Arousal-modulated memory encoding and retrieval in adults with autism spectrum disorder / Nico BAST in Autism Research, 15-9 (September 2022)  

Public ISBD [article]  inAutism Research > 15-9 (September 2022) . - p.1609-1620 Titre : Arousal-modulated memory encoding and retrieval in adults with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Nico BAST, Auteur ; Sebastian B. GAIGG, Auteur ; Dermot M. BOWLER, Auteur ; Veit ROESSNER, Auteur ; Christine M. FREITAG, Auteur ; Melanie RING, Auteur Article en page(s) : p.1609-1620 Langues : Anglais (eng) Mots-clés : Adult  Arousal/physiology  Autism Spectrum Disorder/complications  Humans  Locus Coeruleus  Pupil/physiology  Recognition, Psychology  Asd  locus coeruleus-norepinephrine system  memory  pupillometry Index. décimale : PER Périodiques Résumé : Recently, we have shown that pupil dilation during a recognition memory task can serve as an index of memory retrieval difficulties in autism. At the time of publication, we were unaware of specific data-analysis methods that can be used to shed further light on the origins of such memory related pupil dilation. Specifically, by distinguishing "tonic" from "phasic" changes in pupil dilation and considering their temporal progression, it is possible to draw inferences about the functional integrity of a locus coeruleus-norepinephrine system (LC-NE) that is known to play a key role in regulating memory encoding and retrieval processes. We therefore apply these analyses to our previously published eye-tracking data of adults with ASD (N = 24) and neurotypical development (TD, N = 30) during the recognition memory task. In this re-analysis, we related pupil dilation during encoding and retrieval to recognition accuracy in a per-trial analysis of linear mixed models. In ASD, we replicated attenuated recognition accuracy, which was accompanied by attenuated pupil dilation during encoding and retrieval. Group differences in pupil dilation during retrieval occurred late during the trial (after 1.75s) and indicated an altered top-down processing like attenuated attribution of semantic salience in response to previously encoded stimuli. In addition, only in the ASD group were higher pupil dilation during encoding and lower pupil dilation during retrieval associated with decreased recognition accuracy. This supports altered modulation of memory encoding and retrieval in ASD, with LC-NE phasic activity as promising underlying mechanism. LAY SUMMARY: We investigated the changes of pupil size during memory testing in autism spectrum disorder. Adults with ASD remembered fewer items correctly than neurotypical individuals (TD). This reduced memory was related to increased pupillary responses at study and decreased pupil dilation at test only for adults with ASD indicating a different modulation of memory by the locus coeruleus. En ligne : http://dx.doi.org/10.1002/aur.2784 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483 [article] Arousal-modulated memory encoding and retrieval in adults with autism spectrum disorder [Texte imprimé et/ou numérique] / Nico BAST, Auteur ; Sebastian B. GAIGG, Auteur ; Dermot M. BOWLER, Auteur ; Veit ROESSNER, Auteur ; Christine M. FREITAG, Auteur ; Melanie RING, Auteur . - p.1609-1620. Langues : Anglais (eng) in Autism Research > 15-9 (September 2022) . - p.1609-1620 Mots-clés : Adult  Arousal/physiology  Autism Spectrum Disorder/complications  Humans  Locus Coeruleus  Pupil/physiology  Recognition, Psychology  Asd  locus coeruleus-norepinephrine system  memory  pupillometry Index. décimale : PER Périodiques Résumé : Recently, we have shown that pupil dilation during a recognition memory task can serve as an index of memory retrieval difficulties in autism. At the time of publication, we were unaware of specific data-analysis methods that can be used to shed further light on the origins of such memory related pupil dilation. Specifically, by distinguishing "tonic" from "phasic" changes in pupil dilation and considering their temporal progression, it is possible to draw inferences about the functional integrity of a locus coeruleus-norepinephrine system (LC-NE) that is known to play a key role in regulating memory encoding and retrieval processes. We therefore apply these analyses to our previously published eye-tracking data of adults with ASD (N = 24) and neurotypical development (TD, N = 30) during the recognition memory task. In this re-analysis, we related pupil dilation during encoding and retrieval to recognition accuracy in a per-trial analysis of linear mixed models. In ASD, we replicated attenuated recognition accuracy, which was accompanied by attenuated pupil dilation during encoding and retrieval. Group differences in pupil dilation during retrieval occurred late during the trial (after 1.75s) and indicated an altered top-down processing like attenuated attribution of semantic salience in response to previously encoded stimuli. In addition, only in the ASD group were higher pupil dilation during encoding and lower pupil dilation during retrieval associated with decreased recognition accuracy. This supports altered modulation of memory encoding and retrieval in ASD, with LC-NE phasic activity as promising underlying mechanism. LAY SUMMARY: We investigated the changes of pupil size during memory testing in autism spectrum disorder. Adults with ASD remembered fewer items correctly than neurotypical individuals (TD). This reduced memory was related to increased pupillary responses at study and decreased pupil dilation at test only for adults with ASD indicating a different modulation of memory by the locus coeruleus. En ligne : http://dx.doi.org/10.1002/aur.2784 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483

