Characterising Insistence on Sameness and Circumscribed Interests: A Qualitative Study of Parent Perspectives / Alicia GENG ; Luke D. SMILLIE ; Thomas W. FRAZIER ; Antonio Y. HARDAN ; Gail A. ALVAREZ ; Andrew WHITEHOUSE ; Rachel K. SCHUCK ; Sue R. LEEKAM ; Mirko ULJAREVI? in Journal of Autism and Developmental Disorders, 55-8 (August 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-8 (August 2025) . - p.2896-2908 Titre : Characterising Insistence on Sameness and Circumscribed Interests: A Qualitative Study of Parent Perspectives Type de document : Texte imprimé et/ou numérique Auteurs : Alicia GENG, Auteur ; Luke D. SMILLIE, Auteur ; Thomas W. FRAZIER, Auteur ; Antonio Y. HARDAN, Auteur ; Gail A. ALVAREZ, Auteur ; Andrew WHITEHOUSE, Auteur ; Rachel K. SCHUCK, Auteur ; Sue R. LEEKAM, Auteur ; Mirko ULJAREVI?, Auteur Article en page(s) : p.2896-2908 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Manifestations of insistence on sameness (IS) and circumscribed interests (CI) are complex, with individuals varying considerably, not only in the types of behaviours they express, but also in terms of a behaviour?s frequency, intensity, trajectory, adaptive benefits, and impacts. However, current quantitative RRB instruments capture only certain aspects of these behaviours (e.g., mostly frequency or general "severity"). Thus, the current study utilised a semi-structured caregiver interview to provide an in-depth, qualitative characterization of different aspects of IS and CI presentation. Caregivers of 27 autistic children and adolescents displaying IS and/or CI behaviours (3-16 years; 18 males; 9 females) participated in a semi-structured interview. Responses were analysed using thematic framework analysis. Framework analysis identified nine different aspects of IS and CI presentation: (1) intensity, (2) frequency, (3) emergence of behaviour, (4) changes over time, (5) day-to-day fluctuations, (6) purpose/adaptive benefit, (7) experiences of distress, (8) challenges for the individual, their family, and their socialisation, and (9) management strategies and their effectiveness. Autistic children and adolescents were reported to vary greatly on each of these dimensions. Findings demonstrate the complexity of IS and CI presentations and highlight the need for more comprehensive quantitative assessments that independently assess the frequency, intensity, and impact of behaviours. Further, findings reported here emphasize the need for ecologically valid measures that assess the contexts in which these behaviours occur and how their presentations can change within and across days. En ligne : https://doi.org/10.1007/s10803-024-06404-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] Characterising Insistence on Sameness and Circumscribed Interests: A Qualitative Study of Parent Perspectives [Texte imprimé et/ou numérique] / Alicia GENG, Auteur ; Luke D. SMILLIE, Auteur ; Thomas W. FRAZIER, Auteur ; Antonio Y. HARDAN, Auteur ; Gail A. ALVAREZ, Auteur ; Andrew WHITEHOUSE, Auteur ; Rachel K. SCHUCK, Auteur ; Sue R. LEEKAM, Auteur ; Mirko ULJAREVI?, Auteur . - p.2896-2908. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-8 (August 2025) . - p.2896-2908 Index. décimale : PER Périodiques Résumé : Manifestations of insistence on sameness (IS) and circumscribed interests (CI) are complex, with individuals varying considerably, not only in the types of behaviours they express, but also in terms of a behaviour?s frequency, intensity, trajectory, adaptive benefits, and impacts. However, current quantitative RRB instruments capture only certain aspects of these behaviours (e.g., mostly frequency or general "severity"). Thus, the current study utilised a semi-structured caregiver interview to provide an in-depth, qualitative characterization of different aspects of IS and CI presentation. Caregivers of 27 autistic children and adolescents displaying IS and/or CI behaviours (3-16 years; 18 males; 9 females) participated in a semi-structured interview. Responses were analysed using thematic framework analysis. Framework analysis identified nine different aspects of IS and CI presentation: (1) intensity, (2) frequency, (3) emergence of behaviour, (4) changes over time, (5) day-to-day fluctuations, (6) purpose/adaptive benefit, (7) experiences of distress, (8) challenges for the individual, their family, and their socialisation, and (9) management strategies and their effectiveness. Autistic children and adolescents were reported to vary greatly on each of these dimensions. Findings demonstrate the complexity of IS and CI presentations and highlight the need for more comprehensive quantitative assessments that independently assess the frequency, intensity, and impact of behaviours. Further, findings reported here emphasize the need for ecologically valid measures that assess the contexts in which these behaviours occur and how their presentations can change within and across days. En ligne : https://doi.org/10.1007/s10803-024-06404-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565

