[article]
| Titre : |
Prenatal Folic Acid Supplements and Offspring's Autism Spectrum Disorder: A Meta-analysis and Meta-regression |
| Type de document : |
texte imprimé |
| Auteurs : |
X. LIU, Auteur ; M. ZOU, Auteur ; C. SUN, Auteur ; L. WU, Auteur ; W. X. CHEN, Auteur |
| Article en page(s) : |
p.522-539 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Autism Spectrum Disorder/chemically induced/epidemiology Diet Dietary Supplements Female Folic Acid Humans Pregnancy Vitamins Autism spectrum disorder Folic acid Meta-analysis Meta-regression Prenatal |
| Index. décimale : |
PER Périodiques |
| Résumé : |
We systematically reviewed the evidence on the association between maternal folic acid supplementation and the risk of offspring's autism spectrum disorders (ASD). A total of 10 studies with 23 sub-studies (9795 ASD cases) were included. Folic acid supplementation during early pregnancy was associated with a lower risk of offspring's ASD [OR 0.57, 95% CI 0.41-0.78]. The consumption of a daily amount of at least 400 μg folic acid from dietary sources and supplements, was associated with a reduced risk of offspring ASD [OR 0.55, 95% CI 0.36-0.83]. Critical effective maternal folic acid supplementation strategies, such as intake timing and intake dosage, may aid the reduction in the risk of offspring ASD. This meta-analysis provided new insights for the prevention of offspring's ASD. |
| En ligne : |
http://dx.doi.org/10.1007/s10803-021-04951-8 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 |
in Journal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.522-539
|  |
Prenatal Folic Acid Supplements and Offspring's Autism Spectrum Disorder: A Meta-analysis and Meta-regression in Journal of Autism and Developmental Disorders, 52-2 (February 2022)
