Autism spectrum disorder detection using variable frequency complex demodulation of the electroretinogram / Sultan Mohammad MANJUR ; Md Billal HOSSAIN ; Fernando MARMOLEJO-RAMOS ; Irene O. LEE ; David H. SKUSE ; Dorothy A. THOMPSON ; Paul A. CONSTABLE in Research in Autism Spectrum Disorders, 109 (November 2023)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 109 (November 2023) . - 102258 Titre : Autism spectrum disorder detection using variable frequency complex demodulation of the electroretinogram Type de document : Texte imprimé et/ou numérique Auteurs : Sultan Mohammad MANJUR, Auteur ; Md Billal HOSSAIN, Auteur ; Fernando MARMOLEJO-RAMOS, Auteur ; Irene O. LEE, Auteur ; David H. SKUSE, Auteur ; Dorothy A. THOMPSON, Auteur ; Paul A. CONSTABLE, Auteur Article en page(s) : 102258 Langues : Anglais (eng) Mots-clés : Electroretinogram  Signal analysis  Autism spectrum disorder  Machine learning Index. décimale : PER Périodiques Résumé : The early diagnosis of neurodevelopmental conditions such as autism spectrum disorder (ASD), is an unmet need. One difficulty is the identification of a biological signal that relates to the ASD phenotype. The electroretinogram (ERG) waveform has been identified as a possible signal that could categorize neurological conditions such as ASD. The ERG waveform is derived from the electrical activity of photoreceptors and retinal neurons in response to a brief flash of light and provides an indirect 'window' into the central nervous system. Traditionally, the waveform is analyzed in the time-domain, but more recently time-frequency spectrum (TFS) analysis of ERG has been successfully carried out using discrete wavelet transformation (DWT) to characterize the morphological features of the signal. In this study, we propose the use of a high resolution TFS technique, namely variable frequency complex demodulation (VFCDM), to decompose the ERG waveform based on two signal flash strengths to build machine learning (ML) models to categorize ASD. ERG waveforms from N = 217 subjects (71 ASD, 146 control), at two different flash strengths, 446 and 113 Troland seconds (Td.s), from both right and left eyes were included. We analyzed the raw ERG waveforms using DWT and VFCDM. We computed features from the TFSs and trained ML models such as Random Forest, Gradient Boosting, Support Vector Machine to classify ASD from controls. ML models were validated using a subject independent validation strategy, and we found that the ML models with VFCDM features outperformed models using the DWT, achieving an area under the receiver operating characteristics curve of 0.90 (accuracy = 0.81, sensitivity = 0.85, specificity = 0.78). We found that the higher frequency range (80-300 Hz) included more relevant information for classifying ASD compared to the lower frequencies. We also found that the stronger flash strength of 446 Td.s in the right eye provided the best classification result which supports VFCDM analysis of the ERG waveform as a potential tool to aid in the identification of the ASD phenotype. En ligne : https://doi.org/10.1016/j.rasd.2023.102258 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517 [article] Autism spectrum disorder detection using variable frequency complex demodulation of the electroretinogram [Texte imprimé et/ou numérique] / Sultan Mohammad MANJUR, Auteur ; Md Billal HOSSAIN, Auteur ; Fernando MARMOLEJO-RAMOS, Auteur ; Irene O. LEE, Auteur ; David H. SKUSE, Auteur ; Dorothy A. THOMPSON, Auteur ; Paul A. CONSTABLE, Auteur . - 102258. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 109 (November 2023) . - 102258 Mots-clés : Electroretinogram  Signal analysis  Autism spectrum disorder  Machine learning Index. décimale : PER Périodiques Résumé : The early diagnosis of neurodevelopmental conditions such as autism spectrum disorder (ASD), is an unmet need. One difficulty is the identification of a biological signal that relates to the ASD phenotype. The electroretinogram (ERG) waveform has been identified as a possible signal that could categorize neurological conditions such as ASD. The ERG waveform is derived from the electrical activity of photoreceptors and retinal neurons in response to a brief flash of light and provides an indirect 'window' into the central nervous system. Traditionally, the waveform is analyzed in the time-domain, but more recently time-frequency spectrum (TFS) analysis of ERG has been successfully carried out using discrete wavelet transformation (DWT) to characterize the morphological features of the signal. In this study, we propose the use of a high resolution TFS technique, namely variable frequency complex demodulation (VFCDM), to decompose the ERG waveform based on two signal flash strengths to build machine learning (ML) models to categorize ASD. ERG waveforms from N = 217 subjects (71 ASD, 146 control), at two different flash strengths, 446 and 113 Troland seconds (Td.s), from both right and left eyes were included. We analyzed the raw ERG waveforms using DWT and VFCDM. We computed features from the TFSs and trained ML models such as Random Forest, Gradient Boosting, Support Vector Machine to classify ASD from controls. ML models were validated using a subject independent validation strategy, and we found that the ML models with VFCDM features outperformed models using the DWT, achieving an area under the receiver operating characteristics curve of 0.90 (accuracy = 0.81, sensitivity = 0.85, specificity = 0.78). We found that the higher frequency range (80-300 Hz) included more relevant information for classifying ASD compared to the lower frequencies. We also found that the stronger flash strength of 446 Td.s in the right eye provided the best classification result which supports VFCDM analysis of the ERG waveform as a potential tool to aid in the identification of the ASD phenotype. En ligne : https://doi.org/10.1016/j.rasd.2023.102258 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517

