Affective and psychotic reactivity to daily-life stress in adults with 22q11DS: a study using the experience sampling method / Maude SCHNEIDER in Journal of Neurodevelopmental Disorders, 12 (2020)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 12 (2020) Titre : Affective and psychotic reactivity to daily-life stress in adults with 22q11DS: a study using the experience sampling method Type de document : texte imprimé Auteurs : Maude SCHNEIDER, Auteur ; Thomas VAESSEN, Auteur ; Esther D.A. VAN DUIN, Auteur ; Zuzana KASANOVA, Auteur ; Wolfgang VIECHTBAUER, Auteur ; Ulrich REININGHAUS, Auteur ; Claudia VINGERHOETS, Auteur ; Jan BOOIJ, Auteur ; Ann SWILLEN, Auteur ; Jacob A.S. VORSTMAN, Auteur ; Thérèse VAN AMELSVOORT, Auteur ; Inez MYIN-GERMEYS, Auteur Langues : Anglais (eng) Mots-clés : Adult  DiGeorge Syndrome  Ecological Momentary Assessment  Humans  Mental Disorders  Psychotic Disorders/complications  Stress, Psychological/complications  22q11.2 deletion syndrome  Experience sampling method  Momentary psychotic experiences  Negative affect  Positive affect  Stress reactivity Index. décimale : PER Périodiques Résumé : BACKGROUND: 22q11.2 deletion syndrome (22q11DS) is a genetic disorder associated with an increased risk of psychiatric disorders. Vulnerability for psychopathology has been related to an increased reactivity to stress. Here, we examined affective states, perceived stress, affective and psychotic reactivity to various sources of environmental stress using the experience sampling method (ESM), a structured diary technique allowing repeated assessments in the context of daily life. METHODS: Adults with 22q11DS (n = 31; age, 34.1 years) and matched healthy controls (HCs; n = 24; age, 39.9 years) were included. ESM was used to assess affective states, perceived stress, and stress reactivity. Data were analyzed using multilevel regression models. RESULTS: Adults with 22q11DS displayed overall higher levels of negative affect but comparable levels of positive affect compared to HCs. Higher levels of perceived stress were reported by individuals with 22q11DS. Comparable affective and psychotic reactivity in relation to all types of environmental stress was observed between the two groups. CONCLUSION: The results point toward higher levels of negative affect and differences in the perception of daily hassles in 22q11DS but no difference in affective or psychotic reactivity to stress. This study contributes to the growing literature regarding the impact of stress on the development of psychopathology in the 22q11DS population. En ligne : https://dx.doi.org/10.1186/s11689-020-09333-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 [article] Affective and psychotic reactivity to daily-life stress in adults with 22q11DS: a study using the experience sampling method [texte imprimé] / Maude SCHNEIDER, Auteur ; Thomas VAESSEN, Auteur ; Esther D.A. VAN DUIN, Auteur ; Zuzana KASANOVA, Auteur ; Wolfgang VIECHTBAUER, Auteur ; Ulrich REININGHAUS, Auteur ; Claudia VINGERHOETS, Auteur ; Jan BOOIJ, Auteur ; Ann SWILLEN, Auteur ; Jacob A.S. VORSTMAN, Auteur ; Thérèse VAN AMELSVOORT, Auteur ; Inez MYIN-GERMEYS, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 12 (2020) Mots-clés : Adult  DiGeorge Syndrome  Ecological Momentary Assessment  Humans  Mental Disorders  Psychotic Disorders/complications  Stress, Psychological/complications  22q11.2 deletion syndrome  Experience sampling method  Momentary psychotic experiences  Negative affect  Positive affect  Stress reactivity Index. décimale : PER Périodiques Résumé : BACKGROUND: 22q11.2 deletion syndrome (22q11DS) is a genetic disorder associated with an increased risk of psychiatric disorders. Vulnerability for psychopathology has been related to an increased reactivity to stress. Here, we examined affective states, perceived stress, affective and psychotic reactivity to various sources of environmental stress using the experience sampling method (ESM), a structured diary technique allowing repeated assessments in the context of daily life. METHODS: Adults with 22q11DS (n = 31; age, 34.1 years) and matched healthy controls (HCs; n = 24; age, 39.9 years) were included. ESM was used to assess affective states, perceived stress, and stress reactivity. Data were analyzed using multilevel regression models. RESULTS: Adults with 22q11DS displayed overall higher levels of negative affect but comparable levels of positive affect compared to HCs. Higher levels of perceived stress were reported by individuals with 22q11DS. Comparable affective and psychotic reactivity in relation to all types of environmental stress was observed between the two groups. CONCLUSION: The results point toward higher levels of negative affect and differences in the perception of daily hassles in 22q11DS but no difference in affective or psychotic reactivity to stress. This study contributes to the growing literature regarding the impact of stress on the development of psychopathology in the 22q11DS population. En ligne : https://dx.doi.org/10.1186/s11689-020-09333-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573

