Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults / Jinni SU in Development and Psychopathology, 36-4 (October 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-4 (October 2024) . - p.1763-1775 Titre : Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults Type de document : Texte imprimé et/ou numérique Auteurs : Jinni SU, Auteur ; Sally I. Chun KUO, Auteur ; Fazil ALIEV, Auteur ; Jill A. RABINOWITZ, Auteur ; Belal JAMIL, Auteur ; Grace CHAN, Auteur ; Howard J. EDENBERG, Auteur ; Meredith FRANCIS, Auteur ; Victor HESSELBROCK, Auteur ; Chella KAMARAJAN, Auteur ; Sivan KINREICH, Auteur ; John KRAMER, Auteur ; Donbing LAI, Auteur ; Vivia MCCUTCHEON, Auteur ; Jacquelyn MEYERS, Auteur ; Ashwini PANDEY, Auteur ; Gayathri PANDEY, Auteur ; Martin H. PLAWECKI, Auteur ; Marc SCHUCKIT, Auteur ; Jay TISCHFIELD, Auteur ; Danielle M. DICK, Auteur Article en page(s) : p.1763-1775 Langues : Anglais (eng) Mots-clés : COGA  alcohol use  gene-environment interaction  polygenic scores  social support Index. décimale : PER Périodiques Résumé : Alcohol use is influenced by genetic and environmental factors. We examined the interactive effects between genome-wide polygenic risk scores for alcohol use (alc-PRS) and social support in relation to alcohol use among European American (EA) and African American (AA) adults across sex and developmental stages (emerging adulthood, young adulthood, and middle adulthood). Data were drawn from 4,011 EA and 1,274 AA adults from the Collaborative Study on the Genetics of Alcoholism who were between ages 18-65 and had ever used alcohol. Participants completed the Semi-Structured Assessment for the Genetics of Alcoholism and provided saliva or blood samples for genotyping. Results indicated that social support from friends, but not family, moderated the association between alc-PRS and alcohol use among EAs and AAs (only in middle adulthood for AAs); alc-PRS was associated with higher levels of alcohol use when friend support was low, but not when friend support was high. Associations were similar across sex but differed across developmental stages. Findings support the important role of social support from friends in buffering genetic risk for alcohol use among EA and AA adults and highlight the need to consider developmental changes in the role of social support in relation to alcohol use. En ligne : https://dx.doi.org/10.1017/S0954579423001141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539 [article] Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults [Texte imprimé et/ou numérique] / Jinni SU, Auteur ; Sally I. Chun KUO, Auteur ; Fazil ALIEV, Auteur ; Jill A. RABINOWITZ, Auteur ; Belal JAMIL, Auteur ; Grace CHAN, Auteur ; Howard J. EDENBERG, Auteur ; Meredith FRANCIS, Auteur ; Victor HESSELBROCK, Auteur ; Chella KAMARAJAN, Auteur ; Sivan KINREICH, Auteur ; John KRAMER, Auteur ; Donbing LAI, Auteur ; Vivia MCCUTCHEON, Auteur ; Jacquelyn MEYERS, Auteur ; Ashwini PANDEY, Auteur ; Gayathri PANDEY, Auteur ; Martin H. PLAWECKI, Auteur ; Marc SCHUCKIT, Auteur ; Jay TISCHFIELD, Auteur ; Danielle M. DICK, Auteur . - p.1763-1775. Langues : Anglais (eng) in Development and Psychopathology > 36-4 (October 2024) . - p.1763-1775 Mots-clés : COGA  alcohol use  gene-environment interaction  polygenic scores  social support Index. décimale : PER Périodiques Résumé : Alcohol use is influenced by genetic and environmental factors. We examined the interactive effects between genome-wide polygenic risk scores for alcohol use (alc-PRS) and social support in relation to alcohol use among European American (EA) and African American (AA) adults across sex and developmental stages (emerging adulthood, young adulthood, and middle adulthood). Data were drawn from 4,011 EA and 1,274 AA adults from the Collaborative Study on the Genetics of Alcoholism who were between ages 18-65 and had ever used alcohol. Participants completed the Semi-Structured Assessment for the Genetics of Alcoholism and provided saliva or blood samples for genotyping. Results indicated that social support from friends, but not family, moderated the association between alc-PRS and alcohol use among EAs and AAs (only in middle adulthood for AAs); alc-PRS was associated with higher levels of alcohol use when friend support was low, but not when friend support was high. Associations were similar across sex but differed across developmental stages. Findings support the important role of social support from friends in buffering genetic risk for alcohol use among EA and AA adults and highlight the need to consider developmental changes in the role of social support in relation to alcohol use. En ligne : https://dx.doi.org/10.1017/S0954579423001141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539