Disentangling the perceptual underpinnings of autism: Evidence from a face aftereffects experiment / Julius Hennig ; Arne Doose ; Clara Marie Breier ; Alexander Soutschek ; Nicole Beyer ; Stefan Schweinberger ; Ingeborg Kamp-Becker ; Luise POUSTKA ; Katja Albertowski ; Veit ROESSNER ; Stefan EHRLICH in Autism Research, 18-2 (February 2025)  

Public ISBD [article]  inAutism Research > 18-2 (February 2025) . - p.349-361 Titre : Disentangling the perceptual underpinnings of autism: Evidence from a face aftereffects experiment : Autism Research Type de document : Texte imprimé et/ou numérique Auteurs : Julius Hennig, Auteur ; Arne Doose, Auteur ; Clara Marie Breier, Auteur ; Alexander Soutschek, Auteur ; Nicole Beyer, Auteur ; Stefan Schweinberger, Auteur ; Ingeborg Kamp-Becker, Auteur ; Luise POUSTKA, Auteur ; Katja Albertowski, Auteur ; Veit ROESSNER, Auteur ; Stefan EHRLICH, Auteur Article en page(s) : p.349-361 Langues : Anglais (eng) Mots-clés : autism face aftereffects gender processing hierarchical drift diffusion modeling perceptual processing Index. décimale : PER Périodiques Résumé : Abstract Existing literature has documented diminished norm-based adaptation (aftereffects) across several perceptual domains in autism. However, the exact underlying mechanisms, such as sensory dominance possibly caused by imprecise priors and/or increased sensory precision, remain elusive. The ?Bayesian brain? framework offers refined methods to investigate these mechanisms. This study utilized both model-free (frequentist statistics) and model-based (hierarchical Drift Diffusion Modeling) analytical approaches to compare gender face aftereffects in male adolescents with autism (n?=?29) to neurotypical controls (n?=?39) using a behavioral choice experiment. Contrary to our initial hypotheses, our analyses did not find support for imprecise priors or increased sensory precision within the autistic group. Instead, we observed generally decreased drift rates towards male but not female stimuli in the autistic group. Thus, our findings suggest a lack of own-gender bias in face processing among the autistic participants. These findings align with more recent behavioral and neurophysiological research observing intact priors in individuals with autism, suggesting that other mechanisms may better explain the perceptual challenges in autism. Our study contributes to the ongoing discourse on perceptual processing in autism, emphasizing the necessity for more nuanced analytical approaches in order to unravel the complexity of this condition. En ligne : https://doi.org/10.1002/aur.3283 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] Disentangling the perceptual underpinnings of autism: Evidence from a face aftereffects experiment : Autism Research [Texte imprimé et/ou numérique] / Julius Hennig, Auteur ; Arne Doose, Auteur ; Clara Marie Breier, Auteur ; Alexander Soutschek, Auteur ; Nicole Beyer, Auteur ; Stefan Schweinberger, Auteur ; Ingeborg Kamp-Becker, Auteur ; Luise POUSTKA, Auteur ; Katja Albertowski, Auteur ; Veit ROESSNER, Auteur ; Stefan EHRLICH, Auteur . - p.349-361. Langues : Anglais (eng) in Autism Research > 18-2 (February 2025) . - p.349-361 Mots-clés : autism face aftereffects gender processing hierarchical drift diffusion modeling perceptual processing Index. décimale : PER Périodiques Résumé : Abstract Existing literature has documented diminished norm-based adaptation (aftereffects) across several perceptual domains in autism. However, the exact underlying mechanisms, such as sensory dominance possibly caused by imprecise priors and/or increased sensory precision, remain elusive. The ?Bayesian brain? framework offers refined methods to investigate these mechanisms. This study utilized both model-free (frequentist statistics) and model-based (hierarchical Drift Diffusion Modeling) analytical approaches to compare gender face aftereffects in male adolescents with autism (n?=?29) to neurotypical controls (n?=?39) using a behavioral choice experiment. Contrary to our initial hypotheses, our analyses did not find support for imprecise priors or increased sensory precision within the autistic group. Instead, we observed generally decreased drift rates towards male but not female stimuli in the autistic group. Thus, our findings suggest a lack of own-gender bias in face processing among the autistic participants. These findings align with more recent behavioral and neurophysiological research observing intact priors in individuals with autism, suggesting that other mechanisms may better explain the perceptual challenges in autism. Our study contributes to the ongoing discourse on perceptual processing in autism, emphasizing the necessity for more nuanced analytical approaches in order to unravel the complexity of this condition. En ligne : https://doi.org/10.1002/aur.3283 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547