Characterizing restricted and unusual interests in autistic youth / Luke D. SMILLIE ; Thomas W. FRAZIER ; Antonio Y. HARDAN ; Gail A. ALVARES ; Andrew J. O. WHITEHOUSE ; Mirko ULJAREVIĆ in Autism Research, 16-2 (February 2023)  

Public ISBD [article]  inAutism Research > 16-2 (February 2023) . - p.394-405 Titre : Characterizing restricted and unusual interests in autistic youth Type de document : Texte imprimé et/ou numérique Auteurs : Luke D. SMILLIE, Auteur ; Thomas W. FRAZIER, Auteur ; Antonio Y. HARDAN, Auteur ; Gail A. ALVARES, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; Mirko ULJAREVIĆ, Auteur Article en page(s) : p.394-405 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract A broad range of interests characterized by unusual content and/or intensity, labeled as circumscribed interests (CI), are a core diagnostic feature of autism. Recent evidence suggests that a distinction can be drawn between interests that, although characterized by unusually high intensity and/or inflexibility, are otherwise common in terms of their content (e.g., an interest in movies or animals), labeled as restricted interests (RI), and interests that are generally not salient outside of autism (e.g., an interest in traffic lights or categorization), labeled as unusual interests (UI). The current study aimed to further characterize RI and UI by exploring their association with age, sex, IQ, and social motivation, as well as to examine differences in the adaptive benefits and negative impacts of these two subdomains. Parents of 1892 autistic children and adolescents (Mage = 10.82, SDage = 4.14; 420 females) completed an online survey including the Dimensional Assessment of Restricted and Repetitive Behaviors and the Social Communication Questionnaire. Both RI and UI were found to be highly frequent. Sex-based differences were observed in the content, but not intensity, of CI such that females were more likely to show interests with a social component. Finally, RI and UI showed distinct patterns of association with age, sex, IQ, and social motivation, as well as metrics of adaptive benefits and negative impacts. Findings afford a more nuanced understanding of sex-based differences in CI and, crucially, provide preliminary evidence that RI and UI represent distinct constructs that should be studied independently in future research. En ligne : https://doi.org/10.1002/aur.2863 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=496 [article] Characterizing restricted and unusual interests in autistic youth [Texte imprimé et/ou numérique] / Luke D. SMILLIE, Auteur ; Thomas W. FRAZIER, Auteur ; Antonio Y. HARDAN, Auteur ; Gail A. ALVARES, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; Mirko ULJAREVIĆ, Auteur . - p.394-405. Langues : Anglais (eng) in Autism Research > 16-2 (February 2023) . - p.394-405 Index. décimale : PER Périodiques Résumé : Abstract A broad range of interests characterized by unusual content and/or intensity, labeled as circumscribed interests (CI), are a core diagnostic feature of autism. Recent evidence suggests that a distinction can be drawn between interests that, although characterized by unusually high intensity and/or inflexibility, are otherwise common in terms of their content (e.g., an interest in movies or animals), labeled as restricted interests (RI), and interests that are generally not salient outside of autism (e.g., an interest in traffic lights or categorization), labeled as unusual interests (UI). The current study aimed to further characterize RI and UI by exploring their association with age, sex, IQ, and social motivation, as well as to examine differences in the adaptive benefits and negative impacts of these two subdomains. Parents of 1892 autistic children and adolescents (Mage = 10.82, SDage = 4.14; 420 females) completed an online survey including the Dimensional Assessment of Restricted and Repetitive Behaviors and the Social Communication Questionnaire. Both RI and UI were found to be highly frequent. Sex-based differences were observed in the content, but not intensity, of CI such that females were more likely to show interests with a social component. Finally, RI and UI showed distinct patterns of association with age, sex, IQ, and social motivation, as well as metrics of adaptive benefits and negative impacts. Findings afford a more nuanced understanding of sex-based differences in CI and, crucially, provide preliminary evidence that RI and UI represent distinct constructs that should be studied independently in future research. En ligne : https://doi.org/10.1002/aur.2863 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=496

