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Détail de l'auteur
Auteur Thomas W. FRAZIER |
Documents disponibles écrits par cet auteur (19)



Characterizing restricted and unusual interests in autistic youth / Luke D. SMILLIE ; Thomas W. FRAZIER ; Antonio Y. HARDAN ; Gail A. ALVARES ; Andrew J. O. WHITEHOUSE ; Mirko ULJAREVIĆ in Autism Research, 16-2 (February 2023)
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Titre : Characterizing restricted and unusual interests in autistic youth Type de document : Texte imprimé et/ou numérique Auteurs : Luke D. SMILLIE, Auteur ; Thomas W. FRAZIER, Auteur ; Antonio Y. HARDAN, Auteur ; Gail A. ALVARES, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; Mirko ULJAREVIĆ, Auteur Article en page(s) : p.394-405 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract A broad range of interests characterized by unusual content and/or intensity, labeled as circumscribed interests (CI), are a core diagnostic feature of autism. Recent evidence suggests that a distinction can be drawn between interests that, although characterized by unusually high intensity and/or inflexibility, are otherwise common in terms of their content (e.g., an interest in movies or animals), labeled as restricted interests (RI), and interests that are generally not salient outside of autism (e.g., an interest in traffic lights or categorization), labeled as unusual interests (UI). The current study aimed to further characterize RI and UI by exploring their association with age, sex, IQ, and social motivation, as well as to examine differences in the adaptive benefits and negative impacts of these two subdomains. Parents of 1892 autistic children and adolescents (Mage = 10.82, SDage = 4.14; 420 females) completed an online survey including the Dimensional Assessment of Restricted and Repetitive Behaviors and the Social Communication Questionnaire. Both RI and UI were found to be highly frequent. Sex-based differences were observed in the content, but not intensity, of CI such that females were more likely to show interests with a social component. Finally, RI and UI showed distinct patterns of association with age, sex, IQ, and social motivation, as well as metrics of adaptive benefits and negative impacts. Findings afford a more nuanced understanding of sex-based differences in CI and, crucially, provide preliminary evidence that RI and UI represent distinct constructs that should be studied independently in future research. En ligne : https://doi.org/10.1002/aur.2863 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=496
in Autism Research > 16-2 (February 2023) . - p.394-405[article] Characterizing restricted and unusual interests in autistic youth [Texte imprimé et/ou numérique] / Luke D. SMILLIE, Auteur ; Thomas W. FRAZIER, Auteur ; Antonio Y. HARDAN, Auteur ; Gail A. ALVARES, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; Mirko ULJAREVIĆ, Auteur . - p.394-405.
Langues : Anglais (eng)
in Autism Research > 16-2 (February 2023) . - p.394-405
Index. décimale : PER Périodiques Résumé : Abstract A broad range of interests characterized by unusual content and/or intensity, labeled as circumscribed interests (CI), are a core diagnostic feature of autism. Recent evidence suggests that a distinction can be drawn between interests that, although characterized by unusually high intensity and/or inflexibility, are otherwise common in terms of their content (e.g., an interest in movies or animals), labeled as restricted interests (RI), and interests that are generally not salient outside of autism (e.g., an interest in traffic lights or categorization), labeled as unusual interests (UI). The current study aimed to further characterize RI and UI by exploring their association with age, sex, IQ, and social motivation, as