Examining interactions between genetic risk for alcohol problems, peer deviance, and interpersonal traumatic events on trajectories of alcohol use disorder symptoms among African American college students / Jinni SU in Development and Psychopathology, 30-5 (December 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-5 (December 2018) . - p.1749-1761 Titre : Examining interactions between genetic risk for alcohol problems, peer deviance, and interpersonal traumatic events on trajectories of alcohol use disorder symptoms among African American college students Type de document : Texte imprimé et/ou numérique Auteurs : Jinni SU, Auteur ; Sally I. Chun KUO, Auteur ; Jacquelyn L. MEYERS, Auteur ; Mignonne C. GUY, Auteur ; Danielle M. DICK, Auteur Article en page(s) : p.1749-1761 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Numerous studies have demonstrated that genetic and environmental factors interact to influence alcohol problems. Yet prior research has primarily focused on samples of European descent and little is known about gene–environment interactions in relation to alcohol problems in non-European populations. In this study, we examined whether and how genetic risk for alcohol problems and peer deviance and interpersonal traumatic events independently and interactively influence trajectories of alcohol use disorder symptoms in a sample of African American students across the college years (N = 1,119; Mage = 18.44 years). Data were drawn from the Spit for Science study where participants completed multiple online surveys throughout college and provided a saliva sample for genotyping. Multilevel growth curve analyses indicated that alcohol dependence genome-wide polygenic risk scores did not predict trajectory of alcohol use disorder symptoms, while family history of alcohol problems was associated with alcohol use disorder symptoms at the start of college but not with the rate of change in symptoms over time. Peer deviance and interpersonal traumatic events were associated with more alcohol use disorder symptoms across college years. Neither alcohol dependence genome-wide polygenic risk scores nor family history of alcohol problems moderated the effects of these environmental risk factors on alcohol use disorder symptoms. Our findings indicated that peer deviance and experience of interpersonal traumatic events are salient risk factors that elevate risk for alcohol problems among African American college students. Family history of alcohol problems could be a useful indicator of genetic risk for alcohol problems. Gene identification efforts with much larger samples of African descent are needed to better characterize genetic risk for alcohol use disorders, in order to better understand gene–environment interaction processes in this understudied population. En ligne : http://dx.doi.org/10.1017/S0954579418000962 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370 [article] Examining interactions between genetic risk for alcohol problems, peer deviance, and interpersonal traumatic events on trajectories of alcohol use disorder symptoms among African American college students [Texte imprimé et/ou numérique] / Jinni SU, Auteur ; Sally I. Chun KUO, Auteur ; Jacquelyn L. MEYERS, Auteur ; Mignonne C. GUY, Auteur ; Danielle M. DICK, Auteur . - p.1749-1761. Langues : Anglais (eng) in Development and Psychopathology > 30-5 (December 2018) . - p.1749-1761 Index. décimale : PER Périodiques Résumé : Numerous studies have demonstrated that genetic and environmental factors interact to influence alcohol problems. Yet prior research has primarily focused on samples of European descent and little is known about gene–environment interactions in relation to alcohol problems in non-European populations. In this study, we examined whether and how genetic risk for alcohol problems and peer deviance and interpersonal traumatic events independently and interactively influence trajectories of alcohol use disorder symptoms in a sample of African American students across the college years (N = 1,119; Mage = 18.44 years). Data were drawn from the Spit for Science study where participants completed multiple online surveys throughout college and provided a saliva sample for genotyping. Multilevel growth curve analyses indicated that alcohol dependence genome-wide polygenic risk scores did not predict trajectory of alcohol use disorder symptoms, while family history of alcohol problems was associated with alcohol use disorder symptoms at the start of college but not with the rate of change in symptoms over time. Peer deviance and interpersonal traumatic events were associated with more alcohol use disorder symptoms across college years. Neither alcohol dependence genome-wide