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Prenatal Folic Acid Supplements and Offspring's Autism Spectrum Disorder: A Meta-analysis and Meta-regression / X. LIU in Journal of Autism and Developmental Disorders, 52-2 (February 2022)
[article]
Titre : Prenatal Folic Acid Supplements and Offspring's Autism Spectrum Disorder: A Meta-analysis and Meta-regression Type de document : Texte imprimé et/ou numérique Auteurs : X. LIU, Auteur ; M. ZOU, Auteur ; C. SUN, Auteur ; L. WU, Auteur ; W. X. CHEN, Auteur Article en page(s) : p.522-539 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/chemically induced/epidemiology Diet Dietary Supplements Female Folic Acid Humans Pregnancy Vitamins Autism spectrum disorder Folic acid Meta-analysis Meta-regression Prenatal Index. décimale : PER Périodiques Résumé : We systematically reviewed the evidence on the association between maternal folic acid supplementation and the risk of offspring's autism spectrum disorders (ASD). A total of 10 studies with 23 sub-studies (9795 ASD cases) were included. Folic acid supplementation during early pregnancy was associated with a lower risk of offspring's ASD [OR 0.57, 95% CI 0.41-0.78]. The consumption of a daily amount of at least 400 ?g folic acid from dietary sources and supplements, was associated with a reduced risk of offspring ASD [OR 0.55, 95% CI 0.36-0.83]. Critical effective maternal folic acid supplementation strategies, such as intake timing and intake dosage, may aid the reduction in the risk of offspring ASD. This meta-analysis provided new insights for the prevention of offspring's ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-04951-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455
in Journal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.522-539[article] Prenatal Folic Acid Supplements and Offspring's Autism Spectrum Disorder: A Meta-analysis and Meta-regression [Texte imprimé et/ou numérique] / X. LIU, Auteur ; M. ZOU, Auteur ; C. SUN, Auteur ; L. WU, Auteur ; W. X. CHEN, Auteur . - p.522-539.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.522-539
Mots-clés : Autism Spectrum Disorder/chemically induced/epidemiology Diet Dietary Supplements Female Folic Acid Humans Pregnancy Vitamins Autism spectrum disorder Folic acid Meta-analysis Meta-regression Prenatal Index. décimale : PER Périodiques Résumé : We systematically reviewed the evidence on the association between maternal folic acid supplementation and the risk of offspring's autism spectrum disorders (ASD). A total of 10 studies with 23 sub-studies (9795 ASD cases) were included. Folic acid supplementation during early pregnancy was associated with a lower risk of offspring's ASD [OR 0.57, 95% CI 0.41-0.78]. The consumption of a daily amount of at least 400 ?g folic acid from dietary sources and supplements, was associated with a reduced risk of offspring ASD [OR 0.55, 95% CI 0.36-0.83]. Critical effective maternal folic acid supplementation strategies, such as intake timing and intake dosage, may aid the reduction in the risk of offspring ASD. This meta-analysis provided new insights for the prevention of offspring's ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-04951-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 Autism spectrum disorder is associated with an increased risk of development of underweight in children and adolescents: A systematic review and meta-analysis / Chanaka N. KAHATHUDUWA in Research in Autism Spectrum Disorders, 94 (June 2022)
[article]
Titre : Autism spectrum disorder is associated with an increased risk of development of underweight in children and adolescents: A systematic review and meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : Chanaka N. KAHATHUDUWA, Auteur ; Chathurika S. DHANASEKARA, Auteur ; Sarah WAKEFIELD, Auteur ; Naima MOUSTAID-MOUSSA, Auteur ; Ann MASTERGEORGE, Auteur Article en page(s) : 101969 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Underweight Systematic review Meta-analysis Meta-regression Index. décimale : PER Périodiques Résumé : Background & Aims Multiple observational studies have examined the association between autism spectrum disorder (ASD) and underweight, yet the evidence remains ambiguous. We examined the pooled prevalence and relative risk of developing underweight among children with ASD in a systematic review and meta-analysis and examined the effects of potential risk factors in a meta-regression. Methods ProQuest, PubMed, Scopus and Web of Science databases were systematically searched and screened per the PRISMA guidelines. DerSimonian?Laird random-effects meta-analyses were performed using the ?meta? package in R to determine the pooled prevalence and the relative risk of underweight among children with ASD. Meta-regression analyses examined the moderator effects of risk factors. Results Underweight had a prevalence of 6.5% (95% CI, 5.1?8.2) among children with ASD overall (29 study groups). Children with ASD possessed a 28.5% (8 studies) greater risk of being underweight vs. neurotypical controls. Meta-regression analyses revealed that non-Caucasian origin and male sex may increase the risk of being underweight in children with ASD. Conclusions Children with ASD seem to be at an increased risk of being underweight, which may further impair the clinical outcomes and quality of life. Clinicians need to vigilantly monitor weight and height among children with ASD to prevent underweight and associated complications. Future studies should aim to establish factors that may contribute to the development of underweight among children with ASD. En ligne : https://doi.org/10.1016/j.rasd.2022.101969 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476
in Research in Autism Spectrum Disorders > 94 (June 2022) . - 101969[article] Autism spectrum disorder is associated with an increased risk of development of underweight in children and adolescents: A systematic review and meta-analysis [Texte imprimé et/ou numérique] / Chanaka N. KAHATHUDUWA, Auteur ; Chathurika S. DHANASEKARA, Auteur ; Sarah WAKEFIELD, Auteur ; Naima MOUSTAID-MOUSSA, Auteur ; Ann MASTERGEORGE, Auteur . - 101969.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 94 (June 2022) . - 101969
Mots-clés : Autism spectrum disorder Underweight Systematic review Meta-analysis Meta-regression Index. décimale : PER Périodiques Résumé : Background & Aims Multiple observational studies have examined the association between autism spectrum disorder (ASD) and underweight, yet the evidence remains ambiguous. We examined the pooled prevalence and relative risk of developing underweight among children with ASD in a systematic review and meta-analysis and examined the effects of potential risk factors in a meta-regression. Methods ProQuest, PubMed, Scopus and Web of Science databases were systematically searched and screened per the PRISMA guidelines. DerSimonian?Laird random-effects meta-analyses were performed using the ?meta? package in R to determine the pooled prevalence and the relative risk of underweight among children with ASD. Meta-regression analyses examined the moderator effects of risk factors. Results Underweight had a prevalence of 6.5% (95% CI, 5.1?8.2) among children with ASD overall (29 study groups). Children with ASD possessed a 28.5% (8 studies) greater risk of being underweight vs. neurotypical controls. Meta-regression analyses revealed that non-Caucasian origin and male sex may increase the risk of being underweight in children with ASD. Conclusions Children with ASD seem to be at an increased risk of being underweight, which may further impair the clinical outcomes and quality of life. Clinicians need to vigilantly monitor weight and height among children with ASD to prevent underweight and associated complications. Future studies should aim to establish factors that may contribute to the development of underweight among children with ASD. En ligne : https://doi.org/10.1016/j.rasd.2022.101969 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476