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White Matter Microstructure of the Human Mirror Neuron System is Related to Symptom Severity in Adults with Autism / O. FRUNDT in Journal of Autism and Developmental Disorders, 48-2 (February 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-2 (February 2018) . - p.417-429 Titre : White Matter Microstructure of the Human Mirror Neuron System is Related to Symptom Severity in Adults with Autism Type de document : texte imprimé Auteurs : O. FRUNDT, Auteur ; Robert SCHULZ, Auteur ; D. SCHOTTLE, Auteur ; Bastian CHENG, Auteur ; Götz THOMALLA, Auteur ; Hanna BRAASS, Auteur ; Christos GANOS, Auteur ; Nicole DAVID, Auteur ; Ina PEIKER, Auteur ; Andreas K. ENGEL, Auteur ; T. BAUMER, Auteur ; A. MUNCHAU, Auteur Article en page(s) : p.417-429 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Diffusion tensor imaging  Fiber tracking  Imitation  Mirror neuron system Index. décimale : PER Périodiques Résumé : Mirror neuron system (MNS) dysfunctions might underlie deficits in autism spectrum disorders (ASD). Diffusion tensor imaging based probabilistic tractography was conducted in 15 adult ASD patients and 13 matched, healthy controls. Fractional anisotropy (FA) was quantified to assess group differences in tract-related white matter microstructure of both the classical MNS route (mediating "emulation") and the alternative temporo-frontal route (mediating "mimicry"). Multiple linear regression was used to investigate structure-function relationships between MNS connections and ASD symptom severity. There were no significant group differences in tract-related FA indicating an intact classical MNS in ASD. Direct temporo-frontal connections could not be reconstructed challengeing the concept of multiple routes for imitation. Tract-related FA of right-hemispheric parieto-frontal connections was negatively related to autism symptom severity. En ligne : https://doi.org/10.1007/s10803-017-3332-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=337 [article] White Matter Microstructure of the Human Mirror Neuron System is Related to Symptom Severity in Adults with Autism [texte imprimé] / O. FRUNDT, Auteur ; Robert SCHULZ, Auteur ; D. SCHOTTLE, Auteur ; Bastian CHENG, Auteur ; Götz THOMALLA, Auteur ; Hanna BRAASS, Auteur ; Christos GANOS, Auteur ; Nicole DAVID, Auteur ; Ina PEIKER, Auteur ; Andreas K. ENGEL, Auteur ; T. BAUMER, Auteur ; A. MUNCHAU, Auteur . - p.417-429. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-2 (February 2018) . - p.417-429 Mots-clés : Autism spectrum disorders  Diffusion tensor imaging  Fiber tracking  Imitation  Mirror neuron system Index. décimale : PER Périodiques Résumé : Mirror neuron system (MNS) dysfunctions might underlie deficits in autism spectrum disorders (ASD). Diffusion tensor imaging based probabilistic tractography was conducted in 15 adult ASD patients and 13 matched, healthy controls. Fractional anisotropy (FA) was quantified to assess group differences in tract-related white matter microstructure of both the classical MNS route (mediating "emulation") and the alternative temporo-frontal route (mediating "mimicry"). Multiple linear regression was used to investigate structure-function relationships between MNS connections and ASD symptom severity. There were no significant group differences in tract-related FA indicating an intact classical MNS in ASD. Direct temporo-frontal connections could not be reconstructed challengeing the concept of multiple routes for imitation. Tract-related FA of right-hemispheric parieto-frontal connections was negatively related to autism symptom severity. En ligne : https://doi.org/10.1007/s10803-017-3332-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=337