Commentary: The importance of exploring dose-dependent, subtype-specific, and age-related effects of maltreatment on the HPA axis and the mediating link to psychopathology. A response to Fisher (2017) / Lars O. WHITE in Journal of Child Psychology and Psychiatry, 58-9 (September 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-9 (September 2017) . - p.1011-1013 Titre : Commentary: The importance of exploring dose-dependent, subtype-specific, and age-related effects of maltreatment on the HPA axis and the mediating link to psychopathology. A response to Fisher (2017) Type de document : texte imprimé Auteurs : Lars O. WHITE, Auteur ; Marcus ISING, Auteur ; Kai VON KLITZING, Auteur ; Susan SIERAU, Auteur ; Andrea MICHEL, Auteur ; Annette M. KLEIN, Auteur ; Bertram MÃœLLER-MYHSOK, Auteur ; Manfred UHR, Auteur ; Michael J. CROWLEY, Auteur ; Clemens KIRSCHBAUM, Auteur ; Tobias STALDER, Auteur Article en page(s) : p.1011-1013 Langues : Anglais (eng) Mots-clés : Maltreatment  psychopathology Index. décimale : PER Périodiques Résumé : We greatly appreciate Dr. Fisher's commentary that provides an excellent backdrop and well-considered perspective on our findings. We agree that our results mesh well with previous work documenting hypocortisolism among youth who experienced early adversity, especially neglect. Moreover, as also perceptively noted by Dr. Fisher, our cross-sectional data provide support for the notion that hypocortisolism is not simply a transient phenomenon, but, rather, a persistent pattern characterizing maltreated youth. Specifically, the consistency of the between group effect (from age 9.69 onwards) on a multimonth index of cumulative cortisol and the dose-dependent gradient of cortisol secretion within the maltreated group, which was related to the number of subtypes and the length of exposure to maltreatment, lend weight to this view. En ligne : http://dx.doi.org/10.1111/jcpp.12770 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317 [article] Commentary: The importance of exploring dose-dependent, subtype-specific, and age-related effects of maltreatment on the HPA axis and the mediating link to psychopathology. A response to Fisher (2017) [texte imprimé] / Lars O. WHITE, Auteur ; Marcus ISING, Auteur ; Kai VON KLITZING, Auteur ; Susan SIERAU, Auteur ; Andrea MICHEL, Auteur ; Annette M. KLEIN, Auteur ; Bertram MÃœLLER-MYHSOK, Auteur ; Manfred UHR, Auteur ; Michael J. CROWLEY, Auteur ; Clemens KIRSCHBAUM, Auteur ; Tobias STALDER, Auteur . - p.1011-1013. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-9 (September 2017) . - p.1011-1013 Mots-clés : Maltreatment  psychopathology Index. décimale : PER Périodiques Résumé : We greatly appreciate Dr. Fisher's commentary that provides an excellent backdrop and well-considered perspective on our findings. We agree that our results mesh well with previous work documenting hypocortisolism among youth who experienced early adversity, especially neglect. Moreover, as also perceptively noted by Dr. Fisher, our cross-sectional data provide support for the notion that hypocortisolism is not simply a transient phenomenon, but, rather, a persistent pattern characterizing maltreated youth. Specifically, the consistency of the between group effect (from age 9.69 onwards) on a multimonth index of cumulative cortisol and the dose-dependent gradient of cortisol secretion within the maltreated group, which was related to the number of subtypes and the length of exposure to maltreatment, lend weight to this view. En ligne : http://dx.doi.org/10.1111/jcpp.12770 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317

Reduced hair cortisol after maltreatment mediates externalizing symptoms in middle childhood and adolescence / Lars O. WHITE in Journal of Child Psychology and Psychiatry, 58-9 (September 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-9 (September 2017) . - p.998-1007 Titre : Reduced hair cortisol after maltreatment mediates externalizing symptoms in middle childhood and adolescence Type de document : texte imprimé Auteurs : Lars O. WHITE, Auteur ; Marcus ISING, Auteur ; Kai VON KLITZING, Auteur ; Susan SIERAU, Auteur ; Andrea MICHEL, Auteur ; Annette M. KLEIN, Auteur ; Anna ANDREAS, Auteur ; Jan KEIL, Auteur ; Leonhard QUINTERO, Auteur ; Bertram MÃœLLER-MYHSOK, Auteur ; Manfred UHR, Auteur ; Ruth GAUSCHE, Auteur ; Jody T. MANLY, Auteur ; Michael J. CROWLEY, Auteur ; Clemens KIRSCHBAUM, Auteur ; Tobias STALDER, Auteur Article en page(s) : p.998-1007 Langues : Anglais (eng) Mots-clés : Hair cortisol  maltreatment  neglect  externalizing symptoms Index. décimale : PER Périodiques Résumé : Background The enduring impact of childhood maltreatment on biological systems and ensuing psychopathology remains incompletely