Associations between parental broader autism phenotype and child autism spectrum disorder phenotype in the Study to Explore Early Development / E. RUBENSTEIN in Autism, 23-2 (February 2019)  

Public ISBD [article]  inAutism > 23-2 (February 2019) . - p.436-448 Titre : Associations between parental broader autism phenotype and child autism spectrum disorder phenotype in the Study to Explore Early Development Type de document : Texte imprimé et/ou numérique Auteurs : E. RUBENSTEIN, Auteur ; Lisa D. WIGGINS, Auteur ; Laura A. SCHIEVE, Auteur ; C. BRADLEY, Auteur ; Carolyn G. DIGUISEPPI, Auteur ; E. MOODY, Auteur ; J. PANDEY, Auteur ; R. E. PRETZEL, Auteur ; A. G. HOWARD, Auteur ; A. F. OLSHAN, Auteur ; B. W. PENCE, Auteur ; J. DANIELS, Auteur Article en page(s) : p.436-448 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  broader autism phenotype  endophenotypes  subgrouping Index. décimale : PER Périodiques Résumé : The autism spectrum disorder phenotype varies by social and communication ability and co-occurring developmental, behavioral, and medical conditions. Etiology is also diverse, with myriad potential genetic origins and environmental risk factors. Examining the influence of parental broader autism phenotype-a set of sub-clinical characteristics of autism spectrum disorder-on child autism spectrum disorder phenotypes may help reduce heterogeneity in potential genetic predisposition for autism spectrum disorder. We assessed the associations between parental broader autism phenotype and child phenotype among children of age 30-68 months enrolled in the Study to Explore Early Development (N = 707). Child autism spectrum disorder phenotype was defined by a replication of latent classes derived from multiple developmental and behavioral measures: Mild Language Delay with Cognitive Rigidity, Mild Language and Motor Delay with Dysregulation (e.g. anxiety/depression), General Developmental Delay, and Significant Developmental Delay with Repetitive Motor Behaviors. Scores on the Social Responsiveness Scale-Adult measured parent broader autism phenotype. Broader autism phenotype in at least one parent was associated with a child having increased odds of being classified as mild language and motor delay with dysregulation compared to significant developmental delay with repetitive motor behaviors (odds ratio: 2.44; 95% confidence interval: 1.16, 5.09). Children of parents with broader autism phenotype were more likely to have a phenotype qualitatively similar to broader autism phenotype presentation; this may have implications for etiologic research. En ligne : http://dx.doi.org/10.1177/1362361317753563 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383 [article] Associations between parental broader autism phenotype and child autism spectrum disorder phenotype in the Study to Explore Early Development [Texte imprimé et/ou numérique] / E. RUBENSTEIN, Auteur ; Lisa D. WIGGINS, Auteur ; Laura A. SCHIEVE, Auteur ; C. BRADLEY, Auteur ; Carolyn G. DIGUISEPPI, Auteur ; E. MOODY, Auteur ; J. PANDEY, Auteur ; R. E. PRETZEL, Auteur ; A. G. HOWARD, Auteur ; A. F. OLSHAN, Auteur ; B. W. PENCE, Auteur ; J. DANIELS, Auteur . - p.436-448. Langues : Anglais (eng) in Autism > 23-2 (February 2019) . - p.436-448 Mots-clés : autism spectrum disorder  broader autism phenotype  endophenotypes  subgrouping Index. décimale : PER Périodiques Résumé : The autism spectrum disorder phenotype varies by social and communication ability and co-occurring developmental, behavioral, and medical conditions. Etiology is also diverse, with myriad potential genetic origins and environmental risk factors. Examining the influence of parental broader autism phenotype-a set of sub-clinical characteristics of autism spectrum disorder-on child autism spectrum disorder phenotypes may help reduce heterogeneity in potential genetic predisposition for autism spectrum disorder. We assessed the associations between parental broader autism phenotype and child phenotype among children of age 30-68 months enrolled in the Study to Explore Early Development (N = 707). Child autism spectrum disorder phenotype was defined by a replication of latent classes derived from multiple developmental and behavioral measures: Mild Language Delay with Cognitive Rigidity, Mild Language and Motor Delay with Dysregulation (e.g. anxiety/depression), General Developmental Delay, and Significant Developmental Delay with Repetitive Motor Behaviors. Scores on the Social Responsiveness Scale-Adult measured parent broader autism phenotype. Broader autism phenotype in at least one parent was associated with a child having increased odds of being classified as mild language and motor delay with dysregulation compared to significant developmental delay with repetitive motor behaviors (odds ratio: 2.44; 95% confidence interval: 1.16, 5.09). Children of parents with broader autism phenotype were more likely to have a phenotype qualitatively similar to broader autism phenotype presentation; this may have implications for etiologic research. En ligne : http://dx.doi.org/10.1177/1362361317753563 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383