Dynamic functional connectivity in anorexia nervosa: alterations in states of low connectivity and state transitions / Eva MENNIGEN ; Daniel GEISLER ; Nico W. POLLER ; Katrin GRAMATKE ; Vince D. CALHOUN ; Veit ROESSNER ; Joseph A. KING ; Stefan EHRLICH in Journal of Child Psychology and Psychiatry, 65-10 (October 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-10 (October 2024) . - p.1299-1310 Titre : Dynamic functional connectivity in anorexia nervosa: alterations in states of low connectivity and state transitions Type de document : Texte imprimé et/ou numérique Auteurs : Eva MENNIGEN, Auteur ; Daniel GEISLER, Auteur ; Nico W. POLLER, Auteur ; Katrin GRAMATKE, Auteur ; Vince D. CALHOUN, Auteur ; Veit ROESSNER, Auteur ; Joseph A. KING, Auteur ; Stefan EHRLICH, Auteur Article en page(s) : p.1299-1310 Langues : Anglais (eng) Mots-clés : Eating disorder  anorexia nervosa  dynamic functional connectivity  resting state Index. décimale : PER Périodiques Résumé : Background The onset of anorexia nervosa (AN) frequently occurs during adolescence and is associated with preoccupation with body weight and shape and extreme underweight. Altered resting state functional connectivity in the brain has been described in individuals with AN, but only from a static perspective. The current study investigated the temporal dynamics of functional connectivity in adolescents with AN and how it relates to clinical features. Method 99 female patients acutely ill with AN and 99 pairwise age-matched female healthy control (HC) participants were included in the study. Using resting-state functional MRI data and an established sliding-window analytic approach, we identified dynamic resting-state functional connectivity states and extracted dynamic indices such as dwell time (the duration spent in a state), fraction time (the proportion of the total time occupied by a state), and number of transitions (number of switches) from one state to another, to test for group differences. Results Individuals with AN had relatively reduced fraction time in a mildly connected state with pronounced connectivity within the default mode network (DMN) and an overall reduced number of transitions between states. Conclusions These findings revealed by a dynamic, but not static analytic approach might hint towards a more ?rigid? connectivity, a phenomenon commonly observed in internalizing mental disorders, and in AN possibly related to a reduction in energetic costs as a result of nutritional deprivation. En ligne : https://doi.org/10.1111/jcpp.13970 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 [article] Dynamic functional connectivity in anorexia nervosa: alterations in states of low connectivity and state transitions [Texte imprimé et/ou numérique] / Eva MENNIGEN, Auteur ; Daniel GEISLER, Auteur ; Nico W. POLLER, Auteur ; Katrin GRAMATKE, Auteur ; Vince D. CALHOUN, Auteur ; Veit ROESSNER, Auteur ; Joseph A. KING, Auteur ; Stefan EHRLICH, Auteur . - p.1299-1310. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-10 (October 2024) . - p.1299-1310 Mots-clés : Eating disorder  anorexia nervosa  dynamic functional connectivity  resting state Index. décimale : PER Périodiques Résumé : Background The onset of anorexia nervosa (AN) frequently occurs during adolescence and is associated with preoccupation with body weight and shape and extreme underweight. Altered resting state functional connectivity in the brain has been described in individuals with AN, but only from a static perspective. The current study investigated the temporal dynamics of functional connectivity in adolescents with AN and how it relates to clinical features. Method 99 female patients acutely ill with AN and 99 pairwise age-matched female healthy control (HC) participants were included in the study. Using resting-state functional MRI data and an established sliding-window analytic approach, we identified dynamic resting-state functional connectivity states and extracted dynamic indices such as dwell time (the duration spent in a state), fraction time (the proportion of the total time occupied by a state), and number of transitions (number of switches) from one state to another, to test for group differences. Results Individuals with AN had relatively reduced fraction time in a mildly connected state with pronounced connectivity within the default mode network (DMN) and an overall reduced number of transitions between states. Conclusions These findings revealed by a dynamic, but not static analytic approach might hint towards a more ?rigid? connectivity, a phenomenon commonly observed in internalizing mental disorders, and in AN possibly related to a reduction in energetic costs as a result of nutritional deprivation. En ligne : https://doi.org/10.1111/jcpp.13970 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535

