Neural predictors of alcohol use and psychopathology symptoms in adolescents / T.Y. BRUMBACK in Development and Psychopathology, 28-4 pt1 (November 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-4 pt1 (November 2016) . - p.1209-1216 Titre : Neural predictors of alcohol use and psychopathology symptoms in adolescents Type de document : texte imprimé Auteurs : T.Y. BRUMBACK, Auteur ; Matthew WORLEY, Auteur ; Tam T. NGUYEN-LOUIE, Auteur ; Lindsay M. SQUEGLIA, Auteur ; Joanna JACOBUS, Auteur ; Susan F. TAPERT, Auteur Article en page(s) : p.1209-1216 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Adolescence is a period marked by increases in risk taking, sensation seeking, and emotion dysregulation. Neurobiological models of adolescent development propose that lagging development in brain regions associated with affect and behavior control compared to regions associated with reward and emotion processing may underlie these behavioral manifestations. Cross-sectional studies have identified several functional brain networks that may contribute to risk for substance use and psychopathology in adolescents. Determining brain structure measures that prospectively predict substance use and psychopathology could refine our understanding of the mechanisms that contribute to these problems, and lead to improved prevention efforts. Participants (N = 265) were healthy substance-naïve adolescents (ages 12–14) who underwent magnetic resonance imaging and then were followed annually for up to 13 years. Cortical thickness and surface area measures for three prefrontal regions (dorsolateral prefrontal cortex, inferior frontal gyrus, and orbitofrontal cortex) and three cortical regions from identified functional networks (anterior cingulate cortex, insular cortex, and parietal cortex) were used to predict subsequent binge drinking, externalizing symptoms, and internalizing symptoms. Thinner dorsolateral prefrontal cortex and inferior frontal cortex in early adolescence predicted more binge drinking and externalizing symptoms, respectively, in late adolescence (ps < .05). Having a family history of alcohol use disorder predicted more subsequent binge drinking and externalizing symptoms. Thinner parietal cortex, but not family history, predicted more subsequent internalizing symptoms (p < .05). This study emphasizes the temporal association between maturation of the salience, inhibition, and executive control networks in early adolescence and late adolescent behavior outcomes. Our findings indicate that developmental variations in these brain regions predate behavioral outcomes of substance use and psychopathology, and may therefore serve as prospective biomarkers of vulnerability. En ligne : http://dx.doi.org/10.1017/s0954579416000766 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Neural predictors of alcohol use and psychopathology symptoms in adolescents [texte imprimé] / T.Y. BRUMBACK, Auteur ; Matthew WORLEY, Auteur ; Tam T. NGUYEN-LOUIE, Auteur ; Lindsay M. SQUEGLIA, Auteur ; Joanna JACOBUS, Auteur ; Susan F. TAPERT, Auteur . - p.1209-1216. Langues : Anglais (eng) in Development and Psychopathology > 28-4 pt1 (November 2016) . - p.1209-1216 Index. décimale : PER Périodiques Résumé : Adolescence is a period marked by increases in risk taking, sensation seeking, and emotion dysregulation. Neurobiological models of adolescent development propose that lagging development in brain regions associated with affect and behavior control compared to regions associated with reward and emotion processing may underlie these behavioral manifestations. Cross-sectional studies have identified several functional brain networks that may contribute to risk for substance use and psychopathology in adolescents. Determining brain structure measures that prospectively predict substance use and psychopathology could refine our understanding of the mechanisms that contribute to these problems, and lead to improved prevention efforts. Participants (N = 265) were healthy substance-naïve adolescents (ages 12–14) who underwent magnetic resonance imaging and then were followed annually for up to 13 years. Cortical thickness and surface area measures for three prefrontal regions (dorsolateral prefrontal cortex, inferior frontal gyrus, and orbitofrontal cortex) and three cortical regions from identified functional networks (anterior cingulate cortex, insular cortex, and parietal cortex) were used to predict subsequent binge drinking, externalizing symptoms, and internalizing symptoms. Thinner dorsolateral prefrontal cortex and inferior frontal cortex in early adolescence predicted more binge drinking and externalizing symptoms, respectively, in late adolescence (ps < .05). Having a family history of alcohol use disorder predicted more subsequent binge drinking and externalizing symptoms. Thinner parietal cortex, but not family history, predicted more subsequent internalizing symptoms (p < .05). This study emphasizes the temporal association between maturation of the salience, inhibition, and executive control networks in early adolescence and late adolescent behavior outcomes. Our findings indicate that developmental variations in these brain regions predate behavioral outcomes of substance use and psychopathology, and may therefore serve as prospective biomarkers of vulnerability. En ligne : http://dx.doi.org/10.1017/s0954579416000766 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