Brief Report: Maternal Opioid Prescription from Preconception Through Pregnancy and the Odds of Autism Spectrum Disorder and Autism Features in Children / E. RUBENSTEIN in Journal of Autism and Developmental Disorders, 49-1 (January 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.376-382 Titre : Brief Report: Maternal Opioid Prescription from Preconception Through Pregnancy and the Odds of Autism Spectrum Disorder and Autism Features in Children Type de document : Texte imprimé et/ou numérique Auteurs : E. RUBENSTEIN, Auteur ; J. C. YOUNG, Auteur ; Lisa A. CROEN, Auteur ; Carolyn G. DIGUISEPPI, Auteur ; N. F. DOWLING, Auteur ; L. C. LEE, Auteur ; Laura A. SCHIEVE, Auteur ; Lisa D. WIGGINS, Auteur ; J. DANIELS, Auteur Article en page(s) : p.376-382 Langues : Anglais (eng) Mots-clés : Asd  Developmental disorder  Opioid  Pregnancy  Risk factor Index. décimale : PER Périodiques Résumé : Opioid use during pregnancy is associated with suboptimal pregnancy outcomes. Little is known about child neurodevelopmental outcomes. We examined associations between maternal opioid prescriptions preconception to delivery (peri-pregnancy) and child's risk of ASD, developmental delay/disorder (DD) with no ASD features, or ASD/DD with autism features in the Study to Explore Early Development, a case-control study of neurodevelopment. Preconception opioid prescription was associated with 2.43 times the odds of ASD [95% confidence interval (CI) 0.99, 6.02] and 2.64 times the odds of ASD/DD with autism features (95% CI 1.10, 6.31) compared to mothers without prescriptions. Odds for ASD and ASD/DD were non-significantly elevated for first trimester prescriptions. Work exploring mechanisms and timing between peri-pregnancy opioid use and child neurodevelopment is needed. En ligne : http://dx.doi.org/10.1007/s10803-018-3721-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377 [article] Brief Report: Maternal Opioid Prescription from Preconception Through Pregnancy and the Odds of Autism Spectrum Disorder and Autism Features in Children [Texte imprimé et/ou numérique] / E. RUBENSTEIN, Auteur ; J. C. YOUNG, Auteur ; Lisa A. CROEN, Auteur ; Carolyn G. DIGUISEPPI, Auteur ; N. F. DOWLING, Auteur ; L. C. LEE, Auteur ; Laura A. SCHIEVE, Auteur ; Lisa D. WIGGINS, Auteur ; J. DANIELS, Auteur . - p.376-382. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.376-382 Mots-clés : Asd  Developmental disorder  Opioid  Pregnancy  Risk factor Index. décimale : PER Périodiques Résumé : Opioid use during pregnancy is associated with suboptimal pregnancy outcomes. Little is known about child neurodevelopmental outcomes. We examined associations between maternal opioid prescriptions preconception to delivery (peri-pregnancy) and child's risk of ASD, developmental delay/disorder (DD) with no ASD features, or ASD/DD with autism features in the Study to Explore Early Development, a case-control study of neurodevelopment. Preconception opioid prescription was associated with 2.43 times the odds of ASD [95% confidence interval (CI) 0.99, 6.02] and 2.64 times the odds of ASD/DD with autism features (95% CI 1.10, 6.31) compared to mothers without prescriptions. Odds for ASD and ASD/DD were non-significantly elevated for first trimester prescriptions. Work exploring mechanisms and timing between peri-pregnancy opioid use and child neurodevelopment is needed. En ligne : http://dx.doi.org/10.1007/s10803-018-3721-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377

