Dysfunctional representation of expected value is associated with reinforcement-based decision-making deficits in adolescents with conduct problems / Stuart F. WHITE in Journal of Child Psychology and Psychiatry, 57-8 (August 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-8 (August 2016) . - p.938-946 Titre : Dysfunctional representation of expected value is associated with reinforcement-based decision-making deficits in adolescents with conduct problems Type de document : Texte imprimé et/ou numérique Auteurs : Stuart F. WHITE, Auteur ; Patrick M. TYLER, Auteur ; Anna K. ERWAY, Auteur ; Mary L. BOTKIN, Auteur ; Venkata KOLLI, Auteur ; Harma MEFFERT, Auteur ; Kayla POPE, Auteur ; James R. BLAIR, Auteur Article en page(s) : p.938-946 Langues : Anglais (eng) Mots-clés : Conduct problems  decision-making  anterior insula  expected value  prediction error Index. décimale : PER Périodiques Résumé : Background Previous work has shown that patients with conduct problems (CP) show impairments in reinforcement-based decision-making. However, studies with patients have not previously demonstrated any relationships between impairment in any of the neurocomputations underpinning reinforcement-based decision-making and specific symptom sets [e.g. level of CP and/or callous-unemotional (CU) traits]. Methods Seventy-two youths [20 female, mean age = 13.81 (SD = 2.14), mean IQ = 102.34 (SD = 10.99)] from a residential treatment program and the community completed a passive avoidance task while undergoing functional MRI. Results Greater levels of CP were associated with poorer task performance. Reduced representation of expected values (EV) when making avoidance responses within bilateral anterior insula cortex/inferior frontal gyrus (AIC/iFG) and striatum was associated with greater levels of CP but not CU traits. Conclusions The current data indicate that difficulties in the use of value information to motivate decisions to avoid suboptimal choices are associated with increased levels of CP (though not severity of CU traits). Moreover, they account for the behavioral deficits observed during reinforcement-based decision-making in youth with CP. In short, an individual's relative failure to utilize value information within AIC/iFG to avoid bad choices is associated with elevated levels of CP. En ligne : http://dx.doi.org/10.1111/jcpp.12557 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292 [article] Dysfunctional representation of expected value is associated with reinforcement-based decision-making deficits in adolescents with conduct problems [Texte imprimé et/ou numérique] / Stuart F. WHITE, Auteur ; Patrick M. TYLER, Auteur ; Anna K. ERWAY, Auteur ; Mary L. BOTKIN, Auteur ; Venkata KOLLI, Auteur ; Harma MEFFERT, Auteur ; Kayla POPE, Auteur ; James R. BLAIR, Auteur . - p.938-946. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-8 (August 2016) . - p.938-946 Mots-clés : Conduct problems  decision-making  anterior insula  expected value  prediction error Index. décimale : PER Périodiques Résumé : Background Previous work has shown that patients with conduct problems (CP) show impairments in reinforcement-based decision-making. However, studies with patients have not previously demonstrated any relationships between impairment in any of the neurocomputations underpinning reinforcement-based decision-making and specific symptom sets [e.g. level of CP and/or callous-unemotional (CU) traits]. Methods Seventy-two youths [20 female, mean age = 13.81 (SD = 2.14), mean IQ = 102.34 (SD = 10.99)] from a residential treatment program and the community completed a passive avoidance task while undergoing functional MRI. Results Greater levels of CP were associated with poorer task performance. Reduced representation of expected values (EV) when making avoidance responses within bilateral anterior insula cortex/inferior frontal gyrus (AIC/iFG) and striatum was associated with greater levels of CP but not CU traits. Conclusions The current data indicate that difficulties in the use of value information to motivate decisions to avoid suboptimal choices are associated with increased levels of CP (though not severity of CU traits). Moreover, they account for the behavioral deficits observed during reinforcement-based decision-making in youth with CP. In short, an individual's relative failure to utilize value information within AIC/iFG to avoid bad choices is associated with elevated levels of CP. En ligne : http://dx.doi.org/10.1111/jcpp.12557 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292

