Asthma and Allergies in Children With Autism Spectrum Disorders: Results From the CHARGE Study / Kristen LYALL in Autism Research, 8-5 (October 2015)  

Public ISBD [article]  inAutism Research > 8-5 (October 2015) . - p.567-574 Titre : Asthma and Allergies in Children With Autism Spectrum Disorders: Results From the CHARGE Study Type de document : Texte imprimé et/ou numérique Auteurs : Kristen LYALL, Auteur ; Judy VAN DE WATER, Auteur ; Paul ASHWOOD, Auteur ; Irva HERTZ-PICCIOTTO, Auteur Article en page(s) : p.567-574 Langues : Anglais (eng) Mots-clés : autism  asthma  allergy  food allergy Index. décimale : PER Périodiques Résumé : Immune aberrations are often noted in children with autism spectrum disorder (ASD), but whether asthma and allergy are related to ASD is not well defined. This study examined asthma and allergies in association with ASD and phenotypic subsets. Participants were 560 children with confirmed ASD and 391 typically developing children from the CHildhood Autism Risks from Genetics and the Environment study. Maternally reported child asthma and allergy was compared between cases and controls, and in association with cognitive and behavioral test scores. Prevalence of asthma and overall allergies did not differ between cases and controls, but overall allergy in children with ASD was associated with higher stereotypy scores as measured by the Aberrant Behavior Checklist. In addition, reported food allergies were significantly associated with ASD (adjusted odds ratio = 2.23, 95% confidence interval 1.28, 3.89). Our results suggest food allergies and sensitivities may be more common in children with ASD, and that these issues may correlate with other behaviors. Autism Res 2015, 8: 567–574. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1471 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Asthma and Allergies in Children With Autism Spectrum Disorders: Results From the CHARGE Study [Texte imprimé et/ou numérique] / Kristen LYALL, Auteur ; Judy VAN DE WATER, Auteur ; Paul ASHWOOD, Auteur ; Irva HERTZ-PICCIOTTO, Auteur . - p.567-574. Langues : Anglais (eng) in Autism Research > 8-5 (October 2015) . - p.567-574 Mots-clés : autism  asthma  allergy  food allergy Index. décimale : PER Périodiques Résumé : Immune aberrations are often noted in children with autism spectrum disorder (ASD), but whether asthma and allergy are related to ASD is not well defined. This study examined asthma and allergies in association with ASD and phenotypic subsets. Participants were 560 children with confirmed ASD and 391 typically developing children from the CHildhood Autism Risks from Genetics and the Environment study. Maternally reported child asthma and allergy was compared between cases and controls, and in association with cognitive and behavioral test scores. Prevalence of asthma and overall allergies did not differ between cases and controls, but overall allergy in children with ASD was associated with higher stereotypy scores as measured by the Aberrant Behavior Checklist. In addition, reported food allergies were significantly associated with ASD (adjusted odds ratio = 2.23, 95% confidence interval 1.28, 3.89). Our results suggest food allergies and sensitivities may be more common in children with ASD, and that these issues may correlate with other behaviors. Autism Res 2015, 8: 567–574. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1471 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

