ; Robert J. HANCOX, Auteur ; Honalee HARRINGTON, Auteur ; Sean HOGAN, Auteur ; Sandhya RAMRAKHA, Auteur ; Antoinette RIGHARTS, Auteur ; W. Murray THOMSON, Auteur ; Terrie E. MOFFITT, Auteur ; Richie POULTON, Auteur . - p.219-235. Langues : Anglais (eng) in Development and Psychopathology > 36-1 (February 2024) . - p.219-235 Mots-clés : child sexual abuseconsequences  long-term outcomes  longitudinal  multi-morbidity Index. décimale : PER Périodiques Résumé : The aim of this study was to use longitudinal population-based data to examine the associations between childhood sexual abuse (CSA) and risk for adverse outcomes in multiple life domains across adulthood. In 937 individuals followed from birth to age 45y, we assessed associations between CSA (retrospectively reported at age 26y) and the experience of 22 adverse outcomes in seven domains (physical, mental, sexual, interpersonal, economic, antisocial, multi-domain) from young adulthood to midlife (26 to 45y). Analyses controlled for sex, socioeconomic status, prospectively reported child harm and household dysfunction adverse childhood experiences, and adult sexual assault, and considered different definitions of CSA. After adjusting for confounders, CSA survivors were more likely than their peers to experience internalizing, externalizing, and thought disorders, suicide attempts, health risk behaviors, systemic inflammation, poor oral health, sexually transmitted diseases, high-conflict relationships, benefit use, financial difficulties, antisocial behavior, and cumulative problems across multiple domains in adulthood. In sum, CSA was associated with multiple persistent problems across adulthood, even after adjusting for confounding life stressors, and the risk for particular problems incremented with CSA severity. The higher risk for most specific problems was small to moderate, but the cumulative long-term effects across multiple domains reflect considerable individual and societal burden. En ligne : https://dx.doi.org/10.1017/S0954579422001146 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523

Lest we forget: comparing retrospective and prospective assessments of adverse childhood experiences in the prediction of adult health / Aaron REUBEN in Journal of Child Psychology and Psychiatry, 57-10 (October 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-10 (October 2016) . - p.1103-1112 Titre : Lest we forget: comparing retrospective and prospective assessments of adverse childhood experiences in the prediction of adult health Type de document : Texte imprimé et/ou numérique Auteurs : Aaron REUBEN, Auteur ; Terrie E. MOFFITT, Auteur ; Avshalom CASPI, Auteur ; Daniel W. BELSKY, Auteur ; Honalee HARRINGTON, Auteur ; Felix SCHROEDER, Auteur ; Sean HOGAN, Auteur ; Sandhya RAMRAKHA, Auteur ; Richie POULTON, Auteur ; Andrea DANESE, Auteur Article en page(s) : p.1103-1112 Langues : Anglais (eng) Mots-clés : Adverse childhood experiences  physical health  mental health  cognitive health  epidemiology Index. décimale : PER Périodiques Résumé : Background Adverse childhood experiences (ACEs; e.g. abuse, neglect, and parental loss) have been associated with increased risk for later-life disease and dysfunction using adults’ retrospective self-reports of ACEs. Research should test whether associations between ACEs and health outcomes are the same for prospective and retrospective ACE measures. Methods We estimated agreement between ACEs prospectively recorded throughout childhood (by Study staff at Study member ages 3, 5, 7, 9, 11, 13, and 15) and retrospectively recalled in adulthood (by Study members when they reached age 38), in the population-representative Dunedin cohort (N = 1,037). We related both retrospective and prospective ACE measures to physical, mental, cognitive, and social health at midlife measured through both objective (e.g. biomarkers and neuropsychological tests) and subjective (e.g. self-reported) means. Results Dunedin and U.S. Centers for Disease Control ACE distributions were similar. Retrospective and prospective measures of adversity showed moderate agreement (r = .47, p < .001; weighted Kappa = .31, 95% CI: .27–.35). Both associated with all midlife outcomes. As compared to prospective ACEs, retrospective ACEs showed stronger associations with life outcomes that were subjectively assessed, and weaker associations with life outcomes that were objectively assessed. Recalled ACEs and poor subjective outcomes were correlated regardless of whether prospectively recorded ACEs were evident. Individuals who recalled more ACEs than had been prospectively recorded were more neurotic than average, and individuals who recalled fewer ACEs than recorded were more agreeable. Conclusions Prospective ACE records confirm associations between childhood adversity and negative life outcomes