Correction to: Brief Report: Maternal Opioid Prescription from Preconception Through Pregnancy and the Odds of Autism Spectrum Disorder and Autism Features in Children / E. RUBENSTEIN in Journal of Autism and Developmental Disorders, 49-1 (January 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.383-384 Titre : Correction to: Brief Report: Maternal Opioid Prescription from Preconception Through Pregnancy and the Odds of Autism Spectrum Disorder and Autism Features in Children Type de document : Texte imprimé et/ou numérique Auteurs : E. RUBENSTEIN, Auteur ; J. C. YOUNG, Auteur ; Lisa A. CROEN, Auteur ; Carolyn G. DIGUISEPPI, Auteur ; N. F. DOWLING, Auteur ; L. C. LEE, Auteur ; Laura A. SCHIEVE, Auteur ; Lisa D. WIGGINS, Auteur ; J. DANIELS, Auteur Article en page(s) : p.383-384 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The original version of this article unfortunately contained a mistake in Table 2. The "Time of use" should be the column header with the corresponding row with "N = 126" belonging to the "Peri-pregnancy" row. The "Preconception" row should be the row with "N = 17", "Trimester 1" should be the "N = 29" row, "Trimester 2" should be the "N = 25" row, and "Trimester 3" should be the "N = 47" row. En ligne : http://dx.doi.org/10.1007/s10803-018-3746-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377 [article] Correction to: Brief Report: Maternal Opioid Prescription from Preconception Through Pregnancy and the Odds of Autism Spectrum Disorder and Autism Features in Children [Texte imprimé et/ou numérique] / E. RUBENSTEIN, Auteur ; J. C. YOUNG, Auteur ; Lisa A. CROEN, Auteur ; Carolyn G. DIGUISEPPI, Auteur ; N. F. DOWLING, Auteur ; L. C. LEE, Auteur ; Laura A. SCHIEVE, Auteur ; Lisa D. WIGGINS, Auteur ; J. DANIELS, Auteur . - p.383-384. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.383-384 Index. décimale : PER Périodiques Résumé : The original version of this article unfortunately contained a mistake in Table 2. The "Time of use" should be the column header with the corresponding row with "N = 126" belonging to the "Peri-pregnancy" row. The "Preconception" row should be the row with "N = 17", "Trimester 1" should be the "N = 29" row, "Trimester 2" should be the "N = 25" row, and "Trimester 3" should be the "N = 47" row. En ligne : http://dx.doi.org/10.1007/s10803-018-3746-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377

Is the Autism Boom Headed for Medicaid? Patterns in the Enrollment of Autistic Adults in Wisconsin Medicaid, 2008-2018 / E. RUBENSTEIN in Autism Research, 12-10 (October 2019)  