polygenic risk scores nor family history of alcohol problems moderated the effects of these environmental risk factors on alcohol use disorder symptoms. Our findings indicated that peer deviance and experience of interpersonal traumatic events are salient risk factors that elevate risk for alcohol problems among African American college students. Family history of alcohol problems could be a useful indicator of genetic risk for alcohol problems. Gene identification efforts with much larger samples of African descent are needed to better characterize genetic risk for alcohol use disorders, in order to better understand gene–environment interaction processes in this understudied population. En ligne : http://dx.doi.org/10.1017/S0954579418000962 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370

Latent trajectories of alcohol use from early adolescence to young adulthood: Interaction effects between 5-HTTLPR and parenting quality and gender differences / Jinni SU in Development and Psychopathology, 31-2 (May 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-2 (May 2019) . - p.457-469 Titre : Latent trajectories of alcohol use from early adolescence to young adulthood: Interaction effects between 5-HTTLPR and parenting quality and gender differences Type de document : Texte imprimé et/ou numérique Auteurs : Jinni SU, Auteur ; Andrew J. SUPPLE, Auteur ; Esther M. LEERKES, Auteur ; Sally I. Chun KUO, Auteur Article en page(s) : p.457-469 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Using a large and nationally representative sample, we examined how adolescents’ 5-HTTLPR genotype and perceived parenting quality independently and interactively associated with trajectories of alcohol use from early adolescence to young adulthood and whether/how gender may moderate these associations. The sample for this study included 13,749 adolescents (53.3% female; 56.3% non-Hispanic White, 21.5% Black, 16.0% Hispanic, and 6.1% Asian) followed prospectively from adolescence to young adulthood. Using growth mixture modeling, we identified four distinct trajectories of alcohol use (i.e., persistent heavy alcohol use, developmentally limited alcohol use, late-onset heavy alcohol use, and non/light alcohol use). Results indicated that the short allele of 5-HTTLPR was associated with higher risk of membership in the persistent and the late-onset heavy alcohol use trajectories. Parenting quality was associated with lower likelihoods of following the persistent heavy and the developmentally limited alcohol use trajectories but was not associated with risk of membership for the late-onset heavy drinking trajectory. 5-HTTLPR interacted with parenting quality to predict membership in the persistent heavy alcohol use trajectory for males but not for females. Findings highlighted the importance of considering the heterogeneity in trajectories of alcohol use across development and gender in the study of Gene Environment interactions in alcohol use. En ligne : http://dx.doi.org/10.1017/S095457941800024X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393 [article] Latent trajectories of alcohol use from early adolescence to young adulthood: Interaction effects between 5-HTTLPR and parenting quality and gender differences [Texte imprimé et/ou numérique] / Jinni SU, Auteur ; Andrew J. SUPPLE, Auteur ; Esther M. LEERKES, Auteur ; Sally I. Chun KUO, Auteur . - p.457-469. Langues : Anglais (eng) in Development and Psychopathology > 31-2 (May 2019) . - p.457-469 Index. décimale : PER Périodiques Résumé : Using a large and nationally representative sample, we examined how adolescents’ 5-HTTLPR genotype and perceived parenting quality independently and interactively associated with trajectories of alcohol use from early adolescence to young adulthood and whether/how gender may moderate these associations. The sample for this study included 13,749 adolescents (53.3% female; 56.3% non-Hispanic White, 21.5% Black, 16.0% Hispanic, and 6.1% Asian) followed prospectively from adolescence to young adulthood. Using growth mixture modeling, we identified four distinct trajectories of alcohol use (i.e., persistent heavy alcohol use, developmentally limited alcohol use, late-onset heavy alcohol use, and non/light alcohol use). Results indicated that the short allele of 5-HTTLPR was associated with higher risk of membership in the persistent and the late-onset heavy alcohol use trajectories. Parenting quality was associated with lower likelihoods of following the persistent heavy and the developmentally limited alcohol use trajectories but was not associated with risk of membership for the late-onset heavy drinking trajectory. 5-HTTLPR interacted with parenting quality to predict membership in the persistent heavy alcohol use trajectory for males but not for females. Findings highlighted the importance of considering the heterogeneity in trajectories of alcohol use across development and gender in the study of Gene Environment interactions in alcohol use. En ligne : http://dx.doi.org/10.1017/S095457941800024X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393