found previously using retrospective ACE reports. However, more agreeable and neurotic dispositions may, respectively, bias retrospective ACE measures toward underestimating the impact of adversity on objectively measured life outcomes and overestimating the impact of adversity on self-reported outcomes. Associations between personality factors and the propensity to recall adversity were extremely modest and warrant further investigation. Risk predictions based on retrospective ACE reports should utilize objective outcome measures. Where objective outcome measurements are difficult to obtain, correction factors may be warranted. En ligne : http://dx.doi.org/10.1111/jcpp.12621 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295 [article] Lest we forget: comparing retrospective and prospective assessments of adverse childhood experiences in the prediction of adult health [Texte imprimé et/ou numérique] / Aaron REUBEN, Auteur ; Terrie E. MOFFITT, Auteur ; Avshalom CASPI, Auteur ; Daniel W. BELSKY, Auteur ; Honalee HARRINGTON, Auteur ; Felix SCHROEDER, Auteur ; Sean HOGAN, Auteur ; Sandhya RAMRAKHA, Auteur ; Richie POULTON, Auteur ; Andrea DANESE, Auteur . - p.1103-1112. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-10 (October 2016) . - p.1103-1112 Mots-clés : Adverse childhood experiences  physical health  mental health  cognitive health  epidemiology Index. décimale : PER Périodiques Résumé : Background Adverse childhood experiences (ACEs; e.g. abuse, neglect, and parental loss) have been associated with increased risk for later-life disease and dysfunction using adults’ retrospective self-reports of ACEs. Research should test whether associations between ACEs and health outcomes are the same for prospective and retrospective ACE measures. Methods We estimated agreement between ACEs prospectively recorded throughout childhood (by Study staff at Study member ages 3, 5, 7, 9, 11, 13, and 15) and retrospectively recalled in adulthood (by Study members when they reached age 38), in the population-representative Dunedin cohort (N = 1,037). We related both retrospective and prospective ACE measures to physical, mental, cognitive, and social health at midlife measured through both objective (e.g. biomarkers and neuropsychological tests) and subjective (e.g. self-reported) means. Results Dunedin and U.S. Centers for Disease Control ACE distributions were similar. Retrospective and prospective measures of adversity showed moderate agreement (r = .47, p < .001; weighted Kappa = .31, 95% CI: .27–.35). Both associated with all midlife outcomes. As compared to prospective ACEs, retrospective ACEs showed stronger associations with life outcomes that were subjectively assessed, and weaker associations with life outcomes that were objectively assessed. Recalled ACEs and poor subjective outcomes were correlated regardless of whether prospectively recorded ACEs were evident. Individuals who recalled more ACEs than had been prospectively recorded were more neurotic than average, and individuals who recalled fewer ACEs than recorded were more agreeable. Conclusions Prospective ACE records confirm associations between childhood adversity and negative life outcomes found previously using retrospective ACE reports. However, more agreeable and neurotic dispositions may, respectively, bias retrospective ACE measures toward underestimating the impact of adversity on objectively measured life outcomes and overestimating the impact of adversity on self-reported outcomes. Associations between personality factors and the propensity to recall adversity were extremely modest and warrant further investigation. Risk predictions based on retrospective ACE reports should utilize objective outcome measures. Where objective outcome measurements are difficult to obtain, correction factors may be warranted. En ligne : http://dx.doi.org/10.1111/jcpp.12621 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295

A polygenic score for age-at-first-birth predicts disinhibition / Leah S. RICHMOND-RAKERD in Journal of Child Psychology and Psychiatry, 61-12 (December 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-12 (December 2020) . - p.1349-1359 Titre : A polygenic score for age-at-first-birth predicts disinhibition Type de document : Texte imprimé et/ou numérique Auteurs : Leah S. RICHMOND-RAKERD, Auteur ; Terrie E. MOFFITT, Auteur ; Louise ARSENEAULT, Auteur ; Daniel W. BELSKY, Auteur ; Jennie CONNOR, Auteur ; David L. CORCORAN, Auteur ; Honalee HARRINGTON, Auteur ; Renate M. HOUTS, Auteur ; Richie POULTON, Auteur ; Joey A. PRINZ, Auteur ; Sandhya RAMRAKHA, Auteur ; Karen SUGDEN, Auteur ; Jasmin WERTZ, Auteur ; Benjamin S. WILLIAMS, Auteur ; Avshalom CASPI, Auteur Article en page(s) : p.1349-1359 Langues : Anglais (eng) Mots-clés : Reproductive behavior  genetics  