Regional differences in autism and intellectual disability risk associated with cesarean section delivery / Deborah A. BILDER in Autism Research, 17-11 (November 2024)  

Public ISBD [article]  inAutism Research > 17-11 (November 2024) . - p.2418-2429 Titre : Regional differences in autism and intellectual disability risk associated with cesarean section delivery Type de document : Texte imprimé et/ou numérique Auteurs : Deborah A. BILDER, Auteur ; Scott SULLIVAN, Auteur ; Michelle M. HUGHES, Auteur ; Susan DALTON, Auteur ; Jennifer HALL-LANDE, Auteur ; Connor NICHOLLS, Auteur ; Amanda V. BAKIAN, Auteur Article en page(s) : p.2418-2429 Langues : Anglais (eng) Mots-clés : autism  cesarean section  epidemiology  intellectual disability  prenatal risk factors Index. décimale : PER Périodiques Résumé : Abstract Prior epidemiological studies investigating the association between delivery mode (i.e., vaginal birth and cesarean section [C-section]) and autism spectrum disorder (ASD) and intellectual disability (ID) risk have reported mixed findings. This study examined ASD and ID risks associated with primary and repeat C-section within diverse US regions. During even years 2000?2016, 8-years-olds were identified with ASD and/or ID and matched to birth records [ASD only (N?=?8566, 83.6% male), ASD?+?ID (N?=?3445, 79.5% male), ID only (N?=?6158, 60.8% male)] using the Centers for Disease Control and Prevention's Autism and Developmental Disabilities Monitoring Network methodology. The comparison birth cohort (N?=?1,456,914, 51.1% male) comprised all births recorded in the National Center for Health Statistics corresponding to birth years and counties in which surveillance occurred. C-section rates in the birth cohort demonstrated significant regional variation with lowest rates in the West. Overall models demonstrate increased odds of disability associated with primary and repeat C-section. Adjusted models, stratified by region, identified significant variability in disability likelihood associated with repeat C-section: increased odds occurred for all case groups in the Southeast, for ASD only and ID only in the Mid-Atlantic, and no case groups in the West. Regional variability in disability risk associated with repeat C-section coincides with differences in birth cohorts' C-section rates. This suggests increased likelihood of disability is not incurred by the procedure itself, but rather C-section serves as a proxy for exposures with regional variability that influence fetal development and C-section rates. En ligne : https://doi.org/10.1002/aur.3247 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=542 [article] Regional differences in autism and intellectual disability risk associated with cesarean section delivery [Texte imprimé et/ou numérique] / Deborah A. BILDER, Auteur ; Scott SULLIVAN, Auteur ; Michelle M. HUGHES, Auteur ; Susan DALTON, Auteur ; Jennifer HALL-LANDE, Auteur ; Connor NICHOLLS, Auteur ; Amanda V. BAKIAN, Auteur . - p.2418-2429. Langues : Anglais (eng) in Autism Research > 17-11 (November 2024) . - p.2418-2429 Mots-clés : autism  cesarean section  epidemiology  intellectual disability  prenatal risk factors Index. décimale : PER Périodiques Résumé : Abstract Prior epidemiological studies investigating the association between delivery mode (i.e., vaginal birth and cesarean section [C-section]) and autism spectrum disorder (ASD) and intellectual disability (ID) risk have reported mixed findings. This study examined ASD and ID risks associated with primary and repeat C-section within diverse US regions. During even years 2000?2016, 8-years-olds were identified with ASD and/or ID and matched to birth records [ASD only (N?=?8566, 83.6% male), ASD?+?ID (N?=?3445, 79.5% male), ID only (N?=?6158, 60.8% male)] using the Centers for Disease Control and Prevention's Autism and Developmental Disabilities Monitoring Network methodology. The comparison birth cohort (N?=?1,456,914, 51.1% male) comprised all births recorded in the National Center for Health Statistics corresponding to birth years and counties in which surveillance occurred. C-section rates in the birth cohort demonstrated significant regional variation with lowest rates in the West. Overall models demonstrate increased odds of disability associated with primary and repeat C-section. Adjusted models, stratified by region, identified significant variability in disability likelihood associated with repeat C-section: increased odds occurred for all case groups in the Southeast, for ASD only and ID only in the Mid-Atlantic, and no case groups in the West. Regional variability in disability risk associated with repeat C-section coincides with differences in birth cohorts' C-section rates. This suggests increased likelihood of disability is not incurred by the procedure itself, but rather C-section serves as a proxy for exposures with regional variability that influence fetal development and C-section rates. En ligne : https://doi.org/10.1002/aur.3247 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=542

Sex-specific and sex-independent steroid-related biomarkers in early second trimester maternal serum associated with autism / Whitney WORSHAM ; Scott SULLIVAN ; M. Sean ESPLIN ; Paul BURGHARDT ; Alison FRASER ; Amanda V. BAKIAN in Molecular Autism, 14 (2023)  