Research Review: What have we learned about adolescent substance use? / Kylie M. GRAY in Journal of Child Psychology and Psychiatry, 59-6 (June 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-6 (June 2018) . - p.618-627 Titre : Research Review: What have we learned about adolescent substance use? Type de document : texte imprimé Auteurs : Kylie M. GRAY, Auteur ; Lindsay M. SQUEGLIA, Auteur Article en page(s) : p.618-627 Langues : Anglais (eng) Mots-clés : Adolescence  addiction  development  neurobiology  prevention  substance use  treatment Index. décimale : PER Périodiques Résumé : BACKGROUND: Adolescence is a critical biological, psychological, and social developmental stage involving heightened risk for substance use and associated adverse consequences. This review, synthesizing emerging findings on this complex topic, is intended to inform research and clinical care focused on adolescents. METHODS: Literature searches were conducted using PubMed, yielding a cross-section of observational and interventional studies focused on adolescent substance use. Findings were organized and categorized to cover key areas of epidemiology, neurobiology, prevention, and treatment. FINDINGS: Adolescent substance-related attitudes and use patterns have evolved over time, informed by adult and peer behaviors, public policy, media messaging, substance availability, and other variables. A number of risk and resiliency factors contribute to individual differences in substance use and related consequences. Advances in observational techniques have provided enhanced understanding of adolescent brain development and its implications for substance use. Prevention efforts have yielded mixed results, and while a number of adolescent-targeted evidence-based treatments for substance use disorders have been developed, effect sizes are generally modest, indicating the need for further research to enhance prevention and treatment outcomes. CONCLUSIONS: Substance use in adolescence is heterogeneous, ranging from normative to pathological, and can lead to significant acute and long-term morbidity and mortality. Understanding risk and resiliency factors, underlying neurobiology, and optimal developmentally sensitive interventions is critical in addressing substance-associated problems in adolescence. En ligne : http://dx.doi.org/10.1111/jcpp.12783 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363 [article] Research Review: What have we learned about adolescent substance use? [texte imprimé] / Kylie M. GRAY, Auteur ; Lindsay M. SQUEGLIA, Auteur . - p.618-627. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-6 (June 2018) . - p.618-627 Mots-clés : Adolescence  addiction  development  neurobiology  prevention  substance use  treatment Index. décimale : PER Périodiques Résumé : BACKGROUND: Adolescence is a critical biological, psychological, and social developmental stage involving heightened risk for substance use and associated adverse consequences. This review, synthesizing emerging findings on this complex topic, is intended to inform research and clinical care focused on adolescents. METHODS: Literature searches were conducted using PubMed, yielding a cross-section of observational and interventional studies focused on adolescent substance use. Findings were organized and categorized to cover key areas of epidemiology, neurobiology, prevention, and treatment. FINDINGS: Adolescent substance-related attitudes and use patterns have evolved over time, informed by adult and peer behaviors, public policy, media messaging, substance availability, and other variables. A number of risk and resiliency factors contribute to individual differences in substance use and related consequences. Advances in observational techniques have provided enhanced understanding of adolescent brain development and its implications for substance use. Prevention efforts have yielded mixed results, and while a number of adolescent-targeted evidence-based treatments for substance use disorders have been developed, effect sizes are generally modest, indicating the need for further research to enhance prevention and treatment outcomes. CONCLUSIONS: Substance use in adolescence is heterogeneous, ranging from normative to pathological, and can lead to significant acute and long-term morbidity and mortality. Understanding risk and resiliency factors, underlying neurobiology, and optimal developmentally sensitive interventions is critical in addressing substance-associated problems in adolescence. En ligne : http://dx.doi.org/10.1111/jcpp.12783 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363