Public ISBD [article]  inAutism Research > 12-10 (October 2019) . - p.1541-1550 Titre : Is the Autism Boom Headed for Medicaid? Patterns in the Enrollment of Autistic Adults in Wisconsin Medicaid, 2008-2018 Type de document : Texte imprimé et/ou numérique Auteurs : E. RUBENSTEIN, Auteur ; Lauren BISHOP, Auteur Article en page(s) : p.1541-1550 Langues : Anglais (eng) Mots-clés : Medicaid  autism spectrum disorder  enrollment  health service  intellectual disability  longitudinal Index. décimale : PER Périodiques Résumé : Our primary objective was to describe demographic characteristics and enrollment patterns in a unique 11-year full sample of adult Wisconsin Medicaid beneficiaries with identified autism spectrum disorder (ASD) or intellectual disability (ID). We obtained de-identified Medicaid claims data for adults with a recorded ASD or ID diagnosis aged 21 and older with any Medicaid fee-for-service claims between January 1, 2008 and December 31, 2018. We assessed enrollment, age, number of visits, and paid amount per year using generalized linear models with a random intercept for each beneficiary. We identified claims for 4,775 autistic adults without ID, 2,738 autistic adults with ID, 14,945 adults with ID, and 3,484 adults with Down syndrome. The age distribution of the diagnostic group with ASD diagnoses was right skewed with a majority of beneficiaries less than age 30. The ASD without ID diagnostic group had the least visits and paid amount per person per year compared to other groups. In each age category, the ASD with ID diagnostic group had the most paid amount per person per year compared to other groups. It is urgent that we identify the health and health service needs of autistic adults from young adulthood through old age. Our findings have implications for ensuring adequate health coverage across the lifespan and highlight the importance of a strong and accessible health care system for autistic people. Autism Res 2019, 12: 1541-1550. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Medicaid provides health insurance to disabled people who meet income requirements. We assessed patterns of enrollment and service use among autistic adults and adults with developmental disabilities in Wisconsin Medicaid. We found a consistent influx of new young autistic adults without intellectual disability into the Medicaid system, with fewer visits and lower paid amounts compared to other developmental disability groups. The changing population of autistic people using Medicaid has implications for providing health care to autistic adults in the future. En ligne : http://dx.doi.org/10.1002/aur.2173 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 [article] Is the Autism Boom Headed for Medicaid? Patterns in the Enrollment of Autistic Adults in Wisconsin Medicaid, 2008-2018 [Texte imprimé et/ou numérique] / E. RUBENSTEIN, Auteur ; Lauren BISHOP, Auteur . - p.1541-1550. Langues : Anglais (eng) in Autism Research > 12-10 (October 2019) . - p.1541-1550 Mots-clés : Medicaid  autism spectrum disorder  enrollment  health service  intellectual disability  longitudinal Index. décimale : PER Périodiques Résumé : Our primary objective was to describe demographic characteristics and enrollment patterns in a unique 11-year full sample of adult Wisconsin Medicaid beneficiaries with identified autism spectrum disorder (ASD) or intellectual disability (ID). We obtained de-identified Medicaid claims data for adults with a recorded ASD or ID diagnosis aged 21 and older with any Medicaid fee-for-service claims between January 1, 2008 and December 31, 2018. We assessed enrollment, age, number of visits, and paid amount per year using generalized linear models with a random intercept for each beneficiary. We identified claims for 4,775 autistic adults without ID, 2,738 autistic adults with ID, 14,945 adults with ID, and 3,484 adults with Down syndrome. The age distribution of the diagnostic group with ASD diagnoses was right skewed with a majority of beneficiaries less than age 30. The ASD without ID diagnostic group had the least visits and paid amount per person per year compared to other groups. In each age category, the ASD with ID diagnostic group had the most paid amount per person per year compared to other groups. It is urgent that we identify the health and health service needs of autistic adults from young adulthood through old age. Our findings have implications for ensuring adequate health coverage across the lifespan and highlight the importance of a strong and accessible health care system for autistic people. Autism Res 2019, 12: 1541-1550. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Medicaid provides health insurance to disabled people who meet income requirements. We assessed patterns of enrollment and service use among autistic adults and adults with developmental disabilities in Wisconsin Medicaid. We found a consistent influx of new young autistic adults without intellectual disability into the Medicaid system, with fewer visits and lower paid amounts compared to other developmental disability groups. The changing population of autistic people using Medicaid has implications for providing health care to autistic adults in the future. En ligne : http://dx.doi.org/10.1002/aur.2173 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408

A matter of time: The necessity of temporal language in research on health conditions that present with autism spectrum disorder / E. RUBENSTEIN in Autism Research, 12-1 (January 2019)  