Behavioural Neuroscience and Child Psychopathology: Insights from Model Systems / David H. SKUSE in Journal of Child Psychology and Psychiatry, 41-1 (January 2000)

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 41-1 (January 2000) . - p.3-31 Titre : Behavioural Neuroscience and Child Psychopathology: Insights from Model Systems Type de document : Texte imprimé et/ou numérique Auteurs : David H. SKUSE, Auteur Année de publication : 2000 Article en page(s) : p.3-31 Langues : Anglais (eng) Mots-clés : Behavioural neuroscience  neurogenetics  model systems  Drosophila melanogaster  Caenorhabditis elegans  laboratory mouse Index. décimale : PER Périodiques Résumé : We have just emerged from “the Decade of the Brain”, yet in so many ways it was the “Decade of the Genome”. What relevance does the remarkable advance in knowledge in genetics and neuroscience over that period have to our understanding of child psychopathology? When the complexity of the genetic systems involved in behavioural regulation of relatively simple organisms such as the nematode worm Caenorhabditis elegans or the fruitfly Drosophila melanogaster is considered, the possibility of comprehending the links from genes to behaviour in the developing child seems remote. Yet, the principles of investigation in model systems are not so different to those that should apply in humans. This review draws out the parallels, and introduces recent findings from behavioural studies of C. elegans, D. melanogaster, and the laboratory mouse, as well as humans, to illustrate the point. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=125 [article] Behavioural Neuroscience and Child Psychopathology: Insights from Model Systems [Texte imprimé et/ou numérique] / David H. SKUSE, Auteur . - 2000 . - p.3-31. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 41-1 (January 2000) . - p.3-31 Mots-clés : Behavioural neuroscience  neurogenetics  model systems  Drosophila melanogaster  Caenorhabditis elegans  laboratory mouse Index. décimale : PER Périodiques Résumé : We have just emerged from “the Decade of the Brain”, yet in so many ways it was the “Decade of the Genome”. What relevance does the remarkable advance in knowledge in genetics and neuroscience over that period have to our understanding of child psychopathology? When the complexity of the genetic systems involved in behavioural regulation of relatively simple organisms such as the nematode worm Caenorhabditis elegans or the fruitfly Drosophila melanogaster is considered, the possibility of comprehending the links from genes to behaviour in the developing child seems remote. Yet, the principles of investigation in model systems are not so different to those that should apply in humans. This review draws out the parallels, and introduces recent findings from behavioural studies of C. elegans, D. melanogaster, and the laboratory mouse, as well as humans, to illustrate the point. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=125