well as to examine differences in the adaptive benefits and negative impacts of these two subdomains. Parents of 1892 autistic children and adolescents (Mage = 10.82, SDage = 4.14; 420 females) completed an online survey including the Dimensional Assessment of Restricted and Repetitive Behaviors and the Social Communication Questionnaire. Both RI and UI were found to be highly frequent. Sex-based differences were observed in the content, but not intensity, of CI such that females were more likely to show interests with a social component. Finally, RI and UI showed distinct patterns of association with age, sex, IQ, and social motivation, as well as metrics of adaptive benefits and negative impacts. Findings afford a more nuanced understanding of sex-based differences in CI and, crucially, provide preliminary evidence that RI and UI represent distinct constructs that should be studied independently in future research. En ligne : https://doi.org/10.1002/aur.2863 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=496 Characterizing subdomains of insistence on sameness in autistic youth / Luke D. SMILLIE ; Thomas W. FRAZIER ; Antonio Y. HARDAN ; Mirko ULJAREVI? in Autism Research, 16-12 (December 2023)
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Titre : Characterizing subdomains of insistence on sameness in autistic youth Type de document : Texte imprimé et/ou numérique Auteurs : Luke D. SMILLIE, Auteur ; Thomas W. FRAZIER, Auteur ; Antonio Y. HARDAN, Auteur ; Mirko ULJAREVI?, Auteur Article en page(s) : p.2326-2335 Index. décimale : PER Périodiques Résumé : Abstract Insistence on sameness (IS) encompasses a range of behavioral patterns, including resistance to change, routines, and ritualized behaviors, that can be present across social and non-social contexts. Given the breadth of behaviors encompassed by IS, it is important to determine whether this domain is best conceptualized and measured as uni- or a multi-dimensional construct. Therefore, the current study aimed to characterize the structure of IS and explore potentially distinct of patterns of associations between identified IS factors and relevant correlates, including age, sex, IQ, anxiety, social abilities, emotional and behavioral dysregulation, and sensory hypersensitivity. Exploratory graph analysis was conducted using the dimensional assessment of restricted and repetitive behaviors to examine the structure of IS in a sample 1892 autistic youth (Mage = 10.82, SDage = 4.14; range: 3-18?years; 420 females) recruited from the Simons Foundation Powering Autism Research for Knowledge cohort. Three distinct IS subdomains labeled as IS-Ritualistic/sameness, IS-Routines, and IS-Others (referring to IS behaviors during interactions with others) were identified. Generalized additive models demonstrated that each of the IS subdomains showed a unique pattern of association with key variables. More specifically, while sensory hypersensitivity was significantly associated with IS-Ritualistic/sameness and IS-Routines, it was not associated with IS-Others. Further, while emotional dysregulation was a unique predictor of IS-Ritualistic/sameness (but not IS-Routines or IS-Others), social interaction abilities were a unique predictor of IS-Routines (but not IS-Ritualistic/sameness or IS-Others). Current findings provide preliminary evidence that the IS may encompass several distinct subdomains. En ligne : https://doi.org/10.1002/aur.3033 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518
in Autism Research > 16-12 (December 2023) . - p.2326-2335[article] Characterizing subdomains of insistence on sameness in autistic youth [Texte imprimé et/ou numérique] / Luke D. SMILLIE, Auteur ; Thomas W. FRAZIER, Auteur ; Antonio Y. HARDAN, Auteur ; Mirko ULJAREVI?, Auteur . - p.2326-2335.
