[article] 
inJournal of Autism and Developmental Disorders > 48-10 (October 2018) . - p.3460-3473

Titre :	Cerebro-Cerebellar Functional Connectivity is Associated with Cerebellar Excitation-Inhibition Balance in Autism Spectrum Disorder
Type de document :	Texte imprimé et/ou numérique
Auteurs :	J. P. HEGARTY, Auteur ; D. J. WEBER, Auteur ; C. M. CIRSTEA, Auteur ; David Q. BEVERSDORF, Auteur
Article en page(s) :	p.3460-3473
Langues :	Anglais (eng)
Mots-clés :	Cerebellum  Dorsolateral prefrontal cortex  Functional connectivity  Gamma-aminobutyric acid (GABA)  Glutamate  Magnetic resonance spectroscopy (MRS)
Index. décimale :	PER Périodiques
Résumé :	Atypical functional connectivity (FC) and an imbalance of excitation-to-inhibition (E/I) have been previously reported in cerebro-cerebellar circuits in autism spectrum disorder (ASD). The current investigation used resting state fMRI and proton magnetic resonance spectroscopy ((1)H-MRS) to examine the relationships between E/I (glutamate + glutamine/GABA) and FC of the dorsolateral prefrontal cortex and posterolateral cerebellar hemisphere from 14 adolescents/adults with ASD and 12 age/sex/IQ-matched controls. In this pilot sample, cerebro-cerebellar FC was positively associated with cerebellar E/I and listening comprehension abilities in individuals with ASD but not controls. Additionally, a subgroup of individuals with ASD and low FC (n = 5) exhibited reduced E/I and impaired listening comprehension. Thus, altered functional coherence of cerebro-cerebellar circuits in ASD may be related with a cerebellar E/I imbalance.
En ligne :	http://dx.doi.org/10.1007/s10803-018-3613-y
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369

[article] Cerebro-Cerebellar Functional Connectivity is Associated with Cerebellar Excitation-Inhibition Balance in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / J. P. HEGARTY, Auteur ; D. J. WEBER, Auteur ; C. M. CIRSTEA, Auteur ; David Q. BEVERSDORF, Auteur . - p.3460-3473.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 48-10 (October 2018) . - p.3460-3473

Mots-clés :	Cerebellum  Dorsolateral prefrontal cortex  Functional connectivity  Gamma-aminobutyric acid (GABA)  Glutamate  Magnetic resonance spectroscopy (MRS)
Index. décimale :	PER Périodiques
Résumé :	Atypical functional connectivity (FC) and an imbalance of excitation-to-inhibition (E/I) have been previously reported in cerebro-cerebellar circuits in autism spectrum disorder (ASD). The current investigation used resting state fMRI and proton magnetic resonance spectroscopy ((1)H-MRS) to examine the relationships between E/I (glutamate + glutamine/GABA) and FC of the dorsolateral prefrontal cortex and posterolateral cerebellar hemisphere from 14 adolescents/adults with ASD and 12 age/sex/IQ-matched controls. In this pilot sample, cerebro-cerebellar FC was positively associated with cerebellar E/I and listening comprehension abilities in individuals with ASD but not controls. Additionally, a subgroup of individuals with ASD and low FC (n = 5) exhibited reduced E/I and impaired listening comprehension. Thus, altered functional coherence of cerebro-cerebellar circuits in ASD may be related with a cerebellar E/I imbalance.
En ligne :	http://dx.doi.org/10.1007/s10803-018-3613-y
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369