Characterizing subdomains of insistence on sameness in autistic youth / Luke D. SMILLIE ; Thomas W. FRAZIER ; Antonio Y. HARDAN ; Mirko ULJAREVI? in Autism Research, 16-12 (December 2023)  

Public ISBD [article]  inAutism Research > 16-12 (December 2023) . - p.2326-2335 Titre : Characterizing subdomains of insistence on sameness in autistic youth Type de document : Texte imprimé et/ou numérique Auteurs : Luke D. SMILLIE, Auteur ; Thomas W. FRAZIER, Auteur ; Antonio Y. HARDAN, Auteur ; Mirko ULJAREVI?, Auteur Article en page(s) : p.2326-2335 Index. décimale : PER Périodiques Résumé : Abstract Insistence on sameness (IS) encompasses a range of behavioral patterns, including resistance to change, routines, and ritualized behaviors, that can be present across social and non-social contexts. Given the breadth of behaviors encompassed by IS, it is important to determine whether this domain is best conceptualized and measured as uni- or a multi-dimensional construct. Therefore, the current study aimed to characterize the structure of IS and explore potentially distinct of patterns of associations between identified IS factors and relevant correlates, including age, sex, IQ, anxiety, social abilities, emotional and behavioral dysregulation, and sensory hypersensitivity. Exploratory graph analysis was conducted using the dimensional assessment of restricted and repetitive behaviors to examine the structure of IS in a sample 1892 autistic youth (Mage = 10.82, SDage = 4.14; range: 3-18?years; 420 females) recruited from the Simons Foundation Powering Autism Research for Knowledge cohort. Three distinct IS subdomains labeled as IS-Ritualistic/sameness, IS-Routines, and IS-Others (referring to IS behaviors during interactions with others) were identified. Generalized additive models demonstrated that each of the IS subdomains showed a unique pattern of association with key variables. More specifically, while sensory hypersensitivity was significantly associated with IS-Ritualistic/sameness and IS-Routines, it was not associated with IS-Others. Further, while emotional dysregulation was a unique predictor of IS-Ritualistic/sameness (but not IS-Routines or IS-Others), social interaction abilities were a unique predictor of IS-Routines (but not IS-Ritualistic/sameness or IS-Others). Current findings provide preliminary evidence that the IS may encompass several distinct subdomains. En ligne : https://doi.org/10.1002/aur.3033 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518 [article] Characterizing subdomains of insistence on sameness in autistic youth [Texte imprimé et/ou numérique] / Luke D. SMILLIE, Auteur ; Thomas W. FRAZIER, Auteur ; Antonio Y. HARDAN, Auteur ; Mirko ULJAREVI?, Auteur . - p.2326-2335. in Autism Research > 16-12 (December 2023) . - p.2326-2335 Index. décimale : PER Périodiques Résumé : Abstract Insistence on sameness (IS) encompasses a range of behavioral patterns, including resistance to change, routines, and ritualized behaviors, that can be present across social and non-social contexts. Given the breadth of behaviors encompassed by IS, it is important to determine whether this domain is best conceptualized and measured as uni- or a multi-dimensional construct. Therefore, the current study aimed to characterize the structure of IS and explore potentially distinct of patterns of associations between identified IS factors and relevant correlates, including age, sex, IQ, anxiety, social abilities, emotional and behavioral dysregulation, and sensory hypersensitivity. Exploratory graph analysis was conducted using the dimensional assessment of restricted and repetitive behaviors to examine the structure of IS in a sample 1892 autistic youth (Mage = 10.82, SDage = 4.14; range: 3-18?years; 420 females) recruited from the Simons Foundation Powering Autism Research for Knowledge cohort. Three distinct IS subdomains labeled as IS-Ritualistic/sameness, IS-Routines, and IS-Others (referring to IS behaviors during interactions with others) were identified. Generalized additive models demonstrated that each of the IS subdomains showed a unique pattern of association with key variables. More specifically, while sensory hypersensitivity was significantly associated with IS-Ritualistic/sameness and IS-Routines, it was not associated with IS-Others. Further, while emotional dysregulation was a unique predictor of IS-Ritualistic/sameness (but not IS-Routines or IS-Others), social interaction abilities were a unique predictor of IS-Routines (but not IS-Ritualistic/sameness or IS-Others). Current findings provide preliminary evidence that the IS may encompass several distinct subdomains. En ligne : https://doi.org/10.1002/aur.3033 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518

