[article] 
inJournal of Autism and Developmental Disorders > 48-2 (February 2018) . - p.417-429

Titre :	White Matter Microstructure of the Human Mirror Neuron System is Related to Symptom Severity in Adults with Autism
Type de document :	Texte imprimé et/ou numérique
Auteurs :	O. FRUNDT, Auteur ; R. SCHULZ, Auteur ; D. SCHOTTLE, Auteur ; B. CHENG, Auteur ; G. THOMALLA, Auteur ; H. BRAASS, Auteur ; C. GANOS, Auteur ; N. DAVID, Auteur ; I. PEIKER, Auteur ; A. K. ENGEL, Auteur ; T. BAUMER, Auteur ; A. MUNCHAU, Auteur
Article en page(s) :	p.417-429
Langues :	Anglais (eng)
Mots-clés :	Autism spectrum disorders  Diffusion tensor imaging  Fiber tracking  Imitation  Mirror neuron system
Index. décimale :	PER Périodiques
Résumé :	Mirror neuron system (MNS) dysfunctions might underlie deficits in autism spectrum disorders (ASD). Diffusion tensor imaging based probabilistic tractography was conducted in 15 adult ASD patients and 13 matched, healthy controls. Fractional anisotropy (FA) was quantified to assess group differences in tract-related white matter microstructure of both the classical MNS route (mediating "emulation") and the alternative temporo-frontal route (mediating "mimicry"). Multiple linear regression was used to investigate structure-function relationships between MNS connections and ASD symptom severity. There were no significant group differences in tract-related FA indicating an intact classical MNS in ASD. Direct temporo-frontal connections could not be reconstructed challengeing the concept of multiple routes for imitation. Tract-related FA of right-hemispheric parieto-frontal connections was negatively related to autism symptom severity.
En ligne :	https://doi.org/10.1007/s10803-017-3332-9
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=337

[article] White Matter Microstructure of the Human Mirror Neuron System is Related to Symptom Severity in Adults with Autism [Texte imprimé et/ou numérique] / O. FRUNDT, Auteur ; R. SCHULZ, Auteur ; D. SCHOTTLE, Auteur ; B. CHENG, Auteur ; G. THOMALLA, Auteur ; H. BRAASS, Auteur ; C. GANOS, Auteur ; N. DAVID, Auteur ; I. PEIKER, Auteur ; A. K. ENGEL, Auteur ; T. BAUMER, Auteur ; A. MUNCHAU, Auteur . - p.417-429.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 48-2 (February 2018) . - p.417-429

Mots-clés :	Autism spectrum disorders  Diffusion tensor imaging  Fiber tracking  Imitation  Mirror neuron system
Index. décimale :	PER Périodiques
Résumé :	Mirror neuron system (MNS) dysfunctions might underlie deficits in autism spectrum disorders (ASD). Diffusion tensor imaging based probabilistic tractography was conducted in 15 adult ASD patients and 13 matched, healthy controls. Fractional anisotropy (FA) was quantified to assess group differences in tract-related white matter microstructure of both the classical MNS route (mediating "emulation") and the alternative temporo-frontal route (mediating "mimicry"). Multiple linear regression was used to investigate structure-function relationships between MNS connections and ASD symptom severity. There were no significant group differences in tract-related FA indicating an intact classical MNS in ASD. Direct temporo-frontal connections could not be reconstructed challengeing the concept of multiple routes for imitation. Tract-related FA of right-hemispheric parieto-frontal connections was negatively related to autism symptom severity.
En ligne :	https://doi.org/10.1007/s10803-017-3332-9
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=337