Anxious/depressed symptoms are related to microstructural maturation of white matter in typically developing youths / Matthew D. ALBAUGH in Development and Psychopathology, 29-3 (August 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-3 (August 2017) . - p.751-758 Titre : Anxious/depressed symptoms are related to microstructural maturation of white matter in typically developing youths Type de document : Texte imprimé et/ou numérique Auteurs : Matthew D. ALBAUGH, Auteur ; Simon DUCHARME, Auteur ; Sherif KARAMA, Auteur ; Richard WATTS, Auteur ; John D. LEWIS, Auteur ; Catherine ORR, Auteur ; Tuong-Vi NGUYEN, Auteur ; Robert C. MCKINSTRY, Auteur ; Kelly N. BOTTERON, Auteur ; Alan C. EVANS, Auteur ; James J. HUDZIAK, Auteur Article en page(s) : p.751-758 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract There are multiple recent reports of an association between anxious/depressed (A/D) symptomatology and the rate of cerebral cortical thickness maturation in typically developing youths. We investigated the degree to which anxious/depressed symptoms are tied to age-related microstructural changes in cerebral fiber pathways. The participants were part of the NIH MRI Study of Normal Brain Development. Child Behavior Checklist A/D scores and diffusion imaging were available for 175 youths (84 males, 91 females; 241 magnetic resonance imagings) at up to three visits. The participants ranged from 5.7 to 18.4 years of age at the time of the scan. Alignment of fractional anisotropy data was implemented using FSL/Tract-Based Spatial Statistics, and linear mixed model regression was carried out using SPSS. Child Behavior Checklist A/D was associated with the rate of microstructural development in several white matter pathways, including the bilateral anterior thalamic radiation, bilateral inferior longitudinal fasciculus, left superior longitudinal fasciculus, and right cingulum. Across these pathways, greater age-related fractional anisotropy increases were observed at lower levels of A/D. The results suggest that subclinical A/D symptoms are associated with the rate of microstructural development within several white matter pathways that have been implicated in affect regulation, as well as mood and anxiety psychopathology. En ligne : http://dx.doi.org/10.1017/s0954579416000444 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=311 [article] Anxious/depressed symptoms are related to microstructural maturation of white matter in typically developing youths [Texte imprimé et/ou numérique] / Matthew D. ALBAUGH, Auteur ; Simon DUCHARME, Auteur ; Sherif KARAMA, Auteur ; Richard WATTS, Auteur ; John D. LEWIS, Auteur ; Catherine ORR, Auteur ; Tuong-Vi NGUYEN, Auteur ; Robert C. MCKINSTRY, Auteur ; Kelly N. BOTTERON, Auteur ; Alan C. EVANS, Auteur ; James J. HUDZIAK, Auteur . - p.751-758. Langues : Anglais (eng) in Development and Psychopathology > 29-3 (August 2017) . - p.751-758 Index. décimale : PER Périodiques Résumé : Abstract There are multiple recent reports of an association between anxious/depressed (A/D) symptomatology and the rate of cerebral cortical thickness maturation in typically developing youths. We investigated the degree to which anxious/depressed symptoms are tied to age-related microstructural changes in cerebral fiber pathways. The participants were part of the NIH MRI Study of Normal Brain Development. Child Behavior Checklist A/D scores and diffusion imaging were available for 175 youths (84 males, 91 females; 241 magnetic resonance imagings) at up to three visits. The participants ranged from 5.7 to 18.4 years of age at the time of the scan. Alignment of fractional anisotropy data was implemented using FSL/Tract-Based Spatial Statistics, and linear mixed model regression was carried out using SPSS. Child Behavior Checklist A/D was associated with the rate of microstructural development in several white matter pathways, including the bilateral anterior thalamic radiation, bilateral inferior longitudinal fasciculus, left superior longitudinal fasciculus, and right cingulum. Across these pathways, greater age-related fractional anisotropy increases were observed at lower levels of A/D. The results suggest that subclinical A/D symptoms are associated with the rate of microstructural development within several white matter pathways that have been implicated in affect regulation, as well as mood and anxiety psychopathology. En ligne : http://dx.doi.org/10.1017/s0954579416000444 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=311