Editorial Perspective: How to optimise frequency band neurofeedback for ADHD / Annet BLUSCHKE in Journal of Child Psychology and Psychiatry, 57-4 (April 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-4 (April 2016) . - p.457-461 Titre : Editorial Perspective: How to optimise frequency band neurofeedback for ADHD Type de document : Texte imprimé et/ou numérique Auteurs : Annet BLUSCHKE, Auteur ; Veit ROESSNER, Auteur ; Christian BESTE, Auteur Article en page(s) : p.457-461 Langues : Anglais (eng) Mots-clés : ADHD  cognitive deficits  neurofeedback  treatment optimisation Index. décimale : PER Périodiques Résumé : Attention deficit/hyperactivity disorder (ADHD) is one of the most prevalent paediatric neuropsychiatric disorders and is characterised by hyperactivity, inattention and increased impulsivity. Children with ADHD are often also characterised by deficits in a variety of cognitive domains, including problems in working memory, a generally slower and more variable style of information processing and deficits in temporal processing, inhibitory functions and delay processing. Overarching executive functions like information updating, response inhibition and mental set shifting are also impaired in many, but not all, children with ADHD, demonstrating the neuropsychological heterogeneity characterising this disorder. Deficits in executive functions can persist into adulthood and have a substantial negative impact on everyday life. A variety of approaches are commonly considered for the treatment of ADHD (including pharmacological interventions, patient-centred cognitive-behavioural therapy approaches and specific teacher/parent training programmes). More recently, adding to this multimodal treatment approach, neurofeedback has grown in popularity as an intervention option for patients with ADHD. This article considers this intervention approach and the opportunities for optimising treatment for executive control dysfunctions in ADHD using theta/beta neurofeedback. En ligne : http://dx.doi.org/10.1111/jcpp.12521 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285 [article] Editorial Perspective: How to optimise frequency band neurofeedback for ADHD [Texte imprimé et/ou numérique] / Annet BLUSCHKE, Auteur ; Veit ROESSNER, Auteur ; Christian BESTE, Auteur . - p.457-461. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-4 (April 2016) . - p.457-461 Mots-clés : ADHD  cognitive deficits  neurofeedback  treatment optimisation Index. décimale : PER Périodiques Résumé : Attention deficit/hyperactivity disorder (ADHD) is one of the most prevalent paediatric neuropsychiatric disorders and is characterised by hyperactivity, inattention and increased impulsivity. Children with ADHD are often also characterised by deficits in a variety of cognitive domains, including problems in working memory, a generally slower and more variable style of information processing and deficits in temporal processing, inhibitory functions and delay processing. Overarching executive functions like information updating, response inhibition and mental set shifting are also impaired in many, but not all, children with ADHD, demonstrating the neuropsychological heterogeneity characterising this disorder. Deficits in executive functions can persist into adulthood and have a substantial negative impact on everyday life. A variety of approaches are commonly considered for the treatment of ADHD (including pharmacological interventions, patient-centred cognitive-behavioural therapy approaches and specific teacher/parent training programmes). More recently, adding to this multimodal treatment approach, neurofeedback has grown in popularity as an intervention option for patients with ADHD. This article considers this intervention approach and the opportunities for optimising treatment for executive control dysfunctions in ADHD using theta/beta neurofeedback. En ligne : http://dx.doi.org/10.1111/jcpp.12521 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285