Erratum to: Neural correlates of reward processing in adults with 22q11 deletion syndrome / Esther D.A. VAN DUIN in Journal of Neurodevelopmental Disorders, 8-1 (December 2016)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 8-1 (December 2016) . - p.31 Titre : Erratum to: Neural correlates of reward processing in adults with 22q11 deletion syndrome Type de document : texte imprimé Auteurs : Esther D.A. VAN DUIN, Auteur ; Liesbet GOOSSENS, Auteur ; Dennis HERNAUS, Auteur ; Fabiana Da Silva ALVES, Auteur ; Nicole SCHMITZ, Auteur ; Koen SCHRUERS, Auteur ; Thérèse VAN AMELSVOORT, Auteur Article en page(s) : p.31 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : [This corrects the article DOI: 10.1186/s11689-016-9158-5.]. En ligne : http://dx.doi.org/10.1186/s11689-016-9163-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=349 [article] Erratum to: Neural correlates of reward processing in adults with 22q11 deletion syndrome [texte imprimé] / Esther D.A. VAN DUIN, Auteur ; Liesbet GOOSSENS, Auteur ; Dennis HERNAUS, Auteur ; Fabiana Da Silva ALVES, Auteur ; Nicole SCHMITZ, Auteur ; Koen SCHRUERS, Auteur ; Thérèse VAN AMELSVOORT, Auteur . - p.31. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 8-1 (December 2016) . - p.31 Index. décimale : PER Périodiques Résumé : [This corrects the article DOI: 10.1186/s11689-016-9158-5.]. En ligne : http://dx.doi.org/10.1186/s11689-016-9163-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=349

Female-specific association of NOS1 genotype with white matter microstructure in ADHD patients and controls / Hanneke VAN EWIJK in Journal of Child Psychology and Psychiatry, 58-8 (August 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.958-966 Titre : Female-specific association of NOS1 genotype with white matter microstructure in ADHD patients and controls Type de document : texte imprimé Auteurs : Hanneke VAN EWIJK, Auteur ; Janita B. BRALTEN, Auteur ; Esther D.A. VAN DUIN, Auteur ; Marina HAKOBJAN, Auteur ; Jan K. BUITELAAR, Auteur ; Dirk J. HESLENFELD, Auteur ; Pieter J. HOEKSTRA, Auteur ; Catharina A. HARTMAN, Auteur ; Martine HOOGMAN, Auteur ; Jaap OOSTERLAAN, Auteur ; Barbara FRANKE, Auteur Article en page(s) : p.958-966 Langues : Anglais (eng) Mots-clés : attention-deficit/hyperactivity disorder  NOS1  imaging genetics  diffusion tensor imaging Index. décimale : PER Périodiques Résumé : Background The nitric oxide synthase gene (NOS1) exon 1f (ex1f) VNTR is a known genetic risk factor for Attention-Deficit/Hyperactivity Disorder (ADHD), particularly in females. NOS1 plays an important role in neurite outgrowth and may thus influence brain development, specifically white matter (WM) microstructure, which is known to be altered in ADHD. The current study aimed to investigate whether NOS1 is associated with WM microstructure in (female) individuals with and without ADHD. Methods Diffusion Tensor Imaging (DTI) scans were collected from 187 participants with ADHD (33% female) and 103 controls (50% female), aged 8–26 years, and NOS1-ex1f VNTR genotype was determined. Whole-brain analyses were conducted for fractional anisotropy (FA) and mean diffusivity (MD) to examine associations between NOS1 and WM microstructure, including possible interactions with gender and diagnosis. Results Consistent with previous literature, NOS1-ex1f was associated with total ADHD and hyperactivity-impulsivity symptoms, but not inattention; this effect was independent of gender. NOS1-ex1f was also associated with MD values in several major WM tracts in females, but not males. In females, homozygosity for the short allele was linked to higher MD values than carriership of the long allele. MD values in these regions did not correlate with ADHD symptoms. Results were similar for participants with and without ADHD. Conclusions NOS1-ex1f VNTR is associated with WM microstructure in females in a large sample of participants with ADHD and healthy controls. Whether