Commentary: The observed association between autistic severity measured by the Social Responsiveness Scale (SRS) and general psychopathology – a response to Hus et al.() / John N. CONSTANTINO in Journal of Child Psychology and Psychiatry, 54-6 (June 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-6 (June 2013) . - p.695-697 Titre : Commentary: The observed association between autistic severity measured by the Social Responsiveness Scale (SRS) and general psychopathology – a response to Hus et al.() Type de document : Texte imprimé et/ou numérique Auteurs : John N. CONSTANTINO, Auteur ; Thomas W. FRAZIER, Auteur Article en page(s) : p.695-697 Langues : Anglais (eng) Mots-clés : Autistic disorder  diagnosis  child behavior check list  social behavior  pervasive developmental disorder Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1111/jcpp.12064 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=200 [article] Commentary: The observed association between autistic severity measured by the Social Responsiveness Scale (SRS) and general psychopathology – a response to Hus et al.() [Texte imprimé et/ou numérique] / John N. CONSTANTINO, Auteur ; Thomas W. FRAZIER, Auteur . - p.695-697. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-6 (June 2013) . - p.695-697 Mots-clés : Autistic disorder  diagnosis  child behavior check list  social behavior  pervasive developmental disorder Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1111/jcpp.12064 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=200

Confirmatory factor analytic structure and measurement invariance of quantitative autistic traits measured by the Social Responsiveness Scale-2 / Thomas W. FRAZIER in Autism, 18-1 (January 2014)  

Public ISBD [article]  inAutism > 18-1 (January 2014) . - p.31-44 Titre : Confirmatory factor analytic structure and measurement invariance of quantitative autistic traits measured by the Social Responsiveness Scale-2 Type de document : Texte imprimé et/ou numérique Auteurs : Thomas W. FRAZIER, Auteur ; Kristin R. RATLIFF, Auteur ; Chris GRUBER, Auteur ; Yi ZHANG, Auteur ; Paul A. LAW, Auteur ; John N. CONSTANTINO, Auteur Article en page(s) : p.31-44 Langues : Anglais (eng) Mots-clés : Asperger syndrome  autism  factor structure  pervasive developmental disorder Index. décimale : PER Périodiques Résumé : Understanding the factor structure of autistic symptomatology is critical to the discovery and interpretation of causal mechanisms in autism spectrum disorder. We applied confirmatory factor analysis and assessment of measurement invariance to a large (N = 9635) accumulated collection of reports on quantitative autistic traits using the Social Responsiveness Scale, representing a broad diversity of age, severity, and reporter type. A two-factor structure (corresponding to social communication impairment and restricted, repetitive behavior) as elaborated in the updated Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-5) criteria for autism spectrum disorder exhibited acceptable model fit in confirmatory factor analysis. Measurement invariance was appreciable across age, sex, and reporter (self vs other), but somewhat less apparent between clinical and nonclinical populations in this sample comprised of both familial and sporadic autism spectrum disorders. The statistical power afforded by this large sample allowed relative differentiation of three factors among items encompassing social communication impairment (emotion recognition, social avoidance, and interpersonal relatedness) and two factors among items encompassing restricted, repetitive behavior (insistence on sameness and repetitive mannerisms). Cross-trait correlations remained extremely high, that is, on the order of 0.66–0.92. These data clarify domains of statistically significant factoral separation that may relate to partially—but not completely—overlapping biological mechanisms, contributing to variation in human social competency. Given such robust intercorrelations among symptom domains, understanding their co-emergence remains a high priority in conceptualizing common neural mechanisms underlying autistic syndromes. En ligne : http://dx.doi.org/10.1177/1362361313500382 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221 [article] Confirmatory factor analytic structure and measurement invariance of quantitative autistic traits measured by the Social Responsiveness Scale-2 [Texte imprimé et/ou numérique] / Thomas W. FRAZIER, Auteur ; Kristin R. RATLIFF, Auteur ; Chris GRUBER, Auteur ; Yi ZHANG, Auteur ; Paul A. LAW, Auteur ; John N. CONSTANTINO, Auteur . - p.31-44. Langues : Anglais (eng) in Autism > 18-1 (January 2014) . - p.31-44 Mots-clés : Asperger syndrome  autism  factor structure  pervasive developmental disorder Index. décimale : PER Périodiques Résumé : Understanding the factor structure of autistic symptomatology is critical to the discovery and interpretation of causal mechanisms in autism spectrum disorder. We applied confirmatory factor analysis and assessment of measurement invariance to a large (N = 9635) accumulated collection of reports on quantitative autistic traits using the Social Responsiveness Scale, representing a broad diversity of age, severity, and reporter type. A two-factor structure (corresponding to social communication impairment and restricted, repetitive behavior) as elaborated in the updated Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-5) criteria for autism spectrum disorder exhibited acceptable model fit in confirmatory factor analysis. Measurement invariance was appreciable across age, sex, and reporter (self vs other), but somewhat less apparent between clinical and nonclinical populations in this sample comprised of both familial and sporadic autism spectrum disorders. The statistical power afforded by this large sample allowed relative differentiation of three factors among items encompassing social communication impairment (emotion recognition, social avoidance, and interpersonal relatedness) and two factors among items encompassing restricted, repetitive behavior (insistence on sameness and repetitive mannerisms). Cross-trait correlations remained extremely high, that is, on the order of 0.66–0.92. These data clarify domains of statistically significant factoral separation that may relate to partially—but not completely—overlapping biological mechanisms, contributing to variation in human social competency. Given such robust intercorrelations among symptom domains, understanding their co-emergence remains a high priority in conceptualizing common neural mechanisms underlying autistic syndromes. En ligne : http://dx.doi.org/10.1177/1362361313500382 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221