Association of cumulative prenatal adversity with infant subcortical structure volumes and child problem behavior and its moderation by a coexpression polygenic risk score of the serotonin system / Henriette ACOSTA in Development and Psychopathology, 36-3 (August 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-3 (August 2024) . - p.1027-1042 Titre : Association of cumulative prenatal adversity with infant subcortical structure volumes and child problem behavior and its moderation by a coexpression polygenic risk score of the serotonin system Type de document : Texte imprimé et/ou numérique Auteurs : Henriette ACOSTA, Auteur ; Katri KANTOJARVI, Auteur ; Jetro J. TUULARI, Auteur ; John D. LEWIS, Auteur ; Niloofar HASHEMPOUR, Auteur ; Noora M. SCHEININ, Auteur ; Satu J. LEHTOLA, Auteur ; Saara NOLVI, Auteur ; Vladimir S. FONOV, Auteur ; D. Louis COLLINS, Auteur ; Alan C. EVANS, Auteur ; Riitta PARKKOLA, Auteur ; Tuire LÄHDESMÄKI, Auteur ; Jani SAUNAVAARA, Auteur ; Harri MERISAARI, Auteur ; Linnea KARLSSON, Auteur ; Tiina PAUNIO, Auteur ; Hasse KARLSSON, Auteur Article en page(s) : p.1027-1042 Langues : Anglais (eng) Mots-clés : MRI  SDQ  amygdala  hyperactivity  prenatal stress Index. décimale : PER Périodiques Résumé : Prenatal adversity has been linked to later psychopathology. Yet, research on cumulative prenatal adversity, as well as its interaction with offspring genotype, on brain and behavioral development is scarce. With this study, we aimed to address this gap. In Finnish mother-infant dyads, we investigated the association of a cumulative prenatal adversity sum score (PRE-AS) with (a) child emotional and behavioral problems assessed with the Strengths and Difficulties Questionnaire at 4 and 5 years (N = 1568, 45.3% female), (b) infant amygdalar and hippocampal volumes (subsample N = 122), and (c) its moderation by a hippocampal-specific coexpression polygenic risk score based on the serotonin transporter (SLC6A4) gene. We found that higher PRE-AS was linked to greater child emotional and behavioral problems at both time points, with partly stronger associations in boys than in girls. Higher PRE-AS was associated with larger bilateral infant amygdalar volumes in girls compared to boys, while no associations were found for hippocampal volumes. Further, hyperactivity/inattention in 4-year-old girls was related to both genotype and PRE-AS, the latter partially mediated by right amygdalar volumes as preliminary evidence suggests. Our study is the first to demonstrate a dose-dependent sexually dimorphic relationship between cumulative prenatal adversity and infant amygdalar volumes. En ligne : https://dx.doi.org/10.1017/S0954579423000275 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 [article] Association of cumulative prenatal adversity with infant subcortical structure volumes and child problem behavior and its moderation by a coexpression polygenic risk score of the serotonin system [Texte imprimé et/ou numérique] / Henriette ACOSTA, Auteur ; Katri KANTOJARVI, Auteur ; Jetro J. TUULARI, Auteur ; John D. LEWIS, Auteur ; Niloofar HASHEMPOUR, Auteur ; Noora M. SCHEININ, Auteur ; Satu J. LEHTOLA, Auteur ; Saara NOLVI, Auteur ; Vladimir S. FONOV, Auteur ; D. Louis COLLINS, Auteur ; Alan C. EVANS, Auteur ; Riitta PARKKOLA, Auteur ; Tuire LÄHDESMÄKI, Auteur ; Jani SAUNAVAARA, Auteur ; Harri MERISAARI, Auteur ; Linnea KARLSSON, Auteur ; Tiina PAUNIO, Auteur ; Hasse KARLSSON, Auteur . - p.1027-1042. Langues : Anglais (eng) in Development and Psychopathology > 36-3 (August 2024) . - p.1027-1042 Mots-clés : MRI  SDQ  amygdala  hyperactivity  prenatal stress Index. décimale : PER Périodiques Résumé : Prenatal adversity has been linked to later psychopathology. Yet, research on cumulative prenatal adversity, as well as its interaction with offspring genotype, on brain and behavioral development is scarce. With this study, we aimed to address this gap. In Finnish mother-infant dyads, we investigated the association of a cumulative prenatal adversity sum score (PRE-AS) with (a) child emotional and behavioral problems assessed with the Strengths and Difficulties Questionnaire at 4 and 5 years (N = 1568, 45.3% female), (b) infant amygdalar and hippocampal volumes (subsample N = 122), and (c) its moderation by a hippocampal-specific coexpression polygenic risk score based on the serotonin transporter (SLC6A4) gene. We found that higher PRE-AS was linked to greater child emotional and behavioral problems at both time points, with partly stronger associations in boys than in girls. Higher PRE-AS was associated with larger bilateral infant amygdalar volumes in girls compared to boys, while no associations were found for hippocampal volumes. Further, hyperactivity/inattention in 4-year-old girls was related to both genotype and PRE-AS, the latter partially mediated by right amygdalar volumes as preliminary evidence suggests. Our study is the first to demonstrate a dose-dependent sexually dimorphic relationship between cumulative prenatal adversity and infant amygdalar volumes. En ligne : https://dx.doi.org/10.1017/S0954579423000275 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538

---

1 (1 - 2 / 2)