A systematic review of gene-by-intervention studies of alcohol and other substance use / Zoe E. NEALE in Development and Psychopathology, 33-4 (October 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-4 (October 2021) . - p.1410-1427 Titre : A systematic review of gene-by-intervention studies of alcohol and other substance use Type de document : Texte imprimé et/ou numérique Auteurs : Zoe E. NEALE, Auteur ; Sally I. Chun KUO, Auteur ; Danielle M. DICK, Auteur Article en page(s) : p.1410-1427 Langues : Anglais (eng) Mots-clés : alcohol  G×I  gene-by-intervention  prevention  substance use Index. décimale : PER Périodiques Résumé : Alcohol and other substance use problems are common, and the efficacy of current prevention and intervention programs is limited. Genetics may contribute to differential effectiveness of psychosocial prevention and intervention programs. This paper reviews gene-by-intervention (G×I) studies of alcohol and other substance use, and implications for integrating genetics into prevention science. Systematic review yielded 17 studies for inclusion. Most studies focused on youth substance prevention, alcohol was the most common outcome, and measures of genotype were heterogeneous. All studies reported at least one significant G×I interaction. We discuss these findings in the context of the history and current state of genetics, and provide recommendations for future G×I research. These include the integration of genome-wide polygenic scores into prevention studies, broad outcome measurement, recruitment of underrepresented populations, testing mediators of G×I effects, and addressing ethical implications. Integrating genetic research into prevention science, and training researchers to work fluidly across these fields, will enhance our ability to determine the best intervention for each individual across development. With growing public interest in obtaining personalized genetic information, we anticipate that the integration of genetics and prevention science will become increasingly important as we move into the era of precision medicine. En ligne : http://dx.doi.org/10.1017/S0954579420000590 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] A systematic review of gene-by-intervention studies of alcohol and other substance use [Texte imprimé et/ou numérique] / Zoe E. NEALE, Auteur ; Sally I. Chun KUO, Auteur ; Danielle M. DICK, Auteur . - p.1410-1427. Langues : Anglais (eng) in Development and Psychopathology > 33-4 (October 2021) . - p.1410-1427 Mots-clés : alcohol  G×I  gene-by-intervention  prevention  substance use Index. décimale : PER Périodiques Résumé : Alcohol and other substance use problems are common, and the efficacy of current prevention and intervention programs is limited. Genetics may contribute to differential effectiveness of psychosocial prevention and intervention programs. This paper reviews gene-by-intervention (G×I) studies of alcohol and other substance use, and implications for integrating genetics into prevention science. Systematic review yielded 17 studies for inclusion. Most studies focused on youth substance prevention, alcohol was the most common outcome, and measures of genotype were heterogeneous. All studies reported at least one significant G×I interaction. We discuss these findings in the context of the history and current state of genetics, and provide recommendations for future G×I research. These include the integration of genome-wide polygenic scores into prevention studies, broad outcome measurement, recruitment of underrepresented populations, testing mediators of G×I effects, and addressing ethical implications. Integrating genetic research into prevention science, and training researchers to work fluidly across these fields, will enhance our ability to determine the best intervention for each individual across development. With growing public interest in obtaining personalized genetic information, we anticipate that the integration of genetics and prevention science will become increasingly important as we move into the era of precision medicine. En ligne : http://dx.doi.org/10.1017/S0954579420000590 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

