Editorial Perspective: From schizophrenia polygenic risk score to vulnerability (endo-)phenotypes: translational pathways in child and adolescent mental health / M. POLETTI in Journal of Child Psychology and Psychiatry, 59-7 (July 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-7 (July 2018) . - p.822-825 Titre : Editorial Perspective: From schizophrenia polygenic risk score to vulnerability (endo-)phenotypes: translational pathways in child and adolescent mental health Type de document : Texte imprimé et/ou numérique Auteurs : M. POLETTI, Auteur ; A. RABALLO, Auteur Article en page(s) : p.822-825 Langues : Anglais (eng) Mots-clés : Schizophrenia  development  phenotype  polygenic risk score  psychopathology  vulnerability Index. décimale : PER Périodiques Résumé : The Polygenic Risk Scores (PRS) approach is becoming increasingly prominent in psycho-behavioral research, however, its translational potential is still relatively underconceptualized. Indeed, PRS paradigm (which capitalizes on the combination of multiple genetic markers into a single proxy score to predict lifetime outcomes) has the potential to unravel some of the developmental complexities leading to severe mental disorders. With respect to schizophrenia, the application of PRS approach to child-adolescent cohorts from the general population, provides a crucial vantage point for understanding how presumed genetic predisposition is manifested during developmental years. Clearly, this is essential for etiological research as well as for the timely identification of the earliest stages of those specific psychopathological trajectories leading to psychosis. Therefore, the translational import of the PRS approach could improve our etiopathogenetic understanding of schizophrenia (e.g., allowing the disentanglement of the respective contribution of genetic and environmental risk factors along neurodevelopment) and further refine current staging models for early detection of vulnerability to psychosis (e.g., providing the rationale for more developmentally oriented reformulations of clinical high-risk criteria). En ligne : http://dx.doi.org/10.1111/jcpp.12857 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] Editorial Perspective: From schizophrenia polygenic risk score to vulnerability (endo-)phenotypes: translational pathways in child and adolescent mental health [Texte imprimé et/ou numérique] / M. POLETTI, Auteur ; A. RABALLO, Auteur . - p.822-825. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-7 (July 2018) . - p.822-825 Mots-clés : Schizophrenia  development  phenotype  polygenic risk score  psychopathology  vulnerability Index. décimale : PER Périodiques Résumé : The Polygenic Risk Scores (PRS) approach is becoming increasingly prominent in psycho-behavioral research, however, its translational potential is still relatively underconceptualized. Indeed, PRS paradigm (which capitalizes on the combination of multiple genetic markers into a single proxy score to predict lifetime outcomes) has the potential to unravel some of the developmental complexities leading to severe mental disorders. With respect to schizophrenia, the application of PRS approach to child-adolescent cohorts from the general population, provides a crucial vantage point for understanding how presumed genetic predisposition is manifested during developmental years. Clearly, this is essential for etiological research as well as for the timely identification of the earliest stages of those specific psychopathological trajectories leading to psychosis. Therefore, the translational import of the PRS approach could improve our etiopathogenetic understanding of schizophrenia (e.g., allowing the disentanglement of the respective contribution of genetic and environmental risk factors along neurodevelopment) and further refine current staging models for early detection of vulnerability to psychosis (e.g., providing the rationale for more developmentally oriented reformulations of clinical high-risk criteria). En ligne : http://dx.doi.org/10.1111/jcpp.12857 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

Editorial Perspective: Psychosis risk in adolescence - outcomes, comorbidity, and antipsychotics / A. RABALLO in Journal of Child Psychology and Psychiatry, 63-2 (February 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-2 (February 2022) . - p.241-244 Titre : Editorial Perspective: Psychosis risk in adolescence - outcomes, comorbidity, and antipsychotics Type de document : Texte imprimé et/ou numérique Auteurs : A. RABALLO, Auteur ; M. POLETTI, Auteur ; A. PRETI, Auteur Article en page(s) : p.241-244 Langues : Anglais (eng) Mots-clés : Psychosis  adolescence  childhood  clinical high-risk state for psychosis  evidence  first-episode  prediction  prevention  psychosis risk  schizophrenia Index. décimale : PER Périodiques Résumé : Research on Clinical High-Risk for Psychosis (CHR-P) has led to a vigorous change in the field of early detection in psychiatry and is gradually expanding its focus toward early development. The Annual Research Review on psychosis risk in adolescents (Journal of Child Psychology and Psychiatry, 62, 2020 and 657) offers a wide-angle meta-analytical picture of such emerging trends in all areas relevant to CHR-P Research, that is, detection, prognosis, and intervention. This editorial perspective is meant to expand the clinical and conceptual reach of these meta-analytic findings in relation to (a) the influence of age on transition rate and scalability of the early detection model across the child-adolescent vs adult periods; (b) potential latent heterogeneity of the pathogenetic trajectories leading to CHR-P as suggested by comorbid psychopathologies; (c) controversial (or at least problematic) prognostic significance of antipsychotic exposure in CHR-P subjects, especially in children and adolescents. En ligne : http://dx.doi.org/10.1111/jcpp.13438 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] Editorial Perspective: Psychosis risk in adolescence - outcomes, comorbidity, and antipsychotics [Texte imprimé et/ou numérique] / A. RABALLO, Auteur ; M. POLETTI, Auteur ; A. PRETI, Auteur . - p.241-244. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-2 (February 2022) . - p.241-244 Mots-clés : Psychosis  adolescence  childhood  clinical high-risk state for psychosis  evidence  first-episode  prediction  prevention  psychosis risk  schizophrenia Index. décimale : PER Périodiques Résumé : Research on Clinical High-Risk for Psychosis (CHR-P) has led to a vigorous change in the field of early detection in psychiatry and is gradually expanding its focus toward early development. The Annual Research Review on psychosis risk in adolescents (Journal of Child Psychology and Psychiatry, 62, 2020 and 657) offers a wide-angle meta-analytical picture of such emerging trends in all areas relevant to CHR-P Research, that is, detection, prognosis, and intervention. This editorial perspective is meant to expand the clinical and conceptual reach of these meta-analytic findings in relation to (a) the influence of age on transition rate and scalability of the early detection model across the child-adolescent vs adult periods; (b) potential latent heterogeneity of the pathogenetic trajectories leading to CHR-P as suggested by comorbid psychopathologies; (c) controversial (or at least problematic) prognostic significance of antipsychotic exposure in CHR-P subjects, especially in children and adolescents. En ligne : http://dx.doi.org/10.1111/jcpp.13438 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

