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Auteur Shafali JESTE |
Documents disponibles écrits par cet auteur (3)
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Early predictors of language skills at 3?years of age vary based on diagnostic outcome: A baby siblings research consortium study / Meredith PECUKONIS in Autism Research, 15-7 (July 2022)
[article]
Titre : Early predictors of language skills at 3?years of age vary based on diagnostic outcome: A baby siblings research consortium study Type de document : Texte imprimé et/ou numérique Auteurs : Meredith PECUKONIS, Auteur ; Gregory S. YOUNG, Auteur ; Jessica BRIAN, Auteur ; Tony CHARMAN, Auteur ; Katarzyna CHAWARSKA, Auteur ; Mayada ELSABBAGH, Auteur ; Jana M. IVERSON, Auteur ; Shafali JESTE, Auteur ; Rebecca LANDA, Auteur ; Daniel S. MESSINGER, Auteur ; A. J. SCHWICHTENBERG, Auteur ; Sara Jane WEBB, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Helen TAGER-FLUSBERG, Auteur Article en page(s) : p.1324-1335 Langues : Anglais (eng) Mots-clés : gesture infant sibling language maternal education motor nonverbal cognition Index. décimale : PER Périodiques Résumé : While previous work has identified the early predictors of language skills in infants at elevated familial risk (ER) and low familial risk (LR) for autism spectrum disorder (ASD), no studies to date have explored whether these predictors vary based on diagnostic outcome of ASD or no ASD. The present study used a large, multisite dataset to examine associations between a set of commonly studied predictor variables (infant gesture abilities, fine motor skills, nonverbal cognition, and maternal education level), measured at 12?months, and language skills, measured at 3?years, across three diagnostic outcome groups-infants with ASD ("ASD"), ER infants without ASD ("ER-no ASD"), and LR infants without ASD ("LR-no ASD"). Findings revealed that the predictors of language skills differed across groups, as gesture abilities were positively associated with language skills in the ER-no ASD group but negatively associated with language skills in the ASD group. Furthermore, maternal education level was positively associated with language skills in the ASD and LR-no ASD groups only. Variability in these early predictors may help explain why language skills are heterogeneous across the autism spectrum, and, with further study, may help clinicians identify those in need of additional and/or specialized intervention services that support language development. LAY SUMMARY: The present study identified predictors of language skills in infants with and without autism spectrum disorder (ASD). Maternal education level and 12-month gesture abilities predicted 3-year language skills in infants with ASD. Measuring these predictors early in life may help identify infants and families in need of additional and/or specialized intervention services that support language development. En ligne : http://dx.doi.org/10.1002/aur.2760 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477
in Autism Research > 15-7 (July 2022) . - p.1324-1335[article] Early predictors of language skills at 3?years of age vary based on diagnostic outcome: A baby siblings research consortium study [Texte imprimé et/ou numérique] / Meredith PECUKONIS, Auteur ; Gregory S. YOUNG, Auteur ; Jessica BRIAN, Auteur ; Tony CHARMAN, Auteur ; Katarzyna CHAWARSKA, Auteur ; Mayada ELSABBAGH, Auteur ; Jana M. IVERSON, Auteur ; Shafali JESTE, Auteur ; Rebecca LANDA, Auteur ; Daniel S. MESSINGER, Auteur ; A. J. SCHWICHTENBERG, Auteur ; Sara Jane WEBB, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Helen TAGER-FLUSBERG, Auteur . - p.1324-1335.
Langues : Anglais (eng)
in Autism Research > 15-7 (July 2022) . - p.1324-1335
Mots-clés : gesture infant sibling language maternal education motor nonverbal cognition Index. décimale : PER Périodiques Résumé : While previous work has identified the early predictors of language skills in infants at elevated familial risk (ER) and low familial risk (LR) for autism spectrum disorder (ASD), no studies to date have explored whether these predictors vary based on diagnostic outcome of ASD or no ASD. The present study used a large, multisite dataset to examine associations between a set of commonly studied predictor variables (infant gesture abilities, fine motor skills, nonverbal cognition, and maternal education level), measured at 12?months, and language skills, measured at 3?years, across three diagnostic outcome groups-infants with ASD ("ASD"), ER infants without ASD ("ER-no ASD"), and LR infants without ASD ("LR-no ASD"). Findings revealed that the predictors of language skills differed across groups, as gesture abilities were positively associated with language skills in the ER-no ASD group but negatively associated with language skills in the ASD group. Furthermore, maternal education level was positively associated with language skills in the ASD and LR-no ASD groups only. Variability in these early predictors may help explain why language skills are heterogeneous across the autism spectrum, and, with further study, may help clinicians identify those in need of additional and/or specialized intervention services that support language development. LAY SUMMARY: The present study identified predictors of language skills in infants with and without autism spectrum disorder (ASD). Maternal education level and 12-month gesture abilities predicted 3-year language skills in infants with ASD. Measuring these predictors early in life may help identify infants and families in need of additional and/or specialized intervention services that support language development. En ligne : http://dx.doi.org/10.1002/aur.2760 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 Frontal EEG alpha asymmetry in youth with autism: Sex differences and social-emotional correlates / Megha SANTHOSH ; Anna KRESSE ; Elizabeth AYLWARD ; Raphael BERNIER ; Susan BOOKHEIMER ; Shafali JESTE ; Allison JACK ; James C. MCPARTLAND ; Adam NAPLES ; John D. VAN HORN ; Kevin PELPHREY ; Sara Jane WEBB ; ACE GENDAAR NETWORK in Autism Research, 16-12 (December 2023)