understood. Long-term effects of stress may be reflected in cumulative cortisol secretion over several months, which is now quantifiable via hair cortisol concentrations (HCC). We conducted a first comprehensive investigation utilizing the potential of hair cortisol analysis in a large sample of maltreated and nonmaltreated children and adolescents. Method Participants included 537 children and adolescents (3–16 years; 272 females) with maltreatment (n = 245) or without maltreatment histories (n = 292). Maltreated subjects were recruited from child protection services (CPS; n = 95), youth psychiatric services (n = 56), and the community (n = 94). Maltreatment was coded using the Maltreatment Classification System drawing on caregiver interviews and complemented with CPS records. Caregivers and teachers reported on child mental health. HCC were assessed in the first 3 cm hair segment. Results Analyses uniformly supported that maltreatment coincides with a gradual and dose-dependent reduction in HCC from 9 to 10 years onwards relative to nonmaltreated controls. This pattern emerged consistently from both group comparisons between maltreated and nonmaltreated subjects (27.6% HCC reduction in maltreated 9–16-year-olds) and dimensional analyses within maltreated subjects, with lower HCC related to greater maltreatment chronicity and number of subtypes. Moreover, both group comparisons and dimensional analyses within maltreated youth revealed that relative HCC reduction mediates the effect of maltreatment on externalizing symptoms. Conclusions From middle childhood onwards, maltreatment coincides with a relative reduction in cortisol secretion, which, in turn, may predispose to externalizing symptoms. En ligne : http://dx.doi.org/10.1111/jcpp.12700 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317 [article] Reduced hair cortisol after maltreatment mediates externalizing symptoms in middle childhood and adolescence [texte imprimé] / Lars O. WHITE, Auteur ; Marcus ISING, Auteur ; Kai VON KLITZING, Auteur ; Susan SIERAU, Auteur ; Andrea MICHEL, Auteur ; Annette M. KLEIN, Auteur ; Anna ANDREAS, Auteur ; Jan KEIL, Auteur ; Leonhard QUINTERO, Auteur ; Bertram MÃœLLER-MYHSOK, Auteur ; Manfred UHR, Auteur ; Ruth GAUSCHE, Auteur ; Jody T. MANLY, Auteur ; Michael J. CROWLEY, Auteur ; Clemens KIRSCHBAUM, Auteur ; Tobias STALDER, Auteur . - p.998-1007. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-9 (September 2017) . - p.998-1007 Mots-clés : Hair cortisol  maltreatment  neglect  externalizing symptoms Index. décimale : PER Périodiques Résumé : Background The enduring impact of childhood maltreatment on biological systems and ensuing psychopathology remains incompletely understood. Long-term effects of stress may be reflected in cumulative cortisol secretion over several months, which is now quantifiable via hair cortisol concentrations (HCC). We conducted a first comprehensive investigation utilizing the potential of hair cortisol analysis in a large sample of maltreated and nonmaltreated children and adolescents. Method Participants included 537 children and adolescents (3–16 years; 272 females) with maltreatment (n = 245) or without maltreatment histories (n = 292). Maltreated subjects were recruited from child protection services (CPS; n = 95), youth psychiatric services (n = 56), and the community (n = 94). Maltreatment was coded using the Maltreatment Classification System drawing on caregiver interviews and complemented with CPS records. Caregivers and teachers reported on child mental health. HCC were assessed in the first 3 cm hair segment. Results Analyses uniformly supported that maltreatment coincides with a gradual and dose-dependent reduction in HCC from 9 to 10 years onwards relative to nonmaltreated controls. This pattern emerged consistently from both group comparisons between maltreated and nonmaltreated subjects (27.6% HCC reduction in maltreated 9–16-year-olds) and dimensional analyses within maltreated subjects, with lower HCC related to greater maltreatment chronicity and number of subtypes. Moreover, both group comparisons and dimensional analyses within maltreated youth revealed that relative HCC reduction mediates the effect of maltreatment on externalizing symptoms. Conclusions From middle childhood onwards, maltreatment coincides with a relative reduction in cortisol secretion, which, in turn, may predispose to externalizing symptoms. En ligne : http://dx.doi.org/10.1111/jcpp.12700 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317

