DNA methylation profiles in adults born at extremely low birth weight / Karen J. MATHEWSON in Development and Psychopathology, 34-1 (February 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-1 (February 2022) . - p.19-36 Titre : DNA methylation profiles in adults born at extremely low birth weight Type de document : texte imprimé Auteurs : Karen J. MATHEWSON, Auteur ; Patrick O. MCGOWAN, Auteur ; Wilfred C. DE VEGA, Auteur ; Ryan J. VAN LIESHOUT, Auteur ; Katherine M. MORRISON, Auteur ; Saroj SAIGAL, Auteur ; Louis A. SCHMIDT, Auteur Article en page(s) : p.19-36 Langues : Anglais (eng) Mots-clés : DNA methylation profiling  epigenetic modification  extremely low birth weight (ELBW)  sex differences  stress reactivity and vulnerability Index. décimale : PER Périodiques Résumé : Effects of stresses associated with extremely preterm birth may be biologically ?recorded? in the genomes of individuals born preterm via changes in DNA methylation (DNAm) patterns. Genome-wide DNAm profiles were examined in buccal epithelial cells from 45 adults born at extremely low birth weight (ELBW; 1000 g) in the oldest known cohort of prospectively followed ELBW survivors (Mage = 32.35 years, 17 male), and 47 normal birth weight (NBW; 2500 g) control adults (Mage = 32.43 years, 20 male). Sex differences in DNAm profiles were found in both birth weight groups, but they were greatly enhanced in the ELBW group (77,895 loci) versus the NBW group (3,424 loci), suggesting synergistic effects of extreme prenatal adversity and sex on adult DNAm profiles. In men, DNAm profiles differed by birth weight group at 1,354 loci on 694 unique genes. Only two loci on two genes distinguished between ELBW and NBW women. Gene ontology (GO) and network analyses indicated that loci differentiating between ELBW and NBW men were abundant in genes within biological pathways related to neuronal development, synaptic transportation, metabolic regulation, and cellular regulation. Findings suggest increased sensitivity of males to long-term epigenetic effects of extremely preterm birth. Group differences are discussed in relation to particular gene functions. En ligne : http://dx.doi.org/10.1017/s0954579420000899 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 [article] DNA methylation profiles in adults born at extremely low birth weight [texte imprimé] / Karen J. MATHEWSON, Auteur ; Patrick O. MCGOWAN, Auteur ; Wilfred C. DE VEGA, Auteur ; Ryan J. VAN LIESHOUT, Auteur ; Katherine M. MORRISON, Auteur ; Saroj SAIGAL, Auteur ; Louis A. SCHMIDT, Auteur . - p.19-36. Langues : Anglais (eng) in Development and Psychopathology > 34-1 (February 2022) . - p.19-36 Mots-clés : DNA methylation profiling  epigenetic modification  extremely low birth weight (ELBW)  sex differences  stress reactivity and vulnerability Index. décimale : PER Périodiques Résumé : Effects of stresses associated with extremely preterm birth may be biologically ?recorded? in the genomes of individuals born preterm via changes in DNA methylation (DNAm) patterns. Genome-wide DNAm profiles were examined in buccal epithelial cells from 45 adults born at extremely low birth weight (ELBW; 1000 g) in the oldest known cohort of prospectively followed ELBW survivors (Mage = 32.35 years, 17 male), and 47 normal birth weight (NBW; 2500 g) control adults (Mage = 32.43 years, 20 male). Sex differences in DNAm profiles were found in both birth weight groups, but they were greatly enhanced in the ELBW group (77,895 loci) versus the NBW group (3,424 loci), suggesting synergistic effects of extreme prenatal adversity and sex on adult DNAm profiles. In men, DNAm profiles differed by birth weight group at 1,354 loci on 694 unique genes. Only two loci on two genes distinguished between ELBW and NBW women. Gene ontology (GO) and network analyses indicated that loci differentiating between ELBW and NBW men were abundant in genes within biological pathways related to neuronal development, synaptic transportation, metabolic regulation, and cellular regulation. Findings suggest increased sensitivity of males to long-term epigenetic effects of extremely preterm birth. Group differences are discussed in relation to particular gene functions. En ligne : http://dx.doi.org/10.1017/s0954579420000899 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474