Brief Report: Perception of Genuine and Posed Smiles by Individuals with Autism / Zillah L. BORASTON in Journal of Autism and Developmental Disorders, 38-3 (March 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-3 (March 2008) . - p.574-580 Titre : Brief Report: Perception of Genuine and Posed Smiles by Individuals with Autism Type de document : Texte imprimé et/ou numérique Auteurs : Zillah L. BORASTON, Auteur ; Sarah-Jayne BLAKEMORE, Auteur ; Ben CORDEN, Auteur ; Lynden K. MILES, Auteur ; David H. SKUSE, Auteur Année de publication : 2008 Article en page(s) : p.574-580 Langues : Anglais (eng) Mots-clés : Asperger-syndrome Social-cognition Face-processing Smile Eye-tracking Index. décimale : PER Périodiques Résumé : Individuals with autism are impaired in the recognition of fear, which may be due to their reduced tendency to look at the eyes. Here we investigated another potential perceptual and social consequence of reduced eye fixation. The eye region of the face is critical for identifying genuine, or sincere, smiles. We therefore investigated this ability in adults with autism. We used eye-tracking to measure gaze behaviour to faces displaying posed and genuine smiles. Adults with autism were impaired on the posed/genuine smile task and looked at the eyes significantly less than did controls. Also, within the autism group, task performance correlated with social interaction ability. We conclude that reduced eye contact in autism leads to reduced ability to discriminate genuine from posed smiles with downstream effects on social interaction. En ligne : http://dx.doi.org/10.1007/s10803-007-0421-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=336 [article] Brief Report: Perception of Genuine and Posed Smiles by Individuals with Autism [Texte imprimé et/ou numérique] / Zillah L. BORASTON, Auteur ; Sarah-Jayne BLAKEMORE, Auteur ; Ben CORDEN, Auteur ; Lynden K. MILES, Auteur ; David H. SKUSE, Auteur . - 2008 . - p.574-580. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-3 (March 2008) . - p.574-580 Mots-clés : Asperger-syndrome Social-cognition Face-processing Smile Eye-tracking Index. décimale : PER Périodiques Résumé : Individuals with autism are impaired in the recognition of fear, which may be due to their reduced tendency to look at the eyes. Here we investigated another potential perceptual and social consequence of reduced eye fixation. The eye region of the face is critical for identifying genuine, or sincere, smiles. We therefore investigated this ability in adults with autism. We used eye-tracking to measure gaze behaviour to faces displaying posed and genuine smiles. Adults with autism were impaired on the posed/genuine smile task and looked at the eyes significantly less than did controls. Also, within the autism group, task performance correlated with social interaction ability. We conclude that reduced eye contact in autism leads to reduced ability to discriminate genuine from posed smiles with downstream effects on social interaction. En ligne : http://dx.doi.org/10.1007/s10803-007-0421-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=336

Can autistic children read the mind of an animated triangle? / Gemma SALTER in Autism, 12-4 (July 2008)  

Public ISBD [article]  inAutism > 12-4 (July 2008) . - p.349-371 Titre : Can autistic children read the mind of an animated triangle? Type de document : Texte imprimé et/ou numérique Auteurs : Gemma SALTER, Auteur ; David H. SKUSE, Auteur ; Anna SEIGAL, Auteur ; Melanie CLAXTON, Auteur ; Kate LAWRENCE, Auteur Année de publication : 2008 Article en page(s) : p.349-371 Langues : Anglais (eng) Mots-clés : animations Asperger-syndrome autism mentalizing theory-of-mind Index. décimale : PER Périodiques Résumé : Are children with an autism spectrum disorder (ASD), but normal-range intelligence, impaired on theory of mind skills measured by responses to abstract animations in the form of a computerized cartoon? Fifty-six cases and closely matched comparisons were tested. We rated verbal responses according to the length of their descriptions, their appropriateness and the children's use of `mentalizing' terms. Children with ASD used `mentalizing' language to describe the animations as well as comparisons, although the content of their descriptions was significantly less appropriate. Performance on this task was not well correlated with standardized measures of parent-reported behaviour or the child's interactions with an observer. The implications of our results are discussed in relation to previous studies that have used this methodology. En ligne : http://dx.doi.org/10.1177/1362361308091654 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 [article] Can autistic children read the mind of an animated triangle? [Texte imprimé et/ou numérique] / Gemma SALTER, Auteur ; David H. SKUSE, Auteur ; Anna SEIGAL, Auteur ; Melanie CLAXTON, Auteur ; Kate LAWRENCE, Auteur . - 2008 . - p.349-371. Langues : Anglais (eng) in Autism > 12-4 (July 2008) . - p.349-371 Mots-clés : animations Asperger-syndrome autism mentalizing theory-of-mind Index. décimale : PER Périodiques Résumé : Are children with an autism spectrum disorder (ASD), but normal-range intelligence, impaired on theory of mind skills measured by responses to abstract animations in the form of a computerized cartoon? Fifty-six cases and closely matched comparisons were tested. We rated verbal responses according to the length of their descriptions, their appropriateness and the children's use of `mentalizing' terms. Children with ASD used `mentalizing' language to describe the animations as well as comparisons, although the content of their descriptions was significantly less appropriate. Performance on this task was not well correlated with standardized measures of parent-reported behaviour or the child's interactions with an observer. The implications of our results are discussed in relation to previous studies that have used this methodology. En ligne : http://dx.doi.org/10.1177/1362361308091654 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535

A Case-comparison Study of the Characteristics of Children with a Short Stature Syndrome Induced by Stress (Hyperphagic Short Stature) and a Consecutive Series of Unaffected “Stressed” Children / Jane GILMOUR in Journal of Child Psychology and Psychiatry, 40-6 (September 1999)