Behavioral Correlates of Maternal Antibody Status Among Children with Autism / Daniel BRAUNSCHWEIG in Journal of Autism and Developmental Disorders, 42-7 (July 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-7 (July 2012) . - p.1435-1445 Titre : Behavioral Correlates of Maternal Antibody Status Among Children with Autism Type de document : Texte imprimé et/ou numérique Auteurs : Daniel BRAUNSCHWEIG, Auteur ; Paul DUNCANSON, Auteur ; Robert BOYCE, Auteur ; David J. HANSEN, Auteur ; Paul ASHWOOD, Auteur ; Isaac N. PESSAH, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Judy VAN DE WATER, Auteur Année de publication : 2012 Article en page(s) : p.1435-1445 Langues : Anglais (eng) Mots-clés : Autism  Maternal antibodies  Autoantibodies  Fetal brain  Immunologie Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) affect approximately 1 in 110 children in the United States. This report profiles fetal-brain reactive autoantibodies of a large cohort of mothers of children with autism and controls, yielding significant associations between the presence of IgG reactivity to fetal brain proteins at 37 and 73 kDa and a childhood diagnosis of full autism (p = 0.0005), which also correlated with lower expressive language scores (p = 0.005). Additionally, we report on reactivity to proteins at 39 and 73 kDa, which correlated with the broader diagnosis of ASD (p = 0.0007) and increased irritability on the Aberrant Behavioral Checklist (p = 0.05). This study provides evidence of multiple patterns of reactivity to fetal brain proteins by maternal antibodies associated with ASD and specific childhood behavioral outcomes. En ligne : http://dx.doi.org/10.1007/s10803-011-1378-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166 [article] Behavioral Correlates of Maternal Antibody Status Among Children with Autism [Texte imprimé et/ou numérique] / Daniel BRAUNSCHWEIG, Auteur ; Paul DUNCANSON, Auteur ; Robert BOYCE, Auteur ; David J. HANSEN, Auteur ; Paul ASHWOOD, Auteur ; Isaac N. PESSAH, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Judy VAN DE WATER, Auteur . - 2012 . - p.1435-1445. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-7 (July 2012) . - p.1435-1445 Mots-clés : Autism  Maternal antibodies  Autoantibodies  Fetal brain  Immunologie Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) affect approximately 1 in 110 children in the United States. This report profiles fetal-brain reactive autoantibodies of a large cohort of mothers of children with autism and controls, yielding significant associations between the presence of IgG reactivity to fetal brain proteins at 37 and 73 kDa and a childhood diagnosis of full autism (p = 0.0005), which also correlated with lower expressive language scores (p = 0.005). Additionally, we report on reactivity to proteins at 39 and 73 kDa, which correlated with the broader diagnosis of ASD (p = 0.0007) and increased irritability on the Aberrant Behavioral Checklist (p = 0.05). This study provides evidence of multiple patterns of reactivity to fetal brain proteins by maternal antibodies associated with ASD and specific childhood behavioral outcomes. En ligne : http://dx.doi.org/10.1007/s10803-011-1378-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166

Brief Report: Hyperbaric Oxygen Therapy (HBOT) in Children with Autism Spectrum Disorder: A Clinical Trial / Stephen BENT in Journal of Autism and Developmental Disorders, 42-6 (June 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-6 (June 2012) . - p.1127-1132 Titre : Brief Report: Hyperbaric Oxygen Therapy (HBOT) in Children with Autism Spectrum Disorder: A Clinical Trial Type de document : Texte imprimé et/ou numérique Auteurs : Stephen BENT, Auteur ; Kiah BERTOGLIO, Auteur ; Paul ASHWOOD, Auteur ; Edward NEMETH, Auteur ; Robert L. HENDREN, Auteur Année de publication : 2012 Article en page(s) : p.1127-1132 Langues : Anglais (eng) Mots-clés : Autism  Clinical trial  Alternative therapy Index. décimale : PER Périodiques Résumé : We sought to determine whether HBOT leads to parental reported behavioral changes and alterations in cytokines in children with ASD. Ten children completed 80 sessions of HBOT and all improved by 2 points on the clinician-rated CGI-I scale (much improved) as well as several parent-completed measures of behavior. The lack of a control group limits the ability to determine if improvements were related to HBOT. Enrolled children did not exhibit abnormal cytokine levels at baseline and no significant changes in mean cytokine levels were observed. Although this study was limited by the small sample size and by the variable nature of cytokines, we found no evidence that HBOT affects cytokine levels or that cytokine levels were associated with behavioral changes. En ligne : http://dx.doi.org/10.1007/s10803-011-1337-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=156 [article] Brief Report: Hyperbaric Oxygen Therapy (HBOT) in Children with Autism Spectrum Disorder: A Clinical Trial [Texte imprimé et/ou numérique] / Stephen BENT, Auteur ; Kiah BERTOGLIO, Auteur ; Paul ASHWOOD, Auteur ; Edward NEMETH, Auteur ; Robert L. HENDREN, Auteur . - 2012 . - p.1127-1132. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-6 (June 2012) . - p.1127-1132 Mots-clés : Autism  Clinical trial  Alternative therapy Index. décimale : PER Périodiques Résumé : We sought to determine whether HBOT leads to parental reported behavioral changes and alterations in cytokines in children with ASD. Ten children completed 80 sessions of HBOT and all improved by 2 points on the clinician-rated CGI-I scale (much improved) as well as several parent-completed measures of behavior. The lack of a control group limits the ability to determine if improvements were related to HBOT. Enrolled children did not exhibit abnormal cytokine levels at baseline and no significant changes in mean cytokine levels were observed. Although this study was limited by the small sample size and by the variable nature of cytokines, we found no evidence that HBOT affects cytokine levels or that cytokine levels were associated with behavioral changes. En ligne : http://dx.doi.org/10.1007/s10803-011-1337-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=156