The role of adolescent social relationships in promoting alcohol resistance: Interrupting the intergenerational transmission of alcohol misuse / Mallory STEPHENSON in Development and Psychopathology, 34-5 (December 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-5 (December 2022) . - p.1841-1855 Titre : The role of adolescent social relationships in promoting alcohol resistance: Interrupting the intergenerational transmission of alcohol misuse Type de document : Texte imprimé et/ou numérique Auteurs : Mallory STEPHENSON, Auteur ; Fazil ALIEV, Auteur ; Sally I. Chun KUO, Auteur ; Alexis C. EDWARDS, Auteur ; Gayathri PANDEY, Auteur ; Jinni SU, Auteur ; Chella KAMARAJAN, Auteur ; Danielle DICK, Auteur ; Jessica E. SALVATORE, Auteur Article en page(s) : p.1841-1855 Langues : Anglais (eng) Mots-clés : adolescence  alcohol  parenting  peer relationships  resistance Index. décimale : PER Périodiques Résumé : Genetic factors contribute to the intergenerational transmission of alcohol misuse, but not all individuals at high genetic risk develop problems. The present study examined adolescent relationships with parents, peers, and romantic partners as predictors of realized resistance, defined as high biological risk for disorder combined with a healthy outcome, to alcohol initiation, heavy episodic drinking, and alcohol use disorder (AUD). Data were from the Collaborative Study on the Genetics of Alcoholism (N = 1,858; 49.9% female; mean age at baseline = 13.91 years). Genetic risk, indexed using family history density and polygenic risk scores for alcohol problems and AUD, was used to define alcohol resistance. Adolescent predictors included parent-child relationship quality, parental monitoring, peer drinking, romantic partner drinking, and social competence. There was little support for the hypothesis that social relationship factors would promote alcohol resistance, with the exception that higher father-child relationship quality was associated with higher resistance to alcohol initiation ( $$\hat \beta $$ = â’0.19, 95% CI = â’0.35, â’0.03). Unexpectedly, social competence was associated with lower resistance to heavy episodic drinking ( $$\hat \beta $$ = 0.10, 95% CI = 0.01, 0.20). This pattern of largely null effects underscores how little is known about resistance processes among those at high genetic risk for AUD. En ligne : http://dx.doi.org/10.1017/S0954579422000785 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 [article] The role of adolescent social relationships in promoting alcohol resistance: Interrupting the intergenerational transmission of alcohol misuse [Texte imprimé et/ou numérique] / Mallory STEPHENSON, Auteur ; Fazil ALIEV, Auteur ; Sally I. Chun KUO, Auteur ; Alexis C. EDWARDS, Auteur ; Gayathri PANDEY, Auteur ; Jinni SU, Auteur ; Chella KAMARAJAN, Auteur ; Danielle DICK, Auteur ; Jessica E. SALVATORE, Auteur . - p.1841-1855. Langues : Anglais (eng) in Development and Psychopathology > 34-5 (December 2022) . - p.1841-1855 Mots-clés : adolescence  alcohol  parenting  peer relationships  resistance Index. décimale : PER Périodiques Résumé : Genetic factors contribute to the intergenerational transmission of alcohol misuse, but not all individuals at high genetic risk develop problems. The present study examined adolescent relationships with parents, peers, and romantic partners as predictors of realized resistance, defined as high biological risk for disorder combined with a healthy outcome, to alcohol initiation, heavy episodic drinking, and alcohol use disorder (AUD). Data were from the Collaborative Study on the Genetics of Alcoholism (N = 1,858; 49.9% female; mean age at baseline = 13.91 years). Genetic risk, indexed using family history density and polygenic risk scores for alcohol problems and AUD, was used to define alcohol resistance. Adolescent predictors included parent-child relationship quality, parental monitoring, peer drinking, romantic partner drinking, and social competence. There was little support for the hypothesis that social relationship factors would promote alcohol resistance, with the exception that higher father-child relationship quality was associated with higher resistance to alcohol initiation ( $$\hat \beta $$ = â’0.19, 95% CI = â’0.35, â’0.03). Unexpectedly, social competence was associated with lower resistance to heavy episodic drinking ( $$\hat \beta $$ = 0.10, 95% CI = 0.01, 0.20). This pattern of largely null effects underscores how little is known about resistance processes among those at high genetic risk for AUD. En ligne : http://dx.doi.org/10.1017/S0954579422000785 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492

The role of parental genotype in the intergenerational transmission of externalizing behavior: Evidence for genetic nurturance / Sally I. Chun KUO in Development and Psychopathology, 34-5 (December 2022)  

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