in Autism Research > 16-12 (December 2023) . - p.2326-2335
Index. décimale : PER Périodiques Résumé : Abstract Insistence on sameness (IS) encompasses a range of behavioral patterns, including resistance to change, routines, and ritualized behaviors, that can be present across social and non-social contexts. Given the breadth of behaviors encompassed by IS, it is important to determine whether this domain is best conceptualized and measured as uni- or a multi-dimensional construct. Therefore, the current study aimed to characterize the structure of IS and explore potentially distinct of patterns of associations between identified IS factors and relevant correlates, including age, sex, IQ, anxiety, social abilities, emotional and behavioral dysregulation, and sensory hypersensitivity. Exploratory graph analysis was conducted using the dimensional assessment of restricted and repetitive behaviors to examine the structure of IS in a sample 1892 autistic youth (Mage = 10.82, SDage = 4.14; range: 3-18?years; 420 females) recruited from the Simons Foundation Powering Autism Research for Knowledge cohort. Three distinct IS subdomains labeled as IS-Ritualistic/sameness, IS-Routines, and IS-Others (referring to IS behaviors during interactions with others) were identified. Generalized additive models demonstrated that each of the IS subdomains showed a unique pattern of association with key variables. More specifically, while sensory hypersensitivity was significantly associated with IS-Ritualistic/sameness and IS-Routines, it was not associated with IS-Others. Further, while emotional dysregulation was a unique predictor of IS-Ritualistic/sameness (but not IS-Routines or IS-Others), social interaction abilities were a unique predictor of IS-Routines (but not IS-Ritualistic/sameness or IS-Others). Current findings provide preliminary evidence that the IS may encompass several distinct subdomains. En ligne : https://doi.org/10.1002/aur.3033 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518 Commentary: The observed association between autistic severity measured by the Social Responsiveness Scale (SRS) and general psychopathology – a response to Hus et al.() / John N. CONSTANTINO in Journal of Child Psychology and Psychiatry, 54-6 (June 2013)
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Titre : Commentary: The observed association between autistic severity measured by the Social Responsiveness Scale (SRS) and general psychopathology – a response to Hus et al.() Type de document : Texte imprimé et/ou numérique Auteurs : John N. CONSTANTINO, Auteur ; Thomas W. FRAZIER, Auteur Article en page(s) : p.695-697 Langues : Anglais (eng) Mots-clés : Autistic disorder diagnosis child behavior check list social behavior pervasive developmental disorder Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1111/jcpp.12064 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=200
in Journal of Child Psychology and Psychiatry > 54-6 (June 2013) . - p.695-697[article] Commentary: The observed association between autistic severity measured by the Social Responsiveness Scale (SRS) and general psychopathology – a response to Hus et al.() [Texte imprimé et/ou numérique] / John N. CONSTANTINO, Auteur ; Thomas W. FRAZIER, Auteur . - p.695-697.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 54-6 (June 2013) . - p.695-697
Mots-clés : Autistic disorder diagnosis child behavior check list social behavior pervasive developmental disorder Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1111/jcpp.12064 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=200 Confirmatory factor analytic structure and measurement invariance of quantitative autistic traits measured by the Social Responsiveness Scale-2 / Thomas W. FRAZIER in Autism, 18-1 (January 2014)
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Titre : Confirmatory factor analytic structure and measurement invariance of quantitative autistic traits measured by the Social Responsiveness Scale-2 Type de document : Texte imprimé et/ou numérique Auteurs : Thomas W. FRAZIER, Auteur ; Kristin R. RATLIFF, Auteur ; Chris GRUBER, Auteur ; Yi ZHANG, Auteur ; Paul A. LAW, Auteur ; John N. CONSTANTINO, Auteur Article en page(s) : p.31-44 Langues : Anglais (eng) Mots-clés : Asperger syndrome autism factor structure pervasive developmental disorder Index. décimale : PER Périodiques Résumé : Understanding the factor structure of autistic symptomatology is critical to the discovery and interpretation of causal mechanisms in autism spectrum disorder. We applied confirmatory factor analysis and assessment of measurement invariance to a large (N = 9635) accumulated collection of reports on quantitative autistic traits using the Social Responsiveness Scale, representing a broad diversity of age, severity, and reporter type. A two-factor structure (corresponding to social communication impairment and restricted, repetitive behavior) as elaborated in the updated Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-5) criteria for autism spectrum disorder exhibited acceptable model fit in confirmatory factor analysis. Measurement invariance was appreciable across age, sex, and reporter (self vs other), but somewhat less apparent between clinical and nonclinical populations in this sample comprised of both familial and sporadic autism spectrum disorders. The statistical power afforded by this large sample allowed relative differentiation of three factors among items encompassing social communication impairment (emotion recognition, social avoidance, and interpersonal relatedness) and two factors among items encompassing restricted, repetitive behavior (insistence on sameness and repetitive mannerisms). Cross-trait correlations remained extremely high, that is, on the order of 0.66–0.92. These data clarify domains of statistically significant factoral separation that may relate to partially—but not completely—overlapping biological mechanisms, contributing to variation in human social competency. Given such robust intercorrelations among symptom domains, understanding their co-emergence remains a high priority in conceptualizing common neural mechanisms underlying autistic syndromes. En ligne : http://dx.doi.org/10.1177/1362361313500382 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221
in Autism > 18-1 (January 2014) . - p.31-44[article] Confirmatory factor analytic structure and measurement invariance of quantitative autistic traits measured by the Social Responsiveness Scale-2 [Texte imprimé et/ou numérique] / Thomas W. FRAZIER, Auteur ; Kristin R. RATLIFF, Auteur ; Chris GRUBER, Auteur ; Yi ZHANG, Auteur ; Paul A. LAW, Auteur ; John N. CONSTANTINO, Auteur . - p.31-44.