Editorial Perspective: Rethinking child and adolescent mental health care after COVID-19 / A. RABALLO in Journal of Child Psychology and Psychiatry, 62-9 (September 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-9 (September 2021) . - p.1067-1069 Titre : Editorial Perspective: Rethinking child and adolescent mental health care after COVID-19 Type de document : Texte imprimé et/ou numérique Auteurs : A. RABALLO, Auteur ; M. POLETTI, Auteur ; L. VALMAGGIA, Auteur ; P. D. MCGORRY, Auteur Article en page(s) : p.1067-1069 Langues : Anglais (eng) Mots-clés : Adolescent  Adolescent Psychiatry/trends  COVID-19/epidemiology  Child  Child Psychiatry/trends  Humans  Mental Health Services/trends  Pandemics  Social Isolation Index. décimale : PER Périodiques Résumé : While COVID-19 pandemic has allegedly passed its first peak in most western countries, health systems are progressively adapting to the 'new normality'. In child and adolescent mental health services (CAMHS), such organizational envisioning is needed to cope with the foreseeable psychological effects of prolonged social isolation induced by nation-wide public health measures such as school closure. CAMHS need to ensure flexible responses to the psychopathological consequences of evolving societal dynamics, as dramatically actualized by the unexpected COVID-19 pandemic. This would imply (a) shifting the focus of intervention from symptom reduction and containment of acute crises in a comparatively small number of severe cases to a broader preventive strategy, guided by a gradient of increasing intensity and specificity of treatment; (b) promoting smooth access pathways into services and encouraging participation of families; (c) adopting a transdiagnostic staging model to capture the developmental fluctuations from subsyndromal to syndromal states and back, with related changes in the intensity of the need of care; and (d) implementing digital tools to encourage help-seeking and compliance by digitally native youth. En ligne : http://dx.doi.org/10.1111/jcpp.13371 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Editorial Perspective: Rethinking child and adolescent mental health care after COVID-19 [Texte imprimé et/ou numérique] / A. RABALLO, Auteur ; M. POLETTI, Auteur ; L. VALMAGGIA, Auteur ; P. D. MCGORRY, Auteur . - p.1067-1069. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-9 (September 2021) . - p.1067-1069 Mots-clés : Adolescent  Adolescent Psychiatry/trends  COVID-19/epidemiology  Child  Child Psychiatry/trends  Humans  Mental Health Services/trends  Pandemics  Social Isolation Index. décimale : PER Périodiques Résumé : While COVID-19 pandemic has allegedly passed its first peak in most western countries, health systems are progressively adapting to the 'new normality'. In child and adolescent mental health services (CAMHS), such organizational envisioning is needed to cope with the foreseeable psychological effects of prolonged social isolation induced by nation-wide public health measures such as school closure. CAMHS need to ensure flexible responses to the psychopathological consequences of evolving societal dynamics, as dramatically actualized by the unexpected COVID-19 pandemic. This would imply (a) shifting the focus of intervention from symptom reduction and containment of acute crises in a comparatively small number of severe cases to a broader preventive strategy, guided by a gradient of increasing intensity and specificity of treatment; (b) promoting smooth access pathways into services and encouraging participation of families; (c) adopting a transdiagnostic staging model to capture the developmental fluctuations from subsyndromal to syndromal states and back, with related changes in the intensity of the need of care; and (d) implementing digital tools to encourage help-seeking and compliance by digitally native youth. En ligne : http://dx.doi.org/10.1111/jcpp.13371 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

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