[article] 
inAutism Research > 17-11 (November 2024) . - p.2418-2429

Titre :	Regional differences in autism and intellectual disability risk associated with cesarean section delivery
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Deborah A. BILDER, Auteur ; Scott SULLIVAN, Auteur ; Michelle M. HUGHES, Auteur ; Susan DALTON, Auteur ; Jennifer HALL-LANDE, Auteur ; Connor NICHOLLS, Auteur ; Amanda V. BAKIAN, Auteur
Article en page(s) :	p.2418-2429
Langues :	Anglais (eng)
Mots-clés :	autism  cesarean section  epidemiology  intellectual disability  prenatal risk factors
Index. décimale :	PER Périodiques
Résumé :	Abstract Prior epidemiological studies investigating the association between delivery mode (i.e., vaginal birth and cesarean section [C-section]) and autism spectrum disorder (ASD) and intellectual disability (ID) risk have reported mixed findings. This study examined ASD and ID risks associated with primary and repeat C-section within diverse US regions. During even years 2000?2016, 8-years-olds were identified with ASD and/or ID and matched to birth records [ASD only (N?=?8566, 83.6% male), ASD?+?ID (N?=?3445, 79.5% male), ID only (N?=?6158, 60.8% male)] using the Centers for Disease Control and Prevention's Autism and Developmental Disabilities Monitoring Network methodology. The comparison birth cohort (N?=?1,456,914, 51.1% male) comprised all births recorded in the National Center for Health Statistics corresponding to birth years and counties in which surveillance occurred. C-section rates in the birth cohort demonstrated significant regional variation with lowest rates in the West. Overall models demonstrate increased odds of disability associated with primary and repeat C-section. Adjusted models, stratified by region, identified significant variability in disability likelihood associated with repeat C-section: increased odds occurred for all case groups in the Southeast, for ASD only and ID only in the Mid-Atlantic, and no case groups in the West. Regional variability in disability risk associated with repeat C-section coincides with differences in birth cohorts' C-section rates. This suggests increased likelihood of disability is not incurred by the procedure itself, but rather C-section serves as a proxy for exposures with regional variability that influence fetal development and C-section rates.
En ligne :	https://doi.org/10.1002/aur.3247
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=542

[article] Regional differences in autism and intellectual disability risk associated with cesarean section delivery [Texte imprimé et/ou numérique] / Deborah A. BILDER, Auteur ; Scott SULLIVAN, Auteur ; Michelle M. HUGHES, Auteur ; Susan DALTON, Auteur ; Jennifer HALL-LANDE, Auteur ; Connor NICHOLLS, Auteur ; Amanda V. BAKIAN, Auteur . - p.2418-2429.
Langues : Anglais (eng)
in Autism Research > 17-11 (November 2024) . - p.2418-2429

Mots-clés :	autism  cesarean section  epidemiology  intellectual disability  prenatal risk factors
Index. décimale :	PER Périodiques
Résumé :	Abstract Prior epidemiological studies investigating the association between delivery mode (i.e., vaginal birth and cesarean section [C-section]) and autism spectrum disorder (ASD) and intellectual disability (ID) risk have reported mixed findings. This study examined ASD and ID risks associated with primary and repeat C-section within diverse US regions. During even years 2000?2016, 8-years-olds were identified with ASD and/or ID and matched to birth records [ASD only (N?=?8566, 83.6% male), ASD?+?ID (N?=?3445, 79.5% male), ID only (N?=?6158, 60.8% male)] using the Centers for Disease Control and Prevention's Autism and Developmental Disabilities Monitoring Network methodology. The comparison birth cohort (N?=?1,456,914, 51.1% male) comprised all births recorded in the National Center for Health Statistics corresponding to birth years and counties in which surveillance occurred. C-section rates in the birth cohort demonstrated significant regional variation with lowest rates in the West. Overall models demonstrate increased odds of disability associated with primary and repeat C-section. Adjusted models, stratified by region, identified significant variability in disability likelihood associated with repeat C-section: increased odds occurred for all case groups in the Southeast, for ASD only and ID only in the Mid-Atlantic, and no case groups in the West. Regional variability in disability risk associated with repeat C-section coincides with differences in birth cohorts' C-section rates. This suggests increased likelihood of disability is not incurred by the procedure itself, but rather C-section serves as a proxy for exposures with regional variability that influence fetal development and C-section rates.
En ligne :	https://doi.org/10.1002/aur.3247
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=542