Extremely low birth weight babies grown up: Gene–environment interaction predicts internalizing problems in the third and fourth decades of life / Ayelet LAHAT in Development and Psychopathology, 29-3 (August 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-3 (August 2017) . - p.837-843 Titre : Extremely low birth weight babies grown up: Gene–environment interaction predicts internalizing problems in the third and fourth decades of life Type de document : texte imprimé Auteurs : Ayelet LAHAT, Auteur ; Ryan J. VAN LIESHOUT, Auteur ; Karen J. MATHEWSON, Auteur ; James MACKILLOP, Auteur ; Saroj SAIGAL, Auteur ; Katherine M. MORRISON, Auteur ; Michael H. BOYLE, Auteur ; Louis A. SCHMIDT, Auteur Article en page(s) : p.837-843 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Extremely low birth weight (ELBW; 5-HTTLPR). We followed the oldest longitudinal cohort of ELBW survivors to adulthood. Participants provided buccal cells and reported on internalizing problems, using the Young Adult Self-Report when they were in their mid-20s (ELBW/SGA, N = 28; ELBW/AGA, N = 60; NBW, N = 81) and mid-30s (ELBW/SGA, N = 27; ELBW/AGA, N = 58; NBW, N = 76). The findings indicate that ELBW/SGAs carrying the 5-HTTLPR short allele reported increased internalizing problems, particularly depression, during the third and fourth decades of life. This is the first known report on gene–environment interactions predicting psychopathology among ELBW survivors. Our findings elucidate putative neurobiological pathways that underlie risk for psychopathology. En ligne : http://dx.doi.org/10.1017/s0954579416000511 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=311 [article] Extremely low birth weight babies grown up: Gene–environment interaction predicts internalizing problems in the third and fourth decades of life [texte imprimé] / Ayelet LAHAT, Auteur ; Ryan J. VAN LIESHOUT, Auteur ; Karen J. MATHEWSON, Auteur ; James MACKILLOP, Auteur ; Saroj SAIGAL, Auteur ; Katherine M. MORRISON, Auteur ; Michael H. BOYLE, Auteur ; Louis A. SCHMIDT, Auteur . - p.837-843. Langues : Anglais (eng) in Development and Psychopathology > 29-3 (August 2017) . - p.837-843 Index. décimale : PER Périodiques Résumé : Abstract Extremely low birth weight (ELBW; 5-HTTLPR). We followed the oldest longitudinal cohort of ELBW survivors to adulthood. Participants provided buccal cells and reported on internalizing problems, using the Young Adult Self-Report when they were in their mid-20s (ELBW/SGA, N = 28; ELBW/AGA, N = 60; NBW, N = 81) and mid-30s (ELBW/SGA, N = 27; ELBW/AGA, N = 58; NBW, N = 76). The findings indicate that ELBW/SGAs carrying the 5-HTTLPR short allele reported increased internalizing problems, particularly depression, during the third and fourth decades of life. This is the first known report on gene–environment interactions predicting psychopathology among ELBW survivors. Our findings elucidate putative neurobiological pathways that underlie risk for psychopathology. En ligne : http://dx.doi.org/10.1017/s0954579416000511 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=311

Trajectories of psychopathology in extremely low birth weight survivors from early adolescence to adulthood: a 20-year longitudinal study / Ryan J. VAN LIESHOUT in Journal of Child Psychology and Psychiatry, 59-11 (November 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-11 (November 2018) . - p.1192-1200 Titre : Trajectories of psychopathology in extremely low birth weight survivors from early adolescence to adulthood: a 20-year longitudinal study Type de document : texte imprimé Auteurs : Ryan J. VAN LIESHOUT, Auteur ; Mark A. FERRO, Auteur ; Louis A. SCHMIDT, Auteur ; Michael H. BOYLE, Auteur ; Saroj SAIGAL, Auteur ; Katherine M. MORRISON, Auteur ; Karen J. MATHEWSON, Auteur Article en page(s) : p.1192-1200 Langues : Anglais (eng) Mots-clés : Extremely low birth weight  adolescent  adult  internalizing disorder  longitudinal studies Index. décimale : PER Périodiques Résumé : BACKGROUND: Individuals born extremely preterm are exposed to significant perinatal stresses