[article]
Titre : Frontal EEG alpha asymmetry in youth with autism: Sex differences and social-emotional correlates Type de document : Texte imprimé et/ou numérique Auteurs : Megha SANTHOSH, Auteur ; Anna KRESSE, Auteur ; Elizabeth AYLWARD, Auteur ; Raphael BERNIER, Auteur ; Susan BOOKHEIMER, Auteur ; Shafali JESTE, Auteur ; Allison JACK, Auteur ; James C. MCPARTLAND, Auteur ; Adam NAPLES, Auteur ; John D. VAN HORN, Auteur ; Kevin PELPHREY, Auteur ; Sara Jane WEBB, Auteur ; ACE GENDAAR NETWORK, Auteur Article en page(s) : p.2364-2377 Index. décimale : PER Périodiques Résumé : Abstract In youth broadly, EEG frontal alpha asymmetry (FAA) associates with affective style and vulnerability to psychopathology, with relatively stronger right activity predicting risk for internalizing and externalizing behaviors. In autistic youth, FAA has been related to ASD diagnostic features and to internalizing symptoms. Among our large, rigorously characterized, sex-balanced participant group, we attempted to replicate findings suggestive of altered FAA in youth with an ASD diagnosis, examining group differences and impact of sex assigned at birth. Second, we examined relations between FAA and behavioral variables (ASD features, internalizing, and externalizing) within autistic youth, examining effects by sex. Third, we explored whether the relation between FAA, autism features, and mental health was informed by maternal depression history. In our sample, FAA did not differ by diagnosis, age, or sex. However, youth with ASD had lower total frontal alpha power than youth without ASD. For autistic females, FAA and bilateral frontal alpha power correlated with social communication features, but not with internalizing or externalizing symptoms. For autistic males, EEG markers correlated with social communication features, and with externalizing behaviors. Exploratory analyses by sex revealed further associations between youth FAA, behavioral indices, and maternal depression history. In summary, findings suggest that individual differences in FAA may correspond to social-emotional and mental health behaviors, with different patterns of association for females and males with ASD. Longitudinal consideration of individual differences across levels of analysis (e.g., biomarkers, family factors, and environmental influences) will be essential to parsing out models of risk and resilience among autistic youth. En ligne : https://doi.org/10.1002/aur.3032 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518
in Autism Research > 16-12 (December 2023) . - p.2364-2377[article] Frontal EEG alpha asymmetry in youth with autism: Sex differences and social-emotional correlates [Texte imprimé et/ou numérique] / Megha SANTHOSH, Auteur ; Anna KRESSE, Auteur ; Elizabeth AYLWARD, Auteur ; Raphael BERNIER, Auteur ; Susan BOOKHEIMER, Auteur ; Shafali JESTE, Auteur ; Allison JACK, Auteur ; James C. MCPARTLAND, Auteur ; Adam NAPLES, Auteur ; John D. VAN HORN, Auteur ; Kevin PELPHREY, Auteur ; Sara Jane WEBB, Auteur ; ACE GENDAAR NETWORK, Auteur . - p.2364-2377.
in Autism Research > 16-12 (December 2023) . - p.2364-2377
Index. décimale : PER Périodiques Résumé : Abstract In youth broadly, EEG frontal alpha asymmetry (FAA) associates with affective style and vulnerability to psychopathology, with relatively stronger right activity predicting risk for internalizing and externalizing behaviors. In autistic youth, FAA has been related to ASD diagnostic features and to internalizing symptoms. Among our large, rigorously characterized, sex-balanced participant group, we attempted to replicate findings suggestive of altered FAA in youth with an ASD diagnosis, examining group differences and impact of sex assigned at birth. Second, we examined relations between FAA and behavioral variables (ASD features, internalizing, and externalizing) within autistic youth, examining effects by sex. Third, we explored whether the relation between FAA, autism features, and mental health was informed by maternal depression history. In our sample, FAA did not differ by diagnosis, age, or sex. However, youth with ASD had lower total frontal alpha power than youth without ASD. For autistic females, FAA and bilateral frontal alpha power correlated with social communication features, but not with internalizing or externalizing symptoms. For autistic males, EEG markers correlated with social communication features, and with externalizing behaviors. Exploratory analyses by sex revealed further associations between youth FAA, behavioral indices, and maternal depression history. In summary, findings suggest that individual differences in FAA may correspond to social-emotional and mental health behaviors, with different patterns of association for females and males with ASD. Longitudinal consideration of individual differences across levels of analysis (e.g., biomarkers, family factors, and environmental influences) will be essential to parsing out models of risk and resilience among autistic youth. En ligne : https://doi.org/10.1002/aur.3032 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518 Patterns of intervention utilization among school-aged children on the autism spectrum: Findings from a multi-site research consortium / Aksheya SRIDHAR in Research in Autism Spectrum Disorders, 94 (June 2022)
