Maternal multivitamin supplementation is associated with symptoms in offspring with autism spectrum disorder: A multi-center study in China / Ting YANG ; Jie CHEN ; Li CHEN ; Ying DAI ; Hua WEI ; Feiyong JIA ; Lijie WU ; Yan HAO ; Ling LI ; Jie ZHANG ; Xiaoyan KE ; Mingji YI ; Qi HONG ; Jinjin CHEN ; Shuanfeng FANG ; Yichao WANG ; Qi WANG ; Chunhua JIN ; Tingyu LI in Research in Autism Spectrum Disorders, 111 (March 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 111 (March 2024) . - p.102309 Titre : Maternal multivitamin supplementation is associated with symptoms in offspring with autism spectrum disorder: A multi-center study in China Type de document : Texte imprimé et/ou numérique Auteurs : Ting YANG, Auteur ; Jie CHEN, Auteur ; Li CHEN, Auteur ; Ying DAI, Auteur ; Hua WEI, Auteur ; Feiyong JIA, Auteur ; Lijie WU, Auteur ; Yan HAO, Auteur ; Ling LI, Auteur ; Jie ZHANG, Auteur ; Xiaoyan KE, Auteur ; Mingji YI, Auteur ; Qi HONG, Auteur ; Jinjin CHEN, Auteur ; Shuanfeng FANG, Auteur ; Yichao WANG, Auteur ; Qi WANG, Auteur ; Chunhua JIN, Auteur ; Tingyu LI, Auteur Article en page(s) : p.102309 Mots-clés : Vitamin D  Multivitamin  Pregnancy  Autism spectrum disorder  Symptom  Children Index. décimale : PER Périodiques Résumé : Background We aimed to investigate the relationship between maternal vitamin D and multivitamin supplementation during pregnancy and the risk of autism spectrum disorder (ASD) and symptoms in offspring with ASD. Methods This study enrolled 1321 children with ASD and 1200 typically developing (TD) children under 7 years old in China. Maternal vitamin supplements were classified for vitamin D, multivitamin (with or without vitamin D), and none (no use of vitamin D or multivitamin). For children with ASD, symptoms were assessed with the Autism Behavior Checklist (ABC), Social Responsiveness Scale (SRS) and Childhood Autism Rating Scale (CARS), and neurodevelopmental levels were evaluated with the Children Neuropsychological and Behavior Scale-Revision 2016 (CNBS-R2016). Results Maternal vitamin D and multivitamin supplementation during pregnancy were both significantly associated with a decreased risk of ASD in offspring (P = 0.024 and P < 0.001). The ASD children born to mothers with gestational multivitamin supplementation had lower CARS [? = ?1.342 (?2.275, ?0.409), P = 0.005] and communication warning behavior [? = ?6.631 (?9.899, ?3.363), P < 0.001] scores and higher personal-social quotient [? = 3.347 (0.190, 6.504), P = 0.038] than children born to mothers without supplementation. Maternal vitamin D supplementation was not associated with symptoms and development quotients in ASD children (P > 0.05). Conclusions This study supports a protective association between maternal vitamin D and multivitamin supplementation during pregnancy and the risk of ASD in offspring. Maternal multivitamin supplementation may potentially moderate the symptoms and personal-social ability in ASD children. Further studies are needed on the role of maternal nutrition in the etiology and autistic symptoms and the underlying molecular mechanisms. En ligne : https://doi.org/10.1016/j.rasd.2023.102309 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=521 [article] Maternal multivitamin supplementation is associated with symptoms in offspring with autism spectrum disorder: A multi-center study in China [Texte imprimé et/ou numérique] / Ting YANG, Auteur ; Jie CHEN, Auteur ; Li CHEN, Auteur ; Ying DAI, Auteur ; Hua WEI, Auteur ; Feiyong JIA, Auteur ; Lijie WU, Auteur ; Yan HAO, Auteur ; Ling LI, Auteur ; Jie ZHANG, Auteur ; Xiaoyan KE, Auteur ; Mingji YI, Auteur ; Qi HONG, Auteur ; Jinjin CHEN, Auteur ; Shuanfeng FANG, Auteur ; Yichao WANG, Auteur ; Qi WANG, Auteur ; Chunhua JIN, Auteur ; Tingyu LI, Auteur . - p.102309. in Research in Autism Spectrum Disorders > 111 (March 2024) . - p.102309 Mots-clés : Vitamin D  Multivitamin  Pregnancy  Autism spectrum disorder  Symptom  Children Index. décimale : PER Périodiques Résumé : Background We aimed to investigate the relationship between maternal vitamin D and multivitamin supplementation during pregnancy and the risk of autism spectrum disorder (ASD) and symptoms in offspring with ASD. Methods This study enrolled 1321 children with ASD and 1200 typically developing (TD) children under 7 years old in China. Maternal vitamin supplements were classified for vitamin D, multivitamin (with or without vitamin D), and none (no use of vitamin D or multivitamin). For children with ASD, symptoms were assessed with the Autism Behavior Checklist (ABC), Social Responsiveness Scale (SRS) and Childhood Autism Rating Scale (CARS), and neurodevelopmental levels were evaluated with the Children Neuropsychological and Behavior Scale-Revision 2016 (CNBS-R2016). Results Maternal vitamin D and multivitamin supplementation during pregnancy were both significantly associated with a decreased risk of ASD in offspring (P = 0.024 and P < 0.001). The ASD children born to mothers with gestational multivitamin supplementation had lower CARS [? = ?1.342 (?2.275, ?0.409), P = 0.005] and communication warning behavior [? = ?6.631 (?9.899, ?3.363), P < 0.001] scores and higher