longitudinal  risk-taking  self-control Index. décimale : PER Périodiques Résumé : BACKGROUND: A recent genome-wide association study identified molecular-genetic associations with age-at-first-birth. However, the meaning of these genetic discoveries is unclear. Drawing on evidence linking early pregnancy with disinhibitory behavior, we tested the hypothesis that genetic discoveries for age-at-first-birth predict disinhibition. METHODS: We included participants with genotype data from the two-decade-long Environmental Risk (E-Risk) Study (N = 1,999) and the four-decade-long Dunedin Study (N = 918). We calculated a genome-wide polygenic score for age-at-first-birth and tested whether it was associated with a range of disinhibitory outcomes across the life course, including low childhood self-control; risk for externalizing psychopathology; officially recorded criminal offending; substance dependence; informant reports of disinhibitory problems; and number of lifetime sexual partners. We further tested whether associations were attributable to accelerated pubertal maturation. RESULTS: In both cohorts, the age-at-first-birth polygenic score predicted low childhood self-control, externalizing psychopathology, officially recorded criminal offending, substance dependence, and number of sexual partners. Associations were modest, but robust across replication. Childhood disinhibition partly mediated associations between the polygenic score and reproductive behaviors. In contrast, associations were not attributable to accelerated pubertal timing. CONCLUSIONS: Genomic discoveries for age-at-first-birth are about more than reproductive biology: They provide insight into the disinhibitory traits and behaviors that accompany early parenthood. Age-at-first-birth is a useful proxy phenotype for researchers interested in disinhibition. Further, interventions that improve self-regulation abilities may benefit young parents and their children. En ligne : http://dx.doi.org/10.1111/jcpp.13224 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 [article] A polygenic score for age-at-first-birth predicts disinhibition [Texte imprimé et/ou numérique] / Leah S. RICHMOND-RAKERD, Auteur ; Terrie E. MOFFITT, Auteur ; Louise ARSENEAULT, Auteur ; Daniel W. BELSKY, Auteur ; Jennie CONNOR, Auteur ; David L. CORCORAN, Auteur ; Honalee HARRINGTON, Auteur ; Renate M. HOUTS, Auteur ; Richie POULTON, Auteur ; Joey A. PRINZ, Auteur ; Sandhya RAMRAKHA, Auteur ; Karen SUGDEN, Auteur ; Jasmin WERTZ, Auteur ; Benjamin S. WILLIAMS, Auteur ; Avshalom CASPI, Auteur . - p.1349-1359. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-12 (December 2020) . - p.1349-1359 Mots-clés : Reproductive behavior  genetics  longitudinal  risk-taking  self-control Index. décimale : PER Périodiques Résumé : BACKGROUND: A recent genome-wide association study identified molecular-genetic associations with age-at-first-birth. However, the meaning of these genetic discoveries is unclear. Drawing on evidence linking early pregnancy with disinhibitory behavior, we tested the hypothesis that genetic discoveries for age-at-first-birth predict disinhibition. METHODS: We included participants with genotype data from the two-decade-long Environmental Risk (E-Risk) Study (N = 1,999) and the four-decade-long Dunedin Study (N = 918). We calculated a genome-wide polygenic score for age-at-first-birth and tested whether it was associated with a range of disinhibitory outcomes across the life course, including low childhood self-control; risk for externalizing psychopathology; officially recorded criminal offending; substance dependence; informant reports of disinhibitory problems; and number of lifetime sexual partners. We further tested whether associations were attributable to accelerated pubertal maturation. RESULTS: In both cohorts, the age-at-first-birth polygenic score predicted low childhood self-control, externalizing psychopathology, officially recorded criminal offending, substance dependence, and number of sexual partners. Associations were modest, but robust across replication. Childhood disinhibition partly mediated associations between the polygenic score and reproductive behaviors. In contrast, associations were not attributable to accelerated pubertal timing. CONCLUSIONS: Genomic discoveries for age-at-first-birth are about more than reproductive biology: They provide insight into the disinhibitory traits and behaviors that accompany early parenthood. Age-at-first-birth is a useful proxy phenotype for researchers interested in disinhibition. Further, interventions that improve self-regulation abilities may benefit young parents and their children. En ligne : http://dx.doi.org/10.1111/jcpp.13224 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434

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