Cytoplasm-predominant Pten associates with increased region-specific brain tyrosine hydroxylase and dopamine D2 receptors in mouse model with autistic traits / Xin HE in Molecular Autism, (November 2015)  

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Demographic and clinical correlates of autism symptom domains and autism spectrum diagnosis / Thomas W. FRAZIER in Autism, 18-5 (July 2014)  

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Development and validation of an Arabic language eye-tracking paradigm for the early screening and diagnosis of autism spectrum disorders in Qatar / Iman GHAZAL ; I. Richard THOMPSON ; Eric W. KLINGEMIER ; Mohammed ALDOSARI ; Hawraa AL-SHAMMARI ; Fatema AL-FARAJ ; Saba EL-HAG ; Mohamed TOLEFAT ; Mogahed ALI ; Bisher NASIR ; Thomas W. FRAZIER in Autism Research, 16-12 (December 2023)  

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Equivalence of symptom dimensions in females and males with autism / Thomas W. FRAZIER in Autism, 21-6 (August 2017)  

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Exploratory and Confirmatory Factor Analysis of the Autism Diagnostic Interview-Revised / Thomas W. FRAZIER in Journal of Autism and Developmental Disorders, 38-3 (March 2008)  

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Factor Structure and Psychometric Properties of the Child Social Preference Scale-3 in Children With Autism / Antonio Y. HARDAN ; Emily SPACKMAN ; Emma BAKER ; Thomas W. FRAZIER ; Mirko ULJAREVIC in Autism Research, 18-7 (July 2025)  

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Pivotal Response Treatment Parent Training for Autism: Findings from a 3-Month Follow-Up Evaluation / Grace W. GENGOUX in Journal of Autism and Developmental Disorders, 45-9 (September 2015)  

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Psychometric evaluation of the revised child and family quality of life questionnaire (CFQL-2) / Thomas W. FRAZIER in Research in Autism Spectrum Disorders, 70 (February 2020)  

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Quantitative autism symptom patterns recapitulate differential mechanisms of genetic transmission in single and multiple incidence families / Thomas W. FRAZIER in Molecular Autism, (October 2015)  

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A randomized controlled trial of Pivotal Response Treatment Group for parents of children with autism / Antonio Y. HARDAN in Journal of Child Psychology and Psychiatry, 56-8 (August 2015)  

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