[article]
Titre : Patterns of intervention utilization among school-aged children on the autism spectrum: Findings from a multi-site research consortium Type de document : Texte imprimé et/ou numérique Auteurs : Aksheya SRIDHAR, Auteur ; Jocelyn KUHN, Auteur ; Susan FAJA, Auteur ; Maura SABATOS-DEVITO, Auteur ; Julia I. NIKOLAEVA, Auteur ; Geraldine DAWSON, Auteur ; Charles A. NELSON, Auteur ; Sara J. WEBB, Auteur ; Raphael BERNIER, Auteur ; Shafali JESTE, Auteur ; Katarzyna CHAWARSKA, Auteur ; Catherine A. SUGAR, Auteur ; Frederick SHIC, Auteur ; Adam NAPLES, Auteur ; James DZIURA, Auteur ; James C. MCPARTLAND, Auteur ; THE A. B. C. C. T. CONSORTIUM, Auteur Article en page(s) : 101950 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Child characteristics Family characteristics Geographical location Intervention use Index. décimale : PER Périodiques Résumé : When designing and interpreting results from clinical trials evaluating treatments for children on the autism spectrum, a complicating factor is that most children receive a range of concurrent treatments. Thus, it is important to better understand the types and hours of interventions that participants typically receive as part of standard of care, as well as to understand the child, family, and geographic factors that are associated with different patterns of service utilization. In this multi-site study, we interviewed 280 caregivers of 6-to-11-year-old school-aged children on the autism spectrum about the types and amounts of interventions their children received in the prior 6 weeks. Reported interventions were coded as ?evidence-based practice? or ?other interventions,? reflecting the level of empirical support. Results indicated that children received a variety of interventions with varying levels of empirical evidence and a wide range of hours (0?79.3 h/week). Children with higher autism symptom levels, living in particular states, and who identified as non-Hispanic received more evidence-based intervention hours. Higher parental education level related to more hours of other interventions. Children who were younger, had lower cognitive ability, and with higher autism symptom levels received a greater variety of interventions overall. Thus, based on our findings, it would seem prudent when designing clinical trials to take into consideration a variety of factors including autism symptom levels, age, cognitive ability, ethnicity, parent education and geographic location. Future research should continue to investigate the ethnic, racial, and socioeconomic influences on school-aged intervention services. En ligne : https://doi.org/10.1016/j.rasd.2022.101950 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476
in Research in Autism Spectrum Disorders > 94 (June 2022) . - 101950[article] Patterns of intervention utilization among school-aged children on the autism spectrum: Findings from a multi-site research consortium [Texte imprimé et/ou numérique] / Aksheya SRIDHAR, Auteur ; Jocelyn KUHN, Auteur ; Susan FAJA, Auteur ; Maura SABATOS-DEVITO, Auteur ; Julia I. NIKOLAEVA, Auteur ; Geraldine DAWSON, Auteur ; Charles A. NELSON, Auteur ; Sara J. WEBB, Auteur ; Raphael BERNIER, Auteur ; Shafali JESTE, Auteur ; Katarzyna CHAWARSKA, Auteur ; Catherine A. SUGAR, Auteur ; Frederick SHIC, Auteur ; Adam NAPLES, Auteur ; James DZIURA, Auteur ; James C. MCPARTLAND, Auteur ; THE A. B. C. C. T. CONSORTIUM, Auteur . - 101950.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 94 (June 2022) . - 101950
Mots-clés : Autism spectrum disorder Child characteristics Family characteristics Geographical location Intervention use Index. décimale : PER Périodiques Résumé : When designing and interpreting results from clinical trials evaluating treatments for children on the autism spectrum, a complicating factor is that most children receive a range of concurrent treatments. Thus, it is important to better understand the types and hours of interventions that participants typically receive as part of standard of care, as well as to understand the child, family, and geographic factors that are associated with different patterns of service utilization. In this multi-site study, we interviewed 280 caregivers of 6-to-11-year-old school-aged children on the autism spectrum about the types and amounts of interventions their children received in the prior 6 weeks. Reported interventions were coded as ?evidence-based practice? or ?other interventions,? reflecting the level of empirical support. Results indicated that children received a variety of interventions with varying levels of empirical evidence and a wide range of hours (0?79.3 h/week). Children with higher autism symptom levels, living in particular states, and who identified as non-Hispanic received more evidence-based intervention hours. Higher parental education level related to more hours of other interventions. Children who were younger, had lower cognitive ability, and with higher autism symptom levels received a greater variety of interventions overall. Thus, based on our findings, it would seem prudent when designing clinical trials to take into consideration a variety of factors including autism symptom levels, age, cognitive ability, ethnicity, parent education and geographic location. Future research should continue to investigate the ethnic, racial, and socioeconomic influences on school-aged intervention services. En ligne : https://doi.org/10.1016/j.rasd.2022.101950 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476