Public ISBD [article]  inMolecular Autism > 14 (2023) . - 30 p. Titre : Sex-specific and sex-independent steroid-related biomarkers in early second trimester maternal serum associated with autism Type de document : Texte imprimé et/ou numérique Auteurs : Whitney WORSHAM, Auteur ; Scott SULLIVAN, Auteur ; M. Sean ESPLIN, Auteur ; Paul BURGHARDT, Auteur ; Alison FRASER, Auteur ; Amanda V. BAKIAN, Auteur Article en page(s) : 30 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal exposure to maternal metabolic conditions associated with inflammation and steroid dysregulation has previously been linked to increased autism risk. Steroid-related maternal serum biomarkers have also provided insight into the in utero steroid environment for offspring who develop autism. OBJECTIVE: This study examines the link between autism among offspring and early second trimester maternal steroid-related serum biomarkers from pregnancies enriched for prenatal metabolic syndrome (PNMS) exposure. STUDY DESIGN: Early second trimester maternal steroid-related serum biomarkers (i.e., estradiol, free testosterone, total testosterone, and sex hormone binding globulin) were compared between pregnancies corresponding to offspring with (N=68) and without (N=68) autism. Multiple logistic regression analyses were stratified by sex and gestational duration. One-way ANCOVA with post hoc tests was performed for groups defined by autism status and PNMS exposure. RESULTS: Increased estradiol was significantly associated with autism only in males (AOR=1.13 per 100 pg/ml, 95% CI 1.01-1.27, p=0.036) and only term pregnancies (AOR=1.17 per 100 pg/ml, 95% CI 1.04-1.32, p=0.010). Autism status was significantly associated with decreased sex hormone binding globulin (AOR=0.65 per 50 nmol/L, 95% CI 0.55-0.78, p<0.001) overall and when stratified by sex and term pregnancy status. The inverse association between sex hormone binding globulin and autism was independent of PNMS exposure. LIMITATIONS: The relative racial and ethnic homogeneity of Utah's population limits the generalizability of study results. Although significant differences by autism status were identified in concentrations of sex hormone binding globulin overall and of estradiol in participant subgroups, differences by PNMS exposure failed to reach statistical significance, which may reflect insufficient statistical power. CONCLUSION: Both elevated maternal serum estradiol in males only and low maternal serum sex hormone binding globulin in both sexes are associated with increased autism risk. Further investigation is merited to identify how steroid, metabolic, and inflammatory processes can interact to influence neurodevelopment in early second trimester. En ligne : http://dx.doi.org/10.1186/s13229-023-00562-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513 [article] Sex-specific and sex-independent steroid-related biomarkers in early second trimester maternal serum associated with autism [Texte imprimé et/ou numérique] / Whitney WORSHAM, Auteur ; Scott SULLIVAN, Auteur ; M. Sean ESPLIN, Auteur ; Paul BURGHARDT, Auteur ; Alison FRASER, Auteur ; Amanda V. BAKIAN, Auteur . - 30 p. Langues : Anglais (eng) in Molecular Autism > 14 (2023) . - 30 p. Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal exposure to maternal metabolic conditions associated with inflammation and steroid dysregulation has previously been linked to increased autism risk. Steroid-related maternal serum biomarkers have also provided insight into the in utero steroid environment for offspring who develop autism. OBJECTIVE: This study examines the link between autism among offspring and early second trimester maternal steroid-related serum biomarkers from pregnancies enriched for prenatal metabolic syndrome (PNMS) exposure. STUDY DESIGN: Early second trimester maternal steroid-related serum biomarkers (i.e., estradiol, free testosterone, total testosterone, and sex hormone binding globulin) were compared between pregnancies corresponding to offspring with (N=68) and without (N=68) autism. Multiple logistic regression analyses were stratified by sex and gestational duration. One-way ANCOVA with post hoc tests was performed for groups defined by autism status and PNMS exposure. RESULTS: Increased estradiol was significantly associated with autism only in males (AOR=1.13 per 100 pg/ml, 95% CI 1.01-1.27, p=0.036) and only term pregnancies (AOR=1.17 per 100 pg/ml, 95% CI 1.04-1.32, p=0.010). Autism status was significantly associated with decreased sex hormone binding globulin (AOR=0.65 per 50 nmol/L, 95% CI 0.55-0.78, p<0.001) overall and when stratified by sex and term pregnancy status. The inverse association between sex hormone binding globulin and autism was independent of PNMS exposure. LIMITATIONS: The relative racial and ethnic homogeneity of Utah's population limits the generalizability of study results. Although significant differences by autism status were identified in concentrations of sex hormone binding globulin overall and of estradiol in participant subgroups, differences by PNMS exposure failed to reach statistical significance, which may reflect insufficient statistical power. CONCLUSION: Both elevated maternal serum estradiol in males only and low maternal serum sex hormone binding globulin in both sexes are associated with increased autism risk. Further investigation is merited to identify how steroid, metabolic, and inflammatory processes can interact to influence neurodevelopment in early second trimester. En ligne : http://dx.doi.org/10.1186/s13229-023-00562-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513

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