Langues : Anglais (eng)
in Autism > 18-1 (January 2014) . - p.31-44
Mots-clés : Asperger syndrome autism factor structure pervasive developmental disorder Index. décimale : PER Périodiques Résumé : Understanding the factor structure of autistic symptomatology is critical to the discovery and interpretation of causal mechanisms in autism spectrum disorder. We applied confirmatory factor analysis and assessment of measurement invariance to a large (N = 9635) accumulated collection of reports on quantitative autistic traits using the Social Responsiveness Scale, representing a broad diversity of age, severity, and reporter type. A two-factor structure (corresponding to social communication impairment and restricted, repetitive behavior) as elaborated in the updated Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-5) criteria for autism spectrum disorder exhibited acceptable model fit in confirmatory factor analysis. Measurement invariance was appreciable across age, sex, and reporter (self vs other), but somewhat less apparent between clinical and nonclinical populations in this sample comprised of both familial and sporadic autism spectrum disorders. The statistical power afforded by this large sample allowed relative differentiation of three factors among items encompassing social communication impairment (emotion recognition, social avoidance, and interpersonal relatedness) and two factors among items encompassing restricted, repetitive behavior (insistence on sameness and repetitive mannerisms). Cross-trait correlations remained extremely high, that is, on the order of 0.66–0.92. These data clarify domains of statistically significant factoral separation that may relate to partially—but not completely—overlapping biological mechanisms, contributing to variation in human social competency. Given such robust intercorrelations among symptom domains, understanding their co-emergence remains a high priority in conceptualizing common neural mechanisms underlying autistic syndromes. En ligne : http://dx.doi.org/10.1177/1362361313500382 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221 Cytoplasm-predominant Pten associates with increased region-specific brain tyrosine hydroxylase and dopamine D2 receptors in mouse model with autistic traits / Xin HE in Molecular Autism, (November 2015)
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Titre : Cytoplasm-predominant Pten associates with increased region-specific brain tyrosine hydroxylase and dopamine D2 receptors in mouse model with autistic traits Type de document : Texte imprimé et/ou numérique Auteurs : Xin HE, Auteur ; Stetson THACKER, Auteur ; Todd ROMIGH, Auteur ; Qi YU, Auteur ; Thomas W. FRAZIER, Auteur ; Charis ENG, Auteur Article en page(s) : p.1-10 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by impairment in social communication/interaction and inflexible/repetitive behavior. Several lines of evidence support genetic factors as a predominant cause of ASD. Among those autism susceptibility genes that have been identified, the PTEN tumor suppressor gene, initially identified as predisposing to Cowden heritable cancer syndrome, was found to be mutated in a subset of ASD patients with extreme macrocephaly. However, the ASD-relevant molecular mechanism mediating the effect of PTEN mutations remains elusive. En ligne : http://dx.doi.org/10.1186/s13229-015-0056-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277
in Molecular Autism > (November 2015) . - p.1-10[article] Cytoplasm-predominant Pten associates with increased region-specific brain tyrosine hydroxylase and dopamine D2 receptors in mouse model with autistic traits [Texte imprimé et/ou numérique] / Xin HE, Auteur ; Stetson THACKER, Auteur ; Todd ROMIGH, Auteur ; Qi YU, Auteur ; Thomas W. FRAZIER, Auteur ; Charis ENG, Auteur . - p.1-10.