Public ISBD [article]  inAutism Research > 12-1 (January 2019) . - p.20-25 Titre : A matter of time: The necessity of temporal language in research on health conditions that present with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : E. RUBENSTEIN, Auteur ; Lauren BISHOP-FITZPATRICK, Auteur Article en page(s) : p.20-25 Langues : Anglais (eng) Mots-clés : aging  epidemiology  health  mental health Index. décimale : PER Périodiques Résumé : Relatively consistent findings from recent studies using population-level data identify heightened physical and psychiatric morbidity in autistic people compared to the general population. Health problems that commonly present with autism spectrum disorder (ASD) are generally discussed in the literature as "co-occurring" or "comorbid" regardless of their known or hypothesized causal mechanisms. In this commentary, we introduce a new temporally focused terminology to describe health conditions that present with ASD. Emphasizing the temporal development of health conditions in research will help the field understand whether conditions are (1) "truly co-occurring" (share an etiologic origin with ASD in utero and are a defining characteristic of a subphenotype), (2) "resulting" (caused by ASD related disparity or the health effect of behaviors developed to cope with ASD symptoms), or (3) "associated" (conditions more common in individuals with ASD with etiology not yet known or hypothesized, or an artifact of diagnostic process or trends). Whether a health condition is "truly co-occurring", "resulting", or "associated" has implications for how we design interventions to prevent and treat health conditions in people on the autism spectrum. Ultimately, we think that using clear and temporally focused language can set us on a path to better deduce etiology and develop effective prevention and intervention efforts for health conditions that impact the lives of autistic individuals. We hope that this approach to temporal language to describe health conditions that present with ASD promotes thought and discussion in research, advocate, and autistic communities. Autism Research 2019, 12: 20-25. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Research finds autistic people have more health problems than the general population but we do not understand why. In this commentary, we argue researchers need to use language describing the timing of health problems in autistic people, specifying whether problems truly co-occur (share a cause), result from autism-related disparities, or are more common in autistic people for an unknown reason. Clarifying language can provide more specificity in research and improve efforts to prevent and treat health problems in autistic people. En ligne : http://dx.doi.org/10.1002/aur.2010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376 [article] A matter of time: The necessity of temporal language in research on health conditions that present with autism spectrum disorder [Texte imprimé et/ou numérique] / E. RUBENSTEIN, Auteur ; Lauren BISHOP-FITZPATRICK, Auteur . - p.20-25. Langues : Anglais (eng) in Autism Research > 12-1 (January 2019) . - p.20-25 Mots-clés : aging  epidemiology  health  mental health Index. décimale : PER Périodiques Résumé : Relatively consistent findings from recent studies using population-level data identify heightened physical and psychiatric morbidity in autistic people compared to the general population. Health problems that commonly present with autism spectrum disorder (ASD) are generally discussed in the literature as "co-occurring" or "comorbid" regardless of their known or hypothesized causal mechanisms. In this commentary, we introduce a new temporally focused terminology to describe health conditions that present with ASD. Emphasizing the temporal development of health conditions in research will help the field understand whether conditions are (1) "truly co-occurring" (share an etiologic origin with ASD in utero and are a defining characteristic of a subphenotype), (2) "resulting" (caused by ASD related disparity or the health effect of behaviors developed to cope with ASD symptoms), or (3) "associated" (conditions more common in individuals with ASD with etiology not yet known or hypothesized, or an artifact of diagnostic process or trends). Whether a health condition is "truly co-occurring", "resulting", or "associated" has implications for how we design interventions to prevent and treat health conditions in people on the autism spectrum. Ultimately, we think that using clear and temporally focused language can set us on a path to better deduce etiology and develop effective prevention and intervention efforts for health conditions that impact the lives of autistic individuals. We hope that this approach to temporal language to describe health conditions that present with ASD promotes thought and discussion in research, advocate, and autistic communities. Autism Research 2019, 12: 20-25. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Research finds autistic people have more health problems than the general population but we do not understand why. In this commentary, we argue researchers need to use language describing the timing of health problems in autistic people, specifying whether problems truly co-occur (share a cause), result from autism-related disparities, or are more common in autistic people for an unknown reason. Clarifying language can provide more specificity in research and improve efforts to prevent and treat health problems in autistic people. En ligne : http://dx.doi.org/10.1002/aur.2010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376

A Preliminary Epidemiologic Study of Social (Pragmatic) Communication Disorder Relative to Autism Spectrum Disorder and Developmental Disability Without Social Communication Deficits / S. ELLIS WEISMER in Journal of Autism and Developmental Disorders, 51-8 (August 2021)  

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Remembering Dr Li-Ching Lee, a pioneer of global autism research / E. RUBENSTEIN in Autism, 26-2 (February 2022)  

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