Time-dependent association between prenatal hair glucocorticoid levels and child behavior problems / Richard G. KÃœNZEL in Journal of Child Psychology and Psychiatry, 67-8 (August 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-8 (August 2026) . - p.1297-1306 Titre : Time-dependent association between prenatal hair glucocorticoid levels and child behavior problems Type de document : texte imprimé Auteurs : Richard G. KÃœNZEL, Auteur ; Yinxian CHEN, Auteur ; Marta B. RONDON, Auteur ; Diana JUVINAO-QUINTERO, Auteur ; Laramie E. DUNCAN, Auteur ; Sixto E. SANCHEZ, Auteur ; Luz G. NATEROS, Auteur ; Archana BASU, Auteur ; Amantia AMETAJ, Auteur ; Clemens KIRSCHBAUM, Auteur ; Elizabeth J. LEVEY, Auteur ; Bizu GELAYE, Auteur Article en page(s) : p.1297-1306 Langues : Anglais (eng) Mots-clés : Prenatal  hair cortisol  hair cortisone  internalizing  externalizing  behavior  transgenerational Index. décimale : PER Périodiques Résumé : Background Child internalizing and externalizing behavioral problems are highly prevalent psychiatric symptoms worldwide, for which maternal prenatal stress is a known risk factor. However, underlying neuroendocrine mechanisms remain largely unclear. We investigated whether maternal hair cortisol (HCC) and cortisone concentration (HCNC) are associated with offspring's internalizing and externalizing behavior problems in a prospective pre-birth cohort study from Perú. Methods N?=?271 mother?child dyads were included in this analysis. Recruitment and data collection took place at the Instituto Nacional Materno Perinatal in Lima, Perú. HCC and HCHC were obtained from hair segments representing up to 3 months pre-pregnancy and first trimester, respectively, and were quantified via liquid chromatography tandem mass spectrometry. The Child Behavior Checklist was used to assess internalizing and externalizing behavioral problems of children (mean age at follow-up?=?6.98?years (SD?=?1.05)). Marginal structural models estimated population average associations between HCC, HCNC, and internalizing and externalizing problems, adjusting for established covariates. Results At pre-pregnancy, logHCNC was positively associated with offspring internalizing (??=?2.21, 95% CI: 0.46; 3.96, p?=?.013) and externalizing problems (??=?1.87, 95% CI: 0.34; 3.40, p?=?.016). At the first trimester, logHCNC was negatively associated with internalizing (??=??2.51, 95%CI: ?4.37; ?0.64, p?=?.008), and externalizing problems (??=??2.73, 95% CI: ?4.18; ?1.28, p? En ligne : https://doi.org/10.1111/jcpp.70131 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=591 [article] Time-dependent association between prenatal hair glucocorticoid levels and child behavior problems [texte imprimé] / Richard G. KÃœNZEL, Auteur ; Yinxian CHEN, Auteur ; Marta B. RONDON, Auteur ; Diana JUVINAO-QUINTERO, Auteur ; Laramie E. DUNCAN, Auteur ; Sixto E. SANCHEZ, Auteur ; Luz G. NATEROS, Auteur ; Archana BASU, Auteur ; Amantia AMETAJ, Auteur ; Clemens KIRSCHBAUM, Auteur ; Elizabeth J. LEVEY, Auteur ; Bizu GELAYE, Auteur . - p.1297-1306. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-8 (August 2026) . - p.1297-1306 Mots-clés : Prenatal  hair cortisol  hair cortisone  internalizing  externalizing  behavior  transgenerational Index. décimale : PER Périodiques Résumé : Background Child internalizing and externalizing behavioral problems are highly prevalent psychiatric symptoms worldwide, for which maternal prenatal stress is a known risk factor. However, underlying neuroendocrine mechanisms remain largely unclear. We investigated whether maternal hair cortisol (HCC) and cortisone concentration (HCNC) are associated with offspring's internalizing and externalizing behavior problems in a prospective pre-birth cohort study from Perú. Methods N?=?271 mother?child dyads were included in this analysis. Recruitment and data collection took place at the Instituto Nacional Materno Perinatal in Lima, Perú. HCC and HCHC were obtained from hair segments representing up to 3 months pre-pregnancy and first trimester, respectively, and were quantified via liquid chromatography tandem mass spectrometry. The Child Behavior Checklist was used to assess internalizing and externalizing behavioral problems of children (mean age at follow-up?=?6.98?years (SD?=?1.05)). Marginal structural models estimated population average associations between HCC, HCNC, and internalizing and externalizing problems, adjusting for established covariates. Results At pre-pregnancy, logHCNC was positively associated with offspring internalizing (??=?2.21, 95% CI: 0.46; 3.96, p?=?.013) and externalizing problems (??=?1.87, 95% CI: 0.34; 3.40, p?=?.016). At the first trimester, logHCNC was negatively associated with internalizing (??=??2.51, 95%CI: ?4.37; ?0.64, p?=?.008), and externalizing problems (??=??2.73, 95% CI: ?4.18; ?1.28, p? En ligne : https://doi.org/10.1111/jcpp.70131 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=591

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