Editorial Perspective: Medical body modification in youth with gender dysphoria or body dysmorphic disorder - is current practice coherent and evidence-based? / Gregor KOHLS in Journal of Child Psychology and Psychiatry, 64-7 (July 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-7 (July 2023) . - p.1096-1100 Titre : Editorial Perspective: Medical body modification in youth with gender dysphoria or body dysmorphic disorder - is current practice coherent and evidence-based? Type de document : Texte imprimé et/ou numérique Auteurs : Gregor KOHLS, Auteur ; Veit ROESSNER, Auteur Article en page(s) : p.1096-1100 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : In recent decades, there has been a steady increase in the number of people, including adolescents, undergoing medical body modification (MBM) to alter their physically healthy bodies in invasive and nearly irreversible ways through medical treatment (e.g. surgery). While MBM is often recommended for youth with persisting gender dysphoria (GD), in body dysmorphic disorder (BDD) it has been considered contraindicated. Here, we outline the current controversies surrounding MBM practice and recommendations in adolescents with GD versus those with BDD in order to better understand under what circumstances we may or may not support adolescents who want to change their bodies medically and often irreversibly. We compare the two disorders in terms of the overlap and uniqueness of their behavioural and psychological features. In doing so, we discuss limitations of the existing (often low-quality) evidence for and against MBM in young patients. We conclude that the currently available evidence is too preliminary and far from conclusive to make any robust recommendations in terms of benefits and harms of MBM in youth with persisting GD or BDD. However, we strongly recommend further urgent scientific discussions and systematic research efforts into more robust evaluations and the identification of more precise psychological characteristics that may serve as decision criteria for or against MBM particularly in those adolescents who did not respond to non-MBM, that is, psychiatric/psychological treatment and psychosocial support, if available at all. This will greatly benefit youth healthcare professionals in their challenging clinical practice of making decisions regarding MBM today and in the future. En ligne : https://doi.org/10.1111/jcpp.13717 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 [article] Editorial Perspective: Medical body modification in youth with gender dysphoria or body dysmorphic disorder - is current practice coherent and evidence-based? [Texte imprimé et/ou numérique] / Gregor KOHLS, Auteur ; Veit ROESSNER, Auteur . - p.1096-1100. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-7 (July 2023) . - p.1096-1100 Index. décimale : PER Périodiques Résumé : In recent decades, there has been a steady increase in the number of people, including adolescents, undergoing medical body modification (MBM) to alter their physically healthy bodies in invasive and nearly irreversible ways through medical treatment (e.g. surgery). While MBM is often recommended for youth with persisting gender dysphoria (GD), in body dysmorphic disorder (BDD) it has been considered contraindicated. Here, we outline the current controversies surrounding MBM practice and recommendations in adolescents with GD versus those with BDD in order to better understand under what circumstances we may or may not support adolescents who want to change their bodies medically and often irreversibly. We compare the two disorders in terms of the overlap and uniqueness of their behavioural and psychological features. In doing so, we discuss limitations of the existing (often low-quality) evidence for and against MBM in young patients. We conclude that the currently available evidence is too preliminary and far from conclusive to make any robust recommendations in terms of benefits and harms of MBM in youth with persisting GD or BDD. However, we strongly recommend further urgent scientific discussions and systematic research efforts into more robust evaluations and the identification of more precise psychological characteristics that may serve as decision criteria for or against MBM particularly in those adolescents who did not respond to non-MBM, that is, psychiatric/psychological treatment and psychosocial support, if available at all. This will greatly benefit youth healthcare professionals in their challenging clinical practice of making decisions regarding MBM today and in the future. En ligne : https://doi.org/10.1111/jcpp.13717 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508

Examining a model of anxiety in autistic adults / Saskia RIEDELBAUCH in Autism, 28-3 (March 2024)  

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Finger tapping-related activation differences in treatment-naïve pediatric Tourette syndrome: a comparison of the preferred and nonpreferred hand / Veit ROESSNER in Journal of Child Psychology and Psychiatry, 54-3 (March 2013)  

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Increased putamen and callosal motor subregion in treatment-naïve boys with Tourette syndrome indicates changes in the bihemispheric motor network / Veit ROESSNER in Journal of Child Psychology and Psychiatry, 52-3 (March 2011)  

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Modulations of cognitive flexibility in obsessive compulsive disorder reflect dysfunctions of perceptual categorization / Nicole WOLFF in Journal of Child Psychology and Psychiatry, 58-8 (August 2017)  

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Multicultural assessment of child and adolescent psychopathology with ASEBA and SDQ instruments: research findings, applications, and future directions / Thomas M. ACHENBACH in Journal of Child Psychology and Psychiatry, 49-3 (March 2008)  

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Phenotypic differences between female and male individuals with suspicion of autism spectrum disorder / Sanna STROTH in Molecular Autism, 13 (2022)  

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The impact of depressive and anxious symptoms on quality of life in adults on the autism spectrum / Tobias THIEL in Autism Research, 17-5 (May 2024)  

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The impact of depressive and anxious symptoms on quality of life in adults on the autism spectrum / Saskia RIEDELBAUCH ; Sebastian GAIGG ; Veit ROESSNER ; Melanie RING in Autism Research, 17-6 (June 2024)  

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Using machine learning to improve diagnostic assessment of ASD in the light of specific differential and co-occurring diagnoses / Martin SCHULTE-RUTHER in Journal of Child Psychology and Psychiatry, 64-1 (January 2023)  

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When repetitive mental sets increase cognitive flexibility in adolescent obsessive–compulsive disorder / Nicole WOLFF in Journal of Child Psychology and Psychiatry, 59-9 (September 2018)  

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