Brief Report: Plasma Leptin Levels are Elevated in Autism: Association with Early Onset Phenotype? / Paul ASHWOOD in Journal of Autism and Developmental Disorders, 38-1 (January 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-1 (January 2008) . - p.169-175 Titre : Brief Report: Plasma Leptin Levels are Elevated in Autism: Association with Early Onset Phenotype? Type de document : Texte imprimé et/ou numérique Auteurs : Paul ASHWOOD, Auteur ; Christina KWONG, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Paula KRAKOWIAK, Auteur ; Wynn WALKER, Auteur ; Isaac N. PESSAH, Auteur ; Judy VAN DE WATER, Auteur ; David J. HANSEN, Auteur ; Lisa A. CROEN, Auteur Année de publication : 2008 Article en page(s) : p.169-175 Langues : Anglais (eng) Mots-clés : Inflammation Leptin Autism Regression Index. décimale : PER Périodiques Résumé : There is evidence of both immune dysregulation and autoimmune phenomena in children with autism spectrum disorders (ASD). We examined the hormone/cytokine leptin in 70 children diagnosed with autism (including 37 with regression) compared with 99 age-matched controls including 50 typically developing (TD) controls, 26 siblings without autism, and 23 children with developmental disabilities (DD). Children with autism had significantly higher plasma leptin levels compared with TD controls (p < .006). When further sub-classified into regression or early onset autism, children with early onset autism had significantly higher plasma leptin levels compared with children with regressive autism (p < .042), TD controls (p < .0015), and DD controls (p < .004). We demonstrated an increase in leptin levels in autism, a finding driven by the early onset group. En ligne : http://dx.doi.org/10.1007/s10803-006-0353-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316 [article] Brief Report: Plasma Leptin Levels are Elevated in Autism: Association with Early Onset Phenotype? [Texte imprimé et/ou numérique] / Paul ASHWOOD, Auteur ; Christina KWONG, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Paula KRAKOWIAK, Auteur ; Wynn WALKER, Auteur ; Isaac N. PESSAH, Auteur ; Judy VAN DE WATER, Auteur ; David J. HANSEN, Auteur ; Lisa A. CROEN, Auteur . - 2008 . - p.169-175. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-1 (January 2008) . - p.169-175 Mots-clés : Inflammation Leptin Autism Regression Index. décimale : PER Périodiques Résumé : There is evidence of both immune dysregulation and autoimmune phenomena in children with autism spectrum disorders (ASD). We examined the hormone/cytokine leptin in 70 children diagnosed with autism (including 37 with regression) compared with 99 age-matched controls including 50 typically developing (TD) controls, 26 siblings without autism, and 23 children with developmental disabilities (DD). Children with autism had significantly higher plasma leptin levels compared with TD controls (p < .006). When further sub-classified into regression or early onset autism, children with early onset autism had significantly higher plasma leptin levels compared with children with regressive autism (p < .042), TD controls (p < .0015), and DD controls (p < .004). We demonstrated an increase in leptin levels in autism, a finding driven by the early onset group. En ligne : http://dx.doi.org/10.1007/s10803-006-0353-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316

Decreased Levels of EGF in Plasma of Children with Autism Spectrum Disorder / Charity ONORE in Autism Research and Treatment, (December 2011)  