that are associated with an increased risk of psychopathology. However, a paucity of longitudinal studies has prevented the empirical examination of long-term, dynamic effects of perinatal adversity on mental health. Here, internalizing and externalizing problems from adolescence through adulthood were compared in individuals born at extremely low birth weight (ELBW; <1,000 g) and normal birth weight (NBW; >2,500 g). METHODS: Internalizing and externalizing data were collected over 20 years in three waves, during adolescence, young adulthood, and adulthood. Growth models were used to compare longitudinal trajectories in a geographically based sample of 151 ELBW survivors and 137 NBW control participants born between 1977 and 1982 matched for age, sex, and socioeconomic status at age 8. RESULTS: After adjusting for sex, socioeconomic and immigrant status, and family functioning, ELBW survivors failed to show the normative, age-related decline in internalizing problems over time relative to their NBW peers (beta = .21; p < .01). Both groups exhibited small declines in externalizing problems over the same period. Self-esteem (but not physical health, IQ, or maternal mood) partially mediated the association between ELBW status and internalizing problems. CONCLUSIONS: Extremely low birth weight survivors experienced a blunting of the expected improvement in depression and anxiety from adolescence to adulthood. These findings suggest that altered physiological regulatory systems supporting emotional and cognitive processing may contribute to the maintenance of internalizing problems in this population. En ligne : http://dx.doi.org/10.1111/jcpp.12909 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370 [article] Trajectories of psychopathology in extremely low birth weight survivors from early adolescence to adulthood: a 20-year longitudinal study [texte imprimé] / Ryan J. VAN LIESHOUT, Auteur ; Mark A. FERRO, Auteur ; Louis A. SCHMIDT, Auteur ; Michael H. BOYLE, Auteur ; Saroj SAIGAL, Auteur ; Katherine M. MORRISON, Auteur ; Karen J. MATHEWSON, Auteur . - p.1192-1200. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-11 (November 2018) . - p.1192-1200 Mots-clés : Extremely low birth weight  adolescent  adult  internalizing disorder  longitudinal studies Index. décimale : PER Périodiques Résumé : BACKGROUND: Individuals born extremely preterm are exposed to significant perinatal stresses that are associated with an increased risk of psychopathology. However, a paucity of longitudinal studies has prevented the empirical examination of long-term, dynamic effects of perinatal adversity on mental health. Here, internalizing and externalizing problems from adolescence through adulthood were compared in individuals born at extremely low birth weight (ELBW; <1,000 g) and normal birth weight (NBW; >2,500 g). METHODS: Internalizing and externalizing data were collected over 20 years in three waves, during adolescence, young adulthood, and adulthood. Growth models were used to compare longitudinal trajectories in a geographically based sample of 151 ELBW survivors and 137 NBW control participants born between 1977 and 1982 matched for age, sex, and socioeconomic status at age 8. RESULTS: After adjusting for sex, socioeconomic and immigrant status, and family functioning, ELBW survivors failed to show the normative, age-related decline in internalizing problems over time relative to their NBW peers (beta = .21; p < .01). Both groups exhibited small declines in externalizing problems over the same period. Self-esteem (but not physical health, IQ, or maternal mood) partially mediated the association between ELBW status and internalizing problems. CONCLUSIONS: Extremely low birth weight survivors experienced a blunting of the expected improvement in depression and anxiety from adolescence to adulthood. These findings suggest that altered physiological regulatory systems supporting emotional and cognitive processing may contribute to the maintenance of internalizing problems in this population. En ligne : http://dx.doi.org/10.1111/jcpp.12909 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370

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