this association is part of a neurodevelopmental pathway from NOS1 to ADHD symptoms should be further investigated in future studies. En ligne : http://dx.doi.org/10.1111/jcpp.12742 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317 [article] Female-specific association of NOS1 genotype with white matter microstructure in ADHD patients and controls [texte imprimé] / Hanneke VAN EWIJK, Auteur ; Janita B. BRALTEN, Auteur ; Esther D.A. VAN DUIN, Auteur ; Marina HAKOBJAN, Auteur ; Jan K. BUITELAAR, Auteur ; Dirk J. HESLENFELD, Auteur ; Pieter J. HOEKSTRA, Auteur ; Catharina A. HARTMAN, Auteur ; Martine HOOGMAN, Auteur ; Jaap OOSTERLAAN, Auteur ; Barbara FRANKE, Auteur . - p.958-966. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.958-966 Mots-clés : attention-deficit/hyperactivity disorder  NOS1  imaging genetics  diffusion tensor imaging Index. décimale : PER Périodiques Résumé : Background The nitric oxide synthase gene (NOS1) exon 1f (ex1f) VNTR is a known genetic risk factor for Attention-Deficit/Hyperactivity Disorder (ADHD), particularly in females. NOS1 plays an important role in neurite outgrowth and may thus influence brain development, specifically white matter (WM) microstructure, which is known to be altered in ADHD. The current study aimed to investigate whether NOS1 is associated with WM microstructure in (female) individuals with and without ADHD. Methods Diffusion Tensor Imaging (DTI) scans were collected from 187 participants with ADHD (33% female) and 103 controls (50% female), aged 8–26 years, and NOS1-ex1f VNTR genotype was determined. Whole-brain analyses were conducted for fractional anisotropy (FA) and mean diffusivity (MD) to examine associations between NOS1 and WM microstructure, including possible interactions with gender and diagnosis. Results Consistent with previous literature, NOS1-ex1f was associated with total ADHD and hyperactivity-impulsivity symptoms, but not inattention; this effect was independent of gender. NOS1-ex1f was also associated with MD values in several major WM tracts in females, but not males. In females, homozygosity for the short allele was linked to higher MD values than carriership of the long allele. MD values in these regions did not correlate with ADHD symptoms. Results were similar for participants with and without ADHD. Conclusions NOS1-ex1f VNTR is associated with WM microstructure in females in a large sample of participants with ADHD and healthy controls. Whether this association is part of a neurodevelopmental pathway from NOS1 to ADHD symptoms should be further investigated in future studies. En ligne : http://dx.doi.org/10.1111/jcpp.12742 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317

Neural correlates of reward processing in adults with 22q11 deletion syndrome / Esther D.A. VAN DUIN in Journal of Neurodevelopmental Disorders, 8-1 (December 2016)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 8-1 (December 2016) . - p.25 Titre : Neural correlates of reward processing in adults with 22q11 deletion syndrome Type de document : texte imprimé Auteurs : Esther D.A. VAN DUIN, Auteur ; Liesbet GOOSSENS, Auteur ; Dennis HERNAUS, Auteur ; Fabiana DA SILVA ALVES, Auteur ; Nicole SCHMITZ, Auteur ; Koen SCHRUERS, Auteur ; Thérèse VAN AMELSVOORT, Auteur Article en page(s) : p.25 Langues : Anglais (eng) Mots-clés : 22q11 deletion syndrome  Comt  Psychosis  Reward Index. décimale : PER Périodiques Résumé : BACKGROUND: 22q11.2 deletion syndrome (22q11DS) is caused by a microdeletion on chromosome 22q11.2 and associated with an increased risk to develop psychosis. The gene coding for catechol-O-methyl-transferase (COMT) is located at the deleted region, resulting in disrupted dopaminergic neurotransmission in 22q11DS, which may contribute to the increased vulnerability for psychosis. A dysfunctional motivational reward system is considered one of the salient features in psychosis and thought to be related to abnormal dopaminergic neurotransmission. The functional anatomy of the brain reward circuitry has not yet been investigated in 22q11DS. METHODS: This study aims to investigate neural activity during anticipation of reward and loss in adult patients with 22q11DS. We measured blood-oxygen-level dependent (BOLD) activity in 16 patients with 22q11DS and 12 healthy controls during a monetary incentive delay task using a 3T Philips Intera MRI system. Data were analysed using SPM8. RESULTS: During anticipation of reward, the 22q11DS group alone displayed significant activation in bilateral