[article] 
inAutism Research > 14-6 (June 2021) . - p.1284-1295

Titre :	Replication study of ADOS-2 Toddler Module cut-off scores for autism spectrum disorder classification
Type de document :	Texte imprimé et/ou numérique
Auteurs :	J. S. HONG, Auteur ; V. SINGH, Auteur ; L. KALB, Auteur ; A. ASHKAR, Auteur ; R. LANDA, Auteur
Article en page(s) :	p.1284-1295
Langues :	Anglais (eng)
Mots-clés :	Algorithms  Autism Spectrum Disorder/diagnosis  Autistic Disorder  Child, Preschool  Humans  Infant  ROC Curve  Sensitivity and Specificity  autism spectrum disorder  classification  diagnosis  validity
Index. décimale :	PER Périodiques
Résumé :	The Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) has been regarded as the gold standard assessment of autism spectrum disorder (ASD). While clinical validity of ADOS-2 Modules 1-4 have been extensively studied, there has been very limited research examining the clinical validity of ADOS-2 Toddler Module. The goal of this study was to examine alignment of the ADOS-2 Toddler Module classification with clinicians' determination of ASD, with assessing cut-off scores for diagnosing ASD in toddlers. A total of 412 toddlers ages 12-30?months who received ADOS-2 Toddler Module as well as a best estimate clinical (BEC) diagnosis, were included in this study. ADOS-2 Toddler Module cut-off scores were determined using the appropriate algorithms (Algorithm 1 for toddlers aged 12-20?months and those aged 21-30?months with <5 words, Algorithm 2 for toddlers aged 21-30?months with 5 words or more). Receiver operating characteristic (ROC) curves were used to assess cut-off scores that optimized sensitivity and specificity when compared against BEC diagnosis. The selected cut-off scores were examined using frequency tables to compare ADOS-2 classification against BEC diagnosis. For Algorithm 1, classification statistics were optimized at the cut-off score of 12 with an area under the curve (AUC) of 0.92. For Algorithm 2, classification statistics were optimized at the cut-off score of 10 with an AUC of 0.96. The ADOS-2 Toddler Module classification is strongly aligned with BEC diagnosis. The optimal cut-off scores identified in the current study reflect the same results configured by the prior study. LAY SUMMARY: ADOS-2 Toddler Module has been widely used for the ASD assessment, but there have been limited research on its clinical validity. This study is the first replication of the ADOS-2 Toddler Module with a large independent sample. We examined alignment of the ADOS-2 Toddler Module classification with clinicians' determination of ASD, with assessing cut-off scores, and confirmed the clinical validity of ADOS-2 Toddler Module. Cut-off scores of ADOS-2 Toddler Module cited in the manual yielded best clinical utility for diagnosing ASD in toddlers.
En ligne :	http://dx.doi.org/10.1002/aur.2496
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

[article] Replication study of ADOS-2 Toddler Module cut-off scores for autism spectrum disorder classification [Texte imprimé et/ou numérique] / J. S. HONG, Auteur ; V. SINGH, Auteur ; L. KALB, Auteur ; A. ASHKAR, Auteur ; R. LANDA, Auteur . - p.1284-1295.
Langues : Anglais (eng)
in Autism Research > 14-6 (June 2021) . - p.1284-1295

Mots-clés :	Algorithms  Autism Spectrum Disorder/diagnosis  Autistic Disorder  Child, Preschool  Humans  Infant  ROC Curve  Sensitivity and Specificity  autism spectrum disorder  classification  diagnosis  validity
Index. décimale :	PER Périodiques
Résumé :	The Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) has been regarded as the gold standard assessment of autism spectrum disorder (ASD). While clinical validity of ADOS-2 Modules 1-4 have been extensively studied, there has been very limited research examining the clinical validity of ADOS-2 Toddler Module. The goal of this study was to examine alignment of the ADOS-2 Toddler Module classification with clinicians' determination of ASD, with assessing cut-off scores for diagnosing ASD in toddlers. A total of 412 toddlers ages 12-30?months who received ADOS-2 Toddler Module as well as a best estimate clinical (BEC) diagnosis, were included in this study. ADOS-2 Toddler Module cut-off scores were determined using the appropriate algorithms (Algorithm 1 for toddlers aged 12-20?months and those aged 21-30?months with <5 words, Algorithm 2 for toddlers aged 21-30?months with 5 words or more). Receiver operating characteristic (ROC) curves were used to assess cut-off scores that optimized sensitivity and specificity when compared against BEC diagnosis. The selected cut-off scores were examined using frequency tables to compare ADOS-2 classification against BEC diagnosis. For Algorithm 1, classification statistics were optimized at the cut-off score of 12 with an area under the curve (AUC) of 0.92. For Algorithm 2, classification statistics were optimized at the cut-off score of 10 with an AUC of 0.96. The ADOS-2 Toddler Module classification is strongly aligned with BEC diagnosis. The optimal cut-off scores identified in the current study reflect the same results configured by the prior study. LAY SUMMARY: ADOS-2 Toddler Module has been widely used for the ASD assessment, but there have been limited research on its clinical validity. This study is the first replication of the ADOS-2 Toddler Module with a large independent sample. We examined alignment of the ADOS-2 Toddler Module classification with clinicians' determination of ASD, with assessing cut-off scores, and confirmed the clinical validity of ADOS-2 Toddler Module. Cut-off scores of ADOS-2 Toddler Module cited in the manual yielded best clinical utility for diagnosing ASD in toddlers.
En ligne :	http://dx.doi.org/10.1002/aur.2496
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449