personal-social quotient [? = 3.347 (0.190, 6.504), P = 0.038] than children born to mothers without supplementation. Maternal vitamin D supplementation was not associated with symptoms and development quotients in ASD children (P > 0.05). Conclusions This study supports a protective association between maternal vitamin D and multivitamin supplementation during pregnancy and the risk of ASD in offspring. Maternal multivitamin supplementation may potentially moderate the symptoms and personal-social ability in ASD children. Further studies are needed on the role of maternal nutrition in the etiology and autistic symptoms and the underlying molecular mechanisms. En ligne : https://doi.org/10.1016/j.rasd.2023.102309 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=521

Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder / Khaled SAAD in Journal of Child Psychology and Psychiatry, 59-1 (January 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-1 (January 2018) . - p.20-29 Titre : Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Khaled SAAD, Auteur ; Ahmed A. ABDEL-RAHMAN, Auteur ; Yasser M. ELSEROGY, Auteur ; Abdulrahman A. AL-ATRAM, Auteur ; Amira A. EL-HOUFEY, Auteur ; Hisham A. K. OTHMAN, Auteur ; Geir BJØRKLUND, Auteur ; Feiyong JIA, Auteur ; Mauricio A. URBINA, Auteur ; Mohamed Gamil M. ABO-ELELA, Auteur ; Faisal-Alkhateeb AHMAD, Auteur ; Khaled A. ABD EL-BASEER, Auteur ; Ahmed E. AHMED, Auteur ; Ahmad M. ABDEL-SALAM, Auteur Article en page(s) : p.20-29 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  vitamin D  children  clinical trial Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorder (ASD) is a frequent developmental disorder characterized by pervasive deficits in social interaction, impairment in verbal and nonverbal communication, and stereotyped patterns of interests and activities. It has been previously reported that there is vitamin D deficiency in autistic children; however, there is a lack of randomized controlled trials of vitamin D supplementation in ASD children. Methods This study is a double-blinded, randomized clinical trial (RCT) that was conducted on 109 children with ASD (85 boys and 24 girls; aged 3–10 years). The aim of this study was to assess the effects of vitamin D supplementation on the core symptoms of autism in children. ASD patients were randomized to receive vitamin D3 or placebo for 4 months. The serum levels of 25-hydroxycholecalciferol (25 (OH)D) were measured at the beginning and at the end of the study. The autism severity and social maturity of the children were assessed by the Childhood Autism Rating Scale (CARS), Aberrant Behavior Checklist (ABC), Social Responsiveness Scale (SRS), and the Autism Treatment Evaluation Checklist (ATEC). Trial registration number: UMIN-CTR Study Design: trial number: UMIN000020281. Results Supplementation of vitamin D was well tolerated by the ASD children. The daily doses used in the therapy group was 300 IU vitamin D3/kg/day, not to exceed 5,000 IU/day. The autism symptoms of the children improved significantly, following 4-month vitamin D3 supplementation, but not in the placebo group. This study demonstrates the efficacy and tolerability of high doses of vitamin D3 in children with ASD. Conclusions This study is the first double-blinded RCT proving the efficacy of vitamin D3 in ASD patients. Depending on the parameters measured in the study, oral vitamin D supplementation may safely improve signs and symptoms of ASD and could be recommended for children with ASD. At this stage, this study is a single RCT with a small number of patients, and a great deal of additional wide-scale studies are needed to critically validate the efficacy of vitamin D in ASD. En ligne : http://dx.doi.org/10.1111/jcpp.12652 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=327 [article] Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder [Texte imprimé et/ou numérique] / Khaled SAAD, Auteur ; Ahmed A. ABDEL-RAHMAN, Auteur ; Yasser M. ELSEROGY, Auteur ; Abdulrahman A. AL-ATRAM, Auteur ; Amira A. EL-HOUFEY, Auteur ; Hisham A. K. OTHMAN, Auteur ; Geir BJØRKLUND, Auteur ; Feiyong JIA, Auteur ; Mauricio A. URBINA, Auteur ; Mohamed Gamil M. ABO-ELELA, Auteur ; Faisal-Alkhateeb AHMAD, Auteur ; Khaled A. ABD EL-BASEER, Auteur ; Ahmed E. AHMED, Auteur ; Ahmad M. ABDEL-SALAM, Auteur . - p.20-29. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-1 (January 2018) . - p.20-29 Mots-clés : Autism spectrum disorder  vitamin D  children  clinical trial Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorder (ASD) is a frequent developmental disorder characterized by pervasive deficits in social interaction, impairment in verbal and nonverbal communication, and stereotyped patterns of interests and activities. It has been previously reported that there is vitamin D deficiency in autistic children; however, there is a lack of randomized controlled trials of vitamin D supplementation in ASD children. Methods This study is a double-blinded, randomized clinical trial (RCT) that was conducted on 109 children with ASD (85 boys and 24 girls; aged 3–10 years). The aim of this study was to assess the effects of vitamin D supplementation