middle frontal and temporal brain regions. Compared to healthy controls, significantly less activation in bilateral cingulate gyrus extending to premotor, primary motor and somatosensory areas was found. During anticipation of loss, the 22q11DS group displayed activity in the left middle frontal gyrus and anterior cingulate cortex, and relative to controls, they showed reduced brain activation in bilateral (pre)cuneus and left posterior cingulate. Within the 22q11DS group, COMT Val hemizygotes displayed more activation compared to Met hemizygotes in right posterior cingulate and bilateral parietal regions during anticipation of reward. During anticipation of loss, COMT Met hemizygotes compared to Val hemizygotes showed more activation in bilateral insula, striatum and left anterior cingulate. CONCLUSIONS: This is the first study to investigate reward processing in 22q11DS. Our preliminary results suggest that people with 22q11DS engage a fronto-temporal neural network. Compared to healthy controls, people with 22q11DS primarily displayed reduced activity in medial frontal regions during reward anticipation. COMT hemizygosity affects responsivity of the reward system in this condition. Alterations in reward processing partly underlain by the dopamine system may play a role in susceptibility for psychosis in 22q11DS. En ligne : http://dx.doi.org/10.1186/s11689-016-9158-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=349 [article] Neural correlates of reward processing in adults with 22q11 deletion syndrome [texte imprimé] / Esther D.A. VAN DUIN, Auteur ; Liesbet GOOSSENS, Auteur ; Dennis HERNAUS, Auteur ; Fabiana DA SILVA ALVES, Auteur ; Nicole SCHMITZ, Auteur ; Koen SCHRUERS, Auteur ; Thérèse VAN AMELSVOORT, Auteur . - p.25. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 8-1 (December 2016) . - p.25 Mots-clés : 22q11 deletion syndrome  Comt  Psychosis  Reward Index. décimale : PER Périodiques Résumé : BACKGROUND: 22q11.2 deletion syndrome (22q11DS) is caused by a microdeletion on chromosome 22q11.2 and associated with an increased risk to develop psychosis. The gene coding for catechol-O-methyl-transferase (COMT) is located at the deleted region, resulting in disrupted dopaminergic neurotransmission in 22q11DS, which may contribute to the increased vulnerability for psychosis. A dysfunctional motivational reward system is considered one of the salient features in psychosis and thought to be related to abnormal dopaminergic neurotransmission. The functional anatomy of the brain reward circuitry has not yet been investigated in 22q11DS. METHODS: This study aims to investigate neural activity during anticipation of reward and loss in adult patients with 22q11DS. We measured blood-oxygen-level dependent (BOLD) activity in 16 patients with 22q11DS and 12 healthy controls during a monetary incentive delay task using a 3T Philips Intera MRI system. Data were analysed using SPM8. RESULTS: During anticipation of reward, the 22q11DS group alone displayed significant activation in bilateral middle frontal and temporal brain regions. Compared to healthy controls, significantly less activation in bilateral cingulate gyrus extending to premotor, primary motor and somatosensory areas was found. During anticipation of loss, the 22q11DS group displayed activity in the left middle frontal gyrus and anterior cingulate cortex, and relative to controls, they showed reduced brain activation in bilateral (pre)cuneus and left posterior cingulate. Within the 22q11DS group, COMT Val hemizygotes displayed more activation compared to Met hemizygotes in right posterior cingulate and bilateral parietal regions during anticipation of reward. During anticipation of loss, COMT Met hemizygotes compared to Val hemizygotes showed more activation in bilateral insula, striatum and left anterior cingulate. CONCLUSIONS: This is the first study to investigate reward processing in 22q11DS. Our preliminary results suggest that people with 22q11DS engage a fronto-temporal neural network. Compared to healthy controls, people with 22q11DS primarily displayed reduced activity in medial frontal regions during reward anticipation. COMT hemizygosity affects responsivity of the reward system in this condition. Alterations in reward processing partly underlain by the dopamine system may play a role in susceptibility for psychosis in 22q11DS. En ligne : http://dx.doi.org/10.1186/s11689-016-9158-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=349

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