Public ISBD [article]  inAutism Research and Treatment > (December 2011) . - 4 p. Titre : Decreased Levels of EGF in Plasma of Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Charity ONORE, Auteur ; Judy VAN DE WATER, Auteur ; Paul ASHWOOD, Auteur Année de publication : 2011 Article en page(s) : 4 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder estimated to affect 1 in 110 children in the US, yet the pathology of this disorder is not fully understood. Abnormal levels of several growth factors have been demonstrated in adults with ASD, including epidermal growth factor (EGF) and hepatocyte growth factor (HGF). Both of these growth factors serve important roles in neurodevelopment and immune function. In this study, concentrations of EGF and HGF were assessed in the plasma of 49 children with ASD aged 2–4 years old and 31 typically developing controls of a similar age as part of the Autism Phenome Project (APP). Levels of EGF were significantly reduced in the ASD group compared to typically developing controls (P=0.003). There were no significant differences in HGF levels in young children with ASD and typically developing controls. EGF plays an important role in regulating neural growth, proliferation, differentiation, and migration, and reduced levels of this molecule may negatively impact neurodevelopment in young children with ASD. En ligne : http://dx.doi.org/10.1155/2012/205362 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153 [article] Decreased Levels of EGF in Plasma of Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Charity ONORE, Auteur ; Judy VAN DE WATER, Auteur ; Paul ASHWOOD, Auteur . - 2011 . - 4 p. Langues : Anglais (eng) in Autism Research and Treatment > (December 2011) . - 4 p. Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder estimated to affect 1 in 110 children in the US, yet the pathology of this disorder is not fully understood. Abnormal levels of several growth factors have been demonstrated in adults with ASD, including epidermal growth factor (EGF) and hepatocyte growth factor (HGF). Both of these growth factors serve important roles in neurodevelopment and immune function. In this study, concentrations of EGF and HGF were assessed in the plasma of 49 children with ASD aged 2–4 years old and 31 typically developing controls of a similar age as part of the Autism Phenome Project (APP). Levels of EGF were significantly reduced in the ASD group compared to typically developing controls (P=0.003). There were no significant differences in HGF levels in young children with ASD and typically developing controls. EGF plays an important role in regulating neural growth, proliferation, differentiation, and migration, and reduced levels of this molecule may negatively impact neurodevelopment in young children with ASD. En ligne : http://dx.doi.org/10.1155/2012/205362 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153

Developmental-behavioral profiles in children with autism spectrum disorder and co-occurring gastrointestinal symptoms / Bibiana RESTREPO in Autism Research, 13-10 (October 2020)  

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Family history of immune conditions and autism spectrum and developmental disorders: Findings from the study to explore early development / Lisa A. CROEN in Autism Research, 12-1 (January 2019)  

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Further characterization of autoantibodies to GABAergic neurons in the central nervous system produced by a subset of children with autism / Sharifia WILLS in Molecular Autism, (April 2011)  

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Increased mid-gestational IFN-gamma, IL-4, and IL-5 in women giving birth to a child with autism: a case-control study / Paula GOINES in Molecular Autism, (August 2011)  

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Infection and Fever in Pregnancy and Autism Spectrum Disorders: Findings from the Study to Explore Early Development / Lisa A. CROEN in Autism Research, 12-10 (October 2019)  

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Maternal Immune-Mediated Conditions, Autism Spectrum Disorders, and Developmental Delay / Kristen LYALL in Journal of Autism and Developmental Disorders, 44-7 (July 2014)  

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Neonatal Thyroid Stimulating Hormone and Subsequent Diagnosis of Autism Spectrum Disorders and Intellectual Disability / Jennifer L. AMES in Autism Research, 13-3 (March 2020)  

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A Pilot Randomized Controlled Trial of Omega-3 Fatty Acids for Autism Spectrum Disorder / Stephen BENT in Journal of Autism and Developmental Disorders, 41-5 (May 2011)  

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A profile and review of findings from the Early Markers for Autism study: unique contributions from a population-based case-control study in California / K. LYALL in Molecular Autism, 12 (2021)  

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Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms / Luke HEUER in Autism Research, 1-5 (October 2008)  

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