A neurocomputational investigation of reinforcement-based decision making as a candidate latent vulnerability mechanism in maltreated children / Mattia I. GERIN in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1689-1705 Titre : A neurocomputational investigation of reinforcement-based decision making as a candidate latent vulnerability mechanism in maltreated children Type de document : Texte imprimé et/ou numérique Auteurs : Mattia I. GERIN, Auteur ; Vanessa B. PUETZ, Auteur ; James R. BLAIR, Auteur ; Stuart F. WHITE, Auteur ; Arjun SETHI, Auteur ; Ferdinand HOFFMANN, Auteur ; Amy L. PALMER, Auteur ; Essi VIDING, Auteur ; Eamon J. MCCRORY, Auteur Article en page(s) : p.1689-1705 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Alterations in reinforcement-based decision making may be associated with increased psychiatric vulnerability in children who have experienced maltreatment. A probabilistic passive avoidance task and a model-based functional magnetic resonance imaging analytic approach were implemented to assess the neurocomputational components underlying decision making: (a) reinforcement expectancies (the representation of the outcomes associated with a stimulus) and (b) prediction error signaling (the ability to detect the differences between expected and actual outcomes). There were three main findings. First, the maltreated group (n = 18; mean age = 13), relative to nonmaltreated peers (n = 19; mean age = 13), showed decreased activity during expected value processing in a widespread network commonly associated with reinforcement expectancies representation, including the striatum (especially the caudate), the orbitofrontal cortex, and medial temporal structures including the hippocampus and insula. Second, consistent with previously reported hyperresponsiveness to negative cues in the context of childhood abuse, the maltreated group showed increased prediction error signaling in the middle cingulate gyrus, somatosensory cortex, superior temporal gyrus, and thalamus. Third, the maltreated group showed increased activity in frontodorsal regions and in the putamen during expected value representation. These findings suggest that early adverse environments disrupt the development of decision-making processes, which in turn may compromise psychosocial functioning in ways that increase latent vulnerability to psychiatric disorder. En ligne : http://dx.doi.org/10.1017/S095457941700133X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] A neurocomputational investigation of reinforcement-based decision making as a candidate latent vulnerability mechanism in maltreated children [Texte imprimé et/ou numérique] / Mattia I. GERIN, Auteur ; Vanessa B. PUETZ, Auteur ; James R. BLAIR, Auteur ; Stuart F. WHITE, Auteur ; Arjun SETHI, Auteur ; Ferdinand HOFFMANN, Auteur ; Amy L. PALMER, Auteur ; Essi VIDING, Auteur ; Eamon J. MCCRORY, Auteur . - p.1689-1705. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1689-1705 Index. décimale : PER Périodiques Résumé : Alterations in reinforcement-based decision making may be associated with increased psychiatric vulnerability in children who have experienced maltreatment. A probabilistic passive avoidance task and a model-based functional magnetic resonance imaging analytic approach were implemented to assess the neurocomputational components underlying decision making: (a) reinforcement expectancies (the representation of the outcomes associated with a stimulus) and (b) prediction error signaling (the ability to detect the differences between expected and actual outcomes). There were three main findings. First, the maltreated group (n = 18; mean age = 13), relative to nonmaltreated peers (n = 19; mean age = 13), showed decreased activity during expected value processing in a widespread network commonly associated with reinforcement expectancies representation, including the striatum (especially the caudate), the orbitofrontal cortex, and medial temporal structures including the hippocampus and insula. Second, consistent with previously reported hyperresponsiveness to negative cues in the context of childhood abuse, the maltreated group showed increased prediction error signaling in the middle cingulate gyrus, somatosensory cortex, superior temporal gyrus, and thalamus. Third, the maltreated group showed increased activity in frontodorsal regions and in the putamen during expected value representation. These findings suggest that early adverse environments disrupt the development of decision-making processes, which in turn may compromise psychosocial functioning in ways that increase latent vulnerability to psychiatric disorder. En ligne : http://dx.doi.org/10.1017/S095457941700133X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

Reduced activity within the dorsal endogenous orienting of attention network to fearful expressions in youth with disruptive behavior disorders and psychopathic traits / Stuart F. WHITE in Development and Psychopathology, 24-3 (August 2012)  

Public ISBD [article]  inDevelopment and Psychopathology > 24-3 (August 2012) . - p.1105-16. Titre : Reduced activity within the dorsal endogenous orienting of attention network to fearful expressions in youth with disruptive behavior disorders and psychopathic traits Type de document : Texte imprimé et/ou numérique Auteurs : Stuart F. WHITE, Auteur ; Craig WILLIAMS W., Auteur ; Sarah J., BRISLIN, Auteur ; Stephen SINCLAIR, Auteur ; Karina S. BLAIR, Auteur ; Katherine A. FOWLER, Auteur ; Daniel Samuel PINE, Auteur ; Kayla POPE, Auteur ; James R. BLAIR, Auteur Année de publication : 2012 Article en page(s) : p.1105-16. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Using behavioral and blood oxygen level dependent (BOLD) response indices through functional magnetic resonance imaging (fMRI), the current study investigated whether youths with disruptive behavior disorders (conduct disorder and oppositional defiant disorder) plus psychopathic traits (DBD + PT) show aberrant sensitivity to eye gaze information generally and/or whether they show particular insensitivity to eye gaze information in the context of fearful expressions. The participants were 36 children and adolescents (ages 10–17 years); 17 had DBD + PT and 19 were healthy comparison subjects. Participants performed a spatial attention paradigm where spatial attention was cued by eye gaze in faces displaying fearful, angry, or neutral affect. Eye gaze sensitivity was indexed both behaviorally and as BOLD response. There were no group differences in behavioral response: both groups showed significantly faster responses if the target was in the congruent spatial direction indicated by eye gaze. Neither group showed a Congruence × Emotion interaction; neither group showed an advantage from the displayer's emotional expression behaviorally. However, the BOLD response revealed a significant Group × Congruence × Emotion interaction. The comparison youth showed increased activity within the dorsal endogenous orienting network (superior parietal lobule and inferior parietal sulcus) for fearful congruent relative to incongruent trials relative to the youth with DBD + PT. The results are discussed with reference to current models of DBD + PT and possible treatment innovations. En ligne : http://dx.doi.org/10.1017/S0954579412000569 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178 [article] Reduced activity within the dorsal endogenous orienting of attention network to fearful expressions in youth with disruptive behavior disorders and psychopathic traits [Texte imprimé et/ou numérique] / Stuart F. WHITE, Auteur ; Craig WILLIAMS W., Auteur ; Sarah J., BRISLIN, Auteur ; Stephen SINCLAIR, Auteur ; Karina S. BLAIR, Auteur ; Katherine A. FOWLER, Auteur ; Daniel Samuel PINE, Auteur ; Kayla POPE, Auteur ; James R. BLAIR, Auteur . - 2012 . - p.1105-16. Langues : Anglais (eng) in Development and Psychopathology > 24-3 (August 2012) . - p.1105-16. Index. décimale : PER Périodiques Résumé : Using behavioral and blood oxygen level dependent (BOLD) response indices through functional magnetic resonance imaging (fMRI), the current study investigated whether youths with disruptive behavior disorders (conduct disorder and oppositional defiant disorder) plus psychopathic traits (DBD + PT) show aberrant sensitivity to eye gaze information generally and/or whether they show particular insensitivity to eye gaze information in the context of fearful expressions. The participants were 36 children and adolescents (ages 10–17 years); 17 had DBD + PT and 19 were healthy comparison subjects. Participants performed a spatial attention paradigm where spatial attention was cued by eye gaze in faces displaying fearful, angry, or neutral affect. Eye gaze sensitivity was indexed both behaviorally and as BOLD response. There were no group differences in behavioral response: both groups showed significantly faster responses if the target was in the congruent spatial direction indicated by eye gaze. Neither group showed a Congruence × Emotion interaction; neither group showed an advantage from the displayer's emotional expression behaviorally. However, the BOLD response revealed a significant Group × Congruence × Emotion interaction. The comparison youth showed increased activity within the dorsal endogenous orienting network (superior parietal lobule and inferior parietal sulcus) for fearful congruent relative to incongruent trials relative to the youth with DBD + PT. The results are discussed with reference to current models of DBD + PT and possible treatment innovations. En ligne : http://dx.doi.org/10.1017/S0954579412000569 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178

Research Review: The importance of callous-unemotional traits for developmental models of aggressive and antisocial behavior / Paul J. FRICK in Journal of Child Psychology and Psychiatry, 49-4 (April 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-4 (April 2008) . - p.359–375 Titre : Research Review: The importance of callous-unemotional traits for developmental models of aggressive and antisocial behavior Type de document : Texte imprimé et/ou numérique Auteurs : Paul J. FRICK, Auteur ; Stuart F. WHITE, Auteur Année de publication : 2008 Article en page(s) : p.359–375 Langues : Anglais (eng) Mots-clés : Callous-unemotional-traits aggression antisocial-behavior conduct-problems children-and-adolescents psychopathy Index. décimale : PER Périodiques Résumé : The current paper reviews research suggesting that the presence of a callous and unemotional interpersonal style designates an important subgroup of antisocial and aggressive youth. Specifically, callous-unemotional (CU) traits (e.g., lack of guilt, absence of empathy, callous use of others) seem to be relatively stable across childhood and adolescence and they designate a group of youth with a particularly severe, aggressive, and stable pattern of antisocial behavior. Further, antisocial youth with CU traits show a number of distinct emotional, cognitive, and personality characteristics compared to other antisocial youth. These characteristics of youth with CU traits have important implications for causal models of antisocial and aggressive behavior, for methods used to study antisocial youth, and for assessing and treating antisocial and aggressive behavior in children and adolescents. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01862.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=339 [article] Research Review: The importance of callous-unemotional traits for developmental models of aggressive and antisocial behavior [Texte imprimé et/ou numérique] / Paul J. FRICK, Auteur ; Stuart F. WHITE, Auteur . - 2008 . - p.359–375. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-4 (April 2008) . - p.359–375 Mots-clés : Callous-unemotional-traits aggression antisocial-behavior conduct-problems children-and-adolescents psychopathy Index. décimale : PER Périodiques Résumé : The current paper reviews research suggesting that the presence of a callous and unemotional interpersonal style designates an important subgroup of antisocial and aggressive youth. Specifically, callous-unemotional (CU) traits (e.g., lack of guilt, absence of empathy, callous use of others) seem to be relatively stable across childhood and adolescence and they designate a group of youth with a particularly severe, aggressive, and stable pattern of antisocial behavior. Further, antisocial youth with CU traits show a number of distinct emotional, cognitive, and personality characteristics compared to other antisocial youth. These characteristics of youth with CU traits have important implications for causal models of antisocial and aggressive behavior, for methods used to study antisocial youth, and for assessing and treating antisocial and aggressive behavior in children and adolescents. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01862.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=339

The relationship between large cavum septum pellucidum and antisocial behavior, callous-unemotional traits and psychopathy in adolescents / Stuart F. WHITE in Journal of Child Psychology and Psychiatry, 54-5 (May 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-5 (May 2013) . - p.575-581 Titre : The relationship between large cavum septum pellucidum and antisocial behavior, callous-unemotional traits and psychopathy in adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Stuart F. WHITE, Auteur ; Sarah J., BRISLIN, Auteur ; Stephen SINCLAIR, Auteur ; Katherine A. FOWLER, Auteur ; Kayla POPE, Auteur ; James R. BLAIR, Auteur Article en page(s) : p.575-581 Langues : Anglais (eng) Mots-clés : Conduct disorder  development Index. décimale : PER Périodiques Résumé : Background: The presence of a large cavum septum pellucidum (CSP) has been previously associated with antisocial behavior/psychopathic traits in an adult community sample. Aims: The current study investigated the relationship between a large CSP and symptom severity in disruptive behavior disorders (DBD; conduct disorder and oppositional defiant disorder). Method: Structural MRI scans of youth with DBDs (N = 32) and healthy comparison youth (N = 27) were examined for the presence of a large CSP and if this was related to symptom severity. Results: Replicating previous results, a large CSP was associated with DBD diagnosis, proactive aggression, and level of psychopathic traits in youth. However, the presence of a large CSP was unrelated to aggression or psychopathic traits within the DBD sample. Conclusions: Early brain mal-development may increase the risk of a DBD diagnosis, but does not mark a particularly severe form of DBD within patients receiving these diagnoses. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02603.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=196 [article] The relationship between large cavum septum pellucidum and antisocial behavior, callous-unemotional traits and psychopathy in adolescents [Texte imprimé et/ou numérique] / Stuart F. WHITE, Auteur ; Sarah J., BRISLIN, Auteur ; Stephen SINCLAIR, Auteur ; Katherine A. FOWLER, Auteur ; Kayla POPE, Auteur ; James R. BLAIR, Auteur . - p.575-581. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-5 (May 2013) . - p.575-581 Mots-clés : Conduct disorder  development Index. décimale : PER Périodiques Résumé : Background: The presence of a large cavum septum pellucidum (CSP) has been previously associated with antisocial behavior/psychopathic traits in an adult community sample. Aims: The current study investigated the relationship between a large CSP and symptom severity in disruptive behavior disorders (DBD; conduct disorder and oppositional defiant disorder). Method: Structural MRI scans of youth with DBDs (N = 32) and healthy comparison youth (N = 27) were examined for the presence of a large CSP and if this was related to symptom severity. Results: Replicating previous results, a large CSP was associated with DBD diagnosis, proactive aggression, and level of psychopathic traits in youth. However, the presence of a large CSP was unrelated to aggression or psychopathic traits within the DBD sample. Conclusions: Early brain mal-development may increase the risk of a DBD diagnosis, but does not mark a particularly severe form of DBD within patients receiving these diagnoses. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02603.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=196

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