Langues : Anglais (eng)
in Molecular Autism > (November 2015) . - p.1-10
Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by impairment in social communication/interaction and inflexible/repetitive behavior. Several lines of evidence support genetic factors as a predominant cause of ASD. Among those autism susceptibility genes that have been identified, the PTEN tumor suppressor gene, initially identified as predisposing to Cowden heritable cancer syndrome, was found to be mutated in a subset of ASD patients with extreme macrocephaly. However, the ASD-relevant molecular mechanism mediating the effect of PTEN mutations remains elusive. En ligne : http://dx.doi.org/10.1186/s13229-015-0056-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 Demographic and clinical correlates of autism symptom domains and autism spectrum diagnosis / Thomas W. FRAZIER in Autism, 18-5 (July 2014)
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PermalinkDevelopment and validation of an Arabic language eye-tracking paradigm for the early screening and diagnosis of autism spectrum disorders in Qatar / Iman GHAZAL ; I. Richard THOMPSON ; Eric W. KLINGEMIER ; Mohammed ALDOSARI ; Hawraa AL-SHAMMARI ; Fatema AL-FARAJ ; Saba EL-HAG ; Mohamed TOLEFAT ; Mogahed ALI ; Bisher NASIR ; Thomas W. FRAZIER in Autism Research, 16-12 (December 2023)
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PermalinkEquivalence of symptom dimensions in females and males with autism / Thomas W. FRAZIER in Autism, 21-6 (August 2017)
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PermalinkExploratory and Confirmatory Factor Analysis of the Autism Diagnostic Interview-Revised / Thomas W. FRAZIER in Journal of Autism and Developmental Disorders, 38-3 (March 2008)
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PermalinkPivotal Response Treatment Parent Training for Autism: Findings from a 3-Month Follow-Up Evaluation / Grace W. GENGOUX in Journal of Autism and Developmental Disorders, 45-9 (September 2015)
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PermalinkPsychometric evaluation of the revised child and family quality of life questionnaire (CFQL-2) / Thomas W. FRAZIER in Research in Autism Spectrum Disorders, 70 (February 2020)
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PermalinkQuantitative autism symptom patterns recapitulate differential mechanisms of genetic transmission in single and multiple incidence families / Thomas W. FRAZIER in Molecular Autism, (October 2015)
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PermalinkA randomized controlled trial of Pivotal Response Treatment Group for parents of children with autism / Antonio Y. HARDAN in Journal of Child Psychology and Psychiatry, 56-8 (August 2015)
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PermalinkReliability of the Commonly Used and Newly-Developed Autism Measures / Thomas W. FRAZIER in Journal of Autism and Developmental Disorders, 54-6 (June 2024)
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PermalinkRemote monitoring of social attention in neurogenetic syndromes and idiopathic neurodevelopmental disability / Thomas W. FRAZIER ; Robyn M. BUSCH ; Patricia KLAAS ; Katherine Lachlan ; Shafali JESTE ; Alexander KOLEVZON ; Eva LOTH ; Jacqueline Harris ; Tom Pepper ; Kristin Anthony ; J. Michael Graglia ; Kathryn Helde ; Christal Delagrammatikas ; Sandra Bedrosian-Sermone ; Constance Smith-Hicks ; Mustafa SAHIN ; Eric A. YOUNGSTROM ; Charis ENG ; Lacey CHETCUTI ; Antonio Y. HARDAN ; Mirko ULJAREVIC in Autism Research, 18-2 (February 2025)
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