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 40-6 (September 1999) . - p.969-978 Titre : A Case-comparison Study of the Characteristics of Children with a Short Stature Syndrome Induced by Stress (Hyperphagic Short Stature) and a Consecutive Series of Unaffected “Stressed” Children Type de document : Texte imprimé et/ou numérique Auteurs : Jane GILMOUR, Auteur ; David H. SKUSE, Auteur Année de publication : 1999 Article en page(s) : p.969-978 Langues : Anglais (eng) Mots-clés : Behaviour problems  distress  eating behaviour  endocrinology  growth retardation Index. décimale : PER Périodiques Résumé : Recently a type of growth failure (Hyperphagic Short Stature) has been described, in which there is potentially reversible severe impairment of growth hormone secretion, in association with excessively high levels of psychosocial stress. This condition is a variant of the disorder formerly known as Psychosocial Dwarfism. In the present study we compared children with Hyperphagic Short Stature (N= 25, aged 9.04 years±3.78, 72% male) and a closely matched sample with normal height, drawn from comparably stressful family circumstances (N= 25, aged 10.61±3.04, 60% male). Measures of the psychosocial environment, anthropometry, and developmental history from infancy were obtained. Many symptoms thought previously to be characteristics of psychosocial dwarfism were found to be nonspecific stress responses. Hypotonia (p < .05), enuresis/encopresis (p < .01), and sleep cycle disruption (p < .05) did differentiate the groups. Growth, appetite, and sleep are all influenced by hypothalamic nuclei, suggesting hypothalamic pathology could account for most of the clinical features of Hyperphagic Short Stature. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=124 [article] A Case-comparison Study of the Characteristics of Children with a Short Stature Syndrome Induced by Stress (Hyperphagic Short Stature) and a Consecutive Series of Unaffected “Stressed” Children [Texte imprimé et/ou numérique] / Jane GILMOUR, Auteur ; David H. SKUSE, Auteur . - 1999 . - p.969-978. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 40-6 (September 1999) . - p.969-978 Mots-clés : Behaviour problems  distress  eating behaviour  endocrinology  growth retardation Index. décimale : PER Périodiques Résumé : Recently a type of growth failure (Hyperphagic Short Stature) has been described, in which there is potentially reversible severe impairment of growth hormone secretion, in association with excessively high levels of psychosocial stress. This condition is a variant of the disorder formerly known as Psychosocial Dwarfism. In the present study we compared children with Hyperphagic Short Stature (N= 25, aged 9.04 years±3.78, 72% male) and a closely matched sample with normal height, drawn from comparably stressful family circumstances (N= 25, aged 10.61±3.04, 60% male). Measures of the psychosocial environment, anthropometry, and developmental history from infancy were obtained. Many symptoms thought previously to be characteristics of psychosocial dwarfism were found to be nonspecific stress responses. Hypotonia (p < .05), enuresis/encopresis (p < .01), and sleep cycle disruption (p < .05) did differentiate the groups. Growth, appetite, and sleep are all influenced by hypothalamic nuclei, suggesting hypothalamic pathology could account for most of the clinical features of Hyperphagic Short Stature. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=124

Characteristics and Management of Feeding Problems of Young Children with Cerebral Palsy / Sheena REILLY in Developmental Medicine & Child Neurology, 34-5 (May 1992)

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Detecting Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder Using Multimodal Time-Frequency Analysis with Machine Learning Using the Electroretinogram from Two Flash Strengths / Sultan Mohammad MANJUR in Journal of Autism and Developmental Disorders, 55-4 (April 2024)  

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Editorial / David H. SKUSE in Journal of Child Psychology and Psychiatry, 39-6 (September 1998)

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Editorial / David H. SKUSE in Journal of Child Psychology and Psychiatry, 40-2 (February 1999)

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Editorial / David H. SKUSE in Journal of Child Psychology and Psychiatry, 40-5 (July 1999)

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Editorial / David H. SKUSE in Journal of Child Psychology and Psychiatry, 40-8 (November 1999)

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Emotional Modulation of Perception in Asperger’s Syndrome / Ben CORDEN in Journal of Autism and Developmental Disorders, 38-6 (July 2008)  

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Oral-motor Dysfunction and Failure to Thrive Among Inner-city Infants / Berenice MATHISEN in Developmental Medicine & Child Neurology, 31-3 (June 1989)

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Oral-Motor Dysfunction and Feeding Disorders of Infants with Turner Syndrome / Berenice MATHISEN in Developmental Medicine & Child Neurology, 34-2 (February 1992)

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Recognition of Face and Non-Face Stimuli in Autistic Spectrum Disorder / Leo ARKUSH in Autism Research, 6-6 (December 2013)  

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