The relationship between brain structure and general psychopathology in preadolescents / Louise MEWTON in Journal of Child Psychology and Psychiatry, 63-7 (July 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-7 (July 2022) . - p.734-744 Titre : The relationship between brain structure and general psychopathology in preadolescents Type de document : texte imprimé Auteurs : Louise MEWTON, Auteur ; Briana LEES, Auteur ; Lindsay M. SQUEGLIA, Auteur ; Miriam K. FORBES, Auteur ; Matthew SUNDERLAND, Auteur ; Robert F. KRUEGER, Auteur ; Forrest C. KOCH, Auteur ; Andrew BAILLIE, Auteur ; Tim SLADE, Auteur ; Nicholas HOY, Auteur ; Maree TEESSON, Auteur Article en page(s) : p.734-744 Langues : Anglais (eng) Mots-clés : Adolescent  Bayes Theorem  Brain  Child  Cognition  Humans  Male  Mental Disorders/psychology  Psychopathology  Generalized psychopathology  brain structure  externalizing  internalizing  preadolescence  interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: An emerging body of literature has indicated that broad, transdiagnostic dimensions of psychopathology are associated with alterations in brain structure across the life span. The current study aimed to investigate the relationship between brain structure and broad dimensions of psychopathology in the critical preadolescent period when psychopathology is emerging. METHODS: This study included baseline data from the Adolescent Brain and Cognitive Development (ABCD) Study(®) (n=11,875; age range=9-10 years; male=52.2%). General psychopathology, externalizing, internalizing, and thought disorder dimensions were based on a higher-order model of psychopathology and estimated using Bayesian plausible values. Outcome variables included global and regional cortical volume, thickness, and surface area. RESULTS: Higher levels of psychopathology across all dimensions were associated with lower volume and surface area globally, as well as widespread and pervasive alterations across the majority of cortical and subcortical regions studied, after adjusting for sex, race/ethnicity, parental education, income, and maternal psychopathology. The relationships between general psychopathology and brain structure were attenuated when adjusting for cognitive functioning. There were no statistically significant relationships between psychopathology and cortical thickness in this sample of preadolescents. CONCLUSIONS: The current study identified lower cortical volume and surface area as transdiagnostic biomarkers for general psychopathology in preadolescence. Future research may focus on whether the widespread and pervasive relationships between general psychopathology and brain structure reflect cognitive dysfunction that is a feature across a range of mental illnesses. En ligne : http://dx.doi.org/10.1111/jcpp.13513 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] The relationship between brain structure and general psychopathology in preadolescents [texte imprimé] / Louise MEWTON, Auteur ; Briana LEES, Auteur ; Lindsay M. SQUEGLIA, Auteur ; Miriam K. FORBES, Auteur ; Matthew SUNDERLAND, Auteur ; Robert F. KRUEGER, Auteur ; Forrest C. KOCH, Auteur ; Andrew BAILLIE, Auteur ; Tim SLADE, Auteur ; Nicholas HOY, Auteur ; Maree TEESSON, Auteur . - p.734-744. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-7 (July 2022) . - p.734-744 Mots-clés : Adolescent  Bayes Theorem  Brain  Child  Cognition  Humans  Male  Mental Disorders/psychology  Psychopathology  Generalized psychopathology  brain structure  externalizing  internalizing  preadolescence  interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: An emerging body of literature has indicated that broad, transdiagnostic dimensions of psychopathology are associated with alterations in brain structure across the life span. The current study aimed to investigate the relationship between brain structure and broad dimensions of psychopathology in the critical preadolescent period when psychopathology is emerging. METHODS: This study included baseline data from the Adolescent Brain and Cognitive Development (ABCD) Study(®) (n=11,875; age range=9-10 years; male=52.2%). General psychopathology, externalizing, internalizing, and thought disorder dimensions were based on a higher-order model of psychopathology and estimated using Bayesian plausible values. Outcome variables included global and regional cortical volume, thickness, and surface area. RESULTS: Higher levels of psychopathology across all dimensions were associated with lower volume and surface area globally, as well as widespread and pervasive alterations across the majority of cortical and subcortical regions studied, after adjusting for sex, race/ethnicity, parental education, income, and maternal psychopathology. The relationships between general psychopathology and brain structure were attenuated when adjusting for cognitive functioning. There were no statistically significant relationships between psychopathology and cortical thickness in this sample of preadolescents. CONCLUSIONS: The current study identified lower cortical volume and surface area as transdiagnostic biomarkers for general psychopathology in preadolescence. Future research may focus on whether the widespread and pervasive relationships between general psychopathology and brain structure reflect cognitive dysfunction that is a feature across a range of mental illnesses. En ligne : http://dx.doi.org/10.1111/jcpp.13513 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

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