on the core symptoms of autism in children. ASD patients were randomized to receive vitamin D3 or placebo for 4 months. The serum levels of 25-hydroxycholecalciferol (25 (OH)D) were measured at the beginning and at the end of the study. The autism severity and social maturity of the children were assessed by the Childhood Autism Rating Scale (CARS), Aberrant Behavior Checklist (ABC), Social Responsiveness Scale (SRS), and the Autism Treatment Evaluation Checklist (ATEC). Trial registration number: UMIN-CTR Study Design: trial number: UMIN000020281. Results Supplementation of vitamin D was well tolerated by the ASD children. The daily doses used in the therapy group was 300 IU vitamin D3/kg/day, not to exceed 5,000 IU/day. The autism symptoms of the children improved significantly, following 4-month vitamin D3 supplementation, but not in the placebo group. This study demonstrates the efficacy and tolerability of high doses of vitamin D3 in children with ASD. Conclusions This study is the first double-blinded RCT proving the efficacy of vitamin D3 in ASD patients. Depending on the parameters measured in the study, oral vitamin D supplementation may safely improve signs and symptoms of ASD and could be recommended for children with ASD. At this stage, this study is a single RCT with a small number of patients, and a great deal of additional wide-scale studies are needed to critically validate the efficacy of vitamin D in ASD. En ligne : http://dx.doi.org/10.1111/jcpp.12652 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=327

Retrospective analysis of the correlation between serum vitamin D levels and blood amino acids levels in children with autism: Exploration of possible mechanisms of the effect of vitamin D on autism / Bing WANG in Research in Autism Spectrum Disorders, 80 (February 2021)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 80 (February 2021) . - p.101707 Titre : Retrospective analysis of the correlation between serum vitamin D levels and blood amino acids levels in children with autism: Exploration of possible mechanisms of the effect of vitamin D on autism Type de document : Texte imprimé et/ou numérique Auteurs : Bing WANG, Auteur ; Hanyu DONG, Auteur ; Junyan FENG, Auteur ; Honghua LI, Auteur ; Yu ZHANG, Auteur ; Feiyong JIA, Auteur ; Lin XIE, Auteur Article en page(s) : p.101707 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Vitamin D  Amino acid  Biological metabolism Index. décimale : PER Périodiques Résumé : Hypovitaminosis D has been recognized as a risk factor for autism spectrum disorder (ASD); however, its mechanism remains unclear. Amino acid metabolism is involved in the related factors of ASD, such as neurotransmitters, oxidative stress, and immune dysfunction. Vitamin D not only regulates the activity of the amino acid transport system, but is also closely related to amino acids in the regulation of immunity and oxidative stress. To investigate the possible mechanisms by which vitamin D may influence ASD, the correlation between blood amino acids and serum 25(OH)D levels of 506 children (411 males and 95 females) with ASD were retrospectively analyzed, and possible related pathways were determined via a literature review. According to the results, alanine, arginine, glycine, ornithine, glutamine and histidine were found to be significantly negatively correlated with serum 25(OH)D levels (P? En ligne : https://doi.org/10.1016/j.rasd.2020.101707 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438 [article] Retrospective analysis of the correlation between serum vitamin D levels and blood amino acids levels in children with autism: Exploration of possible mechanisms of the effect of vitamin D on autism [Texte imprimé et/ou numérique] / Bing WANG, Auteur ; Hanyu DONG, Auteur ; Junyan FENG, Auteur ; Honghua LI, Auteur ; Yu ZHANG, Auteur ; Feiyong JIA, Auteur ; Lin XIE, Auteur . - p.101707. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 80 (February 2021) . - p.101707 Mots-clés : Autism spectrum disorder  Vitamin D  Amino acid  Biological metabolism Index. décimale : PER Périodiques Résumé : Hypovitaminosis D has been recognized as a risk factor for autism spectrum disorder (ASD); however, its mechanism remains unclear. Amino acid metabolism is involved in the related factors of ASD, such as neurotransmitters, oxidative stress, and immune dysfunction. Vitamin D not only regulates the activity of the amino acid transport system, but is also closely related to amino acids in the regulation of immunity and oxidative stress. To investigate the possible mechanisms by which vitamin D may influence ASD, the correlation between blood amino acids and serum 25(OH)D levels of 506 children (411 males and 95 females) with ASD were retrospectively analyzed, and possible related pathways were determined via a literature review. According to the results, alanine, arginine, glycine, ornithine, glutamine and histidine were found to be significantly negatively correlated with serum 25(OH)D levels (P? En ligne : https://doi.org/10.1016/j.rasd.2020.101707 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438

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